Clinical trials: sponsored by University of British Columbia
Stroke, Chronic Stroke
Virtual Physical Activity Seated Exercise - Phase 2
This study will determine the acceptability of delivering seated exercises online and if seated exercises can improve balance, mobility, quality of life, and cardiometabolic health in those living with a stroke related mobility…
- Conditions
- Stroke, Chronic Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- V-PASE (NCT05724823)
- Testing
- Virtual Physical Activity Seated Exercises (V-PASE)
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Acute Spinal Cord Injury, Spinal Cord Injuries
Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial
The study involves the 'first-in-human' evaluation of a novel optical sensor which uses near-infrared spectroscopy (NIRS) technology to assess oxygenation and hemodynamics of the injured spinal cord.
- Trial name
- NCT04811235
- Testing
- Near Infra-Red Spectroscopy (NIRS) Sensor
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
Artificial Intelligence
Artificial Intelligence (AI) Assisted Real-time Adenoma Detection and Classification During Colonoscopies
This is a pragmatic, double-blind, randomized, controlled trial, to evaluate the effect of implementing a Computer-assisted detection (CADe) system within the routine clinical practice of Canadian healthcare institutions.
- Trial name
- CAG-SIG-AI (NCT05244278)
- Testing
- Medtronic-GI genius (CADe system for detecting colorectal polyps)
- Where
- Canada
- Volunteers
- 1,596 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Bipolar II Depression
Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II Disorder
This study is a 12-week (in addition to up to 30 days of screening) randomized, double-blind, placebo-controlled, parallel-group trial.
- Trial name
- PAT-BD-01 (NCT06943573)
- Testing
- psilocybin (25 mg), psilocybin 1mg micro-dose
- Where
- 3 sites in Canada
- Volunteers
- 90 people
- Sponsor
- Lakshmi N Yatham
Parkinson Disease, Cognitive Impairment
Theta Deep Brain Stimulation for Cognitive Enhancement in Parkinson's Disease
Cognitive impairment is common in Parkinson's disease. A recent study demonstrated 40% of people with PD suffer from mild cognitive impairment and > 80% of patients develop dementia after a disease duration of 20 years.
- Trial name
- NCT06518824
- Testing
- DBS On, DBS Off
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Pancreatic Cancer, PDAC - Pancreatic Ductal Adenocarcinoma
Monitoring and Managing Glucose Levels in People With Pancreatic Cancer
This study will investigate the prevalence of hyperglycemia (high blood sugar) in approximately 50 participants with pancreatic cancer.
- Conditions
- Pancreatic Cancer, PDAC - Pancreatic Ductal Adenocarcinoma, Hyperglycemia
- Trial name
- PEGASUS (NCT05132244)
- Testing
- Glucose Measurements via Blood Draw
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Inflammatory Bowel Disease (IBD)
Prospective Intestinal Ultrasound Study for Artificial Intelligence Algorithm Development
This observational study will use intestinal ultrasound images to help develop computer programs that may make it easier to assess bowel inflammation.
- Trial name
- PSIUSAD (NCT07814274)
- Testing
- De-identified Intestinal Ultrasound Data Collection
- Where
- Canada
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Persisting Symptoms After Concussion
Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy
The goal of this randomized controlled trial is to evaluate the safety, feasibility, and efficacy of psilocybin assisted therapy as an intervention to reduce symptom burden in adult patients (aged 18-65) with persisting symptoms…
- Trial name
- PatACT (NCT06615908)
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Falls, Frailty
Preventing Falls in Older Adults With Cognitive Frailty
The Problem: The proposed trial will address the problem of how to effectively prevent subsequent falls in community-dwelling cognitively frail older adults with a history of falls.
- Conditions
- Falls, Frailty, Mild Cognitive Impairment
- Trial name
- ACTIVE (NCT06854731)
- Testing
- Balance and Strength Training Exercises with Health Coaching, Education Session
- Where
- Canada
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Post Traumatic Stress Disorder PTSD, Intimate Partner Violence (IPV)
Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence
The goal of this randomized controlled trial is to evaluate the efficacy of psilocybin administered with Acceptance and Commitment Therapy (ACT) as an intervention to reduce post-traumatic stress disorder (PTSD) symptom burden in…
- Trial name
- PsiPTSD (NCT06885996)
- Testing
- Psilocybin
- Where
- 2 sites in Canada
- Volunteers
- 76 people
- Sponsor
- University of Calgary
Prostate Cancer, Oligometastatic
Radioguided Salvage Pelvic Node Dissection in Oligometastatic Prostate Cancer - SALVAGE
The goal of this clinical trial is to learn whether radioguided surgery can help surgeons find and remove lymph nodes containing prostate cancer in men whose cancer has returned in a small number of lymph nodes after previous…
- Trial name
- SALVAGE (NCT07807293)
- Testing
- PSMA 99mTc-MIP-1404 radioguided salvage lymph node dissection, Salvage pelvic lymph node dissection
- Volunteers
- 62 people
- Sponsor
- University of British Columbia
Oral Cavity Cancer, Oral Cancer
Mandibular Reconstruction Preplanning (ViPMR)
Virtual Surgical Planning (VSP), where 3D modeling is used to create 3D-printed surgical guides, has been shown to improve outcomes for patients who undergo mandibular reconstruction surgery, usually due to invasion of cancer…
- Trial name
- ViPMR (NCT05429099)
- Testing
- Virtual Surgical Planning (VSP), Free-Hand Surgery
- Where
- Canada
- Volunteers
- 420 people
- Sponsor
- University of British Columbia
Oral Epithelial Dysplasia (OED), Oral Squamous Cell Carcinoma (SCC)
Evaluating Treatment Strategies for p53 Mutant Oral Cancer and Oral Cancer Precursors
The goal of this clinical trial is to optimize treatment strategies for patients with p53-mutant oral epithelial dysplasia (OED) and early-stage oral squamous cell carcinoma (OSCC).
- Trial name
- p53 RCT (NCT07090070)
- Testing
- Cohort 1 Intervention group, Cohort 2 severe/CIS margins clear, Cohort 2 p53 and severe/CIS margins clear
- Where
- Canada
- Volunteers
- 636 people
- Sponsor
- University of British Columbia
Colorectal Cancer, Polyp of Colon
Hybrid-APC Margin Ablation to Prevent Post EMR Adenoma Recurrence
Endoscopic Mucosal Resection (EMR) is the current standard for effective endoscopic resection of such colon adenomas. If resection is possible in one piece (so-called "en bloc" resection) then recurrence rates are low.
- Trial name
- h-APC_EMR (NCT04015765)
- Testing
- Hybrid Argon Plasma Coagulation and EMR procedure
- Where
- Canada
- Volunteers
- 376 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Limitation, Mobility, Older Adults
SuPA Mobility: Supporting Physical Activity for Mobility in Mobility-Limited Older Adults
The goal of this randomized controlled trial is to investigate the effectiveness of a health-coaching intervention to improve physical activity in older adults with limited mobility when compared to a control, health education…
- Trial name
- NCT05978336
- Testing
- Health Coaching Program, Health Education Program
- Where
- Canada
- Volunteers
- 290 people
- Sponsor
- University of British Columbia
Endometrial Cancer, Lynch Syndrome
Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire
The goal of this study is to find out if self-collected vaginal swabs can be used to detect early signs of uterine cancer or related conditions in people with Lynch syndrome (LS) who still have their uterus.
- Trial name
- Lynch-SCAN (NCT07194551)
- Testing
- Vaginal DNA swab, microbiome swab and pH test
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Type 2 Diabetes
Montbretin Clinical Trial in Healthy Volunteers and Type 2 Diabetics
The goal of this clinical trial is to test the investigational product, Montbretin A (MbA) in either individuals with type 2 diabetes (T2D) or healthy participants.
- Trial name
- MbA (NCT05826054)
- Testing
- Montbretin A
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Robert Petrella
Anesthesia, Analgesia
Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: DPE v CSE v Epidural
As the dural puncture epidural (DPE) is increasing in popularity for labor analgesia, it is important to understand how it impacts outcomes in parturients.
- Trial name
- NCT05514431
- Testing
- Epidural, Dural Puncture Epidural (DPE) technique, Combined Spinal-Epidural (CSE) technique
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson Disease, GBA Gene Mutation
The GBA Multimodal Study in Parkinson's Disease
This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease.
- Conditions
- Parkinson Disease, GBA Gene Mutation, Gaucher Disease
- Trial name
- NCT04101968
- Testing
- PET scan, neuroQWERTY
- Where
- 3 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Pacific Parkinson's Research Centre
Endometriosis, Pain
Quantitative Sensory Testing and Central Sensitization in Endometriosis
Endometriosis is a gynecologic condition where there is growth of endometrial-like tissue outside the uterus, leading to severe pelvic pain.
- Trial name
- NCT06215937
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- BC Women's Hospital & Health Centre
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