Clinical trials: ACL Reconstruction
Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy
Vitamin D to Improve Quadricep Muscle Strength
Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle…
- Conditions
- Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05174611
- Testing
- Vitamin D3
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Pain, Postoperative
A Multicentre, Double-Blind, Double-Dummy, Randomised Study of the Analgesic Efficacy and Safety of Valdecoxib Compared to Diclofenac Sodium in Patients Undergoing Knee Arthroscopy for Anterior Cruciate Ligament (ACL) Reconstruction
To demonstrate non-inferiority of valdecoxib 20 mg twice daily (BID) (with an initial loading dose of 40 mg followed by a second dose of 20 mg on the first day only) with diclofenac sodium delayed release 75 mg BID in analgesic…
- Trial name
- NCT00650598
- Testing
- valdecoxib, diclofenac
- Where
- 25 sites in Australia, Hong Kong and 7 more
- Volunteers
- 328 people
- Sponsor
- Pfizer
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Exploring Prolonged AMR in ACL Reconstructed Patients
The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, ACL
- Trial name
- NCT06430775
- Where
- Belgium
- Volunteers
- 190 people
- Sponsor
- University Ghent
ACL - Anterior Cruciate Ligament Rupture
Intraoperative Analysis of Knee Kinematics During ACL Reconstruction - an Exploratory Study
Reconstruction of anterior cruciate ligament (ACL) is a common procedure in orthopaedic surgery, aimed at restoring stability to your knee.
- Trial name
- CINEGEN (NCT07655726)
- Testing
- Knee Cinematics
- Where
- France
- Volunteers
- 30 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
ACL
ACL-reconstruction vs ACL-reconstruction With EAT
The purpose of this study is to asses functional biomechanical outcomes and patient reported outcome measures following single bundle ACL reconstruction (ACL-R) compared to single bundle ACL reconstruction and extra articular…
- Trial name
- NCT02913404
- Testing
- ACL Reconstruction, ACL Recon. extra-articular-tenodesis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Sleep
Synovial Fluid Sleep Study
This is an observational study of the relationship between perioperative sleep time/quality, synovial fluid cytokine profiles, and clinical outcomes of primary ACL reconstruction with BPTB autograft in 50 subjects.
- Trial name
- NCT04688099
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Anterior Cruciate Ligament (ACL) Reconstruction
Subdermal Implant-bioabsorbable Oxandrolone Pellet For Rehabilitation Following Anterior Cruciate Ligament (ACL) Surgical Reconstruction
Rehabilitation of knee stability and function after anterior cruciate ligament (ACL) reconstruction is slow and costly. The use of anabolic steroids, such as oxandrolone, may aid in the recovery of muscle mass and strength, as…
- Trial name
- IMOX (NCT06974526)
- Testing
- Oxandrolone
- Where
- 6 sites in Brazil
- Volunteers
- 96 people
- Sponsor
- Science Valley Research Institute
Anterior Cruciate Ligament Rupture, Knee Instability
Single and Double Bundle ACL Reconstructions, in Term of Cartilage Damage Due to Remaining Instability After Surgery.
The prevalence of ACL (Anterior Cruciate Ligament) ruptures is relatively high, primarily due to sports and military training injuries.
- Conditions
- Anterior Cruciate Ligament Rupture, Knee Instability, Cartilage Damage
- Trial name
- ACL (NCT04626999)
- Testing
- Single Bundle ACL Reconstruction, Double Bundle ACL Reconstruction
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Anterior Cruciate Ligament Rupture, Ligament Knee Injury
Combined Intra- and Extra-articular ACL Reconstruction Versus Isolated Intra-articular ACL Reconstruction
Abstract Introduction: Autologous hamstring tendons are the most commonly used grafts in ACL reconstruction worldwide. There are several ways to prepare the graft using these tendons.
- Trial name
- NCT06505525
- Testing
- Extra-articular reconstruction with the Anterolateral Ligament
- Where
- 2 sites in Brazil
- Volunteers
- 146 people
- Sponsor
- Federal University of São Paulo
Post ACL Reconstruction
Rate of Force Development vs Isometric Strength of Quadriceps
Peak isometric strength of quadriceps (QI) has been used to help determine an athletes ability to safely return back to sport following an anterior cruciate ligament (ACL) reconstruction surgery.
- Trial name
- NCT04005274
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Kaiser Permanente
Anterior Cruciate Ligament Injury, Knee Injuries
Sensory Deficit Following ACL Reconstruction: PRF Pilot Study
Pilot, single-center, non-randomized, parallel-group clinical study designed to assess whether intraoperative application of autologous platelet-rich fibrin (PRF) at the bone-patellar tendon-bone (BPTB) donor site reduces…
- Conditions
- Anterior Cruciate Ligament Injury, Knee Injuries, Sensory Disorders, Bone-Patellar Tendon-Bone Autograft
- Trial name
- PRF-ACL (NCT07257666)
- Testing
- Platelet-rich fibrin (PRF), Standard Closure (Control)
- Where
- Serbia
- Volunteers
- 53 people
- Sponsor
- University of Belgrade
Anterior Cruciate Ligament Reconstruction
Anterior Cruciate Ligament (ACL) Reconstruction Using Different Grafts and Surgical Techniques
ACL reconstruction in the Division of Orthopaedic surgery at Queen's is currently being performed arthroscopically assisted. The resultant function of the reconstructed ligament is greatly influenced by the placement of the…
- Trial name
- NCT00300300
- Testing
- Computer-assisted surgery
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- Queen's University
Knee Injuries, Rehabilitation
Biomechanical Determinants of Different Rehabilitation Protocols for ACL Reconstruction
Purpose of the study is to investigate the effects of the criterion rehabilitation protocol versus accelerated rehabilitation protocol on the biomechanical determinants of the quality of performance and risk of reinjury.
- Trial name
- NCT05733936
- Testing
- rehabilitation protocol
- Where
- Egypt
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial
In primary pediatric Anterior cruciate ligament (ACL) reconstruction, the quadriceps tendon with either tendon and patellar bone or an all-tendon graft is commonly employed.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT04039971
- Testing
- ACL Reconstruction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Pain, Postoperative, Knee Arthroscopy
Postoperative Pain Between ACB and FNB After ACLR
The aim of this study is to compare the efficacy in pain relief within 24 hours between adductor canal block and femoral nerve block after anterior cruciate ligament reconstruction with hamstring graft.
- Conditions
- Pain, Postoperative, Knee Arthroscopy, Anterior Cruciate Ligament/Surgery
- Trial name
- NCT02411890
- Testing
- Adductor canal block (active), Femoral nerve block (active)
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Thammasat University
PRP, ACL
Prospective Analysis of Introperative RegenLab PRP and Hyaluronic Acid in Patients With Knee ACL Tear
Purpose: The purpose of this article is to examine the clinical application of PRP and PRP+hyaluronic acid in disorders in the knee.
- Conditions
- PRP, ACL, Hyaluronic Acid
- Trial name
- NCT04586361
- Testing
- RegenLab PRP, hyaluronic acid, normal saline
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
ACL - Anterior Cruciate Ligament Rupture
Optimizing Graft Selection for ACL Reconstruction
Purpose: To investigate the differences between the three most common methods for reconstruction of the anterior cruciate ligament (ACL), to support the development of the best method for the individual patient.
- Trial name
- GRASE-ACL (NCT05342441)
- Testing
- QT graft, ST/Gr graft, BPTB graft
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Hvidovre University Hospital
Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy
The Effect of PEMF for Patients With Quadriceps Muscle Weakness After ACLR
In Hong Kong, over 3000 Anterior Cruciate Ligament Reconstructions (ACLR) are performed each year in order to restore knee function after an ACL injury. The ultimate goal of ACLR is to fulfil the return-to-play (RTP) criteria.
- Trial name
- NCT05184023
- Testing
- Pulse Electromagnetic Field
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
ACL Injury
ACL Reconstruction: Clinical Outcome
The study is intended to include all patients who will undergo surgical reconstruction of the anterior cruciate ligament (ACL). The patients will be monitored and evaluated preoperatively and also at 6 months and 1, 2 and 5 years…
- Trial name
- RIC-ACL (NCT03441659)
- Testing
- ACL reconstruction
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Stefano Zaffagnini
Anterior Cruciate Ligament Injuries
Prognosis Study of Different Anterior Cruciate Ligament Surgery Methods
From June 1, 2016, to July 1, 2017, a total of 406 patients with ACL rupture were randomly assigned to three different ACL surgeries: anatomical single-bundle, central axial single-bundle and double-bundle.
- Trial name
- ACLRSurgRCT (NCT05400460)
- Testing
- Anatomical single-bundle reconstruction（ASBR method）, Double-bundle reconstruction （DBR method）, Central axial single-bundle reconstruction（CASBR group）
- Volunteers
- 406 people
- Sponsor
- Yu Jiakuo