Clinical trials: sponsored by NYU Langone Health
Non Small Cell Lung Cancer
CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC
The purpose of this clinical trial is to evaluate the effects of adding CAN-2409 + prodrug for stage III/IV NSCLC patients who are on standard of care first line immune checkpoint inhibitor (ICI) treatment with evidence that the…
- Trial name
- NCT04495153
- Testing
- Aglatimagene besadenovec, Valacyclovir, Standard of Care anti-PD-1/PD-L1 (ICI)
- Where
- 14 sites in United States
- Volunteers
- 90 people
- Sponsor
- Candel Therapeutics, Inc.
Chronic Kidney Disease
Transcutaneous Auricular Vagus Nerve Stimulation Device in CKD Population
The purpose of this pilot interventional study is to collect preliminary data on the application of a transcutaneous auricular vagal nerve stimulation (taVNS) device in patients with chronic kidney disease (CKD).
- Trial name
- NCT05981183
- Testing
- Transcutaneous electrical nerve stimulation unit (TENS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Depression, MDD
Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
This pilot study evaluates the feasibility, safety, and preliminary efficacy of home-based 60Hz intermittent light therapy in adults with a major depressive episode (MDE).
- Conditions
- Depression, MDD, Major Depressive Disorder, Major Depressive Episode
- Trial name
- NCT07111390
- Testing
- 60Hz Intermittent Light Therapy
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- NYU Langone Health
Depressive Disorder, Depressive Symptoms
AI Mental Health Tool vs. Psychoeducation Control
The goal of this clinical trial is to learn if Ash, an AI chat tool for mental health, works better than static psychoedcuation in reducing mental health symptoms.
- Trial name
- NCT07841483
- Testing
- Ash, Psychoeducation
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Slingshot AI
Coronary Microvascular Disease, Ischemic Heart Disease
A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction
Among patients with stable ischemic heart disease who are referred for coronary angiography, a substantial proportion have non-obstructive coronary artery disease (CAD).
- Conditions
- Coronary Microvascular Disease, Ischemic Heart Disease, Myocardial Ischemia
- Trial name
- NCT03537586
- Testing
- Bivalirudin, Adenosine, Heparin
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- NYU Langone Health
Familial Dysautonomia (Riley-Day Syndrome), Hereditary Sensory and Autonomic Neuropathies
The Natural History of Familial Dysautonomia
The study will collect clinical information from patients with FD and allow them to give blood to help develop biological markers of the disease to aid diagnosis and treatment.
- Conditions
- Familial Dysautonomia (Riley-Day Syndrome), Hereditary Sensory and Autonomic Neuropathies, Hereditary Sensory and Autonomic Neuropathy 3
- Trial name
- NCT03920774
- Where
- 2 sites in United States, Israel
- Volunteers
- 400 people
- Sponsor
- NYU Langone Health
End Stage Renal Disease
Safety and Efficacy of Empagliflozin in Hemodialysis
A 12-week, phase II, randomized, double-blind, placebo-controlled, multi-center study to assess the safety, tolerability, and preliminary efficacy of empagliflozin versus placebo among patients initiating hemodialysis (n=60) for…
- Trial name
- SEED (NCT05786443)
- Testing
- Empagliflozin 10 MG
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Atherosclerotic Cardiovascular Disease
EHR Nudges: Optimizing a Clinical Decision Support System for Evidence-Based Statin Medication Prescribing to Reduce the Risk of Cardiovascular Disease
The overall objective of this proposal is to develop and optimize a CDSS, including several nudges, to increase guideline-concordant statin prescribing for CVD risk (Nudge-CVD-CDSS).
- Trial name
- NCT07914777
- Testing
- EHR Nudge
- Where
- United States
- Volunteers
- 7,501 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Health Care Transition, Survivorship Care
Multi-level Intervention to Successfully Transition to Adult Care for Survivors of Childhood and Adolescent Cancers: The BRIDGES-YAS! Study
Although 95% of young adult childhood cancer survivors (YA CCS) will develop chronic health conditions, suboptimal transition to adult-oriented care leads to <20% receiving recommended lifelong survivorship care.
- Conditions
- Health Care Transition, Survivorship Care, Survivors of Childhood Cancer, Patient Navigation
- Trial name
- BRIDGES-YAS! (NCT07915479)
- Testing
- Structured Transition to PCP, Comparison Arm
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- Georgetown University
Lung Cancer
Longitudinal Evaluation of Microbial and Host Signatures During Immunotherapy for Lung Cancer
This study will prospectively collect airway, stool, and blood samples on 80 subjects with lung cancer undergoing immunotherapy.
- Trial name
- NCT04063501
- Testing
- Bronchoscopy, Research Procedures
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- NYU Langone Health
Opioid Use Disorder
ED Observation for Opioid Use Disorder
This is a multicenter, randomized clinical comparative effectiveness trial (RCT) in which patients with untreated OUD presenting to a Northwell Health Emergency Department (ED), NYULH-Brooklyn, NYULH-Tisch, and Bellevue Hospital…
- Trial name
- NCT05064826
- Testing
- Extended Visit with Observation, Standard ED Visit
- Where
- 6 sites in United States
- Volunteers
- 170 people
- Sponsor
- NYU Langone Health
Healthy, Family Research
Pediatric Parenting Support in Flint
Public health disasters have disproportionate impacts on low income communities, through pathways that add to those of poverty and associated stressors, and act over extended periods.
- Trial name
- NCT03945552
- Testing
- Video Interaction Project
- Where
- 2 sites in United States
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Gastric Bypass, Weight Regain
Napoleon Measurement of Gastrojejunal Anastomosis
This is a clinical trial assessing the feasibility of the Napoleon device for measuring the gastrojejunal anastomosis (GJA). The study population is Roux-en-Y gastric bypass (RYGB) patients with weight regain undergoing an…
- Trial name
- NCT04832282
- Testing
- Napoleon, Visual estimation
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- NYU Langone Health
Uterine Fibroid
Life Study: Lifestyle Intervention in Fibroid Elimination
The study will evaluate a lifestyle, nutrition, and exercise program to assess whether this program is acceptable and feasible for patients..Researchers will examine if the LIFE program can modify fibroid recurrence.
- Trial name
- NCT05416424
- Testing
- LIFE program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Dementia Caregivers, Diabetes
NYUCI-ES: Psychosocial Intervention to Improve Health Outcomes for Chinese and Korean ADRD Caregivers
This study will conduct a two-arm randomized controlled trial to test the efficacy of a culturally tailored version of the NYU Caregiver Intervention (NYUCI) plus enhanced support (ES) through online chat groups (the NYUCI plus…
- Conditions
- Dementia Caregivers, Diabetes, Heart Disease, Overweight
- Trial name
- NCT05461495
- Testing
- Treatment Group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- New York University
Ischemic Heart Disease
Use of GeriKit to Better Phenotype Older Adults With Ischemic Heart Disease
This study seeks to expand the use of the NYU GeriKit mobile application ("app") in a diverse range of settings to better phenotype older patients, which will enhance both research and patient care.
- Trial name
- NCT05788666
- Testing
- GeriKit Mobile Application
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Weight Loss, Weight Gain
Time Restricted Eating for WeIght LoSs MainTenance-2
The TWIST 2.0 Study is a 12-month, 2-arm RCT in adults with recent weight loss. We will examine the efficacy of TRE on weight (Aim 1a) and fat mass (Aim 1b) regain, and describe changes in subjective appetite following a…
- Conditions
- Weight Loss, Weight Gain, Weight Loss Maintenance
- Trial name
- TWIST-2 (NCT07190170)
- Testing
- TRE, Weight-Loss Maintenance Advice
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- NYU Langone Health
Dementia
Inpatient Hospice Transitions Checklist
This is an NIH Stage IB single-arm feasibility study will adapt and test the Inpatient Hospice Transitions Checklist (I-HTC), an Epic-embedded intervention supporting hospice eligibility assessment and clinician-surrogate…
- Trial name
- I-HTC (NCT07889830)
- Testing
- I-HTC
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York University
Arthroscopic Medial Meniscus Posterior Root Repair
Medial Unloader Brace After Root Repair
The purpose of this study is to evaluate whether medial unloader bracing improves healing and clinical outcomes following arthroscopic medial meniscus posterior root repair.
- Trial name
- NCT07909369
- Testing
- Medial unloader valgus knee brace
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- NYU Langone Health
Cardiovascular Diseases
Cardiovascular Disease Multimorbidity
This is a hybrid type II effectiveness-implementation trial using a parallel cluster randomized design. Thirty primary healthcare centers (PHCs) in Akwa Ibom State, Nigeria, will be randomized in a 1:1 ratio to the implementation…
- Trial name
- NCT07909395
- Testing
- HEARTS, PF
- Where
- 2 sites in United States, Nigeria
- Volunteers
- 1,050 people
- Sponsor
- NYU Langone Health