Clinical trials: open to volunteers, sponsored by Brigham and Women's Hospital
Implicit Bias, Implicit Association Test
Virtual Reality to Combat Weight-Based Implicit Bias: BWH Pilot Study
The goal of this pilot implementation study is to evaluate the impact of a virtual reality (VR) intervention on implicit bias for resident physicians.
- Trial name
- BWH-VR-1 (NCT07283523)
- Testing
- 360 Video on a Virtual Reality Headset, 360-Control Video
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Inflammatory Bowel Disease (IBD), Clostridioides Difficile Infection
Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients With Inflammatory Bowel Disease
This 3+3 dose escalation pilot trial will assess the safety and efficacy of xylitol as an oral therapeutic for decolonization of C. difficile in the Inflammatory Bowel Disease (IBD) patient population.
- Trial name
- NCT06799039
- Testing
- Xylitol
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Brigham and Women's Hospital
Acute Suicidal Depression (ASD)
Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan
This study is a randomized open-label single-blind non-inferiority comparative effectiveness study of ECT vs. KET for the treatment of Acute Suicidal Depression (ASD).
- Trial name
- REaKT-SD (NCT06034821)
- Testing
- Subanesthetic dose intravenous ketamine (KET), Electroconvulsive therapy (ECT)
- Where
- 10 sites in United States, Canada
- Volunteers
- 1,500 people
- Sponsor
- Brigham and Women's Hospital
Overweight and Obesity
Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment
Obesity has become an important public health issue that leads to insulin resistance, diabetes, hypertension, dyslipidemia, and cardiovascular diseases.
- Trial name
- NCT06069622
- Testing
- 24-hour ambulatory blood pressure, Liberal salt diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
Cerebral/Cortical Visual Impairment (CVI) is the leading cause of childhood visual impairment in the United States and other industrialized countries.
- Trial name
- CVI (NCT07275021)
- Testing
- Prospective Clinical and Neurodevelopmental Data Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Sleep Deprivation, Sex Differences
Evaluation of Sex Differences in Glucose Metabolism in Response to Sleep Curtailment
The goal of this study is to learn whether insufficient sleep affects glucose metabolism differently in healthy men and women.
- Conditions
- Sleep Deprivation, Sex Differences, Glucose Tolerance
- Trial name
- NCT06809023
- Testing
- Sleep restriction
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Lung Cancer Screening
Community-Based Engagement to Improve Lung Cancer Screening and Outcomes: The "Our Lungs Our Health" Study
The main goal of this pilot study is to understand the impact of a mobile lung cancer screening clinics in individuals from neighborhoods and communities with less access to resources in Boston, Massachusetts who are at high risk…
- Trial name
- NCT06909981
- Testing
- Low-Dose Computed Tomography Scan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Appetitive Behavior, Obesity
Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the…
- Trial name
- NCT06105164
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dietary Habits
Dietary Intervention to Mitigate Adverse Consequences of Night Work
The goal of this clinical trial is to test whether our dietary intervention can prevent or lessen the negative health effects of night shift work in healthy participants.
- Trial name
- NCT04868526
- Testing
- dietary intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Suspected Prostate Cancer
MRI Guided Prostate Biopsy
This study aims to assess the feasibility of magnetic resonance (MR) guided prostate biopsy using a needle holder frame. This frame is used to help position the needle used for the biopsy.
- Trial name
- NCT06302595
- Testing
- MRI-guided prostate biopsy using the needle holder frame.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
Obesity, Obesity, Morbid
Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss
The Investigators propose suture plication placement at the distal gastric body drives a significant portion of weight loss in endoscopic sleeve and sutures only need to be placed in the distal gastric body.
- Conditions
- Obesity, Obesity, Morbid, Metabolic Disease, Weight, Body
- Trial name
- NCT06299644
- Testing
- Endoscopic Sleeve Gastroplasty - Belt and Suspenders, Endoscopic Sleeve Gastroplasty - Belt
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Chronic Pain, Musculoskeletal Pain
Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain
Chronic spine pain is one of the most common and conditions in adults over the age of 65. Treatments for pain that are non-pharmacologic (do not use over-the-counter or prescription drugs) are recognized as some of the most…
- Trial name
- GOLDEN (NCT06632535)
- Testing
- Chiropractic care, Group medical visits
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Human Immunodeficiency Virus
The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care
The goal of this clinical trial is to learn if the DSD model (SUSTAIN-DSD) is effective in improving participants HIV treatment adherence.
- Trial name
- NCT06554223
- Testing
- SUSTAIN-DSD, Enhanced (guideline-driven) Standard of Care (E-SoC)
- Where
- South Africa
- Volunteers
- 310 people
- Sponsor
- Brigham and Women's Hospital
Achilles Tendinopathy
RCT of Home-based vs Formal Physical Therapy for Treatment of New Onset Non-insertional Achilles Tendinopathy
The goal of this prospective randomized controlled trial is to compare the effectiveness of a home-based exercise protocol to formal physical therapy in patients who have been diagnosed with Achilles tendinopathy.
- Trial name
- NCT06374654
- Testing
- Home-based Exercise Protocol, Formal Physical Therapy
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mesothelioma
MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI
In this research study, investigators will test whether prophylactic high-dose IV Mg administration attenuates the risk of AKI in patients with malignant mesothelioma receiving intraoperative chemotherapy (HIOC) with cisplatin…
- Trial name
- MAGIC-AKI (NCT05730816)
- Testing
- Magnesium sulfate, Normal Saline
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Brigham and Women's Hospital
Amyloidosis, Primary, Cardiomyopathy
Molecular Imaging of Primary Amyloid Cardiomyopathy
Cardiac amyloidosis is a major cause of early treatment-related death and poor overall survival in individuals with systemic light chain amyloidosis.
- Trial name
- MICA (NCT02641145)
- Testing
- F-18 florbetapir/C-11 acetate PET, MRI, N-13 ammonia PET
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Brigham and Women's Hospital
Lung Cancer
Image Guided VATS vs. VATS Resection
To evaluate workflow and outcomes of iVATS and standard VATS for small pulmonary nodules. The outcomes of the patients will be evaluated separately as there will be no direct comparison of the two arms.
- Trial name
- NCT03623958
- Testing
- Image guided Video-Assisted Thoracic Surgery (VATS) resection, Video-Assisted Thoracic Surgery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Brigham and Women's Hospital
Trauma and Stressor Related Disorders, Violence, Structural
Synergy Between Patient and Clinician: Using a Trauma-Informed Care Plan
The goal of this prospective study is to test the: acceptability of trauma-informed care plans; the intervention appropriateness; and the feasibility of the trauma-informed care plans in the electronic health care record.
- Conditions
- Trauma and Stressor Related Disorders, Violence, Structural, Violence, Domestic, Violence, Sexual
- Trial name
- TICP (NCT06330753)
- Testing
- Trauma-informed Care Plan-
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Opioid Use Disorder
Dynamic Treatment Regimes for Opioid Use Disorder
This study aims to develop and evaluate dynamic treatment regimes (DTRs) to improve personalized care for individuals with opioid use disorder (OUD).
- Trial name
- NCT07011758
- Testing
- Medication for opioid use disorder, psychotherapy
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brigham and Women's Hospital
Stable Coronary Disease
The Impact of Pcsk-9 Inhibition on PET CFR in Patients at High CV Risk
The study protocol is a single-arm, open label pilot study designed to evaluate the impact of PCSK-9 inhibition on coronary blood flow in patients with stable coronary artery disease.
- Trial name
- EMPOWER (NCT05152888)
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital