Specialty
Cardiology clinical trials
Trials in heart failure, arrhythmia, coronary disease, hypertension and other conditions of the heart and blood vessels.
About cardiology research
Cardiovascular studies range from large outcome trials of medicines that lower blood pressure, cholesterol or clotting risk, to device and procedure studies in interventional cardiology and electrophysiology.
Research areas
Open trials in each area. Counts come from the latest copy of the registry.
Recently updated open trials
Studies looking for volunteers, most recently updated by their sponsors first.
Heart Failure
Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)
Background: More than 6.5 million people in the United States live with heart failure (HF), and more than a million new cases are diagnosed each year.
- Trial name
- NCT06280820
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Intrahepatic Cholangiocarcinoma (Icc)
Intraarterial Therapies Plus Tislelizumab Plus Lenvatinib Versus Tislelizumab Plus Gemcitabine-Cisplatin in Unresectable Intrahepatic Cholangiocarcinoma
This is a phase III, multicenter, open-label, randomized controlled trial designed to evaluate the efficacy and safety of arterially directed therapy in combination with tislelizumab plus lenvatinib compared with gemcitabine and…
- Trial name
- RAINBOW (NCT07691515)
- Testing
- Gemcitabine, Cisplatin, Tislelizumab
- Where
- 21 sites in China
- Volunteers
- 140 people
- Sponsor
- Zhejiang Cancer Hospital
Stroke, Acute
Delay AvoIding Primary Evaluation for ThRombectomy of Acute StrokE Patients With Large Vessel OCclusion in the Angiography SuiTe
The purpose of this study is to compare two strategies for treating adults with suspected large vessel occlusion stroke within 7 hours of symptom onset.
- Trial name
- DIRECT (NCT06825897)
- Testing
- Conventional Triage for Mechanical Thrombectomy, Direct Transfer to Angiography Suite (DTAS
- Where
- 15 sites in United States
- Volunteers
- 2,039 people
- Sponsor
- Santiago Ortega Gutierrez
Fibromyalgia (FM) OR Fibromyalgia Syndrome, Manuel Therapy
Effects of Adding Vagal Neuromodulation to Manual Therapy in Women With Fibromyalgia
The aim of this study is to investigate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) added to manual therapy on pain, autonomic nervous system function, and illness perception in female patients…
- Conditions
- Fibromyalgia (FM) OR Fibromyalgia Syndrome, Manuel Therapy, Chronic Widespread Pain, Autonomic Nervous System Dysfunction
- Trial name
- NCT07894588
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Manual Therapy Program, Diaphragmatic Breathing and Stretching Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Hasan Kalyoncu University
Ventricular Arrhythmia
VINTAGE (Ventricular Intramyocardial Navigation for Tachycardia Ablation Guided by Electrograms) Using Commercial Off-The-Shelf (COTS) Catheters
Background: Ventricular arrhythmia is an abnormal pulse rhythm that starts in the lower part of the heart (ventricles). Treatment includes ablation; ablation uses heat to destroy small portions of the heart that are causing short…
- Trial name
- NCT06940752
- Testing
- VINTAGE (Ventricular Intramyocardial Navigation for Tachycardia Ablation Guided by Electrograms)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Relapsed/Refractory Multiple Myeloma
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma
The purpose of this study is to assess the safety, tolerability, and efficacy of sonrotoclax as monotherapy and in various combinations in patients with relapsed/refractory (R/R) multiple myeloma (MM) and chromosomal…
- Trial name
- NCT04973605
- Testing
- Sonrotoclax, Dexamethasone, Carfilzomib
- Where
- 74 sites in United States, Australia and 11 more
- Volunteers
- 246 people
- Sponsor
- BeOne Medicines
Lymphoplasmacytic Lymphoma, Waldenstrom Macroglobulinemia
Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma
This phase II trial studies the effects of venetoclax and rituximab in comparison to ibrutinib and rituximab or zanubrutinib in treating patients with previously untreated Waldenstrom's macroglobulinemia/lymphoplasmacytic…
- Trial name
- NCT04840602
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 146 sites in United States
- Volunteers
- 92 people
- Sponsor
- National Cancer Institute (NCI)
Malignancy, Hematologic, Neoplasms, Hematologic
Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies
Background: Blood cancers (such as leukemias) can be hard to treat, especially if they have mutations in the TP53 or RAS genes. These mutations can cause the cancer cells to create substances called neoepitopes.
- Conditions
- Malignancy, Hematologic, Neoplasms, Hematologic, Neoplasms, Hematopoietic, Blood Cancer
- Trial name
- NCT06904066
- Testing
- aldesleukin, cyclophosphamide, fludarabine phosphate
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- National Cancer Institute (NCI)
Narrow the search
Conditions in cardiology
Conditions with their own page on AzTrials, with the number of registered studies.
- Hypertension 4,695
- Heart Failure 3,815
- Coronary Artery Disease 3,793
- Cardiovascular Diseases 3,055
- Atrial Fibrillation 2,702
- Myocardial Infarction 1,285
- Heart Diseases 1,206
- Cardiovascular Disease 1,035
- Acute Coronary Syndrome 1,031
- Coronary Disease 747
- Pulmonary Hypertension 661
- Acute Myocardial Infarction 545
- Congenital Heart Disease 538
- Pulmonary Arterial Hypertension 530
- Ocular Hypertension 524
- Coronary Heart Disease 518
- Cardiac Surgery 517
- Cardiac Arrest 504
- Congestive Heart Failure 482
- Aortic Valve Stenosis 475
- Myocardial Ischemia 470
Questions about cardiology trials
Which trials are counted as cardiology?
Studies whose conditions, or the medical subject headings the registry adds to them, mention any of these terms: heart, cardiac, cardiovascular, hypertension, atrial fibrillation, coronary, myocardial, cardiomyopathy, arrhythmia. A study can belong to more than one specialty, and the grouping is AzTrials', not the sponsor's.
Are all of these trials recruiting?
No. The lists on this page show studies open to volunteers (recruiting, not yet recruiting or enrolling by invitation), as the sponsor last reported. The full search also includes completed and stopped studies, some with posted results.
How can I refer a patient to one of these trials?
Open the trial and use the contacts and sites it lists; the For doctors view of each trial collects them with the key eligibility criteria. AzTrials does not enrol participants or take referrals.