Clinical trials: sponsored by Brigham and Women's Hospital
Chronic Kidney Diseases
An Individuation Intervention to Reduce Socioeconomic Disparities in Chronic Kidney Disease Care
The goal of this clinical trial is to test whether an individuation intervention can improve the quality of chronic kidney disease (CKD) care for patients with low socioeconomic status (SES) and to understand the mechanisms…
- Trial name
- NCT07921342
- Testing
- Individuation + Implicit Bias Training, Implicit Bias Training Alone
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Brigham and Women's Hospital
Lupus Nephritis (LN)
Dapagliflozin in Active Lupus Nephritis
Lupus nephritis is a chronic and life-threatening autoimmune cause of kidney disease that predominately impacts young people and can lead to kidney failure.
- Trial name
- Dapa-Active LN (NCT07323524)
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Brigham and Women's Hospital
Multiple Myeloma
Blockade of PD-1 in Conjunction With the Dendritic Cell/Myeloma Vaccines Following Stem Cell Transplantation
The purpose of this research study is to determine the safety of CT-011 alone, as well as the combination of the Dendritic cell fusion vaccine and CT-011, after autologous stem cell transplantation (ASCT).
- Trial name
- NCT01067287
- Testing
- CT-011, Dendritic Cell Fusion Vaccine
- Where
- 3 sites in United States, Israel
- Volunteers
- 35 people
- Sponsor
- Beth Israel Deaconess Medical Center
Skilled Nursing Facility, Rehabilitation
Skilled Nursing Facility Care at Home
We will perform a parallel-group multicenter patient-level randomized controlled evaluation of skilled nursing facility care at home.
- Trial name
- NCT06416670
- Testing
- Skilled nursing facility care at home
- Where
- 5 sites in United States
- Volunteers
- 244 people
- Sponsor
- Brigham and Women's Hospital
HIV-1-infection
Safety and Pharmacokinetics of the Combination Broadly Neutralizing Antibodies, 3BNC117-LS-J and 10-1074-LS-J, in Healthy American and African Adults
This is a Phase 1/2 study to evaluate the safety, tolerability, and pharmacokinetics of two broadly neutralizing monoclonal human antibodies (bNAbs), 3BNC117-LS-J, which targets the CD4 binding site on HIV-1 envelope protein, and…
- Trial name
- NCT04173819
- Testing
- 3BNC117-LS-J, 10-1074-LS-J, Combination 3BNC117-LS-J and 10-1074-LS-J
- Where
- 9 sites in United States, Kenya and 3 more
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Kidney Transplant
Sotagliflozin Safety and Tolerability Among Renal Transplant Recipients
This is an investigator-initiated, randomized controlled trial in adult KTRs (N=50) with stable allograft function to assess: 1) the reversibility of the expected acute changes in eGFR with sotagliflozin (donated by Lexicon); 2)…
- Trial name
- START (NCT05405556)
- Testing
- eGFR reporting
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Martina McGrath, MD
Medication Adherence
Personalized Routine and Habit Integration to Support Medication Management
The objective of this study is to test a multidisciplinary care team behavioral intervention to enhance medication adherence among older adults with multiple chronic conditions (MCC).
- Trial name
- PRISM (NCT07914452)
- Testing
- PRISM Arm, Enhanced Usual Care Arm
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Cognition, Cardiometabolic Risk Factors
Trial of Pistachio Consumption in Older Adults
The goal of this study is to evaluate whether a pistachio-enriched diet leads to changes in cognitive function, cardiometabolic risk factors, and life satisfaction in older adults over a 6-month period.
- Conditions
- Cognition, Cardiometabolic Risk Factors, Life Satisfaction
- Trial name
- NCT06992544
- Testing
- Pistachio-enriched diet, Usual diet
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Primary Aldosteronism, Resistant Hypertension
Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension
Primary aldosteronism (PA) is common but rarely recognized cause of hypertension that carries excess cardiovascular and renal risk and has approved targeted treatments.
- Conditions
- Primary Aldosteronism, Resistant Hypertension, Secondary Hypertension, Hyperaldosteronism
- Trial name
- ALERT-PA (NCT05925569)
- Testing
- Best Practice Advisory Computerized Alert
- Where
- United States
- Volunteers
- 12,501 people
- Sponsor
- Brigham and Women's Hospital
Gastric Bypass, Weight Regain
Napoleon Measurement of Gastrojejunal Anastomosis
This is a clinical trial assessing the feasibility of the Napoleon device for measuring the gastrojejunal anastomosis (GJA). The study population is Roux-en-Y gastric bypass (RYGB) patients with weight regain undergoing an…
- Trial name
- NCT04832282
- Testing
- Napoleon, Visual estimation
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- NYU Langone Health
Advanced Prostate Cancer, Metastatic Prostate Cancer
Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT
This research study is studying a positron emission tomography (PET) agent called 18F-fluciclovine to evaluate how well 18F-fluciclovine-PET scans determine the extent of advanced prostate cancer that either has low…
- Conditions
- Advanced Prostate Cancer, Metastatic Prostate Cancer, Metastatic Prostate Neuroendocrine Carcinoma
- Trial name
- NCT06062745
- Testing
- 18F-fluciclovine, PET/CT
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Cardiac Surgery
Randomized Evaluation of Operating Room Extubation After Cardiac Surgery
We are studying whether waking patients up and removing the breathing tube (also known as "extubation") in the operating room after cardiac surgery improves postoperative recovery without causing harm.
- Trial name
- NCT07757880
- Testing
- OR extubation, ICU extubation
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Human Papillomavirus (HPV), HPV Associated Cancers
C2001P-CS3: Testing the Feasibility of Different HPV Screening and Care Strategies for Women Living With HIV
The overall goal of this study is to inform the design and establish feasibility for a future clinical trial to determine the optimal management of women living with HIV (WLWH) with high-risk human papillomavirus (hrHPV) detected…
- Conditions
- Human Papillomavirus (HPV), HPV Associated Cancers, Cervical Cancer, Human Immunodeficiency Virus (HIV)
- Trial name
- NCT07576842
- Testing
- HPV DNA Testing (Abbott Alinity m HPV Assay), Visual Inspection with Acetic Acid, Cervical Histology (Biopsy Procedures)
- Where
- Botswana
- Volunteers
- 750 people
- Sponsor
- University of California, San Diego
Amputation
Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees
The e-OPRA Implant System, is a further development of the OPRA (Osseointegrated Prostheses for the Rehabilitation of Amputees) Implant System.
- Trial name
- TTeOPRA+MB (NCT06391697)
- Testing
- eOPRA Implant System for Transtibial Amputees and Magnetic Bead Tracking System
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
Migraine
Cocoa Extract for Migraine Trial
The goal of this clinical trial is to assess the feasibility of recruitment and adherence to a high-dose cocoa extract supplement in individuals diagnosed with migraine.
- Trial name
- CORAL (NCT06808230)
- Testing
- Cocoa extract
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Brigham and Women's Hospital
Myotonic Dystrophy, Duchenne Muscular Dystrophy
Biomarker Development for Muscular Dystrophies
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies.
- Conditions
- Myotonic Dystrophy, Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy
- Trial name
- NCT05019625
- Where
- 5 sites in United States
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myotonic Dystrophy
Extracellular RNA Biomarkers of Myotonic Dystrophy
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies.
- Trial name
- NCT05020002
- Where
- 3 sites in United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Metastatic Prostate Cancer, Hormone Sensitive Prostate Cancer
PSMAtrack-tracking Changes in PSMA-PET During Initial Therapy for Metastatic Hormone-sensitive Prostate Cancer
The goal of this clinical trial is to learn if serial PSMA-PET/CT scans can be used to monitor response to therapy in metastatic hormone sensitive prostate cancer and can be potentially used to optimize future treatment…
- Conditions
- Metastatic Prostate Cancer, Hormone Sensitive Prostate Cancer, Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
- Trial name
- NCT06479187
- Testing
- 18F-rhPSMA-7.3, PET/CT
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes
Personalizing A1c Using Hematologic Indices and CGM for Accurate Diabetes Diagnosis
The goal of this observational study is to learn why some adults over the age of 65, have A1c tests that do not match up with their blood glucose levels, also known as 'A1c-glucose discordance'.
- Trial name
- PRECISE DM DX (NCT07111416)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Primary Sclerosing Cholangitis (PSC)
FEAST and HOPE: Redox PSC Pilot Study
The goal of this clinical trial is to test whether a type of cell death called disulfidptosis plays a role in primary sclerosing cholangitis (PSC) in adults aged 18 to 70.
- Trial name
- FEAST (NCT07898839)
- Testing
- N-Acetyl Cysteine (NAC), Alpha-Lipoic Acid (ALA), Nicotinamide Riboside (NR)
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
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