Clinical trials: open to volunteers, sponsored by University of Chicago
Lymphoma, B-Cell, Multiple Myeloma
Microbiome Intervention for CAR-T Optimization and Response (MICRO-CART)
Chimeric Antigen Receptor T-Cell (CAR-T) therapy has transformed the management of large B-cell lymphoma, and multiple myeloma by achieving remarkable responses, yet inconsistent durability and severe toxicities remain major…
- Trial name
- (MICRO-CART) (NCT07871747)
- Testing
- Live Biotherapeutic Product (LBP)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Chicago
Ulnar Nerve Transposition
Is Splinting After Ulnar Nerve Transposition Necessary?
The goal of this clinical trial is to learn whether patient recovery after ulnar nerve transposition (UNT) requires a splint. The main questions it aims to answer are: Does the effect that early versus delayed mobilization after…
- Trial name
- NCT07880470
- Testing
- Stiff splint, No splint
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Benign Prostatic Hyperplasia (BPH)
The FLOW Registry.
The purpose of this study is to create a database and prospective registry for data collection on patients with benign prostatic hyperplasia undergoing Aquablation of the prostate.
- Trial name
- NCT07430423
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Chicago
Type 2 Diabetes Mellitus (T2DM), Diabetes Distress
Achieving Routine Intervention and Screening for Emotional Health
The purpose of this project is to evaluate the effectiveness of diabetes distress screening and intervention on patients with type 2 diabetes mellitus (T2DM).
- Trial name
- ARISE (NCT06887049)
- Testing
- ARISE Learning Community Diabetes Distress Screening and Intervention, ARISE Enhanced Care brief training
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- University of Chicago
Colorectal Cancer
FITting Non-invasive Tests in Lynch Syndrome Surveillance
The purpose of this clinical study is to evaluate the accuracy of the fecal immunochemical test (FIT) in comparison to colonoscopy in patients with Lynch Syndrome (LS) who are undergoing colonoscopy surveillance.
- Trial name
- NCT06898996
- Testing
- Fecal immunochemical test
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Chicago
Ulcerative Colitis (UC)
STOP-UC: De-escalation of Therapy in Patients With Ulcerative Colitis With Histological Remission
The goal of this study is to better understand treatment strategies for people with ulcerative colitis (UC). Researchers will compare patients with UC in histologic remission (no evidence of inflammation or active disease on…
- Trial name
- NCT06693310
- Testing
- de-escalation or discontinuation of therapy, continuation of current therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Pediatric Surgery, Informed Consent
Risk Sharing vs Risk Dumping: Parental Attitudes About Risks
This study will evaluate how parents or legal guardians perceive responsibility for surgical risk after the informed consent discussion for their child's operation, focusing on whether the process feels like "risk sharing" with…
- Conditions
- Pediatric Surgery, Informed Consent, Shared Decision-making, Parental Decision Making for Seriously Ill Children
- Trial name
- NCT07875712
- Testing
- Research data collection only
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Lymphatic Reconstruction
Prospective Assessments Following Immediate Lymphatic Reconstruction
Immediate lymphatic reconstruction (ILR) is a novel surgical approach performed at the time of initial lymph node dissection with the goal of preventing lymphedema.(Chang et al.
- Trial name
- NCT07227467
- Testing
- patients who are candidates for immediate lymphatic reconstruction
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
PCOS, PCOS (Polycystic Ovary Syndrome)
PMOS in OSA Pilot Study
The goal of this study is to obtain pilot data investigating the effects of sleep apnea on mitochondrial function and cellular metabolism in Polyendocrine Metabolic Ovarian Syndrome (PMOS) patients.
- Conditions
- PCOS, PCOS (Polycystic Ovary Syndrome), OSA, OSA - Obstructive Sleep Apnea
- Trial name
- NCT07871149
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Autologous Fat Grafting
Quantitative Assessment of Autologous Fat Transfer
This is a single-arm, prospective pilot study that will objectively assess outcomes in patients electively undergoing Autologous Fat Transfer (AFT) for breast or chest wall reconstruction.
- Trial name
- NCT06343831
- Testing
- 2-Dimensional (2-D) Photographs (Visit 1/ Follow up Visit 3-6), 3-Dimensional (3-D) Photographs (Visit 1- 6), Ultrasound Soft Tissue Assessment (Visit 1/ Follow up Visit 4-6)
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Chicago
Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG)
Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial)
The goal of this clinical trial is to learn whether a high-dose vitamin B3 supplement called nicotinamide can protect retinal nerve cells in adults with primary open-angle glaucoma (POAG) who are already receiving standard…
- Trial name
- NADIR (NCT07808333)
- Testing
- Nicotinamide, Standard Glaucoma Therapy
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Chicago
Alzheimer s Disease, Dementia
CommunityRx-Dementia + Peer Navigation (CRxDpeer)
The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and…
- Conditions
- Alzheimer s Disease, Dementia, Caregiver, Loneliness
- Trial name
- CRxDpeer (NCT07346183)
- Testing
- CommunityRx-Dpeer
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Ovarian Cancer, Advanced Malignant Solid Tumor
A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Advanced Malignancies.
This phase I/IIA trial studies the side effects and best dose of gene-modified T cells when given with or without decitabine, and to see how well they work in treating patients with malignancies expressing cancer-testis antigens.
- Trial name
- NCT07389239
- Testing
- Decitabine, Cyclophosphamide Conditioning, NY-ESO-1 TCR/ dnTGFβRII
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Chicago
GERD
PROPER-GERD: A Prospective Crossover Study to Evaluate Probe Placement Optimization for Reflux Testing in Women and Lower-BMI Patients
This is a prospective, within-subject controlled study involving simultaneous dual placement of wireless Bravo pH probes in each participant.
- Trial name
- PROPER-GERD (NCT07716592)
- Testing
- Bravo pH monitoring sessions
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Colorectal (Colon or Rectal) Cancer
Collagenase Biobank Study
The purpose of this study is to look at how bacteria present within the stool at the time of surgery and postoperatively may contribute to the development of cancer recurrence after surgery.
- Trial name
- NCT07211230
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Chicago
Nephrolithiasis
Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain
Post-operative pain and lower urinary tract symptoms are common following ureteroscopy in the treatment of stone disease. The use of bupivacaine as a topical pain medication is used routinely for other urologic procedures…
- Trial name
- NCT06635889
- Testing
- Bupivacaine, Normal saline
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Injection Fear, Injection Pain Prevention
Does Ethyl Chloride Spray Work?
A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal…
- Conditions
- Injection Fear, Injection Pain Prevention, Injection Complication
- Trial name
- NCT06651788
- Testing
- Ethyl Chloride, Cold Saline Spray
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- University of Chicago
HIV, Pre-exposure Prophylaxis
Case Management Dyad
The overall goal of this study is to test whether dyadic and focused case management coupled with contingency management will (1) improve financial wellbeing, (2) improve access to food, (3) increase linkage and retention rates…
- Conditions
- HIV, Pre-exposure Prophylaxis, Case Management, Contingency Management
- Trial name
- CM2 (NCT06162897)
- Testing
- Dyadic Case Management
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Weight Loss
A Novel Intervention for Weight Loss in Young Adults
Obesity and cardiometabolic risks are significant public health issues, with about two-thirds of U.S. adults overweight or obese.
- Trial name
- NCT06230744
- Testing
- Lifestyle, Lifestyle II
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Chicago
HIV
Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men
The goal of this observational study is to learn about the pilot test of the employment program among young men living with HIV or part of a community highly impacted by HIV.
- Trial name
- NCT06894199
- Testing
- The Work Shop
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Chicago