Motion SicknessNCT07619469
Motion Sickness Severity and Sensorimotor Performance
An observational study of Motion Sickness and Somatosensory Disorders, run by Istinye University.
Trial summary
Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. Read more about this study
- Who is it for?
- Ages 18 to 40 years
- Conditions the study is for
- Motion Sickness, Somatosensory Disorders, Dizziness
- What is being tested?
- Standardized Sensorimotor Assessment and Motion Sickness Provocation Protocol
- How many people
- 41 participants
- Where
- No sites listed yet
- Study dates
- 1 Jun 2026to 5 Aug 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- No healthy volunteers
- Adult
Study population: The study population consists of adult individuals aged between 18 and 40 years who exhibit susceptibility to motion sickness.
Who may be able to join
- Individuals aged between 18 and 40 years.
- Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).
- Normal hearing acuity.
- No history of acute or chronic vestibular disease, other than motion sickness.
- Normal or corrected-to-normal vision.
- Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.
Who cannot join
- Presence of any physical or orthopedic problem that could interfere with testing.
- History of acute or chronic instability, unsteadiness, or vertigo.
- Severe visual impairment.
- History of prior ear surgery.
- Presence of any neurological condition or disorder.
- History of migraines.
- Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).
- Use of alcohol or psychoactive substances within the last 48 hours prior to testing.
About this study
Official title: The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study
Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).
- Conditions
- Motion Sickness, Somatosensory Disorders, Dizziness
- Being tested
- Standardized Sensorimotor Assessment and Motion Sickness Provocation Protocol
- Medical subject headings
- Motion Sickness, Somatosensory Disorders, Dizziness
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standardized Sensorimotor Assessment and Motion Sickness Provocation ProtocolOther
Participants will undergo a standardized battery of sensorimotor assessments, including static/dynamic balance tracking, knee joint position sense testing, manual dexterity/coordination tasks, and upper/lower extremity reaction time measurements, alongside a controlled motion sickness provocation session using a randomized chair-rotation protocol."
What is being measured
The primary outcome is the main question the study is designed to answer.
Motion Sickness Severity (Graybiel Score)
Used to grade the clinical severity of acute motion sickness symptoms (including nausea, cold sweating, increased salivation, and dizziness) following a randomized chair-rotation provocation protocol. 0 (Minimum) to 50 points (Maximum). Higher scores indicate greater symptom severity, representing a worse clinical outcome (scores of 16 or above designate frank sickness).
Measured: 1 hour
Static Balance
Evaluated objectively using the ProKin® computerized balance system. Participants stand on the platform under conditions: double-leg with eyes open.
Measured: 1 hour
Dynamic Balance Performance
Evaluated using the ProKin® system.
Measured: 1 hour
Secondary outcomes (4)
Knee Joint Proprioception
Evaluated in supine and prone positions, targeting knee angles of 15°, 30°, 60°, and 90° using the Clinometer digital inclinometer smartphone application.
Measured: 1 hour
Nine-Hole Peg Test (9HPT) Completion Time
Used to assess upper extremity dexterity and fine motor coordination. Participants place nine pegs into the holes one by one and then remove them as quickly as possible.
Measured: 1 hour
Tandem Walk Test Error Count
Participants walk barefoot along a straight line for 10 steps, placing the heel of one foot directly against the toe of the other foot with arms relaxed at their sides.
Measured: 1 hour
Visual Reaction Time
Evaluated using the mobile application-based BlazePod.
Measured: 1 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Jun 2026
- Study start1 Jun 2026 (estimated)
- Primary completion2 Aug 2026 (estimated)
- Study completion5 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Motion SicknessStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 41 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Istinye University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yunus Emre Tutuneken, Istinye University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07619469
- Sponsor's protocol ID
- 25
- Status last verified
- Jun 2026
- First submitted
- 26 May 2026
- Last updated
- 26 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT07619469
- Acronym / sponsor ID
- 25
- Conditions
- Motion Sickness, Somatosensory Disorders, Dizziness
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 41 participants (estimated)
- Lead sponsor
- Istinye UniversityUniversity, hospital or other
- Study start
- 1 Jun 2026 (estimated)
- Primary completion
- 2 Aug 2026 (estimated)
- Study completion
- 5 Aug 2026 (estimated)
- First posted
- 2 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- The study population consists of adult individuals aged between 18 and 40 years who exhibit susceptibility to motion sickness.
Key inclusion criteria (6 listed)
- Individuals aged between 18 and 40 years.
- Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).
- Normal hearing acuity.
- No history of acute or chronic vestibular disease, other than motion sickness.
- Normal or corrected-to-normal vision.
Key exclusion criteria (8 listed)
- Presence of any physical or orthopedic problem that could interfere with testing.
- History of acute or chronic instability, unsteadiness, or vertigo.
- Severe visual impairment.
- History of prior ear surgery.
- Presence of any neurological condition or disorder.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standardized Sensorimotor Assessment and Motion Sickness Provocation ProtocolParticipants will undergo a standardized battery of sensorimotor assessments, including static/dynamic balance tracking, knee joint position sense testing, manual dexterity/coordination tasks, and upper/lower extremity reaction time measurements, alongside a controlled motion sickness provocation session using a randomized chair-rotation protocol." | Other | – |
Primary outcome
Motion Sickness Severity (Graybiel Score)
Time frame: 1 hour
Used to grade the clinical severity of acute motion sickness symptoms (including nausea, cold sweating, increased salivation, and dizziness) following a randomized chair-rotation provocation protocol. 0 (Minimum) to 50 points (Maximum). Higher scores indicate greater symptom severity, representing a worse clinical outcome (scores of 16 or above designate frank sickness).
Static Balance
Time frame: 1 hour
Evaluated objectively using the ProKin® computerized balance system. Participants stand on the platform under conditions: double-leg with eyes open.
Dynamic Balance Performance
Time frame: 1 hour
Evaluated using the ProKin® system.
4 secondary outcomes
Knee Joint Proprioception
Time frame: 1 hour
Nine-Hole Peg Test (9HPT) Completion Time
Time frame: 1 hour
Tandem Walk Test Error Count
Time frame: 1 hour
Visual Reaction Time
Time frame: 1 hour
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Motion Sickness and Somatosensory Disorders, run by Istinye University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 26 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Motion Sickness Severity (Graybiel Score) (time frame: 1 hour). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jun 2026.