Clinical trials: open to volunteers, sponsored by Canadian Cancer Trials Group
Non Small Cell Lung Cancer
Immune Checkpoint Blockade and Chemotherapy With or Without Fecal Microbiota Transplant in Advanced Non-Small Cell Lung Cancer
This study is being done to answer the following question: Can adding a treatment called Fecal Microbiota Transplant (FMT) to the usual treatment delay the growth or spread of cancer better than the usual treatment alone? FMT…
- Trial name
- LUNA-2 (NCT07890493)
- Testing
- LND101, Carboplatin (AUC 5 or 6), pemetrexed
- Volunteers
- 160 people
- Sponsor
- Canadian Cancer Trials Group
Cancer Metastatic
Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy for Painful Non-Spine Bone Metastases
This study is being done to answer the following question: Is Stereotactic Body Radiation Therapy or SBRT (a form of radiation therapy which can deliver high doses of radiation to the specific painful area of the body most…
- Trial name
- NCT06391242
- Testing
- Standard Conventional Radiotherapy, Stereotactic Body Radiotherapy
- Where
- 12 sites in Canada
- Volunteers
- 230 people
- Sponsor
- Canadian Cancer Trials Group
Alveolar Soft Part Sarcoma, Renal Cell Carcinoma
GCAR1, a Chimeric Antigen Receptor (CAR) T-CELL Therapy for Relapsed/Refractory GPNMB-Expressing Solid Tumours
Only enrolling in Canada. The purpose of this study is to identify the highest dose of GCAR1, a chimeric antigen receptor (CAR-T) cell therapy, that can be tolerated without causing very severe side effects, and to see what…
- Conditions
- Alveolar Soft Part Sarcoma, Renal Cell Carcinoma, Triple Negative Breast Cancer
- Trial name
- NCT07297667
- Testing
- Fludarabine, Cyclophosphamide, GCAR1
- Where
- 4 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Canadian Cancer Trials Group
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma:
Utilization data will be collected from all patients entered on the trial at Canadian centres from the time of registration until death, removal from study, or completion of 10 years of follow-up.
- Trial name
- NCT05371808
- Testing
- EQ-5D-5L Instrument, Work Productivity and Daily Activity Impairment (WPAI) survey, Resource Utilization Form (SMRC)
- Where
- 6 sites in Canada
- Volunteers
- 247 people
- Sponsor
- Canadian Cancer Trials Group
Endometrial Cancer
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
This protocol tests de-escalated adjuvant treatment in patients with POLE-mutated or p53wt/NSMP (p53 wildtype/no specific molecular profile) early-stage endometrial cancer (EC).
- Trial name
- NCT05640999
- Testing
- Vaginal brachytherapy, Adjuvant radiotherapy (EBRT +/- brachytherapy), Observation
- Where
- 123 sites in United States, Australia and 7 more
- Volunteers
- 393 people
- Sponsor
- Canadian Cancer Trials Group
Multiple Myeloma
Fixed Duration vs Continuous Anti-CD38 Antibody Therapy Among Transplant Ineligible Older Adults With Newly-Diagnosed Multiple Myeloma
Currently, daratumumab or isatuximab are given continuously (non-stop), along side lenalidomide, and dexamethasone as part of multiple myeloma treatment. are given continuously (non-stop).
- Trial name
- NCT06182774
- Testing
- Daratumumab, Lenalidomide, Dexamethasone
- Where
- 31 sites in Canada
- Volunteers
- 570 people
- Sponsor
- Canadian Cancer Trials Group
Advanced Head and Neck Cancer
Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer
This study is being done to answer the following question: Does stereotactic body radiation therapy (SBRT) provide better cancer control compared to standard radiation therapy (RT) for those with advanced head and neck cancer?
- Trial name
- NCT06641791
- Testing
- Standard Radiotherapy (SRT), Stereotactic Body Radiotherapy (SBRT)
- Where
- 10 sites in Canada
- Volunteers
- 196 people
- Sponsor
- Canadian Cancer Trials Group
Mantle Cell Lymphoma
Sonrotoclax Plus Zanubrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma Planned for Standard of Care CAR-T Cell Therapy
The purpose of this study is to evaluate the effects of adding two oral medications (sonrotoclax plus zanubrutinib) to standard of care chimeric antigen receptor (CAR-T) cell therapy in participants with mantle cell lymphoma.
- Trial name
- NCT07341191
- Testing
- Zanubrutinib, Sonrotoclax, CAR-T Cell Therapy
- Where
- 5 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Canadian Cancer Trials Group
Cancer
Feasibility and Acceptability of Collecting Sociodemographic Data in CCTG Trials
This study is being done to answer the following question: Are patients on a clinical trial willing to provide answers to questions about their social, economic, and environmental factors-sometimes called social determinants of…
- Trial name
- FACTOR (NCT07390435)
- Testing
- Social Determinants of Health Questionnaire
- Where
- 15 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- Canadian Cancer Trials Group
Carcinoma
Canadian Initiative to Measure, Predict and Assess Cancer Treatment Outcomes in Patients Treated With Immuno-Oncotherapeutics
The researchers doing this study are interested in doing the following: Biomarker research using fresh tumour tissue and normal blood cells, and if required, tumour tissue already collected.
- Trial name
- (CAN-IMPACT-IO (NCT06630273)
- Volunteers
- 120 people
- Sponsor
- Canadian Cancer Trials Group
Cancer
A Phase II Study of Durvalumab Treatment - Substudy A: In Patients Who Discontinued Prior Checkpoint Therapy Due to Immune Related Toxicity - Substudy B: For Continued Treatment (+/- Tremelimumab) of Patients Previously Enrolled to Completed CCTG Studies
I238A: The purpose of this study is to find out what effects being treated with durvalumab has on cancer. The researchers doing this study also want to evaluate if prednisone (a type of steroid), when given together with…
- Trial name
- NCT03847649
- Testing
- Durvalumab, Prednisone, Tremelimumab
- Where
- 11 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Canadian Cancer Trials Group
Acute Leukemia
Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia
The purpose of this study is to find out whether a novel manualized intervention, called Emotion and Symptom-focused Engagement (EASE), that combines psychological support with symptom screening plus triggered referral to early…
- Trial name
- EASE (NCT04224974)
- Testing
- Usual Care, EASE-psy
- Where
- 6 sites in Canada
- Volunteers
- 266 people
- Sponsor
- Canadian Cancer Trials Group
Non-hodgkin Lymphoma
Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma
This study is being done to answer the following question: Can the addition of a new drug to the usual treatment lower the chance of primary central nervous system lymphoma growing or spreading? This study is being done to find…
- Trial name
- NCT05998642
- Testing
- Methotrexate, Rituximab (where available), Ibrutinib
- Where
- 8 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Canadian Cancer Trials Group
Melanoma
LND101 for Fecal Microbiota Transplantation in Combination With Immune Checkpoint Blockade in Advanced Melanoma
This study is being done to answer the following question: Can the chance of melanoma growing or spreading be lowered by receiving a treatment called LND101 for Fecal Microbiota Transplant (FMT) in addition to the usual…
- Trial name
- Canbiome2 (NCT06623461)
- Testing
- Standard of Care Immune Checkpoint Blockade, LND101
- Where
- 15 sites in Canada
- Volunteers
- 128 people
- Sponsor
- Canadian Cancer Trials Group
Gastroesophageal Adenocarcinoma
Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma
This study is being done to answer the following question: Can the chance of gastroesophageal cancer growing or spreading be lowered by adding a drug called zanidatamab to the usual combination of drugs? We are doing this study…
- Trial name
- NCT06043427
- Testing
- Paclitaxel, Ramucirumab, Zanidatamab
- Where
- 18 sites in Canada
- Volunteers
- 168 people
- Sponsor
- Canadian Cancer Trials Group
Vulvar Squamous Cell Carcinoma
STRatIfication of Vulvar SCC by HPV and p53 Status to Guide Excision
This study is being done to answer the following question: Are there types of early-stage vulvar cancer that require either less or more treatment than the usual approach?
- Trial name
- STRIVE (NCT06358469)
- Testing
- Surgery, Active Surveillance
- Where
- 12 sites in Canada, New Zealand
- Volunteers
- 249 people
- Sponsor
- Canadian Cancer Trials Group
Hepatocellular Carcinoma
STRIDE (Durvalumab + Tremelimumab) With Lenvatinib vs STRIDE Alone in Unresectable Hepatocellular Carcinoma
The purpose of this study is to compare the effects on participants' and liver cancer by adding a drug that is used on its own to treat this disease to a combination of two other drugs which is also used to treat liver cancer…
- Trial name
- SLIDE-HCC (NCT06880523)
- Testing
- STRIDE (durvalumab + tremelimumab), Durvalumab, Lenvatinib
- Where
- 13 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Canadian Cancer Trials Group
Ovarian Cancer
Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian Cancer
This study is being done to answer the following question: What are the effects of a new drug or drugs on ovarian cancer? The pre-study screening may be done to test a sample of tissue for biomarkers to determine participation in…
- Trial name
- IPROC (NCT04918186)
- Testing
- Durvalumab, BA3011, BA3021
- Where
- 6 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Canadian Cancer Trials Group
Oropharyngeal Cancer
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic…
- Trial name
- SELECT (NCT05451004)
- Testing
- Lymphatic Mapping with SPECT-CT, Ipsilateral and Contralateral Neck
- Where
- 38 sites in United States, Canada
- Volunteers
- 510 people
- Sponsor
- Canadian Cancer Trials Group
Rectal Cancer
Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
This study is being done to answer the following questions: Is the chance of rectal cancer responding the same if chemotherapy alone is given before limited surgery compared to chemotherapy and radiation therapy given together…
- Trial name
- NEO-RT (NCT06205485)
- Testing
- Leucovorin, Oxaliplatin, Fluoruracil
- Where
- 113 sites in United States, Canada
- Volunteers
- 250 people
- Sponsor
- Canadian Cancer Trials Group