Clinical trials: sponsored by Johns Hopkins University
Robotic Hysterectomy (Benign Indications/Early-stage Cancer)
Effect of Preoperative Simulator Warmup on Intraoperative Robotic Surgical Skills
Surgical residents and fellows acquire operative knowledge and skills by assisting attending surgeons in the operating room. Previous research has shown that practising technical skills prior to operating on patients can improve…
- Trial name
- NCT01969487
- Testing
- Preoperative warm-up on simulator
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dermatomyositis
Study of Tofacitinib in Refractory Dermatomyositis
The purpose of this study is to obtain preliminary data regarding the safety and efficacy of Janus kinase (JAK) inhibitor, tofacitinib, in adults with active, treatment-refractory dermatomyositis.
- Trial name
- STIR (NCT03002649)
- Testing
- Tofacitinib
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Sleep Disordered Breathing, Sleep Apnea
Sleep Disordered Breathing and Cardiopulmonary Disease in Peruvian Highlanders
Overall objective: To understand the feasibility of performing a randomized trial using a simple, minimally-invasive postural therapy approach to improve sleep disordered breathing (SDB).
- Trial name
- NCT03927547
- Testing
- Inclined Sleep
- Where
- Peru
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Bowel Preparation
Accuracy of Trans-abdominal Ultrasound in Evaluating Bowel Preparation Adequacy Before Colonoscopy
Adequate preparation of the large bowel is required for a successful colonoscopy. It has been reported that poor preparation exists in 25% of examinations, which may lengthen overall procedure time, lower adenoma detection rate…
- Trial name
- NCT04087265
- Testing
- Transabdominal ultrasound
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Antiphospholipid Antibody Syndrome, End Stage Renal Disease
Eculizumab to Enable Renal Transplantation in Patients With History of Catastrophic Antiphospholipid Antibody Syndrome
Catastrophic Antiphospholipid Antibody Syndrome (CAPS) is a rare condition in which life-threatening blood clots form in multiple organs simultaneously and can lead to multi-organ system failure and death.
- Trial name
- NCT01029587
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Fatigue in Multiple Sclerosis
Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis
Randomized, placebo-controlled, crossover, 4-sequence, 4-period, double-blind (participants and investigators), multicenter trial of 3 commonly used medications for treatment of MS-related fatigue (amantadine, modafinil…
- Trial name
- TRIUMPHANT-MS (NCT03185065)
- Testing
- Amantadine, Modafinil, Methylphenidate
- Where
- 2 sites in United States
- Volunteers
- 141 people
- Sponsor
- Johns Hopkins University
Violence, Domestic, Violence-Related Symptom
The weWomen and ourCircle Intervention for Immigrant, Refugee and Indigenous Women
This study evaluates the impact of administering culturally-specific versions of the Danger Assessment (DA) tool followed by the tailored safety planning/referral via use of internet/smartphone-based safety decision aid (SDA) on…
- Trial name
- NCT03265847
- Testing
- Culturally-tailored Safety Planning
- Where
- United States
- Volunteers
- 688 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid-use Disorder
Evaluating a Novel Medication Device for Methadone Dosing
This study will evaluate whether a commercially available, secure, electronic pill box is a feasible, acceptable, and satisfactory method to manage take-home dosing of methadone for both methadone clinic patients and staff…
- Trial name
- NCT03254043
- Testing
- Take-home Dosing Procedures
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Johns Hopkins University
Post Partum Depression, Bipolar Disorder
Neuroimaging Epigenetics of Prospective Postpartum Depression Biomarkers
Through a recent cross species translational experiment, researchers have identified a set of epigenetic marks capable of predicting postpartum depression with greater than 85% accuracy.
- Trial name
- NCT03638687
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Substance Use Disorders
Activating Community Support for Substance Users
Efforts to improve methadone maintenance outcomes are often thwarted by strong social networks that reinforce substance use and other risk behaviors.
- Trial name
- NCT03194295
- Testing
- Community Support Intervention Group, Substance Use Disorder Educational Group
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Early Labor
Membrane Sweeping in Early Labor and Delivery Outcomes
Membrane sweeping is a routine procedure in obstetrics in term patients. It has been shown to be effective in decreasing post term gestation and in increasing rate of spontaneous vaginal delivery when used in setting of induction…
- Trial name
- NCT03517696
- Testing
- Membrane sweeping
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Exercise, Mobile Health
Monitored Home Exercise in Pregnancy
The Study Investigators intend to study the adherence to and effect of a prescribed, monitored at-home exercise regimen in a pregnant population at risk for gestational diabetes, with a specific goal of understanding factors…
- Conditions
- Exercise, Mobile Health, Pregnancy, Gestational Diabetes
- Trial name
- NCT03551535
- Testing
- Monitored, At-Home Exercise Intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Schizophrenia, Bipolar Disorder
Positron Emission Tomography (PET) Imaging of Glial Activation in Psychotic Disease States
Many neurological diseases, including AIDS dementia, Alzheimer's disease and schizophrenia, involve an inflammatory component thought to specifically involve glial cell activation.
- Trial name
- NCT03257592
- Testing
- [11C]DPA-713
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV
CHWs, mHealth, and Combination HIV Prevention
Kasensero, a fishing community on Lake Victoria in Uganda, is a representative HIV "hotspot" with extremely high HIV prevalence (44.3%) and incidence (~3.9/100py), yet low HIV service utilization.
- Trial name
- mLAKE (NCT02556957)
- Testing
- HealthScouts, Standard of Care
- Where
- Uganda
- Volunteers
- 3,773 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Emergencies
Improvement of Ambulance Response Times in Karachi, Pakistan
The investigators hypothesize that spatial analysis of the location data of ambulance calls can improve prehospital care provided by Aman Foundation in Karachi, Pakistan by decreasing ambulance response times for high acuity…
- Trial name
- NCT02743169
- Testing
- Spatially-Optimized
- Where
- Pakistan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
COVID-19
Keto-diet for Intubated Critical Care COVID-19
Coronavirus disease (COVID-2019) is a devastating viral illness that originated in Wuhan China in late 2019 and there are nearly 2 million confirmed cases.
- Trial name
- KICC-COVID19 (NCT04358835)
- Testing
- Ketogenic diet, standard of care
- Sponsor
- Johns Hopkins University
Diabetic Gastroparesis, Idiopathic Gastroparesis
G-POEM for Treatment of Refractory Gastroparesis
This study is performed to assess the efficacy and outcomes of Gastric Per Oral Endoscopic Myotomy "G-POEM" in patients presenting with gastroparesis.
- Conditions
- Diabetic Gastroparesis, Idiopathic Gastroparesis, Gastroparesis Postoperative
- Trial name
- NCT02732821
- Testing
- Gastric Per Oral Endoscopic Myotomy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Low Bone Density
Stem Cell Recruitment in Osteoporosis Therapy
Osteoporosis is an important health problem in the rapidly-aging demographic. Fragility fractures are devastating consequences of osteoporosis.
- Trial name
- NCT01656629
- Testing
- Teriparatide, Alendronate, calcium and vitamin D
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Johns Hopkins University
Breast Cancer, Cervical Cancer
e-CHEC-uP: Scaling up an Efficacious Cancer Screening Intervention for Women With Limited English
This research is being done to learn more about whether or not Korean American women will improve the screening practices for breast and cervical cancer if subjects receive education and follow-up from community health workers.
- Trial name
- NCT03726619
- Testing
- e-CHEC-uP, CHEC-uP
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Multiple Sclerosis, Fatigue
Ketamine for Treatment of MS Fatigue
Multiple sclerosis (MS) is an inflammatory, demyelinating and degenerative disease of the central nervous system and, after trauma, is the most common cause of disability in young adults, affecting more than 400,000 individuals…
- Trial name
- NCT03500289
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
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