Clinical trials: sponsored by Samsung Medical Center
Cardiogenic Shock, Acute Myocardial Infarction of Inferior Wall
Routine Versus Provisional Distal Perfusion Catheter Placement in Patients Undergoing Mechanical Circulatory Support
A prospective, multi-center, open label, randomized controlled, superiority trial to compare clinical outcomes between routine distal perfusion catheter (DPC) insertion versus provisional distal perfusion catheter (DPC) insertion…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction of Inferior Wall, Congestive Heart Failure, Myocarditis
- Trial name
- PERFUSE-MCS (NCT07482865)
- Testing
- Distal perfusion catheter insertion
- Where
- 6 sites in South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Hepatocellular Carcinoma (HCC), Radiotherapy-Induced Immune Priming
PULSAR Radiotherapy Combined With Immunotherapy for High-Risk Advanced Liver Cancer
The goal of this clinical trial is to learn if adding PULSAR, a personalized adaptive stereotactic radiotherapy, to standard immunotherapy can control cancer longer in adults with high-risk advanced hepatocellular carcinoma…
- Conditions
- Hepatocellular Carcinoma (HCC), Radiotherapy-Induced Immune Priming, Immunotherapy
- Trial name
- HCC-PULSAR (NCT07884877)
- Testing
- PULSAR (Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy), Immune checkpoint inhibitor-based therapy
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Samsung Medical Center
Rotator Cuff Tear Arthropathy, Repair of a Cuff Tear
Efficacy and Safety of Digital Therapeutics for Improving Shoulder Function After Rotator Cuff Repair
1. Importance of Rehabilitation After Rotator Cuff Repair Rotator cuff tears are among the most common shoulder conditions in Korea. They can occur naturally with aging or result from trauma or overuse.
- Trial name
- NCT07255534
- Testing
- digital therapeutics, usual care
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Samsung Medical Center
Gastric Cancer
Assessment of a Robotic Distal Gastrectomy on Non-inferiority of N2 Area Nodal Dissection
Designed as a single arm multi-center prospective phase II trial, which evaluates the number of dissected lymph nodes in the N2-area as a surrogate parameter for adequate D2 lymphadenectomy in robotic distal gastrectomy (RDG) for…
- Trial name
- AaRon (NCT02572050)
- Testing
- Distal Gastrectomy with D2 LND
- Where
- 2 sites in South Korea
- Volunteers
- 87 people
- Sponsor
- National Cancer Center, Korea
Preterm
Efficacy of a Video-based, Parent-centered Home Developmental Intervention for Infants at High Risk for Developmental Delay: a Multicenter Randomized Controlled Trial
The purpose of this study is to determine whether the Motor Composite Score on the Bayley-III (administered at 6 months of corrected age) shows significant improvement in an intervention group-receiving usual care combined with a…
- Trial name
- NCT07882199
- Testing
- Family-centered developmental training intervention
- Volunteers
- 170 people
- Sponsor
- Seoul National University Hospital
Cancer
Immunotherapy With Adaptive Pulse Radiotherapy in Solid Tumors
The goal of this clinical trial is to find out whether Adaptive Pulse Radiotherapy (Pulse RT) combined with immune checkpoint inhibitors (ICIs) helps treat advanced solid tumors.
- Trial name
- I-APT (NCT07381231)
- Testing
- Pulse radiation therapy
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Samsung Medical Center
Lymphoma
Prospective Cohort Study for Lymphoma: Samsung Lymphoma Cohort Study IV
This prospective study enrolls patients who are diagnosed with aggressive lymphoma including Hodgkin and non-Hodgkin lymphomas. Enrolled patients will be treated according to our institution' treatment policy in clinical…
- Trial name
- SMCLYM-IV (NCT07032103)
- Testing
- Immunochemotherapy
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Samsung Medical Center
Communication
Effect of an AI Agent on Caregiver Communication Experience in the Pediatric Emergency Department
This single-center, single-blind, randomized controlled trial evaluates whether the use of a conversational large language model (LLM)-based AI agent, used by caregivers during the waiting period before physician consultation in…
- Trial name
- PED-AI (NCT07867782)
- Testing
- AI Agent (conversational LLM pre-consultation history-taking tool)
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Diabete Type 2, E Cigarette Use
Switching to E-Cigarettes After Type 2 Diabetes Diagnosis and Health Outcomes
Individuals with T2DM who smoke have higher risks of cardiovascular disease and other complications. Many people consider e-cigarette as a "harm-reduction" alternatives to combustible cigarettes, but it is not clear whether…
- Conditions
- Diabete Type 2, E Cigarette Use, Clinical Outcomes
- Trial name
- E-cig-DM (NCT07414355)
- Testing
- Change in smoking behavior after type 2 diabetes diagnosis
- Where
- South Korea
- Volunteers
- 133,320 people
- Sponsor
- Samsung Medical Center
Critical Incident
Feasibility Study of an Interactive Remote Supervising Platform for Critical Care: A Randomized Study
This study investigates the effectiveness of using Hololens2 for remote education and feedback in medical procedures, specifically central venous catheterization.
- Trial name
- NCT07861555
- Testing
- Hololens2(Microsoft), Face-to-face supervision
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Venous Thromboembolism, Active Cancer
Edoxaban Versus Apixaban in Cancer-Associated Venous Thromboembolism
This prospective, multicenter, randomized, open-label, blinded-endpoint trial aims to compare the clinical efficacy and safety of edoxaban-based treatment versus apixaban-based treatment in patients with cancer-associated venous…
- Trial name
- NEXT-CAT (NCT07852637)
- Testing
- edoxaban, Apixaban
- Where
- 12 sites in South Korea
- Volunteers
- 2,300 people
- Sponsor
- Samsung Medical Center
Pediatric Intensive Care Units
A Korean Point Prevalence Study of Acute Rehabilitation for Kids in the PICU (PARK-PICU)
This study investigates the prevalence of acute rehabilitation practices among children in pediatric intensive care units (PICUs).
- Trial name
- NCT07629297
- Testing
- Acute Rehabilitation (Observed Practice)
- Where
- 13 sites in South Korea
- Volunteers
- 396 people
- Sponsor
- Samsung Medical Center
TNBC - Triple-Negative Breast Cancer
Real-world Treatment Outcomes and Safety of Neoadjuvant Pembrolizumab-containing Therapy in Patients With Triple-negative Breast Cancer: Korean Nationwide Multicenter Study (Pembro-Real World)
The purpose of this study is to evaluate the treatment outcomes and safety of neoadjuvant therapy including pembrolizumab in real-world practice for patients with triple-negative breast cancer (TNBC) in a multi-center study in…
- Trial name
- NCT07828652
- Testing
- Medical record use research
- Volunteers
- 2,000 people
- Sponsor
- Yeon Hee Park
Cerebral Palsy
Feasibility of Vision-Language Models for Detecting Physical Assistance as an Observable Criterion Defining GMFCS Levels in Children Aged 2 to 6 Years With Cerebral Palsy
The GMFCS sorts children with cerebral palsy into five levels of gross motor function. What mainly separates one level from the next is two things an observer can see: whether another person has to physically help the child move…
- Trial name
- NCT07824531
- Testing
- Vision-language model assessment of movement video
- Where
- 2 sites in South Korea
- Volunteers
- 26 people
- Sponsor
- Samsung Medical Center
Pain, Postoperative / Acute Pain
Opiranserin Injections PCA Regimens for Postoperative Pain
The purpose of this phase 2 study is to evaluate the efficacy and safety of PCA regimen of opiranserin (VVZ-149) injections in patients undergoing laparoscopic colectomy.
- Trial name
- NCT07821307
- Testing
- VVZ-149 Injections, Fentanyl
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Samsung Medical Center
Pulmonary Disease (COPD), Chronic Obstructive, Lung Resection Surgery
Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP…
- Trial name
- NCT07638176
- Testing
- PEEP0, PEEP5, PEEPi
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Samsung Medical Center
Non-Small Cell Lung Cancer Metastatic
Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment
As the 3rd generation, EGFR TKI has become a standard treatment option for the 1st line therapy in EGFR mutated patients, the necessity for evaluating resistant mechanism to determine the matched subsequent therapeutic option has…
- Trial name
- NCT06106802
- Testing
- Lazertinib, Tepotinib
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Sehhoon Park
Small Cell Carcinoma of Lung
Clinical Trial for Safety and Effectiveness Evaluation of Tarlatamab (AMG757) With Etoposide, Carboplatin and Atezolizumab in Transformed Small Cell Lung Cancer Patients From Adenocarcinoma After EGFR TKI Treatment
The primary treatment option for non-small cell lung cancer (NSCLC) adenocarcinoma (ADC) with activating epidermal growth factor receptor (EGFR) mutation is EGFR tyrosine kinase inhibitor (TKI).
- Trial name
- NCT06830694
- Testing
- Atezolizumab, Etoposide, Carboplatin, Tarlatamab
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Sehhoon Park
Cerebral Palsy (CP)
Wearable Eye Tracking During Bimanual Tasks in Children With Cerebral Palsy
This observational pilot study will include 40 children and adolescents aged 6 to 12 years: 20 with cerebral palsy and 20 with typical development.
- Trial name
- NCT07806994
- Testing
- Wearable Eye-Tracking Assessment During Structured Bimanual Tasks
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Non-small Cell Lung Cancer (NSCLC)
The Prospective Non-randomized Case-control Study From Real-world Lung Cancer Patients
The pragmatic clinical trial to elucidate optimal target population of immunotherapy from real-world lung cancer patients
- Trial name
- OPTIMUS (NCT04909164)
- Testing
- Immunnotherapy group
- Where
- South Korea
- Volunteers
- 1,519 people
- Sponsor
- Myung-Ju Ahn