Cardiac Arrest (CA)NCT07359313
Incidence of Colon Ischemia in Patients After Cardiopulmonary Resuscitation (CPR)
A study testing colonoscopy in people with Cardiac Arrest (CA), run by University Hospital Freiburg at 1 site in Germany.
Trial summary
Bedside colonoscopy 24-36 hours after successful CPR Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest (CA)
- What is being tested?
- colonoscopy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 1 siteGermany
- Study dates
- 7 Jan 2026to 6 Feb 2028
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- adult patients (≥ 18 years) admitted to the participating department AND
- in-hospital or out-of-hospital cardiac arrest (IHCA, OHCA)
Who cannot join
- resuscitation period of ≤ 5 minutes
- awake and contactable patients (GCS ≥ 13)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Germany1 site
Medical Center - University of Freiburg
Freiburg im Breisgau, 79106
Alexander Supady, MD, MPH, +49-761-270-34010, alexander.supady@uniklinik-freiburg.de
Asieb Sekandarzad, MD, +49-761-270-34010, asieb.sekandarzad@uniklinik-freiburg.de
About this study
Official title: Incidence of Colon Ischemia in Patients After Cardiopulmonary Resuscitation (CPR): a Prospective Single-center Epidemiological Incidence Study
Bedside colonoscopy 24-36 hours after successful CPR
Read the detailed description
According to previous observations, many patients after CPR develop acute non-occlusive mesenteric ischemia. However, due to the lack of established screening strategies, the number of unreported cases may be high. Routine colonoscopy at 24-36 hours after CPR may be a safe, easy and cost-effective strategy for early detection of severe mesenteric ischemia and transfer to surgical treatment. However, this strategy has not been formally evaluated in larger prospective cohorts. In our center, we perform routine colonoscopy at 24 to 36 hours after cardiac arrest in all patients who receive extracorporeal CPR (ECPR), i.e., in all patients with prolonged cardiac arrest refractory to conventional CPR measures who therefore receive venoarterial extracorporeal membrane oxygenation (VA ECMO) for cardiocirculatory support. In these patients, colonoscopy screening was feasible and safe, and our data suggest clinical benefit.
- Conditions
- Cardiac Arrest (CA)
- Being tested
- colonoscopy
- Keywords
- cardiac arrest, cardiopulmonary resuscitation, CPR, extracorporeal cardiopulmonary resuscitation, ECPR, VA ECMO, colonoscopy, mesenteric ischemia
- Medical subject headings
- Heart Arrest, Mesenteric Ischemia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
colonoscopyProcedure or surgery
bedside colonoscopy without bowel cleansing early (24-36h) after successful CPR
| Study group | Role | What they receive |
|---|---|---|
| early colonoscopy after successful CPR | Other | bedside colonoscopy 24-36 hours after successful CPR Receives: Procedure: colonoscopy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Detection of colon ischemia
Detection of colon ischemia within 30 days after return of spontaneous circulation
Measured: from baseline (0 hours) until day 30
Secondary outcomes (10)
in-hospital mortality
in-hospital mortality
Measured: from baseline (0 hours) until hospital discharge
abdominal surgery ((hemi-)colectomy)
number of patients requiring/receiving abdominal surgery ((hemi-)colectomy)
Measured: from baseline (0 hours) until hospital discharge
functional outcome
Cerebral Performance Category (CPC)
Measured: day 30, day 60 and day 90
Liver function
Liver function parameters: Quick/INR, AST, ALT, AP, g-GT
Measured: within 0-72 hours after CPR
renal function
Renal function parameters: creatinine, BUN
Measured: within 0-72 hours after CPR
Urine output
Urine output (ml)
Measured: within 0-72 hours after CPR
Renal replacement therapy
Implementation of renal replacement therapy within 30 days after return of spontaneous circulation
Measured: from baseline (day 0) until day 30
Serum lactate
Serum lactate
Measured: within 0-72 hours after CPR
SOFA score
SOFA
Measured: at 0 hours, 24 hours, 48 hours, 72 hours after CPR
SAPS II score
SAPS II
Measured: at 0 hours, 24 hours, 48 hours, 72 hours after CPR
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2026
- Study start7 Jan 2026 (estimated)
- Primary completion6 Jan 2028 (estimated)
- Study completion6 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Prospective epidemiological incidence study
- Masking
- None (open label)
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital Freiburg
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, PD Dr. Alexander Supady, University Hospital Freiburg
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07359313
- Sponsor's protocol ID
- 24-1320-S1
- Status last verified
- Jan 2026
- First submitted
- 19 Dec 2025
- Last updated
- 22 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No