Anterior Cruciate Ligament ReconstructionNCT07859397
Comparison of Analgesic Effects of ACB Versus ACB Combined With BiFeS Block in ACL Reconstruction Surgery
A study testing Adductor Canal Block and BiFeS Block in people with Anterior Cruciate Ligament Reconstruction and Pain Management, run by Ankara Etlik City Hospital at 1 site in Turkey (Türkiye).
Trial summary
Anterior cruciate ligament (ACL) reconstruction is commonly associated with moderate to severe postoperative pain, particularly during the early postoperative period and rehabilitation. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Anterior Cruciate Ligament Reconstruction, Pain Management
- What is being tested?
- Adductor Canal Block and BiFeS Block
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 110 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 5 Oct 2026to 27 Oct 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients aged 18-65 years
- Patients scheduled for elective unilateral anterior cruciate ligament reconstruction surgery
- American Society of Anesthesiologists physical status I-III
- Patients who provide written informed consent
Who cannot join
- Age <18 or >65 years
- ASA physical status IV or higher
- Coagulopathy or ongoing anticoagulant therapy incompatible with peripheral nerve block
- Infection at the block injection site
- Patient refusal
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Ankara Etlik City Hospital
Ankara, 06170
Atakan Sezgi, MD, 00905323327000, kansezgi@gmail.com
Jülide Ergil, Professor, 00905323469216, julideergil@hotmail.com
About this study
Official title: Comparison of Postoperative Analgesic Effects of Adductor Canal Block Versus Adductor Canal Block Combined With Biceps Femoris Short Head Block in Patients Undergoing Anterior Cruciate Ligament Reconstruction Surgery
Anterior cruciate ligament (ACL) reconstruction is commonly associated with moderate to severe postoperative pain, particularly during the early postoperative period and rehabilitation. Effective postoperative analgesia is important to facilitate early mobilization, improve patient comfort, and reduce opioid consumption and opioid-related adverse effects.
Adductor canal block (ACB) is commonly used as part of multimodal analgesia for knee surgery because it provides analgesia while largely preserving quadriceps motor function. However, ACB primarily targets the anteromedial aspect of the knee and may provide limited analgesia for pain arising from the posterior and posterolateral knee.
Read more
The biceps femoris short head (BiFeS) block is a motor-sparing fascial plane block targeting sensory contributions to the posterolateral knee region. Combining BiFeS block with ACB may therefore provide more comprehensive analgesia than ACB alone.
This randomized study aims to compare the postoperative analgesic efficacy of adductor canal block alone with adductor canal block combined with BiFeS block in patients undergoing anterior cruciate ligament reconstruction surgery.
- Being tested
- Adductor Canal Block, BiFeS Block
- Keywords
- Anterior Cruciate Ligament Reconstruction, Adductor Canal Block, Biceps Femoris Short Head Block
- Medical subject headings
- Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Adductor Canal BlockProcedure or surgery
Ultrasound-guided adductor canal block will be performed using 10 mL of 0.25% bupivacaine.
BiFeS BlockProcedure or surgery
Ultrasound-guided BiFeS block will be performed using 20 mL of 0.25% bupivacaine.
| Study group | Role | What they receive |
|---|---|---|
| Adductor Canal Block Group | Active comparator | After induction of general anesthesia, an ultrasound-guided adductor canal block will be performed on the operative side. A linear ultrasound transducer will be placed transversely over the mid-thigh to identify the sartorius muscle, femoral artery, vastus medialis muscle, and adductor canal. A block needle will be advanced using an in-plane technique. After negative aspiration, 10 mL of 0.25% bupivacaine will be injected into the adductor canal. Appropriate spread of the local anesthetic will be confirmed by ultrasound imaging.
All patients will receive standardized postoperative multimodal analgesia consisting of intravenous paracetamol 1 g every 8 hours and intravenous dexketoprofen 50 mg twice daily. Receives: Procedure: Adductor Canal Block |
| Adductor Canal Block + BiFeS Block Group | Active comparator | After induction of general anesthesia, an ultrasound-guided adductor canal block will first be performed on the operative side using the same technique as in the adductor canal block group.
Subsequently, an ultrasound-guided biceps femoris short head (BiFeS) block will be performed. The ultrasound transducer will be positioned at the distal thigh to identify the short head of the biceps femoris muscle and the lateral femoral cortex. A block needle will be advanced using an in-plane technique toward the fascial plane between the biceps femoris short head muscle and the lateral femoral cortex. After negative aspiration, local anesthetic will be injected into this fascial plane, and adequate spread will be confirmed using ultrasound imaging.
All patients will receive standardized postoperative multimodal analgesia consisting of intravenous paracetamol 1 g every 8 hours and intravenous dexketoprofen 50 mg twice daily. Receives: Procedure: Adductor Canal Block; Procedure: BiFeS Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Score
Pain will be assessed at rest using the visual analog scale on a scale from 0 (no pain) to 100 (worst pain). Pain assessment will be done at 6th hour after surgery.
Measured: On the operation day
Secondary outcomes (2)
Pain Scores
Pain will be assessed at rest using the visual analog scale on a scale from 0 (no pain) to 100 (worst pain). Pain assessment will be done at 0st, 1st, 2nd, 12th, and 24th hours after surgery.
Measured: On the operation day
Total Postoperative Morphine Consumption During the First 24 Hours AfterSurgery
Total Postoperative Morphine Consumption During the First 24 HoursAfter Surgery
Measured: On the operation day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Oct 2026
- Study start5 Oct 2026
- Primary completion13 Oct 2027 (estimated)
- Study completion27 Oct 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Anterior Cruciate Ligament ReconstructionStudies of the same condition, open and under way.
- More trials run by Ankara Etlik City HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 110 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ankara Etlik City Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Atakan Sezgi, Ankara Etlik City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07859397
- Sponsor's protocol ID
- AEŞH-EK-2026-208
- Status last verified
- Oct 2026
- First submitted
- 30 Sep 2026
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Postoperative Analgesic Effects of Adductor Canal Block Versus Adductor Canal Block Combined With Biceps Femoris Short Head Block in Patients Undergoing Anterior Cruciate Ligament Reconstruction Surgery
- ClinicalTrials.gov ID
- NCT07859397
- Acronym / sponsor ID
- AEŞH-EK-2026-208
- Keywords
- Anterior Cruciate Ligament Reconstruction, Adductor Canal Block, Biceps Femoris Short Head Block
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 110 participants (estimated)
- Lead sponsor
- Ankara Etlik City HospitalOther government
- Study start
- 5 Oct 2026 (actual)
- Primary completion
- 13 Oct 2027 (estimated)
- Study completion
- 27 Oct 2027 (estimated)
- First posted
- 5 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Anterior cruciate ligament (ACL) reconstruction is commonly associated with moderate to severe postoperative pain, particularly during the early postoperative period and rehabilitation. Effective postoperative analgesia is important to facilitate early mobilization, improve patient comfort, and reduce opioid consumption and opioid-related adverse effects.
Adductor canal block (ACB) is commonly used as part of multimodal analgesia for knee surgery because it provides analgesia while largely preserving quadriceps motor function. However, ACB primarily targets the anteromedial aspect of the knee and may provide limited analgesia for pain arising from the posterior and posterolateral knee.
The biceps femoris short head (BiFeS) block is a motor-sparing fascial plane block targeting sensory contributions to the posterolateral knee region. Combining BiFeS block with ACB may therefore provide more comprehensive analgesia than ACB alone.
This randomized study aims to compare the postoperative analgesic efficacy of adductor canal block alone with adductor canal block combined with BiFeS block in patients undergoing anterior cruciate ligament reconstruction surgery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Adductor Canal Block Group | Active comparator | Procedure: Adductor Canal BlockAfter induction of general anesthesia, an ultrasound-guided adductor canal block will be performed on the operative side. A linear ultrasound transducer will be placed transversely over the mid-thigh to identify the sartorius muscle, femoral artery, vastus medialis muscle, and adductor canal. A block needle will be advanced using an in-plane technique. After negative aspiration, 10 mL of 0.25% bupivacaine will be injected into the adductor canal. Appropriate spread of the local anesthetic will be confirmed by ultrasound imaging. All patients will receive standardized postoperative multimodal analgesia consisting of intravenous paracetamol 1 g every 8 hours and intravenous dexketoprofen 50 mg twice daily. |
| Adductor Canal Block + BiFeS Block Group | Active comparator | Procedure: Adductor Canal Block, Procedure: BiFeS BlockAfter induction of general anesthesia, an ultrasound-guided adductor canal block will first be performed on the operative side using the same technique as in the adductor canal block group. Subsequently, an ultrasound-guided biceps femoris short head (BiFeS) block will be performed. The ultrasound transducer will be positioned at the distal thigh to identify the short head of the biceps femoris muscle and the lateral femoral cortex. A block needle will be advanced using an in-plane technique toward the fascial plane between the biceps femoris short head muscle and the lateral femoral cortex. After negative aspiration, local anesthetic will be injected into this fascial plane, and adequate spread will be confirmed using ultrasound imaging. All patients will receive standardized postoperative multimodal analgesia consisting of intravenous paracetamol 1 g every 8 hours and intravenous dexketoprofen 50 mg twice daily. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients aged 18-65 years
- Patients scheduled for elective unilateral anterior cruciate ligament reconstruction surgery
- American Society of Anesthesiologists physical status I-III
- Patients who provide written informed consent
Key exclusion criteria (5 listed)
- Age <18 or >65 years
- ASA physical status IV or higher
- Coagulopathy or ongoing anticoagulant therapy incompatible with peripheral nerve block
- Infection at the block injection site
- Patient refusal
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Adductor Canal BlockUltrasound-guided adductor canal block will be performed using 10 mL of 0.25% bupivacaine. | Procedure or surgery | Adductor Canal Block + BiFeS Block Group, Adductor Canal Block Group |
| BiFeS BlockUltrasound-guided BiFeS block will be performed using 20 mL of 0.25% bupivacaine. | Procedure or surgery | Adductor Canal Block + BiFeS Block Group |
Primary outcome
Pain Score
Time frame: On the operation day
Pain will be assessed at rest using the visual analog scale on a scale from 0 (no pain) to 100 (worst pain). Pain assessment will be done at 6th hour after surgery.
2 secondary outcomes
Pain Scores
Time frame: On the operation day
Total Postoperative Morphine Consumption During the First 24 Hours AfterSurgery
Time frame: On the operation day
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Oct 2026.
Related trials for Anterior Cruciate Ligament Reconstruction
Not yet recruiting
Stair Biomechanics and Vibration Study After ACLR
Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Injury
Not yet recruiting
Nerve Block of the Vastus Medialis and Anterior Obturator Branch in Anterior Cruciate Ligament Reconstruction With DIDT Graft
Anterior Cruciate Ligament (ACL) Reconstruction Surgery
Not yet recruiting
Supporting Athletes' Return to Sports After ACL Reconstruction: A Study of a Psychological Readiness Program
Anterior Cruciate Ligament Reconstruction, Anterior Cruciate Ligament Injuries
Recruiting
Interventions to Enhance Quadriceps Output After ACLR
ACL
Recruiting
Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction
Anterior Cruciate Ligament Injuries
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Adductor Canal Block and BiFeS Block in people with Anterior Cruciate Ligament Reconstruction and Pain Management, run by Ankara Etlik City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Atakan Sezgi (00905323327000, kansezgi@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Score (time frame: On the operation day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026.