Clinical trials: sponsored by Sun Yat-sen University
Nonmetastatic Locally Advanced Non-Clear Cell Renal Cell Carcinoma
Toripalimab and Lenvatinib With or Without SBRT Before Surgery for Non-Clear Cell Kidney Cancer
This single-center, nonrandomized, two-cohort Phase II study will evaluate neoadjuvant toripalimab and lenvatinib with or without stereotactic body radiotherapy (SBRT) in patients with resectable, nonmetastatic locally advanced…
- Trial name
- TL-SBRT-nccRCC (NCT07922928)
- Testing
- Toripalimab, Lenvatinib, Stereotactic Body Radiotherapy
- Volunteers
- 36 people
- Sponsor
- Sun Yat-sen University
Liver Cirrhosis, Gastroesophageal Varices
The Value of Spleen Thickness and Spleen Diameter for Gastroesophageal Varices Diagnosis in Compensated Cirrhosis
This retrospective cross-sectional diagnostic study compared the diagnostic performance of ultrasound-measured spleen thickness (ST) and spleen diameter (SD) against esophagogastroduodenoscopy (EGD) for gastroesophageal varices…
- Trial name
- NCT07920744
- Testing
- spleen diameter, spleen thickness, esophagogastroduodenoscopy (EGD)
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Cancer, Malignant Neoplasms
Automated Radiation Target Contouring and Treatment Planning Via RATA: A Multi-Center RCT
Radiotherapy, a cornerstone of comprehensive cancer treatment, relies heavily on clinician expertise for target volume contouring and treatment planning.
- Conditions
- Cancer, Malignant Neoplasms, Radiotherapy
- Trial name
- NCT07922902
- Testing
- RATA (Radiotherapy Treatment Multi-Agent Assistant) System, Standard Radiotherapy Planning Workflow
- Where
- China
- Volunteers
- 62 people
- Sponsor
- zhaoxiaohui
Localized Clear Cell Renal Cell Carcinoma
Pucotenlimab, Lenvatinib, and SBRT Before Surgery for Localized Clear Cell Renal Cell Carcinoma
This single-arm Phase II study will evaluate the efficacy and safety of neoadjuvant pucotenlimab, lenvatinib, and stereotactic body radiotherapy (SBRT) in adults with localized clear cell renal cell carcinoma who are candidates…
- Trial name
- PLS-NEO-RCC (NCT07922915)
- Testing
- Pucotenlimab, Lenvatinib, Stereotactic Body Radiotherapy
- Volunteers
- 24 people
- Sponsor
- Sun Yat-sen University
Radiotherapy, Adjuvant, Phyllodes Breast Tumor
Molecular Subtype-Guided Postoperative Radiotherapy for Phyllodes Tumor of the Breast
Phyllodes tumor (PT) of the breast is a rare fibroepithelial neoplasm, and the role of postoperative radiotherapy (PORT) remains controversial.
- Conditions
- Radiotherapy, Adjuvant, Phyllodes Breast Tumor, Prognosis, Molecular Typing
- Trial name
- NCT07657169
- Testing
- Postoperative Radiotherapy (PORT)
- Where
- 4 sites in China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
High Myopia, Intraocular Pressure
Effect of IOP Lowering on Progressive HM
Currently, whether and when intraocular pressure (IOP) lowering medication should be used in progressive high myopia (HM) to control axial elongation is still a dilemma.
- Trial name
- PHM (NCT05850936)
- Testing
- Assigned Interventions: IOP-lowering eye drops
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Sun Yat-sen University
Colorectal Liver Metastases (CRCLM), Colorectal Neoplasms
RAPID for Unresectable Colorectal Liver Metastases
The goal of this clinical trial is to learn if the RAPID procedure works to treat colorectal cancer that has spread to the liver and cannot be removed by surgery. It will also learn about the safety of the procedure.
- Trial name
- RAPID-uCRLM (NCT07919951)
- Testing
- RAPID Procedure
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Diabetes type2
Impact of Short-term Intensive De-escalation Therapy on Long-term Regimen Simplification
Despite advances in diabetes management, many patients with type 2 diabetes in China fail to achieve optimal glycemic control. One of the possible reasons is associated with the delay in therapeutic decision making that lags…
- Trial name
- NCT03958591
- Testing
- CSII and thereafter combination therapy, followed up with wearable devices, CSII and thereafter combination therapy, Basal insulin treatment without wearables
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Yanbing Li
Bladder Cancer
DV Plus Toripalimab With Cetirizine and Mecobalamin Pretreatment in Patients With Locally Advanced Unresectable or Metastatic Bladder Cancer
This is a prospective, open-label, single-arm exploratory clinical study evaluating the efficacy and safety of disitamab vedotin (RC48) plus toripalimab with cetirizine and mecobalamin in patients with locally advanced…
- Trial name
- NCT07853053
- Testing
- Disitamab Vedotin, Toripalimab, Cetirizine
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Presbyopia
PROductivity Study of Presbyopia Elimination in Rural-dwellers III
The investigators will conduct an embedded mixed methods study in which the primary approach is a randomized controlled trial (RCT), and the secondary or embedded approach is a descriptive qualitative study.
- Trial name
- PROSPERIII (NCT04654013)
- Testing
- Spectacles
- Where
- India
- Volunteers
- 1,291 people
- Sponsor
- Queen's University, Belfast
Squamous Cell Carcinoma of Head and Neck (SCCHN)
Becotatug Vedotin Plus Pucotenlimab in Locally Advanced Head and Neck Squamous Cell Carcinoma With Suboptimal Response to Induction Immunochemotherapy
Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) may receive chemotherapy combined with immunotherapy before surgery to reduce tumor size.
- Trial name
- NCT07915258
- Testing
- Becotatug Vedotin (MRG003), Pucotenlimab
- Where
- 4 sites in China
- Volunteers
- 22 people
- Sponsor
- Sun Yat-sen University
Cancer, Precancerous Lesion
Performance of Multi-Cancer Detection Test in Asymptomatic Patients With Neoplastic Lesions
This multicenter, observational case-only study will evaluate the clinical performance of a blood-based, cell-free DNA (cfDNA) methylation multi-cancer early detection (MCED) test in adults aged 50 to 74 years with confirmed…
- Conditions
- Cancer, Precancerous Lesion, Carcinoma in Situ
- Trial name
- NCT07915271
- Testing
- MCED
- Volunteers
- 948 people
- Sponsor
- Sun Yat-sen University
Refractive Errors
Correcting Myopia Among Secondary School Children to Increase Academic High School Attendance Rates in Rural Communities
Chinese children are some of the most short-sighted in the world, but only one in five children in poor areas who needs glasses has them.
- Trial name
- SWISH (NCT04077086)
- Testing
- Spectacles
- Where
- 3 sites in China, United Kingdom
- Volunteers
- 10,000 people
- Sponsor
- Queen's University, Belfast
Muscle-Invasive Bladder Carcinoma, Programmed Cell Death Protein 1 Inhibitor
Treating Muscle-invasive Bladder Cancer With A Non-surgical Method Consisting of Anti-PD-1 Therapy and Chemoradiation
The goal of this Phase 2 trial is to evaluate a non-surgical bladder-preserving treatment mode which consists of neoadjuvant chemotherapy plus anti-programmed cell death protein 1 (anti-PD-1) therapy followed by radiotherapy plus…
- Conditions
- Muscle-Invasive Bladder Carcinoma, Programmed Cell Death Protein 1 Inhibitor, Radiotherapy
- Trial name
- BCIRT-01 (NCT05975307)
- Testing
- Toripalimab, Gemcitabine, Cisplatin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Sun Yat-sen University
Preterm Birth, Neurodevelopmental Disorders
Guangzhou Preterm and Term Birth Cohort Study
The Guangzhou Preterm-Term Birth Cohort (GPTBC) is a prospective observational study of how early-life nutrition, environmental exposures, and family factors relate to the health and development of preterm and term infants and…
- Conditions
- Preterm Birth, Neurodevelopmental Disorders, Overweight, Obesity
- Trial name
- GPTBC (NCT07756177)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Prostate Cancer
Evaluation of Perilesional Biopsy in Diagnosis of Prostate Cancer
The goal of this multicenter randomized controlled trial (RCT) is to evaluate the efficacy of different prostate biopsy schemes, including perilesional biopsy (PB) and combination of systematic biopsy and targeted biopsy (TB+SB).
- Trial name
- NCT06482645
- Testing
- TB+PB, TB+SB
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Peking University First Hospital
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
China HEalthy Aging and Dementia Study (HEAD)
The China HEalthy Aging and Dementia (HEAD) study is a large-scale, community-based, multi-center prospective cohort study covering eastern, northern, southern, and central-western regions of China.
- Conditions
- Alzheimer Disease (AD), Mild Cognitive Impairment (MCI), Dementia, Vascular Dementia (VaD)
- Trial name
- NCT07912710
- Where
- 30 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Esophageal Squamous Cell Carcinoma (ESCC)
The Efficacy of Inflatable Mediastinoscopic-assisted Transhiatal Laparoscopic Esophagectomy
Abstract Background China has a high incidence of esophageal cancer, with surgery being the primary treatment modality. While the right thoracic approach for radical esophagectomy remains the standard surgical method, it is…
- Trial name
- NCT07581236
- Testing
- inflatable video-assisted mediastinoscopic transhiatal esophagectomy (IVMTE) combined with laparoscopy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Sun Yat-sen University
Oral Mucositis (Ulcerative) Due to Radiation, Nasopharyngeal Carcinoma (NPC)
Taurine for the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma
This clinical trial aims to understand whether taurine can prevent and reduce severe radiation-induced oral mucositis in patients with nasopharyngeal carcinoma undergoing radiotherapy.
- Trial name
- NCT07567742
- Testing
- Taurine
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Sun Yat-sen University
Laparoscopic Surgery, Visceral Pain, Postoperative
Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery
Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes.
- Conditions
- Laparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous Analgesia
- Trial name
- NCT07525986
- Testing
- High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon
- Where
- 4 sites in China
- Volunteers
- 140 people
- Sponsor
- Peking University First Hospital
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