Clinical trials: sponsored by Columbia University
Cerebral Palsy
Feasibility of a Robot-Guided Active Play Intervention for Children With Cerebral Palsy
Cerebral palsy can make it difficult for children and adolescents to participate consistently in enjoyable physical activity. This study will examine whether a small humanoid robot called NAO can deliver a short, story-based…
- Trial name
- REACT (NCT07842328)
- Testing
- Humanoid Robot-Guided Active Play Intervention
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Substance Use Risk, Structural Stressors
Structural Stressors, Reward Related Decision Making and Substance Use Risk
The goal of this observational study, which has a pilot phase (R61) and a second, larger phase (R33), is to learn about the impact of indicators of structural stressors (SS) on substance use risk in Puerto Rican adolescents…
- Trial name
- NCT06221839
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Columbia University
Spinal Cord Injuries, Tetraplegia
MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury
The purpose of this study is to develop and test the hardware and software components of the MyHand-SCI device to assist with hand function for individuals with C6-C7 spinal cord injury.
- Trial name
- NCT05553457
- Testing
- Testing of MyHand-SCI Device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Breast Cancer
Decision Support for Chemoprevention
The purpose of this study is to find out whether electronic tools that provide information and reminders to people at high risk for breast cancer and their healthcare providers can increase the use of medications, such as…
- Trial name
- NCT07899151
- Testing
- RealRisks Decision Aid
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Columbia University
Modeling of Recruitment Curves
Adaptive Recruitment Curve Analysis Using Bayesian Modeling
The purpose of this study is to better understand how electrical or magnetic stimulation affect the nervous system by optimizing the way researchers measure muscle responses.
- Trial name
- NCT07561372
- Testing
- Algorithm: Uniform Sampling, Algorithm: hbMEP-adaptive algorithm (version 1), Algorithm: hbMEP-adaptive algorithm (version 2)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis
Topical TOR-582 Treatment of Epistaxis in HHT
People with hereditary hemorrhagic telangiectasia (HHT) often experience frequent and severe nosebleeds that can disrupt daily life and lead to anemia, medical procedures, and reduced quality of life.
- Trial name
- NCT07667413
- Testing
- Topical sirolimus ointment
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Columbia University
Aging, Sarcopenia
Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults
During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adults, which typically decreases with age.
- Conditions
- Aging, Sarcopenia, Sarcopenia in Elderly
- Trial name
- NCT06689618
- Testing
- Exercise
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Parkinson Disease, Anxiety
Treating Anxiety in Parkinson's Disease With a Multi-Strain Probiotic
This study evaluates the use of an oral multi-strain probiotic in the treatment of anxiety in individuals with Parkinson's Disease. Participants will be randomized to either 12-week multi-strain probiotic treatment or placebo.
- Trial name
- TAP (NCT03968133)
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of British Columbia
HIV Testing, STI
HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex Trafficking
This project will assess whether a digital survivor crowdsourced intervention can increase HIV/STI/HCV testing and overdose prevention kit utilization among survivors of sex trafficking living in New York City.
- Conditions
- HIV Testing, STI, HCV, Overdose, Drug
- Trial name
- NCT07264582
- Testing
- Sex Trafficking Survivor-Developed Digital Crowdsourced Intervention
- Where
- United States
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Columbia University
Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis
Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
This single-arm pilot study evaluates the effects of whole-body electrical muscle stimulation (WB-EMS) exercise on neuromuscular and physical function in adults with neuromuscular disease (NMD).
- Conditions
- Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis, Myasthenia Gravis, Lambert-eaton Myasthenic Syndrome
- Trial name
- NCT07478172
- Testing
- Whole-body Electrical Muscle Stimulation Exercise
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Gastric Cancer, Stomach Cancer
Avutometinib and Defactinib in Diffuse Gastric Cancer
The purpose of this study is to determine if the combination study treatment with avutometinib and defactinib will prolong life in participants, is effective in decreasing the size of the tumor(s), and if it is safe in subjects…
- Trial name
- NCT06487221
- Testing
- Avutometinib, Defactinib
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Ryan H. Moy, MD, PhD
Suicidal Ideation, Suicidal Behaviors
Pilot Study of a Modified Safety Planning Intervention for Elementary School-Aged Children - Main Study
The goal of this study is to finalize a version of the Safety Planning Intervention suitable for 6-12-year-old children. This intervention provides individuals with strategies to reduce the risk of suicidal behavior.
- Trial name
- NCT07564583
- Testing
- Child - Safety Planning Intervention, C-SPI+ecological momentary assessment
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Columbia University
Sleep Architecture, Mild Traumatic Brain Injury
Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)
This study will employ cognitive behavioral therapy for insomnia (CBT-I) among individuals with mild traumatic brain injury (mTBI) who experience sleep disturbances.
- Conditions
- Sleep Architecture, Mild Traumatic Brain Injury, Sleep, Sleep and Circadian Problems
- Trial name
- NCT07385105
- Testing
- Cognitive behavioral Therapy for insomnia (CBT-I)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Missouri-Columbia
Internalizing Disorders, Substance Use Disorders
Family Support Protocol for Adolescent Internalizing Disorders
This R34 will develop and test an adjunctive treatment protocol for addressing co-occurring internalizing disorders among adolescents enrolled in usual care for substance use problems.
- Trial name
- Fam-AID (NCT06413979)
- Testing
- Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID)
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage
Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICU
The purpose of this research study is to evaluate whether a smartphone-enabled EEG (electroencephalography) system can be used to detect Cognitive Motor Dissociation (CMD) in patients with acute neurological injuries who appear…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Cardiac Arrest (CA)
- Trial name
- SMART-CMD (NCT07917728)
- Where
- 9 sites in United States, Brazil and 3 more
- Volunteers
- 240 people
- Sponsor
- Columbia University
Visual Disturbance
Visual Symptom Simulator
Some patients presenting with visual symptoms may have difficulty accurately describing their visual experiences. Symptoms such as blurred vision, diplopia, visual field deficits, and transient visual disturbances are subjective…
- Trial name
- Vis_Sym_Sim (NCT07914998)
- Testing
- Visual Simulator
- Volunteers
- 150 people
- Sponsor
- University of British Columbia
Anxiety, Osteoarthritis
Preoperative Music Intervention for Anxiety in Hip and Knee Arthroplasty
Many patients feel anxious before joint replacement surgery. This anxiety is common - affecting roughly 1 in 3 patients - and research has shown that patients who are more anxious before surgery tend to have more pain afterward…
- Trial name
- NCT07845695
- Testing
- Music via Headphones
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Columbia University
Diffuse Large B-cell Lymphoma (DLBCL), Relapsed Diffuse Large B-cell Lymphoma (DLBCL)
Study of the Impact of CD34+ Cell Dose on Absolute Lymphocyte Count Following High-Dose Therapy and Autologous Stem Cell Transplantation for Relapsed and Refractory Diffuse Large B-cell Lymphoma (DLBCL)
The purpose of this study is to study the impact of stem cell dose on outcome after autologous transplant.
- Conditions
- Diffuse Large B-cell Lymphoma (DLBCL), Relapsed Diffuse Large B-cell Lymphoma (DLBCL), Refractory Diffuse Large B-cell Lymphoma (DLBCL)
- Trial name
- NCT02570542
- Testing
- leukapheresis, Plerixafor, carmustine, etoposide, cytarabine, melphalan
- Where
- 14 sites in United States
- Volunteers
- 59 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lymphoma, T-Cell, Cutaneous, Lymphomatoid Papulosis
Tissue Repository: CTCL Collection Protocol
This document is a protocol for a non-interventional human research study in which the investigator hopes to better understand the changes that take place in T cells in Cutaneous T-cell lymphoma (CTCL).
- Conditions
- Lymphoma, T-Cell, Cutaneous, Lymphomatoid Papulosis, Sézary Syndrome
- Trial name
- NCT02840747
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Columbia University
Suicide, Attempted, Suicide Ideation
Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings
This multisite randomized controlled trial will compare two brief interventions for youth and young adults ages 12-24 following an acute care visit for suicide risk: the Stanley-Brown Safety Planning Intervention with follow-up…
- Conditions
- Suicide, Attempted, Suicide Ideation, Suicide, Suicide Prevention
- Trial name
- Project HOPE (NCT06151158)
- Testing
- Stanley Brown Safety Planning Intervention and Follow-up Contacts (SPI+), Interpersonal Psychotherapy for Adolescents Ultra Short Crisis Intervention (IPT-A SCI)
- Where
- 6 sites in United States
- Volunteers
- 484 people
- Sponsor
- Johns Hopkins University
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