Clinical trials: Control
Alopecia Areata
A Trial of Clobetasol Propionate Versus Hydrocortisone in Children With Alopecia Areata
The use of topical steroids in the treatment of alopecia areata in children is common practice. However, no particular potency of steroid is accepted as the standard treatment due to the paucity of high quality evidence in the…
- Trial name
- NCT01453686
- Testing
- Hydrocortisone 1%, Clobetasol Propionate 0.05%
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- The Hospital for Sick Children
Myopia
SEED-LVPEI Myopia Study
This randomized clinical trial study aims to investigate the efficacy of novel SEED's EDOF based mid-lens design in controlling the myopia progression in Indian children with these specific objectives: 1.
- Trial name
- SLIMS (NCT04618510)
- Testing
- SEED 1-dayPure EDOF soft contact lens, Single Vision Spectacles
- Where
- India
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- L.V. Prasad Eye Institute
X-Linked Retinitis Pigmentosa
A Study Comparing Two Doses of AGTC-501 in Male Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (DAWN)
This Phase 2 study is a non-randomized, open-label, study of the safety of AGTC-501 in participants with XLRP who have previously been treated with a full-length AAV vector-based gene therapy targeting RPGR protein.
- Trial name
- NCT06275620
- Testing
- AGTC-501 (high dose and standard corticosteroid regimen), AGTC-501 (low dose and standard corticosteroid regimen), AGTC-501 (high dose and modified corticosteroid regimen)
- Where
- 7 sites in United States
- Volunteers
- 24 people
- Sponsor
- Beacon Therapeutics
Abortion, Induced
Mifepristone Plus Misoprostol Versus Misoprostol Alone for 2nd Trimester Abortion (14 - 21 Weeks Last Menstrual Period (LMP))
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00969982
- Testing
- mifepristone+misoprostol
- Where
- 2 sites in Moldova, Tunisia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Hereditary Angioedema (HAE)
Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE)
The purpose of this study is to determine if a subcutaneous dose of DX-88 (ecallantide; an investigational product) is safe and relieves symptoms of HAE in patients suffering from moderate to severe acute attacks of HAE.
- Trial name
- NCT00262080
- Testing
- ecallantide, Phosphate Buffer Saline (PBS),
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Shire
Myopia Progressing, Childhood
Topical 0.01% Atropine for the Control of Fast Progressing Myopia
Myopia prevalence has dramatically increased worldwide in recent years in the general population and among children. Progressive myopia increases gradually with growth until the age of 20-25 years.
- Trial name
- Myopie-STOP (NCT04173780)
- Testing
- Atropine 0.01%
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Perforated Appendicitis
Surgical Site Infection in Perforated Appendicitis After Peritoneal Lavage With Super-oxidised Solution
This study is to evaluate the effectiveness of peritoneal lavage with super-oxidised solution in reducing surgical site infection after open surgery for perforated appendicitis.
- Trial name
- PLaSSo (NCT04512196)
- Testing
- Superoxidized Water, Normal Saline
- Where
- Malaysia
- Volunteers
- 102 people
- Sponsor
- Hospital Queen Elizabeth, Malaysia
Training, Male
A Study on the Effects of Instability Resistance Training on Dynamic Balance and Rapid Change-of-Direction Ability in College Basketball Recruits
This experiment aims to investigate the effects of unstable resistance training on the dynamic balance ability and rapid directional change mobility of college basketball majors, while comparing it with traditional resistance…
- Conditions
- Training, Male, Athletes
- Trial name
- NCT07697027
- Testing
- Unstable Resistance Training Group, Traditional Resistance Training
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Richen Sun
Molar Incisor Hypomineralization, Dental Caries
Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar incisor hypomineralization (MIH) is a developmental defect of enamel affecting the first permanent molar and frequently the incisors with a prevalence of 16-16.9% in Malaysia.
- Conditions
- Molar Incisor Hypomineralization, Dental Caries, Hypomineralization of Enamel
- Trial name
- NCT04710927
- Testing
- Silver Diamine Fluoride, Papain-Based Gel, High Viscosity Glass Ionomer Cement (HVGIC)
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Emotional Intelligence, Emotion Regulation
The Effects of Group Social Work Intervention on Children's Emotional Intelligence, Emotion Regulation Skills and Empathy Tendencies
The general objective of this study is to determine the effects of an emotion-focused therapy-based group social work intervention on the emotion regulation skills, emotional intelligence, and empathic tendency levels of children…
- Conditions
- Emotional Intelligence, Emotion Regulation, Empathy Skills
- Trial name
- NCT07273786
- Testing
- group social work practice based on emotion-focused therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Color Perception
Determining the Impact of Emotive Intelligent Spaces
Many children (age 3-6) living in the Mountain West (MW) region face unique challenges that can affect their health and welfare, such as lower socioeconomic status, and limited access to healthcare and education.
- Trial name
- EIS (NCT04836286)
- Testing
- Emotive Intelligent Spaces (EIS)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Idaho
Idiopathic Adolescent Scoliosis, Idiopathic Juvenile Scoliosis
Minimal Invasive Scoliosis or Open Surgery
Surgical treatment for idiopathic scoliosis usually involves open surgery from the back (posterior approach). This method corrects the curve and stabilizes the spine using screws and rods, followed by a fusion of the treated…
- Trial name
- MISCOS (NCT07203586)
- Testing
- Minimally invasive scoliosis surgery, Traditional open scoliosis surgery group
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Uppsala University
Melasma, Melasma (Facial Melasma)
Azelaic Acid 20% vs Hydroquinone 4% in Epidermal Melasma
Melasma is a common skin condition that causes dark patches on the face and can significantly affect quality of life. This study compared two commonly used topical treatments, 20% azelaic acid and 4% hydroquinone, in adults with…
- Trial name
- NCT07327983
- Testing
- Topical Azelaic Acid 20% Cream, Topical 4% hydroquinone cream
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- Gujranwala medical college District Headquarters Hospital, Gujranwala
Mental Health, Stigma, Social
"EspaiJove.Net"- a School-based Intervention Program to Promote Mental Health in Adolescent Population
Objective: To evaluate the efficacy of 3 sensitivity and mental health literacy programs for young students in the increase of mental health knowledge, to help seeking and reducing the stigma in order to prevent mental disorders…
- Trial name
- NCT03215654
- Testing
- "EspaiJove.net" mental health literacy program
- Where
- 2 sites in Spain
- Volunteers
- 432 people
- Sponsor
- Centre d'Higiene Mental Les Corts
Keratoconus
Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus
The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression…
- Trial name
- NCT01972854
- Testing
- riboflavin solution, KXL System
- Where
- 11 sites in United States
- Volunteers
- 92 people
- Sponsor
- Glaukos Corporation
Emotion Journal, Pediatric Intensive Care
Emotion Diary Application
Pediatric patients, hospitalization in a pediatric intensive care unit (PICU) is not merely a situation requiring physical treatment, but also an experience that has significant psychosocial effects.
- Conditions
- Emotion Journal, Pediatric Intensive Care, Emotion Regulation, Emotional Awareness
- Trial name
- NCT07860190
- Testing
- Emotion Diary Administration
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Gazi University
Medication Adherence, Depressive Symptoms
Testing THRIVE 365 for Black Sexual Minority Men (On The Daily)
The primary goal of this study is to test a minority stress model of psychological health outcomes for Black sexual minority men (BSMM) while using and not using a novel intervention named THRIVE 365.
- Conditions
- Medication Adherence, Depressive Symptoms, Anxiety Symptoms, Emotion Regulation
- Trial name
- OTD (NCT05376397)
- Testing
- iTHRIVE 365
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Outpatients, Virtual Clinic
A Study Comparing Three Methods of Outpatient Follow up After Surgical Admission; Text Message, Phone Call and In-person Appointment
This study compares three different methods of outpatient follow up after surgical admission to Connolly Hospital Blanchardstown. The three arms of the study are text message, telephone call or in-person outpatient follow up.
- Conditions
- Outpatients, Virtual Clinic, Text Messaging, General Surgery
- Trial name
- ISOTOPE (NCT04245020)
- Testing
- Text message follow up, Telephone follow up, In person follow up
- Where
- Ireland
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Connolly Hospital Blanchardstown
T-Cell Lymphocytic Leukemia, ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
BuCy Vs. TBICy for Allo-HSCT in T-ALL Patients
T-cell acute lymphoblastic leukemia (T-ALL), a hematological malignant neoplasm of immature T cells, accounting for a morbidity of 10-15% among pediatric and 20-25% among adult patients of ALL.
- Conditions
- T-Cell Lymphocytic Leukemia, ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION, Total Body Irradiation, Chemotherapy
- Trial name
- NCT06673459
- Testing
- TBICy, BuCy
- Where
- China
- Volunteers
- 430 people
- Sponsor
- The First Affiliated Hospital of Soochow University
White Spot Lesion of Tooth, Orthodontic Treatment
S-PRG Filler for Preventing White Spot Lesions During Orthodontic Treatment
White spot lesions are early areas of enamel demineralization that may develop during orthodontic treatment with fixed braces. This study aims to evaluate the effectiveness of S-PRG Barrier Coat in preventing white spot lesions…
- Conditions
- White Spot Lesion of Tooth, Orthodontic Treatment, Enamel Demineralization, Fluoride Varnishes
- Trial name
- SPRG-WSL (NCT07839780)
- Testing
- S-PRG Barrier Coat, S-PRG Barrier Coat + 5% Sodium Fluoride Varnish, 5% sodium fluoride varnish
- Where
- Malaysia
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
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