Clinical trials: sponsored by Chinese University of Hong Kong
Prostate Cancer
To Identify Potential New Urine Markers for the Screening of Prostate Cancer
Prostate gland is a clinically important male sexual organ and its main function is for the production of semen. Globally, it is the second most common cancer in men globally and is also the fifth cancer cause for death in male.
- Trial name
- NCT03914391
- Where
- Hong Kong
- Volunteers
- 10,000 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Prostate Irreversible Electroporation Study
Conventional treatment options for localized prostate cancer include prostatectomy, radiotherapy and active surveillance. However, prostatectomy and radiotherapy carry certain degree of morbidity, including the risks of urinary…
- Trial name
- NCT06886321
- Testing
- Prostate Irreversible Electroporation
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Benign Prostatic Hyperplasia
Comparing Rezum and Urolift
This is a randomized controlled trial using a non-inferiority design with the subjects randomized 1:1 to either water vapour thermal treatment (REZUM) arm or prostatic urethral lift (UroLift) arm.
- Trial name
- NCT06820606
- Testing
- Rezum, UroLift
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Patient Preference of Apalutamide Versus Enzalutamide in Patients With Recurrent or Metastatic Hormone-Sensitive Prostate Cancer
This is a prospective, open-label, randomized, controlled, cross-over trial assessing patient preference for apalutamide versus enzalutamide in 146 male patients with recurrent or metastatic hormone-sensitive prostate cancer.
- Trial name
- NCT04409288
- Testing
- Apalutamide, Enzalutamide
- Where
- Hong Kong
- Volunteers
- 74 people
- Sponsor
- Chinese University of Hong Kong
Urolithiasis
Urine Biomarker for Stone Recurrence
Despite the advent of treating stones with Extracorporeal Shock Wave Lithotripsy (ESWL) and Percutaneous nephrolithotomy (PCNL), the recurrence rate for renal stones remains high and this may be due to poor compliance of patients…
- Trial name
- NCT04354181
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Benign Prostatic Hyperplasia
Waterjet Prostate Ablation
Introduction Men with enlarged prostates commonly experience lower urinary tract symptoms and may go on to develop complications such as acute urinary retention (AUR).
- Trial name
- NCT03938194
- Testing
- Aquablation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
A Novel Augmented Reality System (ARssist) for the Assistant Surgeon in Robotic Assisted Surgery
Robotic prostatectomy is a surgery for treating localized prostate cancer. The ARssist system is a novel augmented reality system designed for the assistant surgeon, allowing delivery of augmented reality information via…
- Trial name
- NCT04304079
- Testing
- ARssist system
- Sponsor
- Chinese University of Hong Kong
Bladder Cancer, Bladder Neoplasm
Transurethral Modified En Bloc Resection For Large Bladder Tumours.
Modified en bloc resection is a hybrid technique involving piecemeal resection of the exophytic part of the bladder tumour, followed by en bloc resection of the tumour base.
- Conditions
- Bladder Cancer, Bladder Neoplasm, Bladder Tumor
- Trial name
- NCT04081246
- Testing
- Bipolar transurethral modified en bloc resection of bladder tumour
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Fatty Pancreas, Microbiome Analysis
Microbiome Characterization in Fatty Pancreas
There has been a growing interest in evaluating the role of gut and intra-lesional microbiome in the pathogenesis of various benign and malignant conditions of the GI tract, liver and pancreas.
- Trial name
- FPM1 (NCT06938646)
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Upper Tract Urothelial Carcinoma
Flexible Ureterorenoscopy for Surveillance of Upper Tract Urothelial Carcinoma
It is a prospective single-arm pilot study to investigate the safety and feasibility of flexible ureteroscopy under local anaesthesia.
- Trial name
- NCT07557563
- Testing
- Flexible ureterorenoscopy
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Comparing MRI-Ultrasound Fusion and Cognitive-guided Biopsy for the Detection of csPCa: the PROFUSION Trial
This study is an international multicentre RCT to compare the linically significant prostate cancer (csPCa) detection of cognitive-guided and MRI-USG guided biopsies in men with suspicious MRI lesion.
- Trial name
- NCT06303622
- Testing
- MRI-USG fusion approach, Cognitive-guided approach
- Where
- Hong Kong
- Volunteers
- 1,620 people
- Sponsor
- Chinese University of Hong Kong
Pancreatic Steatosis, Pancreatic Cyst
Determination of Pancreatic Steatosis Prevalence and Correlation With High-risk Cyst Features
Pancreatic cancer is the fifth leading cause of cancer mortality in Hong Kong and the seventh leading cause of cancer mortality worldwide. In 2020, approximately 496000 new cases of pancreatic cancers were diagnosed globally .
- Trial name
- FPPCN (NCT05334836)
- Testing
- MRI for pancreatic fat and liver fat quantitation
- Where
- Hong Kong
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Hemopatch to Prevent Lymphatic Leak After Robotic Prostatectomy and Pelvic Lymph Node Dissection
Robotic prostatectomy (RARP) is a surgery for treatment localized prostate cancer. Bilateral pelvic lymph node dissection (BPLND) will also be performed if there is an estimated risk of occult nodal metastases exceeding 5%.
- Trial name
- NCT04185922
- Testing
- Hemopatch
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
The Investigation of New Biological Markers for Prostate Cancer Diagnosis and Management in Chinese Population
Prostate cancer (PC) is highly prevalent worldwide and is currently the 3rd most commonly diagnosed prostate cancer in Hong Kong male population with more than 1600 new cases diagnosed per year.
- Trial name
- NCT03893929
- Testing
- New Biological markers for prostate cancer diagnosis and management
- Where
- Hong Kong
- Volunteers
- 10,000 people
- Sponsor
- Chinese University of Hong Kong
Bladder Cancer, Hyperthermia
Use of Immediate Hyperthermic Intravesical Chemotherapy Following TURBT
This is a prospective single-arm pilot study investigating the safety and feasibility of giving hyperthermic intravesical chemotherapy immediately following transurethral resection of bladder tumour.
- Conditions
- Bladder Cancer, Hyperthermia, Chemotherapy Effect
- Trial name
- I-HIVEC (NCT03689478)
- Testing
- Hyperthermic intravesical chemotherapy
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Bladder Cancer
Role of ERBT Plus Intravesical BCG in Intermediate-Risk or High-Risk NMBC
This is a prospective, multi-centre randomised trial comparing between cTURBT plus 1-year BCG therapy, and ERBT plus 1-year BCG therapy, in patients with intermediate-risk or high-risk NMIBC.
- Trial name
- NCT07724886
- Testing
- Conventional Transurethral Resection of Bladder Tumour, Transurethral En Bloc Resection of Bladder Tumour
- Where
- 2 sites in Hong Kong
- Volunteers
- 732 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
The Role of 18F-PSMA PET in Prostate Cancer Diagnosis in Equivocal MRI
This study is a multi-center RCT to compare the clinically significant prostate cancer (csPCa) detection and/or change in clinical management in MRI guided (MRI arm) biopsy and MRI+18F-PSMA guided (Combined arm) biopsies in men…
- Trial name
- NCT07386496
- Testing
- MRI+PSMA-guided approach, MRI-guided approach
- Where
- Hong Kong
- Volunteers
- 250 people
- Sponsor
- Chinese University of Hong Kong
Bladder Cancer
Transurethral En Bloc Versus Standard Resection of Bladder Tumour
Conventionally, transurethral standard resection (SR) of bladder tumour is performed in a piecemeal manner. Transurethral en bloc resection (EBR) has been described as an alternate surgical technique in bladder tumour resection.
- Trial name
- NCT02993211
- Testing
- Bipolar transurethral standard resection, Bipolar transurethral en bloc resection
- Where
- 13 sites in Hong Kong
- Volunteers
- 350 people
- Sponsor
- Chinese University of Hong Kong
Kidney Cancer
To Establish a Reproducible Organoid Culture Model With Human Kidney Cancer
Kidney cancer is one of the ten most common malignancies, and the incidence is increasing in recent year. From Hong Kong Cancer Registry, there was about 670 new cases diagnosed in 2016, and had been increased by 46% compared to…
- Trial name
- NCT04342286
- Testing
- Organoid culture
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Bladder Cancer
The Global En Bloc Resection of Bladder Tumour Registry
The study aims to collect data on ERBT globally in order to clarify its role in the management of bladder cancer over a 5-year observation period.
- Trial name
- NCT04934540
- Testing
- En bloc resection of bladder tumour
- Where
- 2 sites in Hong Kong
- Volunteers
- 5,000 people
- Sponsor
- Chinese University of Hong Kong
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