Clinical trials: Phase 4, open to volunteers
Cutaneous Squamous Cell Carcinoma, Skin Cancer
Cosibelimab for CSCC in Patients With Kidney Transplant or Hematologic Malignancy
This is study is to evaluate the safety and efficacy of cosibelimab in special populations with advanced cutaneous squamous cell carcinoma (CSCC).
- Trial name
- NCT07426484
- Testing
- Cosibelimab, Prednisone, Sirolimus
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Dana-Farber Cancer Institute
Phobia, Social
Investigating the Effects of Cannabidiol on Social Anxiety Disorder
The purpose of this study is to test whether a single-dose of Epidiolex (cannabidiol) is associated with reduced psychological, physiological, and neuroimaging measures of anxiety in people diagnosed with social anxiety disorder…
- Trial name
- CAN-SAD (NCT05649059)
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts Institute of Technology
Coronary Artery Disease, Percutaneous Coronary Intervention
NOAC Therapy Guided by PARIS Risk Score and D-dimer in Patients With ACS After PCI
The goal of this clinical trial is to compare short-term Triple Antithrombotic Therapy (DAPT + Rivaroxaban) followed by DAPT with standard DAPT in selected ACS patients with high ischemic risk.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome
- Trial name
- NCT05638867
- Testing
- Aspirin + Clopidogrel + Rivaroxaban, Aspirin + Clopidogrel
- Where
- China
- Volunteers
- 3,944 people
- Sponsor
- China National Center for Cardiovascular Diseases
AML (Acute Myeloid Leukemia), Glioma
Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies
A open-label drug-drug interaction (DDI) study to evaluate the effects of olutasidenib on the pharmacokinetics (PK) of a CYP450 and OATP1B1 probe substrate cocktail in participants with IDH1 mutation-positive malignancies.
- Conditions
- AML (Acute Myeloid Leukemia), Glioma, Cholangiocarcinoma, Solid Tumor Malignancies
- Trial name
- NCT07486713
- Testing
- Olutasidenib, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, and OATP1B1 Probe Substrates
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Rigel Pharmaceuticals
Ulcerative Colitis Acute
Feasibility Pilot Sequential Multiple Assignment Randomized Trial (SMART) for Acute Severe Ulcerative Colitis
The goal of this trial is to create personalized treatments for each patient admitted to the hospital with acute severe ulcerative colitis (ASUC).
- Trial name
- NCT05867329
- Testing
- Cyclosporine Injection (IV), Cyclosporine Oral Product, Upadacitinib Extended Release Oral Tablet
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Berinstein, Jeffrey
Hypotension
Treatment of Orthostatic Hypotension in SCI
The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic…
- Trial name
- SCI (NCT05839652)
- Testing
- Midodrine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Esophagectomy, Pneumonectomy
Stellate Ganglion Block
The purpose of this study is to determine if the addition of an ultrasound guided left sided stellate ganglion block with bupivacaine in patients undergoing esophagectomy, pneumonectomy, or lobectomy will result in lower rates of…
- Conditions
- Esophagectomy, Pneumonectomy, Lobectomy
- Trial name
- NCT06271707
- Testing
- 0.5% bupivacaine, Saline
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Minnesota
Functional Dyspepsia
A Study to Evaluate the Efficacy and Safety of DA-9701 in Patients With Functional Dyspepsia
This study will evaluate the efficacy and safety of DA-9701 in patients with functional dyspepsia
- Trial name
- NCT07686679
- Testing
- DA-9701, DA-9701-R
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Dong-A ST Co., Ltd.
NSCLC (Non-small Cell Lung Cancer)
Oral Paclitaxel Solution With Immunotherapy and Concurrent SBRT as Neoadjuvant Treatment for Older Adults With NSCLC
his multicenter, open-label, single-arm phase I/II trial will evaluate the safety, tolerability, and preliminary efficacy of oral paclitaxel solution combined with an immune checkpoint inhibitor and concurrent stereotactic body…
- Trial name
- NCT07754812
- Testing
- Oral Paclitaxel Solution, PD-1/PD-L1 inhibitor, Stereotactic Body Radiotherapy (SBRT)
- Where
- 5 sites in China
- Volunteers
- 78 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Arthritis, Obesity & Overweight
GLP-1s in Hip and Knee Arthroplasty
The number of people living with hip and knee arthritis continues to grow. A large amount of these people are also overweight and diagnosed with obesity.
- Conditions
- Arthritis, Obesity & Overweight, GLP - 1
- Trial name
- NCT07755085
- Testing
- GLP-1 Receptor Agonists + Behavioral modification
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Nova Scotia Health Authority
Atrial Fibrillation (AF), Obesity & Overweight
Waiting on Atrial Fibrillation Intervention Therapy (WAIT) Study
Atrial fibrillation (AF) is the most common heart rhythm disorder and is associated with symptoms, reduced quality of life, heart failure, stroke, and a high risk of recurrence after catheter ablation.
- Trial name
- WAIT (NCT07275697)
- Testing
- Semaglutide 2.4 mg, Standard medical treatment
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Emma Svennberg
NSCLC (Non-small Cell Lung Cancer), Thyroid Cancer
Pralsetinib DDI Study in Patients With Advanced or Metastatic Solid Tumors
An open-label drug-drug interaction study to evaluate the effects of pralsetinib (Gavreto) on the pharmacokinetics of a CYP450 probe substrate cocktail and, in female participants, a hormonal probe substrate, in participants with…
- Conditions
- NSCLC (Non-small Cell Lung Cancer), Thyroid Cancer, Solid Tumor Malignancies, Advanced Malignancies
- Trial name
- NCT07704658
- Testing
- Pralsetinib, CYP3A4, CYP2C8, and CYP2C9 substrates, and hormonal contraceptive
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- Rigel Pharmaceuticals
Pouch, Ileal, Pouches, Ileoanal
Tirzepatide for Ileal Pouch-anal Anastomosis (IPAA) and Chronic High Bowel Frequency (I8F-NS-X008)
The goal of this clinical trial is to learn if Tirzepatide (Zepbound) can decrease bowel frequency in patients that have an ileal-pouch anal anastomosis (IPAA or pouch) better than standard of care anti-diarrheal therapy.
- Conditions
- Pouch, Ileal, Pouches, Ileoanal, Bowel Diseases, Inflammatory
- Trial name
- PROP-ZEP (NCT07756359)
- Testing
- Tirzepatide, Loperamide, Diphenoxylate/Atropine
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Cytomegalovirus (CMV) Infection
CytoGam for CMV Infection or Disease in Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a significant opportunistic pathogen and a major cause of morbidity and mortality in solid organ transplant recipients.
- Trial name
- NCT07009548
- Testing
- Cytogam
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fernanda P Silveira, MD, MS
Arthroplasty
Postoperative Oral Tranexamic Acid in Patients Undergoing Primary Total Joint Arthroplasty
The purpose of this study is to evaluate the impact of an extended oral Tranexamic Acid regimen on patient reported outcome scores, time to independent ambulation, postoperative range of motion, swelling, change in hemoglobin…
- Trial name
- NCT06832878
- Testing
- Oral Tranexamic Acid
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Mayo Clinic
Freezing of Gait Symptoms in Parkinson's Disease, Deep Brain Stimulation
Imaging Biomarkers of FOG Response to DBS
For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS).
- Trial name
- NCT06951906
- Testing
- fMRI
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Medical University of South Carolina
Atrial Fibrillation (AF), Coronary Arterial Disease (CAD)
Net Clinical Benefit of Edoxaban Versus Apixaban in Patients With Atrial Fibrillation and Coronary Artery Disease
Non-vitamin K antagonist oral anticoagulants(NOACs) are standard care for thromboembolism prevention in patients with Aterial Fibrillation(AF).
- Trial name
- SMARTDECISION3 (NCT07753200)
- Testing
- Edoxaban, Apixaban
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Samsung Medical Center
Peripartum Cardiomyopathy, Postpartum
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
The study will enroll 200 women newly diagnosed with peripartum cardiomyopathy within 5 months postpartum in a randomized placebo controlled trial of bromocriptine therapy to evaluate its impact on myocardial recovery and…
- Trial name
- REBIRTH (NCT05180773)
- Testing
- Bromocriptine, Guideline Directed Medical Therapy for Heart Failure (GDMT), Rivaroxaban
- Where
- 64 sites in United States
- Volunteers
- 250 people
- Sponsor
- Dennis M. McNamara, MD, MS
Acute Heart Failure
Efficacy and Safety With Early Treatment of Finerenone in Hospitalized Patients With Heart Failure
FACILITATE-HF is a multicenter, randomized, double-blind, placebo-controlled trial designed to determine whether initiation of finerenone during the early phase of hospitalization has beneficial effects in patients with AHF who…
- Trial name
- FACILITATE-HF (NCT07397650)
- Testing
- Finerenone Oral Tablet
- Where
- 21 sites in Japan
- Volunteers
- 550 people
- Sponsor
- Juntendo University
Thyroidectomy, Cervical Plexus Block
The Effect of Bilateral Intermediate Cervical Plexus Block on the Surgical Stress Response Following Total Thyroidectomy
Total thyroidectomy triggers a systemic surgical stress response involving neuroendocrine and inflammatory pathways. Ultrasound-guided bilateral intermediate cervical plexus block (BICPB) is commonly utilized for postoperative…
- Conditions
- Thyroidectomy, Cervical Plexus Block, Surgical Stress Response
- Trial name
- NCT07740460
- Testing
- Ultrasound-Guided Bilateral Intermediate Cervical Plexus Block Using 0,25% Levobupivacaine
- Volunteers
- 48 people
- Sponsor
- University Hospital Dubrava
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