Clinical trials: completed, sponsored by University of Michigan
Peri-implant Mucositis
Treatment of Peri-implant Mucositis and Supportive Peri-implant Therapy
The investigators are evaluating the therapeutic outcomes of two cleaning instruments on treating peri-implant mucositis. Peri-implant mucositis is inflammation around an implant that is limited to only the gum tissue and is…
- Trial name
- NCT06137846
- Testing
- Air-Polish, Ultrasonic
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Platelet Function and Reactivity Tests
Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs
This study will identify the potential benefits of regulating platelet activation with sotagliflozin compared to other FDA-approved drugs known to limit platelet activation.
- Trial name
- NCT06933056
- Testing
- Sotagliflozin (SOTA) followed by 3 drugs in a random order, Aspirin followed by 3 drugs in a random order, Clopidogrel followed by 3 drugs in a random order
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Aging Well
Healthy Lifetime - Phase 2
HealthyLifetime (HL) is a person-centered program that enables older adults to maximize health and optimize functioning - the necessary requisite to successfully remaining independent in their preferred home setting as long as…
- Trial name
- NCT05920733
- Testing
- Nurse-led health coaching
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Michigan
Type 2 Diabetes
The Lifestyle Education About Nutrition for Diabetes (Legend) Study
This study is being completed to compare two dietary approaches for participants with type 2 diabetes. This research will test whether a very low-carbohydrate or a plate-method diet better improves outcomes for blood glucose…
- Trial name
- LEGEND (NCT05237128)
- Testing
- Very low-carbohydrate diet, Moderate-carbohydrate plate-method diet
- Where
- 2 sites in United States
- Volunteers
- 182 people
- Sponsor
- University of Michigan
Violence, Physical, Maltreatment, Child
Evaluating a School-based Social and Material Needs Identification System to Prevent Youth Violence Involvement
The goal of this observational study is to evaluate the effects of Pathways to Potential (P2P) on youth violence involvement in Michigan public K-12 students.
- Trial name
- NCT05986188
- Testing
- Pathways to Potential
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Type 2 Diabetes
The Breakfast Study
The investigators conducted an acceptability, feasibility, preliminary effectiveness trial of a 4-month, online, very low-carbohydrate breakfast-focused program in 120 adults with type 2 diabetes.
- Trial name
- NCT05986097
- Testing
- Breakfast
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Michigan
Gingival Recession
Treatment of Gingival Recession Defects Using Platelet-Rich Fibrin With an Allogenic Dermal Matrix
The study aims to test the non-inferiority of an Allogenic Dermal Matrix with Platelet-Rich Fibrin for treatment of gingival recessions in comparison to the Connective Tissue Graft.
- Trial name
- NCT05819515
- Testing
- Tunneled coronally advanced flap
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetes Mellitus, Type 2, Depressive Symptoms
Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
The Michigan Men's Diabetes Project III: Mind \& Motion is an 7-month pilot randomized clinical trial. The investigators are looking to recruit 80 Black men with type 2 diabetes (T2D) (need to have diagnosis for at least one…
- Conditions
- Diabetes Mellitus, Type 2, Depressive Symptoms, Depression
- Trial name
- MenDIII (NCT06574035)
- Testing
- Cognitive Behavioral Therapy, Exercise, Group Discussions - Ongoing Support
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Michigan
Atrial Fibrillation
Metformin as an Adjunctive Therapy to Catheter Ablation in Atrial Fibrillation
This clinical trial is being done to determine if metformin, a drug which is normally used in diabetes, can reduce atrial fibrillation in patients who are having an ablation for atrial fibrillation (AF).
- Trial name
- NCT04625946
- Testing
- Metformin, Recommendations for lifestyle modification., AliveCor
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Michigan
PreDiabetes
The Lifestyle Education About Prediabetes (Leap) Study
This research tested whether a standard version or very low-carbohydrate version of the Diabetes Prevention Program better improves outcomes like blood glucose control and body weight for patients with prediabetes.
- Trial name
- LEAP (NCT05235425)
- Testing
- Standard NDPP, Very low-carbohydrate diet
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Michigan
Substance Use Disorders, Substance Use
Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients
The purpose of this trial is to test new programs to see if they might help people manage their health and health behaviors related to alcohol use and well-being.
- Conditions
- Substance Use Disorders, Substance Use, Substance Dependence
- Trial name
- NCT05410561
- Testing
- Enhanced Usual Care (EUC), TeleTx intervention
- Where
- 2 sites in United States
- Volunteers
- 277 people
- Sponsor
- University of Michigan
Major Depressive Disorder
Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback
The purpose of this study is to develop a technique called real time fMRI neurofeedback. This technique uses a regular MRI scanner, except that special software allows the researchers to measure activity in participants brain…
- Trial name
- NCT06050070
- Testing
- FMRI with real time feedback
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Michigan
Recession, Gingival, Surgical Procedure, Unspecified
Alternative Gingival De-Epithelialization Techniques
The goal of this clinical trial is to compare different de-epithelialization methods in patients undergoing soft tissue augmentation surgery.
- Conditions
- Recession, Gingival, Surgical Procedure, Unspecified, Graft Complication, Wound Heal
- Trial name
- NCT05947305
- Testing
- Surgical Blade, Mucotome, Diamond Bur
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity
Evaluation of Patient Coach Support for Older Adults With Obesity
The purpose of the present pilot is to evaluate the outcomes of adding a patient coach to support the Optimal Health Weight and Lifestyle (OHWL) Clinic plan developed by PI Dewar, specifically to address barriers and facilitators…
- Trial name
- NCT06624163
- Testing
- OHWL Clinic Activities (Standard of Care), Coach Activities
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Michigan
Constipation
A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation
This research is studying how the availability of a Food and Drug Administration (FDA)-cleared point-of-care, bedside device bedside device called Rectal Expulsion Device (RED) can be used to evaluate constipation in the…
- Trial name
- NCT07032376
- Testing
- Survey, Rectal Expulsion Device use
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Michigan
Suicide, Alcohol Use Disorder
Facilitating Use of the National Suicide Prevention Lifeline in Alcohol Patients (Reach Out)
The purpose of this research study is to learn about people who use the National Suicide Prevention (NSP) Lifeline during a suicidal crisis and those who don't.
- Trial name
- NCT04488055
- Testing
- Crisis Line Facilitation (CLF), Enhanced Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 530 people
- Sponsor
- University of Michigan
Chronic Pelvic Pain
Exploring Patient Treatment Preferences for Chronic Pelvic Pain: A Mixed Methods Study
This research is studying what things change the way people think about treatment for chronic pelvic pain (CPP). The study team is also interested in whether a web-based educational and self-management program for chronic pelvic…
- Trial name
- NCT06540560
- Testing
- My Pelvic Plan website
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan
Polyneuropathies, Obesity
Effect of Exercise and Surgical Weight Loss on Polyneuropathy
The purpose of this research study is to evaluate how exercise and surgical weight loss affect how likely an individual is to develop peripheral neuropathy and other neurologic complications.
- Conditions
- Polyneuropathies, Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03617185
- Testing
- High Intensity Interval Training (HIIT), Routine Exercise, Bariatric surgery
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Michigan
Type2diabetes, Foot Ulcer
Non-weight Bearing Exercise for Accelerated Healing of Diabetic Foot Ulcers
The goal of this study is to improve the therapeutic management of diabetic foot ulcers (DFU). The main questions to answer are if a program of non-weight bearing exercise helps the DFU heal faster than standard wound care.
- Trial name
- NCT05603273
- Testing
- non-weight bearing exercise
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Michigan
Social Determinants of Health (SDOH), Health Care Utilization
Healthy Moms Healthy Babies Pilot Project Evaluation
This study is designed to learn whether providing additional resources to home visiting agencies in Michigan's Maternal Infant Health Program (MIHP) help them better serve families with high levels of need for basic services.
- Trial name
- HMHB (NCT07817407)
- Testing
- Enhanced Billing Opportunities, Discharge Visit Only
- Where
- United States
- Volunteers
- 10,927 people
- Sponsor
- University of Michigan