Clinical trials: open to volunteers, sponsored by Brigham and Women's Hospital
OSA
Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA
Obstructive sleep apnea (OSA) is a highly prevalent disorder that has major consequences for cardiovascular health, neurocognitive function, risk of traffic accidents, daytime sleepiness, and quality of life.
- Trial name
- NCT06091085
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Brigham and Women's Hospital
Hematologic Malignancy, Febrile Neutropenia
Early Neutropenic Fever De-escalation of Antibiotics Study
This is a randomized, open label clinical trial among individuals with hematologic conditions. The trial aims to evaluate the safety and clinical outcomes of de-escalating antibiotic therapy among stable individuals diagnosed…
- Conditions
- Hematologic Malignancy, Febrile Neutropenia, Antibiotic Stewardship
- Trial name
- END (NCT06278896)
- Testing
- Cessation of antibiotics
- Volunteers
- 260 people
- Sponsor
- Brigham and Women's Hospital
Bladder Cancer
Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol
To determine if Alvimopan during open or robotic radical cystectomy with urinary diversion results in quicker return of bowel function (GI-2 recovery = time to upper [first toleration of solid food] and lower [first bowel…
- Trial name
- NCT03216525
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Brigham and Women's Hospital
Facet Joints; Degeneration, Neuropathy
MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine
The objective of this study is to provide pain relief to patients with facet joint disease or head and neck pain related to compression of a nerve root.
- Conditions
- Facet Joints; Degeneration, Neuropathy, Neuralgia
- Trial name
- NCT01788410
- Testing
- Cryoablation under image guidance, MRI Seednet Cryotherapy System (Galil Medical)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Pharmacological Activation of HMN for OSA Aim 2
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- NCT03858751
- Testing
- LTM1201AZ, LTM1201AT, LTM1201AG
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital