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Anterior Cruciate Ligament Reconstruction (ACLR)NCT07862881

The Effect of Plyometric Training in Post-ACLR Surgery

A study testing Standard program and Plyometrics Training in people with Anterior Cruciate Ligament Reconstruction (ACLR) and Anterior Cruciate Ligament Reconstruction Rehabilitation, run by Cairo University at 1 site in Egypt.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

The primary goal of this RCT is to evaluate the effect of adding plyometric training on standard program intervention in patients aged 18-40 years who have undergone ACLR surgery. Read more about this study

Who is it for?
Ages 18 to 40 years
What is being tested?
Standard program and Plyometrics Training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
40 participants
Where
1 siteEgypt
Study dates
1 Oct 2026to 1 May 2027
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 40 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Age 18-40 years
  • Primary unilateral ACL reconstruction
  • Reconstruction using bone-patellar tendon-bone (BPTB) or hamstring tendon (HT) autograft
  • Cleared by operating surgeon for progressive resistance and functional training
  • Able to perform full weight-bearing ambulation without assistive devices

Who cannot join

  • Revision ACL reconstruction
  • Associated grade III ligament injury
  • Meniscal repair (meniscectomy is not an exclusion)
  • Concomitant chondral defect requiring surgical intervention or cartilage repair
  • Contralateral lower limb injury within the preceding 12 months
  • Body mass index (BMI) > 35 kg/m²

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Ahmed El Melhat, PhD contact

+201112595022

ahmed.elmelhat@cu.edu.eg

Marwa J. Awkal, DPT contact

81666932 ext. +961

marwaawkal3@gmail.com

Egypt1 site, 1 recruiting

  • PTOC South Valley University

    Qina, Qena Governorate, 2356

    Ahmed El Melhat, PhD, +201112595022 ext. +961, ahmed.elmelhat@cu.edu.eg

    Marwa J. Awkal, DPT, 81666932 ext. +961, marwaawkal3@gmail.com

    Recruiting

Other trials in Egypt

About this study

Official title: The Effect of Adding Plyometric Training to Rehabilitation Program in Post-ACL Reconstruction Surgery

The primary goal of this RCT is to evaluate the effect of adding plyometric training on standard program intervention in patients aged 18-40 years who have undergone ACLR surgery.

The primary question to answer is does adding plyometrics training to the standard rehabilitation program has superior effect in the improvement of muscular strength, dynamic balance and functional performance in ACLR patients. Participants will be divided into two groups. Group 1 (control) receives standard program for 24 weeks, and Group 2 (interventional) receives the same standard program for 16 weeks, followed by adding plyometrics for additional 8 weeks alongside with the standard program (total of 24 weeks).

Read the detailed description

Achieving full recovery after ACLR is still challenging as persistent deficits of muscular strength have still reported. Plyometrics consists of rapid muscle stretch (eccentric action) followed immediately by a shortening (concentric action) of the same muscle and connective tissue.

This study hypothesizes that adding plyometric training to standard physiotherapy will improve muscular strength, proprioception, dynamic balance and functional performance

Being tested
Standard program, Plyometrics Training
Keywords
plyometrics training, plyometrics, muscular strength, peak torque, functional performance, dynamic balance, proprioception

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Standard programOther

    Participants will receive only standard therapy for 24 weeks.

  • Plyometrics TrainingOther

    Participants will receive standard therapy for 16 weeks, followed by an additional 8 weeks of plyometrics training alongside with standard therapy. (total=24 weeks).

Study groups in NCT07862881
Study groupRoleWhat they receive
Control GroupExperimentalThe subjects will receive standard rehabilitation program.
Receives: Other: Standard program
Plyometrics GroupExperimentalThe subjects will receive Plyometrics Training added to the standard rehabilitation program.
Receives: Other: Standard program; Other: Plyometrics Training

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Joint Position Sense (JPS)

    JPS was assessed by the Biodex System 4Pro isokinetic dynamometer by the Active Angle Reproduction technique (AAR) with eyes closed. The measurements are taken along 30° and 60° for both involved and uninvolved legs. The mean reproduced angle value is calculated at each angle to then calculate the JPS error. The smaller the error, the better the participant's perception of joint position is.

    Measured: Baseline (week 16), post-intervention (week 24) and follow up (week 32).

Secondary outcomes (3)

  1. Dynamic Stability

    Y-Balance Test is used to assess stability and balance in different directions. It is performed by leg reaches along 3 dimensions: anterior, posteromedial and posterolateral. The participant stands on one leg and reaches as far as possible with the second one along all three dimensions.

    Measured: Baseline (week 16), post-intervention (week 24) and follow up (week 32).

  2. Isokinetic Quadriceps Peak Torques Normalized to Body Weight

    The peak torque of quadriceps at 60°/s and 180°/s is considered as the highest peak torque along the 5 repetitions, each. It is then normalized to body mass by the following equation: PTrelative = Peak Torque (Nm) / Body Mass (kg).

    Measured: Baseline (week 16), post-intervention (week 24) and follow up (week 32).

  3. Functional Performance test

    For the distance tests (single-leg, triple ho, crossover hop), the longest distance (cm) is the best and is measured in centimeters using calibrated floor markings. For the time related test (6-meter timed hop), the shortest time (s) is considered and is measured using a digital stopwatch. For all four hop tests, 3 trials will be performed. The best trial will be taken to statistical analysis.

    Measured: Baseline (week 16), post-intervention (week 24) and follow up (week 32).

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted7 Oct 2026
  2. Study start1 Oct 2026 (estimated)
  3. Primary completion1 Apr 2027 (estimated)
  4. Study completion1 May 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Outcomes assessor
Enrolment
40 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07862881
Sponsor's protocol ID
ACLR-Plyo-2026
Status last verified
Oct 2026
First submitted
2 Oct 2026
Last updated
15 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Kasmi S, Zouhal H, Hammami R, Clark CCT, Hackney AC, Hammami A, Chtara M, Chortane SG, Salah FZB, Granacher U, Ounis OB. The Effects of Eccentric and Plyometric Training Programs and Their Combination on Stability and the Functional Performance in the Post-ACL-Surgical Rehabilitation Period of Elite Female Athletes. Front Physiol. 2021 Jul 2;12:688385. doi: 10.3389/fphys.2021.688385. eCollection 2021.

    PubMed 34276409

  • Zhao Y, Chen Z, Li L, Wu X, Li W. Changes in proprioception at different time points following anterior cruciate ligament injury or reconstruction. J Orthop Surg Res. 2023 Jul 31;18(1):547. doi: 10.1186/s13018-023-04044-5.

    PubMed 37518000

  • Kipp JD, Bednarek AL, Sherry MA, Keefe MW, Chumanov ES. Isokinetic Quadriceps and Hamstring Peak Torque in Athletes Aged 10-50+: Preoperative Uninvolved Limb Reference Values for ACL Reconstruction. Int J Sports Phys Ther. 2026 Sep 1;21(9):832-842. doi: 10.26603/001c.166786. eCollection 2026.

    PubMed 42694075

  • Buckthorpe M, Della Villa F. Recommendations for Plyometric Training after ACL Reconstruction - A Clinical Commentary. Int J Sports Phys Ther. 2021 Jun 1;16(3):879-895. doi: 10.26603/001c.23549.

    PubMed 34123540

Questions about this trial

What is this clinical trial studying?

A study testing Standard program and Plyometrics Training in people with Anterior Cruciate Ligament Reconstruction (ACLR) and Anterior Cruciate Ligament Reconstruction Rehabilitation, run by Cairo University at 1 site in Egypt.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 15 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Ahmed El Melhat, PhD (+201112595022, ahmed.elmelhat@cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Joint Position Sense (JPS) (time frame: Baseline (week 16), post-intervention (week 24) and follow up (week 32).). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07862881, which also lists 4 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Oct 2026.

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