Clinical trials: completed, sponsored by Brigham and Women's Hospital
Multiple Sclerosis
Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue
The overarching aim is to assess the role of microglial activation and norepinephrine transporter binding in pathogenesis of MS-related fatigue, using novel Positron Emission Tomography (PET) radiotracers, [F-18]PBR06 and…
- Trial name
- NCT04144257
- Testing
- [F-18]PBR06, [C-11]Methylreboxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brigham and Women's Hospital
Acute Kidney Injury
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Multiple lines of evidence support a central role of iron in causing acute kidney injury (AKI), including the finding that prophylactic administration of iron chelators attenuates AKI in animal models.
- Trial name
- DEFEAT-AKI (NCT04633889)
- Testing
- Deferoxamine, Normal saline
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Design and Usability Testing of a Tailored Intervention About Sleep and Sleep Disorders Among Transportation Workers
The objective of this protocol is to conduct a focus group to identify OSA beliefs, attitudes, and knowledge among employees in the transportation industry on shift schedules.
- Trial name
- NCT05039528
- Testing
- Personalized OSA messages, Control
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Metabolic Syndrome, Hypertension
Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity
This study will evaluate whether the mineralocorticoid receptor antagonist eplerenone, when compared to chlorthalidone plus potassium chloride, can improve cardiac MRI-derived myocardial perfusion reserve and fibrosis…
- Conditions
- Metabolic Syndrome, Hypertension, Overweight and Obesity
- Trial name
- NCT04519164
- Testing
- Eplerenone, Chlorthalidone with potassium chloride
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Brigham and Women's Hospital
Depressive Disorder, Major, Depression
Individualized Functional Connectivity Targeting in aiTBS for Depression
The goal of this clinical trial is to estimate the importance of neuroimaging in accelerated intermittent theta burst stimulation (aiTBS) for depression.
- Conditions
- Depressive Disorder, Major, Depression, Mood Disorders, Mental Disorder
- Trial name
- AINT (NCT05680727)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Hematologic Malignancy, Hematopoietic/Lymphoid Cancer
A Proof-of-Concept Trial of a Positive Psychology Intervention for Allogeneic Stem Cell Transplant Patients
The goal of this research study is to find out if a novel phone-based positive psychology intervention that focuses on improving health behaviors and positive emotions can help improve mood, health related quality of life, and…
- Conditions
- Hematologic Malignancy, Hematopoietic/Lymphoid Cancer, Blood Cancer
- Trial name
- NCT03654404
- Testing
- Positive Psychology Intervention
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Brigham and Women's Hospital
Labor Pain, Analgesia
Optimal Bupivacaine Dose for Initiation of Labor Epidural Techniques
To estimate the dose of bupivacaine required to achieve initial effective comfort in 90% of patients (ED90) via the epidural (DPE or EPL) technique in women undergoing labor.
- Trial name
- NCT04814537
- Testing
- Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Seemingly Healthy, Genetic Predisposition to Disease
Return of Genomic Results and Aggregate Penetrance in Population-Based Cohorts
The PopSeq Project is a prospective cohort study that will develop and implement a genomic return of results (gRoR) process in the Framingham Heart Study (FHS) and Jackson Heart Study (JHS) cohorts and explore associated medical…
- Trial name
- PopSeq (NCT04196374)
- Testing
- Genomic Sequencing
- Where
- 2 sites in United States
- Volunteers
- 7,603 people
- Sponsor
- Brigham and Women's Hospital
Alzheimer Disease, Mild Cognitive Impairment
Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges
The objectives of this study are to demonstrate the feasibility of implementing a deprescribing nudge intervention using pragmatic methods, confirm that outcomes can be feasibly measured and evaluated at scale in a subsequent…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06347172
- Testing
- Nudge Intervention
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Disease, Cancer
COcoa Supplement and Multivitamin Outcomes Study
The purpose of this study is to determine whether taking daily, dietary supplements of cocoa extract (containing cocoa flavanols and theobromine from the cocoa bean) and/or a standard multivitamin reduces the risk of developing…
- Trial name
- COSMOS (NCT02422745)
- Testing
- Cocoa extract, Multivitamin
- Where
- 2 sites in United States
- Volunteers
- 21,442 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Falls, Fall Injury
Electronic Strategies for Tailored Exercise to Prevent FallS
The objectives of this proposal are to evaluate the eSTEPS CDS (eSTEPS) in a cluster randomized controlled trial. The intervention includes the following: 1) A machine learning-based fall injury risk screening algorithm to…
- Conditions
- Falls, Fall Injury, Exercise Self-Efficacy, Falls Self-Efficacy
- Trial name
- eSTEPS (NCT04993781)
- Testing
- eSTEPS CDS
- Where
- United States
- Volunteers
- 11,945 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea
A Novel Pharmacological Therapy for Obstructive Sleep Apnea
A pharmacological, non-mechanical therapy for OSA that is efficacious and tolerable remains elusive. Here the investigators study the effect on sleep apnea severity of a combination of pharmacological agents (atomoxetine and…
- Trial name
- NCT03919955
- Testing
- Atomoxetine, Oxybutynin
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Brigham and Women's Hospital
Bladder Cancer, Urothelial Carcinoma
18Fluorine-Fluciclovine PET/CT for Staging Muscle Invasive Bladder Cancer Preceding Radical Cystectomy
This research study is studying a positron emission tomography (PET) agent called 18F-fluciclovine to evaluate how well 18F-fluciclovine-PET scans determine the extent of muscle invasive bladder cancer (as compared to regular CT…
- Trial name
- NCT04018053
- Testing
- 18F-fluciclovine, PET/CT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Acute Respiratory Distress Syndrome
Safety and Efficacy Study of Inhaled Carbon Monoxide to Treat Acute Respiratory Distress Syndrome (ARDS)
This study will be a multi-center, prospective, randomized, partially double-blind, placebo-controlled Phase II clinical trial of inhaled CO (iCO) for the treatment of ARDS.
- Trial name
- NCT03799874
- Testing
- Inhaled Carbon Monoxide at 200 ppm, Inhaled Medical air
- Where
- 7 sites in United States
- Volunteers
- 4 people
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Metabolic Syndrome
Evaluating the Navajo Community Outreach and Patient Empowerment (COPE) Program
Since 2009, a programmatic community-based strategy (COPE) has been implemented to address health disparities among Navajo individuals living with multiple chronic conditions.
- Conditions
- Diabetes Mellitus, Metabolic Syndrome, Hypertension, Chronic Disease
- Trial name
- NCT03326206
- Where
- 6 sites in United States
- Volunteers
- 28,813 people
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis
Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis
There are two cartilage structures, called menisci, in each knee joint. A torn meniscus can be caused by a traumatic injury or aging-related degeneration.
- Trial name
- NCT00597012
- Testing
- Arthroscopic partial menisectomy, Standard physical therapy, Postoperative rehabilitative physical therapy
- Where
- 7 sites in United States
- Volunteers
- 351 people
- Sponsor
- Brigham and Women's Hospital
Wound of Skin, Wound Heal
Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds
The use of topical beta-blockers, such as 0.25% timolol, in promoting wound healing is currently emerging in the academic literature.
- Conditions
- Wound of Skin, Wound Heal, Wound Open, Surgical Wound
- Trial name
- NCT03452072
- Testing
- 0.25% Timolol gel with paraffin gauze dressings, Vaseline dressing
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
COPD, Emphysema
Anti-Platelets in Chronic Obstructive Pulmonary Disease
This is a 6 week crossover study in current and former smokers with and without COPD to evaluate whether 2 weeks of dual antiplatelet therapy (aspirin 81mg and clopidogrel 75mg) improves pulmonary perfusion (i.e.
- Conditions
- COPD, Emphysema, Emphysema or COPD
- Trial name
- NCT05567562
- Testing
- dual anti-platelet therapy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Asthma
Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART)
Vitamin D supplementation given to pregnant women will prevent asthma in their offspring and children.
- Trial name
- VDAART (NCT00920621)
- Testing
- Vitamin D 3 cholecalciferol, Vitamin D3
- Where
- 3 sites in United States
- Volunteers
- 876 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Spinal Cord Injuries
Multimodality Intervention for Function and Metabolism in SCI
The proposed phase 2 trial a randomized, placebo-controlled, parallel group trial in persons with cervical or thoracic SCI, AIS grade A, B, C, or D, 6 months or later after injury.
- Trial name
- NCT03576001
- Testing
- Testosterone Undecanoate, hybrid exercise
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital