Clinical trials: sponsored by Dana-Farber Cancer Institute
Graft Vs Host Disease, Acute-graft-versus-host Disease
Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial
This study is about determining if an aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD (Graft-Versus-Host Disease) after having an allogeneic stem cell transplant.
- Conditions
- Graft Vs Host Disease, Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease
- Trial name
- RESTART (NCT05236062)
- Testing
- Exercise, Attention control
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Dana-Farber Cancer Institute
Cancer Survivorship
Exercise and Nutrition for Older Cancer Survivors and Their Support Person: The Vitality Study
This research study will compare the impact of virtually supervised and unsupervised home-based exercise and diet programs on cognitive and physical function among cancer survivors and support persons.
- Trial name
- VITALITY (NCT06623097)
- Testing
- Supervised Exercise and Diet Program, Unsupervised Exercise and Diet Program
- Where
- 2 sites in United States
- Volunteers
- 1,528 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer, Survivorship
Dance Study for Post-surgical Pain in Breast Cancer Survivors
The purpose of this study is to examine how a 12-week, virtual dance program may improve pain and quality of life in participants with persistent post-surgical pain, or PPSP, following mastectomy or lumpectomy.
- Conditions
- Breast Cancer, Survivorship, Pain, Postoperative
- Trial name
- NCT06758102
- Testing
- Dance Program
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Lung Cancer
Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial
The purpose of this study is to examine the feasibility and effects of 12-week exercise training at different intensities among individuals with advanced lung cancer receiving immune checkpoint inhibitors.
- Trial name
- ENHANCE (NCT06026111)
- Testing
- High-Intensity Interval Training (HIIT), Moderate-Intensity Continuous Training (MICT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dana-Farber Cancer Institute
Small Cell Lung Cancer
SMARCA4/2 Inhibitor for POU2F3-Positive SCLC
This is a single-arm, phase II clinical trial evaluating the efficacy and safety of FHD-286, a SMARCA4/2 inhibitor, in participants with POU2F3-expressing small cell lung cancer who have received at least one prior line of…
- Trial name
- NCT07551635
- Testing
- FHD-286
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dana-Farber Cancer Institute
Metastatic Bladder Cancer, Peripheral Neuropathy
Acupuncture and Exercise for EV-Pembro-Induced Peripheral Neuropathy
The goal of this study is to evaluate the feasibility and preliminary efficacy of a combined acupuncture and exercise intervention for the management of chemotherapy-induced peripheral neuropathy (CIPN) in participants with…
- Conditions
- Metastatic Bladder Cancer, Peripheral Neuropathy, Advanced Urothelial Cancer, Metastatic Urothelial Cancer
- Trial name
- ACE (NCT07548476)
- Testing
- Acupuncture, Exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer, Breast Cancer Female
Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)
The goal of this study is to learn more about how exercise might lower the risk of developing breast cancer in women with dense breast tissue by studying changes that occur in breast tissue and blood as a result of participating…
- Trial name
- NCT06322888
- Testing
- Exercise Training Program
- Where
- 2 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor
International PPB/DICER1 Registry
PPB has strong genetic implications, with a unique set of conditions in an individual or their family, occurring mostly in childhood and adolescence.
- Conditions
- Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma
- Trial name
- NCT03382158
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Breast Cancer
Physical Activity, Proliferation and Immune Markers in Benign Breast Tissue
This research study is evaluating the effect of exercise on markers in breast tissue and blood of premenopausal women who have been found to have dense breast tissue on mammogram.
- Trial name
- NCT03657628
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Endometrial Cancer, ARID1A Gene Mutation
Avelumab and M1774 in ARID1A-mutated Endometrial Cancer
The purpose of this research study is to see if the combination of study drugs avelumab and M1774 is effective and safe for participants with endometrial cancer.
- Conditions
- Endometrial Cancer, ARID1A Gene Mutation, Recurrent Endometrial Carcinoma
- Trial name
- NCT06518564
- Testing
- Avelumab, M1774
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Panagiotis Konstantinopoulos, MD, PhD
Renal Carcinoma, Renal Cell Carcinoma
Memory-like Natural Killer (NK) Cell Therapy in Patients With Renal Cell Carcinoma or Urothelial Carcinoma
The goal of this research study is to establish the safety and then to explore the effectiveness of infusing the combination of cytokine-induced memory-like (CIML) natural killer (NK) cells, a type of immune cell in the blood…
- Conditions
- Renal Carcinoma, Renal Cell Carcinoma, Urothelial Carcinoma, Chromophobe Renal Cell Carcinoma
- Trial name
- NCT06318871
- Testing
- Cytokine Induced Memory-like Natural Killer (CIML NK) Cells, Interleukin-2 (IL-2)
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Dana-Farber Cancer Institute
Ovarian Sex-cord Stromal Tumor, Testicular Stromal Tumors
International Ovarian & Testicular Stromal Tumor Registry
Rare tumors are understudied, yet have the potential to shed light on vast areas of cancer research. Ovarian sex cord-stromal tumors, rare tumors of childhood and young adulthood, have recently been found to be associated with a…
- Conditions
- Ovarian Sex-cord Stromal Tumor, Testicular Stromal Tumors, Ovarian Small Cell Carcinoma
- Trial name
- OTST (NCT01970696)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Lymphoma
Study of Ruxolitinib in Relapsed or Refractory T or NK Cell Lymphoma
The purpose of this study is to test any good and bad effects of the study drug called ruxolitinib. Ruxolitinib works by blocking a protein called JAK.
- Trial name
- NCT02974647
- Testing
- Ruxolitinib
- Where
- 10 sites in United States
- Volunteers
- 83 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Salivary Gland Cancer, Recurrent Salivary Gland Cancer
9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma
This trial is investigating an intravenous (IV) medication called 9-ING-41 in combination with chemotherapy (carboplatin) for the treatment of advanced salivary gland cancers.
- Conditions
- Salivary Gland Cancer, Recurrent Salivary Gland Cancer, Metastatic Cancer, Adenoid Cystic Carcinoma
- Trial name
- NCT05010629
- Testing
- 9-ING-41, Carboplatin, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Robert Haddad, MD
Lymphoma, Primary Central Nervous System Lymphoma
Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL
This research study is studying if the investigational drug, Pembrolizumab, in combination with chemotherapy helps primary central nervous system lymphoma with acceptable side effects.
- Trial name
- NCT06475235
- Testing
- Pembrolizumab, Methotrexate, Temozolomide
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Dana-Farber Cancer Institute
Acute Myeloid Leukemia
Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve AML
This research study is studying the combination of venetoclax and chemotherapy as a possible treatment for acute myelogenous leukemia (AML). The drugs involved in this study are: Venetoclax Daunorubicin Cytarabine
- Trial name
- NCT03709758
- Testing
- Venetoclax, Daunorubicin, Cytarabine
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Dana-Farber Cancer Institute
Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer
Reach and Engagement of GENetic Education, Risk Assessment, and TEsting Feasibility Trial
This study will test a remote approach to help people who may be at higher risk for pancreatic cancer learn about and decide whether to get genetic testing and a blood test that looks for signs of several cancers (MCED testing).
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer, Genetic Testing, Multi-cancer Early Detection
- Trial name
- REGENERATE (NCT07787156)
- Testing
- Telephone education session, Online educational materials
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Chronic Graft Versus Host Disease
Improving Outcomes Assessment in Chronic GVHD
The purpose of this study is to see if recent guidelines proposed by the National Institutes of Health for the diagnosis, staging, and response assessment of people with chronic GVHD can improve our understanding of this…
- Trial name
- NCT00637689
- Where
- 9 sites in United States
- Volunteers
- 601 people
- Sponsor
- Fred Hutchinson Cancer Center
Chronic Lymphocytic Leukemia
A Phase 1b/2 Study of IPI-145 Plus FCR in Previously Untreated, Younger Patients With CLL
This research study is evaluating a new drug called IPI-145 in combination with the standard drugs fludarabine, cyclophosphamide, and rituximab (FCR), as a possible treatment for chronic lymphocytic leukemia (CLL).
- Trial name
- NCT02158091
- Testing
- IPI-145, Fludarabine, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Dana-Farber Cancer Institute
Non-Small Cell Lung Cancer
Osimertinib and Gefitinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer
This research study is studying a combination of two drugs as a possible treatment for Non-Small Cell Lung Cancer (NSCLC) with an EGFR mutation.
- Trial name
- NCT03122717
- Testing
- Gefitinib, Osimertinib
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Dana-Farber Cancer Institute
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