Clinical trials: sponsored by University of Michigan
Violence Prevention
YES: Innovative Discussion for Engagement, Achievement, and Service
The purpose of this study is to evaluate the efficacy of YES-IDEAS (YES: Innovative Discussion for Engagement, Achievement, and Service)compared to regular after school programming in increasing youth empowerment, promoting…
- Trial name
- YES-IDEAS (NCT05337410)
- Testing
- YES IDEAS
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Heart Failure
Mobile Health Intervention to Increase Activity in Heart Failure Study
Physical activity is known to help patients with heart failure feel better and live longer though few patients with heart failure are sufficiently active.
- Trial name
- MOVIN-HF (NCT07750262)
- Testing
- Mobile application intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Accidental Fall
Effects of a Novel Perturbation Balance Training Program on Laboratory and Real-World Trip-Induced Losses of Balance and Falls Among Balance-Impaired Older Adults
The goal of this clinical trial is to learn if a novel balance training stepping exercise can reduce the risk of falling among adults over the age of 65.
- Trial name
- NCT07891637
- Testing
- Step Training, Treadmill Training, Otago Exercise Program
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Mantle Cell Lymphoma
Natalizumab for the Prevention of ICANS in Patients With Recurrent or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma Receiving CAR T-Cell Therapy
This phase II studies how well natalizumab works in preventing immune effector cell associated neurologic syndrome (ICANS) in patients with diffuse large B-cell lymphoma (DLBCL) or mantle cell lymphoma (MCL) that has come back…
- Conditions
- Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Mantle Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma, Refractory Mantle Cell Lymphoma
- Trial name
- NCT07892027
- Testing
- Axicabtagene Ciloleucel, Biospecimen Collection, Brexucabtagene Autoleucel
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Michigan Rogel Cancer Center
Substance Use, HIV Infections
Expanding the Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples
This study utilizes a randomized controlled trial design to evaluate the efficacy of two intervention components for couples HIV testing and counseling (CHTC): a communication skills training video and a substance use module.
- Trial name
- 4Us (NCT05000866)
- Testing
- Communication skills training video, Drug use module
- Where
- 2 sites in United States
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
ADHD, Autism Spectrum Disorder
AWARE: Management of ADHD in Autism Spectrum Disorder
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism.
- Trial name
- NCT05916339
- Testing
- Randomization to either Amphetamine (AMP) class of stimulant medication or Methylphenidate (MPH) class of stimulant medication, Randomization to either Alpha 2 agonist class of medication or alternate class of stimulant.
- Where
- 13 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- Daniel Coury
Peri-implant Mucositis
Treatment of Peri-implant Mucositis and Supportive Peri-implant Therapy
The investigators are evaluating the therapeutic outcomes of two cleaning instruments on treating peri-implant mucositis. Peri-implant mucositis is inflammation around an implant that is limited to only the gum tissue and is…
- Trial name
- NCT06137846
- Testing
- Air-Polish, Ultrasonic
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Platelet Function and Reactivity Tests
Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs
This study will identify the potential benefits of regulating platelet activation with sotagliflozin compared to other FDA-approved drugs known to limit platelet activation.
- Trial name
- NCT06933056
- Testing
- Sotagliflozin (SOTA) followed by 3 drugs in a random order, Aspirin followed by 3 drugs in a random order, Clopidogrel followed by 3 drugs in a random order
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Mental Health
Enlace Familiar: Supporting the Mental Health of Latino Adolescents
The goal of this clinical trial is to pilot and evaluate Enlace Familiar, a culturally responsive intervention designed to support Latino adolescents in discussing their mental health needs with caregivers or other trusted…
- Trial name
- NCT07547631
- Testing
- Enlace Familiar
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Michigan
Child Development, Brain Development
Baby's First Years
Recent advances in developmental neuroscience suggest that experiences early in life can have profound and enduring influences on the developing brain.
- Conditions
- Child Development, Brain Development, Household and Family Processes
- Trial name
- BFY (NCT03593356)
- Testing
- Monthly cash gift payments of $333, Monthly cash gift payments of $20
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, Irvine
Suicide and Self-harm
Suicide Prevention for Criminal Legal Involved Managed Care Subscribers
The goal of this clinical trial is to test the effects of a suicide prevention intervention for individuals released from jail. The main question it aims to answer is: Does the use of Caring Contacts improve subscriber engagement…
- Trial name
- NCT05579600
- Testing
- Caring Contacts letters
- Where
- United States
- Volunteers
- 45,155 people
- Sponsor
- Butler Hospital
Mobile Phone Use, Mother-Infant Interaction
Investigating Baby Behavior and Family Technology Use Study
Maternal sensitivity and contingent responsiveness to infant behavioral cues is an important contributor to infants' developing capacities to self-regulate.
- Conditions
- Mobile Phone Use, Mother-Infant Interaction, Infant Development, Self-Regulation, Emotion
- Trial name
- iBaby (NCT05781100)
- Testing
- Technology Use during Feeding Conditions
- Where
- United States
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Aging Well
Healthy Lifetime - Phase 2
HealthyLifetime (HL) is a person-centered program that enables older adults to maximize health and optimize functioning - the necessary requisite to successfully remaining independent in their preferred home setting as long as…
- Trial name
- NCT05920733
- Testing
- Nurse-led health coaching
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Michigan
Colorectal Cancer
FITting Non-invasive Tests in Lynch Syndrome Surveillance
The purpose of this clinical study is to evaluate the accuracy of the fecal immunochemical test (FIT) in comparison to colonoscopy in patients with Lynch Syndrome (LS) who are undergoing colonoscopy surveillance.
- Trial name
- NCT06898996
- Testing
- Fecal immunochemical test
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Chicago
Painful Diabetic Neuropathy (PDN), Diabetic Nephropathies
Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy
The research team will perform a comparative-effectiveness sequential, multiple assignment, randomized trial in painful diabetic neuropathy (PDN) patients for 8 total months, divided into two 4-month stages.
- Trial name
- MCPAIN (NCT07795593)
- Testing
- Cognitive Behavioral Therapy (CBT), Oral Medication, Topical Medication
- Where
- 23 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of Michigan
Bicuspid Aortic Valve
Bicuspid Aortic Valve (BAV) Registry
The purpose of this registry is to gather information on patients with bicuspid aortic valve disease.
- Trial name
- BAV (NCT01756222)
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Neck Pain
Effects of Osteopathic Manipulative Treatment on Neuromuscular Control of the Head-neck System
The overall goal of this project is to develop sensitive and objective clinical research tools for the assessment of head-neck motor control.
- Trial name
- NCT02261259
- Testing
- Osteopathic manipulative treatment, No intervention
- Where
- 3 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Polybrominated Biphenyl Poisoning
Weight Loss Aid in an Exposed Population
This study will explore whether the use of orlistat results in weight loss that is accompanied by a reduction in the body burdens of polybrominated biphenyls (PBB) and other Persistent Organic Pollutants (POPs).
- Trial name
- NCT03582722
- Testing
- Orlistat, Multivitamin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Tinnitus, Noise Induced
TNF-α Treatment of Blast-Induced Tinnitus
The purpose of this multi-site research study is to determine if Etanercept, compared to a placebo, significantly reduces the severity of tinnitus (ringing in the ears) associated with history of blast and/or noise exposure or…
- Trial name
- NCT04066348
- Testing
- Etanercept, Saline
- Where
- 4 sites in United States
- Volunteers
- 88 people
- Sponsor
- Wayne State University
Type 2 Diabetes
The Lifestyle Education About Nutrition for Diabetes (Legend) Study
This study is being completed to compare two dietary approaches for participants with type 2 diabetes. This research will test whether a very low-carbohydrate or a plate-method diet better improves outcomes for blood glucose…
- Trial name
- LEGEND (NCT05237128)
- Testing
- Very low-carbohydrate diet, Moderate-carbohydrate plate-method diet
- Where
- 2 sites in United States
- Volunteers
- 182 people
- Sponsor
- University of Michigan