Clinical trials: Methylation
Metachronous Neoplasm, Gastric Cancer
Aberrant DNA Methylation to Predict Metachronous Gastric Neoplasms
The study is a prospective cohort study to investigate whether aberrant DNA methylation can be useful for the prediction of metachronous recurrence after endoscopic resection of gastric neoplasms (dysplasia or cancer).
- Conditions
- Metachronous Neoplasm, Gastric Cancer, Gastric Neoplasm, Aberrant DNA Methylation
- Trial name
- NCT04830618
- Volunteers
- 300 people
- Sponsor
- Seoul National University Hospital
Endometrial Cancer, Methylation
Clinical Studies of Endometrial Cytology and Cervical Methylation Assays in Endometrial Cancer Screening and Fertility-Preservation Evaluation
The current study aims to assess high-risk patients using both liquid-based cytology and cervical methylation testing. The results will be compared with the traditional hysteroscopic pathological findings to determine the…
- Conditions
- Endometrial Cancer, Methylation, Cytology, Fertility Preservation
- Trial name
- NCT06672341
- Testing
- Endometrial Cytology Testing, Cervical Methylation Testing
- Volunteers
- 200 people
- Sponsor
- Yulan Ren
Gastric Carcinoma
DNA Methylation Biomarkers and Metastasis of Gastric Carcinoma
Gastric carcinoma (GC) is the second leading cause of cancer death throughout the world. In previous multi-center study, we have found that the prevalence of GDNF family receptor alpha 1(GFRA1), serum response factor (SRF), and…
- Trial name
- NCT02159339
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Peking University Cancer Hospital & Institute
Endocrine Tumors, Thyroid Neoplasms
Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms
Background: Endocrine neoplasms (tumors) are among the fastest growing tumors in incidence in the United States. Furthermore, it is often difficult to distinguish between benign or malignant tumors in cancers of the thyroid…
- Conditions
- Endocrine Tumors, Thyroid Neoplasms, Parathyroid Neoplasms, Adrenal Neoplasm
- Trial name
- NCT01005654
- Where
- United States
- Volunteers
- 2,415 people
- Sponsor
- National Cancer Institute (NCI)
Tension-Type Headache, Unspecified, Intractable
Tension-Type Headache Gene Expression and Methylation
Tension-type headache (TTH) refers to pain radiating from the forehead to the back of the head as a bilateral band. It often occurs without warning and spreads to the neck muscles.
- Trial name
- TTH (NCT06562855)
- Testing
- Peripheral blood sampling
- Where
- 2 sites in Turkey (Türkiye)
- Sponsor
- University of Gaziantep
Autism Spectrum Disorder (ASD)
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study
The goal of this observational study is to investigate the genetic and epigenetic mechanisms that may contribute to the development of Autism Spectrum Disorder (ASD) in individuals of different age groups.
- Trial name
- ASD-Omics-TR (NCT06662591)
- Where
- 20 sites in Turkey (Türkiye)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Research and Treatment Society of Genetic Disorders
Ovarian Neoplasms, Ovarian Cancer
Prospective Sample Collection Study for a Blood-Based cfDNA Methylation Assay for Ovarian Cancer Detection
The goal of this observational study is to learn whether a blood-based cell-free DNA (cfDNA) methylation assay can help detect ovarian cancer, especially early-stage ovarian cancer, in women undergoing clinical evaluation for…
- Conditions
- Ovarian Neoplasms, Ovarian Cancer, Early Detection of Cancer
- Trial name
- NCT07593833
- Testing
- Blood-Based cfDNA Methylation Assay for Ovarian Cancer Detection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tongji Hospital
Bone and Soft Tissue Tumors
Molecular and Clinical Studies of Bone and Soft Tissue Tumors
The goal of this observational study is to learn whether tumors of bone and soft tissue can be sorted into groups by their genes. Today these tumors are named mainly by how they look under a microscope.
- Trial name
- NCT07822204
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska Institutet
Stunting, Development, Child
Methylation, mIcrobiome, NUtritional sTatus, and dEvelopment of Stunted Children
The investigators will conduct a case-control study among under-two children in Lombok Timur, West Nusa Tenggara, Indonesia. The power required to detect changes in epigenetic markers may not be sufficient in the cohort study.
- Conditions
- Stunting, Development, Child, DNA Methylation, Epigenetics
- Trial name
- MINUTES (NCT05779904)
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Oral Epithelial Dysplasia, Mild or Moderate Grade
Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia
Oral epithelial dysplasia (OED) is one of the common precancerous lesions among Chinese adults. Biomarker is not available for detection of malignant potential of OED till now.
- Trial name
- NCT00835341
- Where
- China
- Volunteers
- 93 people
- Sponsor
- Peking University
Mother-Child Interaction
Effects of Contact Restrictions During the COVID-19 Pandemic on Newborns and Their Parents
In the study, the researchers aim to investigate the impact of contact restrictions during the pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on newborns…
- Trial name
- NCT04732702
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University of Cologne
Amelia, Femur Fibula Ulna Syndrome
Methylome Study in Sporadic Limb Malformations
Some limb malformations are known to be sporadic (non hereditary). For these malformations, no molecular cause was identified, even after whole genome sequencing.
- Trial name
- METHYLIMB (NCT05555225)
- Testing
- Methylome
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Leukemia
Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of tissue from patients with cancer the in laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT01229956
- Testing
- DNA methylation analysis, gene expression analysis, microarray analysis
- Volunteers
- 32 people
- Sponsor
- Children's Oncology Group
Mother-Child Interaction
Analysis of Mother-child Interaction and Regulation of Candidate Genes of Stress Signaling Pathways in Mature Infants
The planned study will investigate the quality of mother-child interaction at the age of 6 months as well as the expression and methylation of candidate genes of stress signaling pathway in mature infants.
- Trial name
- NCT03926923
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Cologne
Preterm Birth, Parent-Child Relations
Epigenetics and Protective Factors in the Preterm Infant
Preterm infants (PT) spend their first weeks of life in the Neonatal Intensive Care Unit (NICU) where they are exposed to unfavorable conditions with different effects on child development including long-term alterations in…
- Conditions
- Preterm Birth, Parent-Child Relations, Epigenetics
- Trial name
- EPIC (NCT04804280)
- Testing
- DNA methylation of target genes, Functional Magnetic Resonance Imaging (fMRI) acquisition
- Where
- Italy
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Colorectal Cancer, Adenomatous Polyp of Colon
CRC Screening Using mSEPT9 (Methylated Septin 9) in Chinese Population
The purpose of this study is to evaluate the performance of the SEPT9 gene methylation assay in Colorectal cancer (CRC) high-risk population in Chinese hospitals using the opportunistic screening method.
- Conditions
- Colorectal Cancer, Adenomatous Polyp of Colon, Polyps, Other Disease/Injury
- Trial name
- RESEPT (NCT02540850)
- Where
- 4 sites in China
- Volunteers
- 1,031 people, healthy volunteers welcome
- Sponsor
- BioChain (Beijing) Science and Technology, Inc.
Preterm Birth, Parent-Child Relations
Biological Underpinnings of Socio-emotional Regulation in Preterm Infants and Healthy Controls
Preterm infants (PT) often need to spend their first weeks of life in the Neonatal Intensive Care Unit (NICU) where they are exposed to several adverse conditions.
- Conditions
- Preterm Birth, Parent-Child Relations, Epigenetics
- Trial name
- NCT05253924
- Testing
- DNA methylation of target genes, EEG acquisition
- Where
- Italy
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Tobacco Use Disorder, Smoking Cessation
p16 Methylation for Smoking Cessation
Smoking cessation is often difficult for smokers to achieve for a variety of reasons including: difficulty with nicotine withdrawal, failure to perceive the benefits of smoking cessation, and failure to perceive the risks…
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Lung Cancer
- Trial name
- NCT01038492
- Testing
- p16 Methylation and Lung Cancer Education
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Chronic Myelogenous Leukemia
Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Chronic Phase Who Are Refractory to Imatinib Mesylate (Gleevec)
To determine the safety and efficacy of decitabine in patients with Philadelphia chromosome-positive chronic myelogenous leukemia chronic phase that were previously treated with imatinib mesylate (STI 571) and became…
- Trial name
- NCT00042016
- Testing
- decitabine (5-aza-2'deoxycytidine)
- Where
- 8 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- Astex Pharmaceuticals, Inc.
Asthma, Wheezing
Vitamin C Supplementation to Pregnant Smokers: Follow-up of 2 Randomized Trials Plus Changes in DNA Methylation
In a randomized clinical trial (RCT) published in JAMA, the investigators have provided evidence that vitamin C supplementation (500 mg daily during pregnancy) ameliorates the effects of maternal smoking during pregnancy on…
- Conditions
- Asthma, Wheezing, In Utero Nicotine, Pulmonary Function
- Trial name
- VCSIP-ECHO (NCT03206710)
- Testing
- No current intervention
- Where
- 2 sites in United States
- Volunteers
- 395 people
- Sponsor
- Oregon Health and Science University