Clinical trials: active, sponsored by University of Pennsylvania
HIV, HIV Treatment
Evaluating the Impact of Using the B-OK Bottles for HIV and ART Literacy in South Africa
Consistent use of antiretroviral therapy (ART) is essential for achieving suppression among people with HIV (PWH). Yet despite improvements in access to ART and improving viral suppression rates, an estimated one-third of PWH…
- Trial name
- NCT07703891
- Testing
- B-OK Bead Bottles Intervention (delivered in person), B-OK Bottles Intervention (delivered by video), Control
- Where
- South Africa
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Traumatic Brain Injury, Post-traumatic Epilepsy
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)
The overarching goal of this study is to improve understanding of the long-range natural history of TBI and post-traumatic epilepsy (PTE) by extending follow-up of a previously enrolled cohort (TRACK-TBI) beyond the first 12…
- Trial name
- NCT05823766
- Testing
- In-Person Outcome Assessment, 3T Magnetic Resonance Imaging (MRI), Clinical Visit
- Where
- 9 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Labor Induction, Cesarean Birth
Implementation of a Disparities in Labor Outcomes Dashboard
This proposal will determine if a Disparities in Labor Outcomes dashboard can be used as an implementation strategy to increase compliance to an evidence-based set of interventions for labor induction in a two-site…
- Trial name
- NCT07756424
- Testing
- Disparities in Labor Outcomes Dashboard
- Where
- United States
- Volunteers
- 2,300 people
- Sponsor
- University of Pennsylvania
Heart Failure
MUTTON-HF Pilot Expansion
The goal of this study is to learn whether a meal program for people with heart failure works well when it is brought to new American Indian and Alaska Native communities, and how it affects patients, their households and local…
- Trial name
- MUTTON-HF (NCT07922863)
- Testing
- Culturally and Medically Tailored Meals Incorporating Traditional Indigenous Foods and Recipes
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
- Trial name
- KSAW (NCT06559995)
- Testing
- ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Sickle Cell Disease (SCD), Vaso-Occlusive Pain Episode in Sickle Cell Disease
Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease
This research is being conducted to see if using an injectable contraception, Depot Medroxyprogesterone Acetate (Depo-Provera), can reduce the pain experienced by women with sickle cell disease.
- Trial name
- SCD Depo (NCT06665997)
- Testing
- Depot medroxyprogesterone acetate (DMPA)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of Pennsylvania
Firearm Safety, Firearm Safety Storage
Firearm Secure Storage Device Distribution RCT
This study aims to learn how to best promote safe firearm storage in the community. Firearm injuries are a major public health concern, and securely storing firearms can help prevent accidental injuries, suicide, and unauthorized…
- Trial name
- NCT07886983
- Testing
- Cable locks, Lock box, Lock box and cable locks
- Where
- United States
- Volunteers
- 1,858 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Psoriatic Arthritis
Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients
The trial is an open-label randomized study that will examine whether switching to a selective IL23 inhibitor (guselkumab) is more effective than switching to a second TNFi (golimumab) among patients with PsA who have an…
- Trial name
- EVOLUTION (NCT05669833)
- Testing
- Guselkumab, Golimumab
- Where
- 14 sites in United States
- Volunteers
- 63 people
- Sponsor
- University of Pennsylvania
Stressor, Individual, Alcohol Impairment
Neurobehavioral Changes Following Spaceflight Stressors
This study aims to investigate the impairing effects of known central nervous system (CNS) stressors in a controlled environment in order to predict and mitigate analogous risks in spaceflight.
- Conditions
- Stressor, Individual, Alcohol Impairment, Sleep Deprivation, Impairment, Cognitive
- Trial name
- NeuroSTAR (NCT07293494)
- Testing
- Alcohol Administration, Sleep Deprivation, Control
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Documentation of Serious Illness Communication for Critically Ill Patients
Pilot Trial of Ambient Listening for Intensive Care Unit Family Meeting Summaries
The goal of this clinical trial is to learn whether ambient listening can help healthcare providers create written summaries of conversations with the families of patients in the medical intensive care unit (ICU).
- Trial name
- PALMS (NCT07915908)
- Testing
- Receipt of ambient listening-generated draft clinical note
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Non Hodgkin Lymphoma
TmCD19-IL18 in CD19+ Cancers
This is a Phase I, open-label dose finding study to assess the safety and feasibility, pharmacokinetics, and preliminary efficacy of TmCD19-IL18 CAR T cells in patients with CD19+ cancers.
- Trial name
- NCT05989204
- Testing
- TmCD19-IL18
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Pennsylvania
Noise Exposure
Federal Aviation Administration (FAA) National Sleep Study
This observational study will examine the relationship between aircraft noise exposure in the bedroom and objectively assessed sleep disturbance.
- Trial name
- NSS (NCT05035940)
- Where
- United States
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Catheter Ablation, Radiofrequency
Early Ambulation Safety Evaluation, Ultrasound-guided Percutaneous Venous Closure
The purpose of this study is to evaluate whether patients can safely walk sooner after catheter-based heart procedures when the VASCADE MVP or VASCADE MVP XL vascular closure device is used.
- Trial name
- NCT07910227
- Testing
- VASCADE MVP and MVP XL
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
huCART19-IL18-CD428z Cells for the Treatment of Patients With HIV With CD19+ Cancers
This research study is being conducted to evaluate an experimental drug called huCART19-IL18-CD428z cells in patients living with HIV who have been diagnosed with Non-Hodgkin Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL)…
- Conditions
- Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Acute Lymphoblastic Leukemia, Richter's Transformation
- Trial name
- NCT07891468
- Testing
- huCART19-IL18-CD428z cells
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pennsylvania
Hyperparathyroidism
Flurpiridaz F-18 PET/CT Imaging for Detecting Parathyroid Adenomas
Study of Flurpiridaz F-18 PET/CT as a diagnostic imaging tool to detect abnormal parathyroid glands in patients with primary hyperparathyroidism, prior to multi-parathyroid gland surgical exploration.
- Trial name
- NCT07910097
- Testing
- Flurpiridaz PET/CT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Dental Implants, TNF-alpha Inhibitors
Dental Implant Healing With TNF-Alpha Inhibitors
The goal of this pilot study is to learn about healing after dental implant placement in patients taking a class of biologic drug called Tumor Necrosis Factor or TNF-alpha antagonist or inhibitor.
- Conditions
- Dental Implants, TNF-alpha Inhibitors, Edentulism
- Trial name
- NCT06538870
- Testing
- Placement of dental implants
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Serious Illness, Palliative
Nudging Effective and Equitable Delivery of Specialty Palliative Care
This stepped-wedge, cluster randomized pragmatic trial among 9 MedStar hospitals for patients with serious illness and unmet palliative care (PC) needs will test two interventions embedded within the electronic health record…
- Trial name
- NEEDS-PC (NCT06596577)
- Testing
- Palliative care needs information, Default consult order
- Where
- 9 sites in United States
- Volunteers
- 18,000 people
- Sponsor
- University of Pennsylvania
Inflammatory Bowel Diseases
Duloxetine in Inflammatory Bowel Diseases
This open-label, prospective, single-arm pilot study investigates the use of duloxetine, a central neuromodulator, for improving psychological distress and functional impairment in adults with inflammatory bowel disease (IBD).
- Trial name
- Duloxetine in (NCT07431606)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pennsylvania
Radiation Protection, Image Enhancement
Next-Generation Photon-Counting CT Technology: Development and Clinical Evaluation
This project aims to develop and evaluate a next-generation photon-counting CT prototype, and assess whether next-generation photon-counting CT--which enables reduced radiation dose, high spatial resolution, and spectral…
- Trial name
- CT-DACE (NCT06691659)
- Testing
- CT-DACE
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Pennsylvania
Chemotherapy Resistant Acute Lymphoblastic Leukemia, Refractory Acute Lymphoblastic Leukemia
CART22 Alone or in Combination With huCART19 for ALL
This is a single center, open-label, phase 1 study to determine the safety and feasibility of infusing CART22-65s with or without huCART19 after administration of lymphodepleting chemotherapy in adult patients with relapsed or…
- Trial name
- NCT03620058
- Testing
- CART22-65s cells, huCART19 Cells
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania