Clinical trials: open to volunteers, sponsored by Mayo Clinic
Renal Failure Congenital, Congenital Renal Anomaly Nos
Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia
Congenital lower urinary tract obstruction (LUTO) is a heterogeneous group of congenital anomalies that lead bladder outlet obstruction.
- Conditions
- Renal Failure Congenital, Congenital Renal Anomaly Nos, Renal Agenesis and Dysgenesis, Lower Urinary Tract Obstructive Syndrome
- Trial name
- NCT03723564
- Testing
- Lactated Ringers Solution for Injection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
This clinical trial studies the effect of cancer directed therapy given at-home versus in the clinic for patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the…
- Conditions
- Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma, Advanced Bladder Carcinoma, Advanced Breast Carcinoma
- Trial name
- NCT05969860
- Testing
- Clinical Encounter, Home Health Encounter, Quality-of-Life Assessment
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- Mayo Clinic
Myelomeningocele, Spina Bifida
Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida
A study to use transcutaneous spinal cord stimulation to characterize sensorimotor deficits in a pediatric population of individuals with spina bifida.
- Trial name
- NCT06918119
- Testing
- Transcutaneous stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Biochemically Recurrent Prostate Carcinoma, Locally Advanced Prostate Carcinoma
Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer
This phase II trial evaluates the impact of cancer therapy in the patients' home compared to in the clinic on safety, side effects, patient preference, and satisfaction in Black men with prostate cancer that has spread to nearby…
- Conditions
- Biochemically Recurrent Prostate Carcinoma, Locally Advanced Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage III Prostate Cancer AJCC v8
- Trial name
- NCT07073794
- Testing
- Cancer Therapeutic Procedure, Health Care Delivery, Questionnaire Administration
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Congenital Diaphragmatic Hernia
North American Fetal Therapy Network Prospective Registry for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia
The purpose of this research is to determine if babies who undergo a Fetoscopic Endoluminal Tracheal Occlusion (FETO) procedure survive more often and have less long-term complications than babies who have similarly severe…
- Trial name
- NCT07564297
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion, Standard of Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Locally Advanced Oral Cavity Squamous Cell Carcinoma, Locally Recurrent Oral Cavity Squamous Cell Carcinoma
Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial
This phase II trial compares the effect of adding proton spatially fractionated radiotherapy (SFRT) or photon stereotactic body radiotherapy (SBRT) to standard immunotherapy pembrolizumab before surgery (neoadjuvant) in treating…
- Conditions
- Locally Advanced Oral Cavity Squamous Cell Carcinoma, Locally Recurrent Oral Cavity Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma
- Trial name
- NCT07783581
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Endometrial Cancer, Cervical Cancer
Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer
The overarching objective of this project is to develop a pan-gynecologic cancer detection test using gynecologic (unique endometrial, cervical, and ovarian cancer) cancer-specific methylated DNA markers and high-risk human…
- Conditions
- Endometrial Cancer, Cervical Cancer, Atypical Endometrial Hyperplasia, Cervical Dysplasia
- Trial name
- ECHO (NCT05051722)
- Testing
- Vaginal Fluid Collection, Blood Collection
- Where
- 25 sites in United States
- Volunteers
- 3,110 people
- Sponsor
- Mayo Clinic
Breast Carcinoma
Collecting Patient-Reported Experiences With Radiation Dermatitis in Breast Cancer Patients Undergoing Radiotherapy
This study evaluates patient-reported experiences of radiation dermatitis in patients with breast cancer undergoing radiotherapy.
- Trial name
- NCT06953245
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Diffuse Glioma, Malignant Glioma
Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma
This early phase I trial studies brain tumor (glioma) metabolism in response to eflornithine (DFMO) and polyamine transport inhibitor AMXT-1501 dicaprate (AMXT 1501) in patients with diffused or high grade glioma.
- Trial name
- NCT05717153
- Testing
- Biospecimen Collection, Computed Tomography, Eflornithine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Estrogen Receptor-Positive Breast Carcinoma
Reishi Mushroom Extract for Fatigue and/or Arthralgias/Myalgias in Patients With Breast Cancer on Aromatase Inhibitors
This phase II trial tests how well Reishi mushroom extract works in treating fatigue and/or joint/muscle pain (arthralgias/myalgias) in patients with breast cancer on aromatase inhibitors.
- Trial name
- NCT06028022
- Testing
- Mushroom Extract, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 23 sites in United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Genetic Predisposition, Exposure, Environmental
Mayo Clinic Tapestry 2.0: Applying Multi-Omics for Scientific Discovery
The purpose of this study is to use multi-omics testing on samples collected from Mayo Clinic patients to build and expand on what has been learned about genomic data.
- Trial name
- NCT06456320
- Where
- 3 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Mayo Clinic
Ostomy
Conducting Wound, Ostomy, and Continence (WOC) Nurse Telephone Follow-up for Post-discharge Ostomy Patients to Reduce Hospital Readmission
The purpose of this research is to assess the impact of a telephone follow-up visit on rehospitalizations after ostomy surgery.
- Trial name
- NCT07879872
- Testing
- Wound, Ostomy, and Continence (WOC) Nurse Telephone Follow-up
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Epilepsy, Seizures
Genetic Markers of Cardiovascular Disease in Epilepsy
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age.
- Conditions
- Epilepsy, Seizures, Syncope, Channelopathy
- Trial name
- NCT02824822
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mayo Clinic
Opioid Use Disorder
Using Facebook to Support Opioid Recovery Among American Indian Women
The purpose of this study is to find out whether a Facebook group will help Native women in recovery from opioid use.
- Trial name
- NCT05995886
- Testing
- Wiidookaage'win Facebook Group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Gastrointestinal Diseases, Chest Pain
Virtual Reality for Non-cardiac Chest Pain
The purpose of this study is to determine if virtual reality (VR) will improve symptoms in non-cardiac chest pain (NCCP).
- Trial name
- NCT06262126
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Endometrial Carcinoma, Endometrial High Grade Endometrioid Adenocarcinoma
Molecular and ctDNA Characterization of High-Risk Endometrial Cancer
This study seeks to better understand the recurrence of high-risk endometrial cancer. It will collect information about cancer genetics to find out various hereditary or cancer specific genetic variants that may have a role in…
- Conditions
- Endometrial Carcinoma, Endometrial High Grade Endometrioid Adenocarcinoma, Stage II Endometrial Cancer, Stage III Endometrial Cancer
- Trial name
- NCT07062016
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Chronic Pancreatitis
Metabolic Impact of Pancreatic Duct Decompression
This study is a pilot study evaluating the impact of clearing out the pancreatic duct in patients with chronic pancreatitis who have a blockage in their pancreatic duct.
- Trial name
- NCT07810309
- Testing
- Endoscopic pancreatic duct decompression
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Major Depressive Disorder (MDD), Treatment Resistant Depression
EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression
The purpose of this research is to see if an experimental treatment for depression called intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation (TMS) can be improved for better results using…
- Conditions
- Major Depressive Disorder (MDD), Treatment Resistant Depression, Major Depression
- Trial name
- CLEOPATRA (NCT07862205)
- Testing
- MagVenture TMS Therapy System with Localite Navigation System and actiCHamp EEG
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell
Family Study of Lymphoproliferative Disorders
Blood and lymph node cancers can begin in either the lymphatic tissues (as in the case of lymphoma) or in the bone marrow (as with leukemia and myeloma), and they all are involved with the uncontrolled growth of white blood…
- Conditions
- Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-Cell, Monoclonal B-Cell Lymphocytosis
- Trial name
- NCT00626496
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colorectal Carcinoma
Addressing Disparities in Colorectal Cancer Screening in Black and Underserved Phoenix Communities
This clinical trial studies disparities involving colorectal cancer prevention and screening in Black and underserved communities in the Phoenix metropolitan area.
- Trial name
- NCT05447923
- Testing
- Educational Intervention, Fecal Immunochemical Test, Patient Navigation
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic