StrokeV-PASENCT05724823
Virtual Physical Activity Seated Exercise - Phase 2
A study testing Virtual Physical Activity Seated Exercises (V-PASE) in people with Stroke and Chronic Stroke, run by University of British Columbia at 5 sites in Canada.
Trial summary
This study will determine the acceptability of delivering seated exercises online and if seated exercises can improve balance, mobility, quality of life, and cardiometabolic health in those living with a stroke related mobility impairment. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Stroke, Chronic Stroke, Stroke, Ischemic
- What is being tested?
- Virtual Physical Activity Seated Exercises (V-PASE)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 5 sitesCanada
- Study dates
- 11 Oct 2023to 31 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participants must meet the following inclusion criteria:
- Adult (as defined by Province)
- Chronic stroke (more than 6 months post-stroke)
- Ability to stand up from a chair
- Mobility impairment of lower extremity (requires a walking aid, with or without close supervision)
- Able to safely engage in exercise and tolerate 60 minutes of exercises
- Able to communicate in English
- Have access to a tablet, computer, or laptop with internet and email access
Who cannot join
- Participants will be excluded if they meet any of the following criteria:
- Participating in formal exercise or rehabilitation activities
- Participating in > 30 minutes/day of physical activity (moderate intensity)
- Participating in another study that may affect outcomes to this study
- Severe loss of vision, hearing, speech (including aphasia) or cognition that would preclude use of a computer/tablet and communication over videoconference software
- A serious comorbid condition (eg., amputation, Parkinson's disease, active cancer)
- Clinically diagnosed with acute/chronic illness or other condition which has known physical activity contraindications or limits their ability to complete each experimental condition (i.e., chronic low back pain aggravated by prolonged sitting)
Trial locations and contacts
5 sites in 1 country.
5 sites in 1 country
Canada5 sites
Nova Scotia Health
Halifax, Nova Scotia
Western University
London, Ontario
University of Saskatchewan
Saskatoon, Saskatchewan
GF Strong Rehabilitation Centre
Vancouver, British Columbia, V5Z 2G9
University of Manitoba
Winnipeg, Manitoba
About this study
Official title: Assessing a Telehealth Seated Exercise Program on Post-stroke Balance and Mobility: A Mixed-method Design
This study will determine the acceptability of delivering seated exercises online and if seated exercises can improve balance, mobility, quality of life, and cardiometabolic health in those living with a stroke related mobility impairment.
Participants will be allocated to either a 10-week seated exercise program or a delayed 2-week Boot Camp program. All seated exercises sessions and assessments will be conducted virtually.
Read the detailed description
The study will be a virtual 10-week multi-site, assessor-blinded, randomized controlled trial with an embedded qualitative component. The study will be conducted in real time using secure videoconferencing software (Zoom). Participants will be randomized 1:1 to a 10-week Seated Exercise group or a delayed 2-week Seated Exercise Group (Boot Camp). Seated exercise sessions will be delivered and supervised by a trained instructor.
Participants will use their own computer, laptop, or tablet for the zoom sessions. No Zoom sessions will be recorded. Caregivers will be invited to attend each exercise session to provide support and assistance but are not obliged to attend. A caregiver, friend, or family member will be required for each assessment to participate in the study.
- Conditions
- Stroke, Chronic Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Being tested
- Virtual Physical Activity Seated Exercises (V-PASE)
- Keywords
- Stroke, Seated Exercise, Balance, Mobility, Cardiometabolic health, Randomized Controlled Trial
- Medical subject headings
- Stroke, Ischemic Stroke, Hemorrhagic Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Virtual Physical Activity Seated Exercises (V-PASE)Other
The seated exercise program includes a variety of upper and lower limb strengthening, core strengthening, agility (fast arm and leg movements), and flexibility exercises. Participants will be supervised during each session thru videoconferencing by a trained instructor.
| Study group | Role | What they receive |
|---|---|---|
| 10-week group | Experimental | Will receive a 10-week seated exercise program, occurring 3 times per week. Sessions will be 60 minutes in duration. Receives: Other: Virtual Physical Activity Seated Exercises (V-PASE) |
| Delayed 2-week group (Boot Camp) | No intervention | The Boot Camp group will complete a 2-week seated exercise program following the 10-week active trial period. |
What is being measured
The primary outcome is the main question the study is designed to answer.
30 Second Sit-to-Stand
Assessment of balance and lower extremity strength.
Measured: Immediately post-intervention (following 10-week trial)
Secondary outcomes (13)
Timed Up and Go
Participants stand up from a chair, walk 3 metres, turn around and then sit back down. The TUG assesses balance, mobility and turning ability
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Tandem Stance
Measures balance in standing as reported in the Short Physical Performance Battery Protocol
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Modified Telehealth Fugl-Meyer
The modified virtual Fugl-Meyer assess lower extremity impairments in those with stroke
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Stroke Impact Scale
A self-reported measure of stroke-related disability. There are 8 domains with each item rated using a 5-point Likert scale, where lower scores mean greater difficulty to complete the item.
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Activities-Specific Balance Confidence (ABC)
The ABC scale is a 16-item questionnaire where a participant rates their confidence in performing activities from 0% to 100% (higher percentages indicate greater self-efficacy).
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Fatigue Severity Scale
Questionnaire assessing the impact of fatigue on daily tasks and activities. There are 9 questions, each scored from 1 to 7 (1 = strongly disagree; 7 = strong agreement).
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Quality of Life (EQ-5D-5L)
The EQ-5D-5L assess self-care, mobility, depression/anxiety, pain, and usual activities. Each is scored with 5 levels (1=no problems, 5=major problems). Overall health on the day is scored from 0% (worst health) to 100% (best health).
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Patient Health Questionnaire-4 (PHQ-4)
The PHQ-4 focuses on depression and anxiety. Questions are scored from 0 to 3 (0=not at all; 3 = Nearly every day).
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Montreal Cognitive Assessment scale (MoCA-BLIND)
The MoCA-BLIND assess six different cognitive domains (excludes visual stimulus) over the phone: memory, attention, language, abstraction, delayed recall, and orientation. The MoCA-BLIND is scored from 0-22 (22 = no cognitive impairments).
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Lipid Profiles
Blood samples will be collected following a 12-hour over-night fast
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Fasting Glucose
Blood samples will be collected following a 12-hour over-night fast
Measured: Immediately post-intervention, and retention (2-months post-intervention)
Glucose (HbA1c)
Blood samples will be collected following a 12-hour over-night fast
Measured: Immediately post-intervention, and retention (2-months post-intervention)
30 Second Sit-to-Stand
Assessment of balance and lower extremity strength.
Measured: Retention (2-months post-intervention)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Feb 2023
- Study start11 Oct 2023
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by University of British ColumbiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of British Columbia
- Sponsor type
- University, hospital or other
- Collaborators
- Canadian Institutes of Health Research (CIHR), Michael Smith Foundation for Health Research
- Responsible party
- Principal investigator, Janice Eng, University of British Columbia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05724823
- Sponsor's protocol ID
- H22-02549
- Acronym
- V-PASE
- Status last verified
- Sep 2026
- First submitted
- 17 Jan 2023
- Last updated
- 23 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Mackie P, Ashe MC, Barclay R, Bayley MT, Donkers SJ, Fleet JL, Mortenson WB, Peters S, Pollock CL, Pooyania S, Quigley A, Sakakibara BM, Schneeberg A, Sheehy L, Stelling S, Yao J, Eng JJ. Transferability of a 10-week remotely delivered Virtual Physical Activity Seated Exercise (V-PASE) program on post-stroke functional mobility: study protocol for a multisite randomized controlled trial. Trials. 2026 Feb 6;27(1):198. doi: 10.1186/s13063-026-09523-8.
PubMed 41645237
Study at a glance
From the registry record, last updated by the sponsor on 23 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessing a Telehealth Seated Exercise Program on Post-stroke Balance and Mobility: A Mixed-method Design
- ClinicalTrials.gov ID
- NCT05724823
- Acronym / sponsor ID
- V-PASE / H22-02549
- Conditions
- Stroke, Chronic Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Keywords
- Stroke, Seated Exercise, Balance, Mobility, Cardiometabolic health, Randomized Controlled Trial
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- University of British ColumbiaUniversity, hospital or other
- Collaborators
- Canadian Institutes of Health Research (CIHR), Michael Smith Foundation for Health Research
- Study start
- 11 Oct 2023 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Mar 2027 (estimated)
- First posted
- 13 Feb 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will determine the acceptability of delivering seated exercises online and if seated exercises can improve balance, mobility, quality of life, and cardiometabolic health in those living with a stroke related mobility impairment.
Participants will be allocated to either a 10-week seated exercise program or a delayed 2-week Boot Camp program. All seated exercises sessions and assessments will be conducted virtually.
Detailed description
The study will be a virtual 10-week multi-site, assessor-blinded, randomized controlled trial with an embedded qualitative component. The study will be conducted in real time using secure videoconferencing software (Zoom). Participants will be randomized 1:1 to a 10-week Seated Exercise group or a delayed 2-week Seated Exercise Group (Boot Camp). Seated exercise sessions will be delivered and supervised by a trained instructor.
Participants will use their own computer, laptop, or tablet for the zoom sessions. No Zoom sessions will be recorded. Caregivers will be invited to attend each exercise session to provide support and assistance but are not obliged to attend. A caregiver, friend, or family member will be required for each assessment to participate in the study.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| 10-week group | Experimental | Other: Virtual Physical Activity Seated Exercises (V-PASE)Will receive a 10-week seated exercise program, occurring 3 times per week. Sessions will be 60 minutes in duration. |
| Delayed 2-week group (Boot Camp) | No intervention | –The Boot Camp group will complete a 2-week seated exercise program following the 10-week active trial period. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Adult (as defined by Province)
- Chronic stroke (more than 6 months post-stroke)
- Ability to stand up from a chair
- Mobility impairment of lower extremity (requires a walking aid, with or without close supervision)
- Able to safely engage in exercise and tolerate 60 minutes of exercises
Key exclusion criteria (7 listed)
- Participating in formal exercise or rehabilitation activities
- Participating in > 30 minutes/day of physical activity (moderate intensity)
- Participating in another study that may affect outcomes to this study
- Severe loss of vision, hearing, speech (including aphasia) or cognition that would preclude use of a computer/tablet and communication over videoconference software
- A serious comorbid condition (eg., amputation, Parkinson's disease, active cancer)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Virtual Physical Activity Seated Exercises (V-PASE)The seated exercise program includes a variety of upper and lower limb strengthening, core strengthening, agility (fast arm and leg movements), and flexibility exercises. Participants will be supervised during each session thru videoconferencing by a trained instructor. | Other | 10-week group |
Primary outcome
30 Second Sit-to-Stand
Time frame: Immediately post-intervention (following 10-week trial)
Assessment of balance and lower extremity strength.
13 secondary outcomes
Timed Up and Go
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Tandem Stance
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Modified Telehealth Fugl-Meyer
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Stroke Impact Scale
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Activities-Specific Balance Confidence (ABC)
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Fatigue Severity Scale
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Quality of Life (EQ-5D-5L)
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Patient Health Questionnaire-4 (PHQ-4)
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Montreal Cognitive Assessment scale (MoCA-BLIND)
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Lipid Profiles
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Fasting Glucose
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
Glucose (HbA1c)
Time frame: Immediately post-intervention, and retention (2-months post-intervention)
30 Second Sit-to-Stand
Time frame: Retention (2-months post-intervention)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Sep 2026.
- Derived from this study: PubMed 41645237Mackie P, Ashe MC, Barclay R, Bayley MT, Donkers SJ, Fleet JL, Mortenson WB, Peters S, Pollock CL, Pooyania S, Quigley A, Sakakibara BM, Schneeberg A, Sheehy L, Stelling S, Yao J, Eng JJ. Transferability of a 10-week remotely delivered Virtual Physical Activity Seated Exercise (V-PASE) program on post-stroke functional mobility: study protocol for a multisite randomized controlled trial. Trials. 2026 Feb 6;27(1):198. doi: 10.1186/s13063-026-09523-8.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
5 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Virtual Physical Activity Seated Exercises (V-PASE) in people with Stroke and Chronic Stroke, run by University of British Columbia at 5 sites in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 23 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 5 sites in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
30 Second Sit-to-Stand (time frame: Immediately post-intervention (following 10-week trial)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05724823, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Sep 2026.