Clinical trials: Bronchiectasis
Bronchiectasis Adult, Lung Infection
The Effect of Long Term Therapy With High Flow Humidification Compared to Usual Care in Patients With Bronchiectasis (BX)
The study is intended to understand the benefit of Long Term Home care Therapy with nasal High flow in Bronchiectasis patients at home.
- Conditions
- Bronchiectasis Adult, Lung Infection, Quality of Life, Humidifier Lung
- Trial name
- BX (NCT04142827)
- Testing
- High Flow Humidification
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Dr. Giuseppe Fiorentino
Healthy Children, Bronchiectasis Adult
The Utility of Lung Clearance Index in Ethnic Groups and in Disease
Introduction: Non-CF, non-PCD bronchiectasis in children is a chronic, suppurative lung disease diagnosed by high resolution computed tomography (HRCT) imaging of the lungs.
- Conditions
- Healthy Children, Bronchiectasis Adult, Lung Clearance Index
- Trial name
- LUCI-ED (NCT05989360)
- Testing
- Lung Clearance Index
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Non-Cystic Fibrosis Bronchiectasis
A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis
The primary objective of this study is to evaluate the effect of brensocatib at 10 mg and 25 mg compared with placebo on the rate of pulmonary exacerbations (PEs) over the 52-week treatment period.
- Trial name
- ASPEN (NCT04594369)
- Testing
- Brensocatib 10 mg, Brensocatib 25 mg
- Where
- 373 sites in United States, Argentina and 34 more
- Volunteers
- 1,767 people
- Sponsor
- Insmed Incorporated
Hay Fever, Asthma
Evaluating the Potential of Large Language Models for Respiratory Disease Consultations
The clinical trial aimes to evaluate multiple large language models in respiratory disease consultations by comparing their performance to that of human doctors across three major medical consultation scenarios.
- Conditions
- Hay Fever, Asthma, Acute Upper Respiratory Infection, Pulmonary Embolism
- Trial name
- EPLLMMRDC (NCT06457269)
- Testing
- Diagnosis by three human doctors, Diagnosis by ChatGPT-3.5 (with search capabilities), Diagnosis by ChatGPT-3.5 (without search capabilities)
- Where
- China
- Volunteers
- 703 people
- Sponsor
- North Sichuan Medical College
Bronchiectasis
Does Addition of Oscillatory Positive Expiratory Pressure (OPEP) Device to a Chest Physiotherapy Program Provide Further Health Benefits in Children With Bronchiectasis?
Oscillatory positive expiratory pressure (OPEP) devices such as Flutter®, Aerobika® or Shaker ® are commonly prescribed in the clinical practice for airway clearance in children with chronic lung diseases including…
- Trial name
- NCT05034900
- Testing
- Chest physiotherapy, Oscillatory Positive Expiratory Pressure (OPEP) device
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Izmir Bakircay University
Pediatric Patients With Bronchiectasis
Determination of Physical Fitness Level in Bronchiectasis
The aim of this study is to assess the physical fitness level of children with bronchiectasis. To determine your physical fitness level, we will conduct some game-like tests.
- Trial name
- NCT07121218
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Melis Usul
Bronchiectasis
Long-term Prognosis of Children With Bronchiectasis Treated With Low-dose Erythromycin Intervention
According to their compliance, the children were divided into two groups: low dose erythromycin treated group (erythromycin 3-5mg/kg.d orally for 6 months) and non-erythromycin treatment group.
- Trial name
- NCT03966066
- Testing
- erythromycin
- Volunteers
- 70 people
- Sponsor
- Beijing Children's Hospital
Chronic Respiratory Disease, Cystic Fibrosis
The Effect of Proprioceptive Neuromuscular Facilitation (PNF) Technique for Children With Chronic Pulmonary Diseases.
Cystic fibrosis and bronchiectasis are the most seen problems in children with chronic pulmonary diseases. İt is a genetic, chronic system disease that reduces life expectancy, and life quality as well.
- Conditions
- Chronic Respiratory Disease, Cystic Fibrosis, Bronchiectasis
- Trial name
- NCT03420209
- Testing
- Group applying PNF technique
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Bronchiectasis
Airway Clearance in Bronchiectasis: is Non-Invasive Ventilation a Useful Adjunct in Moderate to Severe Disease?
This clinical trial is investigating the efficacy of Non Invasive Ventilation (NIV) as a method of airway clearance in patients with an acute exacerbation and moderate to severe bronchiectasis disease.
- Trial name
- NCT00522314
- Testing
- NIV and ACBT, Active Cycle of Breathing Techniques
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Ulster
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
The purpose of this research study is to learn about the safety of transplanting lungs obtained from non-heart-beating donors (NHBDs) that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01615484
- Testing
- Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Bronchiectasis
Safety and Efficacy of Bronchitol in Bronchiectasis
Study will assess the safety and effectiveness of 12 week treatment with the study medication, Bronchitol, in subjects with bronchiectasis (a lung disease where patients have trapped, and often infected, thick, sticky mucus).
- Trial name
- NCT00277537
- Testing
- Mannitol
- Where
- 22 sites in Australia, New Zealand and 1 more
- Volunteers
- 354 people
- Sponsor
- Syntara
Bronchiectasis
Trial on The Efficacy of Hypertonic Saline on Non-CF CSLD.
To determine the efficacy of nebulized 5% hypertonic saline on cough severity and quality of life, in children with non-CF CSLD. Secondary Aims: To determine the: 1.
- Trial name
- NCT04765033
- Testing
- Nebulized 5% Hypertonic saline
- Where
- Malaysia
- Volunteers
- 46 people
- Sponsor
- University of Malaya
Primary Ciliary Dyskinesia, Kartagener Syndrome
International Primary Ciliary Dyskinesia Cohort
The iPCD Cohort is an international cohort that assembles available retrospective datasets and prospectively newly collected clinical and diagnostic data from patients suffering from primary ciliary dyskinesia (PCD) worldwide, to…
- Trial name
- iPCD (NCT03517865)
- Where
- Switzerland
- Volunteers
- 3,400 people
- Sponsor
- University of Bern
Non-cystic Fibrosis Bronchiectasis
Procalcitonin as a Marker of Severity of Non-cystic Fibrosis Bronchiectasis in Children
The aim of this study is to evaluate the role of procalcitonin in bronchoalveolar lavage as a biomarker for assessment of severity of non-CF bronchiectasis in children in correlation with other markers (functional and…
- Trial name
- NCT06352944
- Testing
- procalcitonin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Bronchiectasis With Pseudomonas Aeruginosa Colonization
A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization
AZD0292 is a bispecific IgG1k mAb being evaluated for the prevention of exacerbations in bronchiectasis patients chronically colonized with PsA.
- Trial name
- CLEAR (NCT07088926)
- Testing
- AZD0292
- Where
- 186 sites in United States, Argentina and 23 more
- Volunteers
- 435 people
- Sponsor
- AstraZeneca
Primary Ciliary Dyskinesia
Early Detection and Characterization of Primary Ciliary Dyskinesia
Primary Ciliary Dyskinesia (PCD) is a severe genetic disorder caused by various mutations in genes affecting ciliary motility. Various new and complementary diagnostic techniques, including measurements of nasal nitric oxide…
- Trial name
- NCT01070914
- Where
- Israel
- Volunteers
- 130 people
- Sponsor
- Ziv Hospital
Bronchiectasis
The Effect of Different Virtual Reality-Based Exercise Trainings on Pulmonary Function, Respiratory and Peripheral Muscle Strength, Functional Capacity and Balance in Children With Bronchiectasis
Bronchiectasis is defined as abnormal, chronic and permanent enlargement of one or more bronchi. Disease symptoms; often productive cough, dyspnea, fatigue and wheezing.
- Trial name
- NCT04038892
- Testing
- Conventional Chest Physiotherapy, Nintendo Wii Fit Based Exercise Training, BreathingLabs Breathing Games Based Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Bezmialem Vakif University
Bronchiectasis
Comparison of Sit-to-stand Test With Six-minute Walk Test in Bronchiectasis and Healthy Children
Children with bronchiectasis and age-matched healthy controls will be evaluated with sit-to-stand test and six-minute walk test and utilization of STST in determining functional capacity will be investigated.
- Trial name
- NCT04153448
- Testing
- Measurement of functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Bronchiectasis
Aetiology of Children With Bronchiectasis in China
This multicenter retrospective observation study is designed to investigate the etiology of children with bronchiectasis by review the medical records.
- Trial name
- NCT02555865
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Children's Hospital
Kartagener Syndrome
Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease
Primary ciliary dyskinesia (PCD), also known as Kartagener syndrome, is a genetic disorder of the cilia, which are microscopic hair-like cells.
- Trial name
- NCT00722878
- Where
- 6 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill