Clinical trials: sponsored by Yonsei University
Leukemia, Lymphoid
Efficacy of Risk-Stratified Treatment in Newly Diagnosed Infant Leukemia
This clinical trial is an open-label, multicenter, prospective phase 2 clinical trial targeting pediatric leukemia patients of infant age.
- Trial name
- NCT06516679
- Testing
- Consolidation #4(without daunorubicin), Consolidation #4(with daunorubicin), Allogeneic hematopoietic stem cell transplantation after Consolidation #4(with daunorubicin)
- Where
- 10 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Healthy Volunteers, Robotic Exoskeleton
Effects of Hip-Assist Exoskeleton Torque on Gait Parameters
This study aims to evaluate the impact of assistive torque from a hip-assist exoskeleton on gait patterns in healthy adults. The investigators will analyze how different torque settings affect spatiotemporal parameters, joint…
- Conditions
- Healthy Volunteers, Robotic Exoskeleton, Wearable Devices, Assistive Devices
- Trial name
- NCT07450989
- Testing
- ANGEL SUIT H10 (Hip-assist exoskeleton)
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Gait Disorders, Neurologic
Home-based Rehabilitation Monitoring System With Wearable Devices and Self-Report Application
The goal of this clinical trial is to evaluate whether monitoring and providing feedback on the performance of a home-based exercise program using an integrated wearable monitoring system improves physical and cognitive function…
- Trial name
- NCT06410755
- Testing
- Integrated Wearable devices Monitoring sys-Assisted Home Rehabilitation Program
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Cardiovascular Diseases, Heart Failure, Systolic
HeartMate App-Based Remote Monitoring for Cardiovascular Risk Factor Management
This exploratory pilot randomized controlled trial evaluates whether a HeartMate application-based remote patient monitoring (RPM) and digital cardiac rehabilitation program improves cardiovascular, functional, and psychological…
- Conditions
- Cardiovascular Diseases, Heart Failure, Systolic, Coronary Artery Disease, Heart Valve Diseases
- Trial name
- NCT07721584
- Testing
- HeartMate App-Based Remote Cardiac Rehabilitation Program, Usual Care with HeartMate App-Based rPPG Measurement Only
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Patent Foramen Ovale, Cryptogenic Stroke
Long-term Outcomes After Percutaneous Patent Foramen Ovale Closure (Severance PFO Registry)
Patent foramen ovale (PFO) is a congenital interatrial communication present in about one quarter of the general population and is recognized as a major cause of cryptogenic stroke.
- Conditions
- Patent Foramen Ovale, Cryptogenic Stroke, Transient Ischemic Attack Due to Embolism, Atrial Fibrillation
- Trial name
- NCT07724171
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Yonsei University
Stroke
Evaluate the Effectiveness and Safety of At-Home Rehabilitation Gait Training Using a Hip-assisted Wearable Robot in Stroke Patients
The goal of this clinical trial is to learn whether a wearable monitoring system can help adults who have had a stroke get more out of a home exercise program.
- Trial name
- NCT07716475
- Testing
- hip-assisted wearable robot
- Where
- South Korea
- Volunteers
- 8 people
- Sponsor
- Yonsei University
Diffuse Large B-cell Lymphoma
A Study of Polatuzumab Vedotin and Glofitamab in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma Within 12 Months After R-CHOP
Patients with diffuse large B-cell lymphoma (DLBCL) who are primary refractory to first-line R-CHOP therapy or relapse within 12 months after R-CHOP have a poor prognosis and limited treatment options.
- Trial name
- NCT07702851
- Testing
- Polatuzumab vedotin, Glofitamab
- Volunteers
- 47 people
- Sponsor
- Yonsei University
Non-small Cell Lung Cancer (NSCLC)
An Open-label, Multicenter, Phase II Study of LDK378 in Patients With Non-small Cell Lung Cancer Harboring ROS1 Rearrangement
ROS1 is a receptor tyrosine kinase with constitutive kinase activity. ROS1 was previously discovered in cell lines where ROS1 fused with other proteins to act as a driver oncogene.
- Trial name
- NCT01964157
- Testing
- LDK378
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Yonsei University
Chronic Obstructive Pulmonary Disease
Evaluation of the Effectiveness, Safety, and Cost of a Smart Hospital System for Patients With Chronic Obstructive Pulmonary Disease
This study aims to analyze the effectiveness/safety/cost of the Smart Homespital system that provides a service that allows patients with Chronic Obstructive Pulmonary Disease to easily access and use biosignals generated using…
- Trial name
- NCT06601777
- Testing
- Immediate application of the Smart Homespital system, Delayed application of the Smart Homespital system after 3 months
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Yonsei University
Severe Aortic Stenosis or Severe Aortic Regurgitation
Prognostic Value of Soluble Urokinase-type Plasminogen Activator Receptor in Valvular Heart Disease
This study investigates the association between level of suPAR and valvular heart disease in patients who have severe aortic stenosis or severe aortic regurgitation using commercially available suPARnostic standard enzyme-linked…
- Trial name
- NCT04571372
- Where
- South Korea
- Volunteers
- 222 people
- Sponsor
- Yonsei University
Diabetes Mellitus, Hypoglycemia
Perioperative Hypoglycemia in Diabetic Patients Undergoing Vitrectomy: a Masked CGM Prospective Observational Study
Patients with diabetes are at increased risk of perioperative glycemic disturbances due to preoperative fasting, the surgical stress response, and the use of insulin or oral hypoglycemic agents.
- Trial name
- NCT07696910
- Testing
- Masked continuous glucose monitoring (FreeStyle Libre 2®)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Patients With Locally Advanced or Metastatic But Resectable Clear Cell Renal Cell Carcinoma
A Phase 2 Multicenter Single-Arm Clinical Trial of Zanzalintinib and Pembrolizumab in Subjects With Resectable Clear Cell Renal Cell Carcinoma
This is a multicenter, single-arm, phase 2 clinical trial designed to evaluate the clinical efficacy of combination therapy with zanzalintinib and pembrolizumab in patients with locally advanced intermediate- to high-risk…
- Trial name
- NCT07691476
- Testing
- Zanzalintinib and Pembrolizumab
- Volunteers
- 48 people
- Sponsor
- Yonsei University
Radiation Exposure
Comparison of Operator Radiation Exposure During Percutaneous Coronary Intervention Between Left Distal and Right Conventional Radial Access
This study aims to compare the operator's radiation exposure between left distal radial access (LDRA) and right transradial access (RTRA) in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- DOSE-PCI (NCT07579169)
- Testing
- Radial Artery Puncture Method for Coronary Angiography and Intervention
- Where
- 4 sites in Japan, South Korea
- Volunteers
- 748 people
- Sponsor
- Yonsei University
Non-small Cell Lung Cancer
Neoadjuvant Lazertinib With or Without Chemotherapy for Patients With EGFR-mutated Resectable Non-small Cell Lung Cancer
In the randomized, multicenter Phase II clinical trial, we aim to evaluate the efficacy and safety of Lazertinib monotherapy or the combination of Lazertinib and cytotoxic chemotherapy as neoadjuvant therapy in patients with…
- Trial name
- NeoLazer (NCT06268210)
- Testing
- Lazertinib+Pemetrexed+Carboplatin, Lazertinib
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Yonsei University
Stomach Neoplasms, Pain
A Phase IV Randomized Trial of Maxigesic® Versus Standard Analgesia After Radical Gastrectomy
Background: Radical gastrectomy causes moderate-to-severe pain during the first 48 hours after surgery. Opioids are effective but carry adverse effects and risks of prolonged use, so ERAS-based care recommends multimodal…
- Conditions
- Stomach Neoplasms, Pain, Postoperative
- Trial name
- NCT07687394
- Testing
- Acetaminophen (Newaminophen Premix), Maxigesic IV (acetaminophen/ibuprofen)
- Volunteers
- 160 people
- Sponsor
- Yonsei University
Interstitial Lung Disease
Evaluation of the Effectiveness, Safety, and Cost of a Smart Home-based Hospital System for Patients With Interstitial Lung Disease: Prospective Multicenter Randomized Controlled Trial
This study aims to analyze the effectiveness/safety/cost of the Smart Homespital system that provides a service that allows patients with interstitial lung disease to easily access and use biosignals generated using biosignal…
- Trial name
- NCT06601790
- Testing
- Immediate application of the Smart Homespital system, Delayed application of the Smart Homespital system after 3 months
- Where
- South Korea
- Volunteers
- 83 people
- Sponsor
- Yonsei University
Atrial Fibrillation Patients With Intermediate Stroke Risk
The Efficacy and Safety of Non-vItamiN K antaGonist oraL Anticoagulants for intermEdiate Stroke Risk in Patients With Atrial Fibrillation (SINGLE-AF)
Atrial fibrillation (AF) increases the risk of stroke, and oral anticoagulation is strongly recommended for patients at high thromboembolic risk.
- Trial name
- NCT04437654
- Testing
- Anticoagulation group(DOAC group)
- Where
- South Korea
- Volunteers
- 1,803 people
- Sponsor
- Yonsei University
Spontaneous Intracranial Hypotension
ONSD Changes and Treatment Response After Epidural Blood Patch in Spontaneous Intracranial Hypotension
"This is a prospective observational study investigating changes in optic nerve sheath diameter (ONSD) and its association with clinical improvement following epidural blood patch (EBP) in patients with spontaneous intracranial…
- Trial name
- NCT07085260
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Yonsei University
Adult, Laryngeal Masks, Remimazolam, Remifentanil
The Appropriate Remifentanil Dose for Optimal Insertion of Laryngeal Mask Airway in Adult Patients During Induction of General Anesthesia Using Remimazolam.
The laryngeal mask airway (LMA) is an airway maintenance device that is easy to insert and has the advantage of causing less sore throat and autonomic nervous system stimulation.
- Trial name
- NCT06289829
- Testing
- remifentanil of the assigned dose, Ambu Auragain for airway management
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Atrial Fibrillation/Flutter in Patients With High Risk of Stroke
A Clinical Trial to Evaluate the Detection of Atrial Fibrillation for an One Day Versus More Than or Equal to Eight Days Using MEMO Patch PLUS in Individuals Aged ≥ 75 Years, or Those at High Risk of Stroke
The purpose of this study is to evaluate the benefits in the atrial fibrillation detection rate of the continuous ECG monitoring group for more than 8 days by contrasting with one-day ECG monitoring using MEMO Patch PLUS in 1000…
- Trial name
- MEMO-DAF8 (NCT05355948)
- Testing
- MEMO Patch PLUS for 1 day, MEMO Patch PLUS for More than 8-days
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Yonsei University
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