Clinical trials: open to volunteers, sponsored by Brigham and Women's Hospital
Inflammatory Bowel Disease (IBD), Clostridioides Difficile Infection
Use of Fidaxomicin Compared to Vancomycin for Decolonization of C. Difficile in Patients With Inflammatory Bowel Disease
This is a randomized, double-blind study to assess the safety and efficacy of fidaxomicin compared to vancomycin for decolonization of C. difficile in IBD patients.
- Trial name
- NCT06794944
- Testing
- Vancomycin (POC), Fidaxomicin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Chronic Migraine
Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine
The goal of this clinical trial is to learn if the behavioral treatment called Acceptance and Commitment Therapy (ACT) works to improve disability in adults with chronic migraine.
- Trial name
- NCT06795867
- Testing
- acceptance and commitment therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Disease, Kidney Transplant
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol.
- Conditions
- Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
- Trial name
- RESTORE (NCT07222683)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Edema, Pneumonia
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second.
- Conditions
- Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion
- Trial name
- NCT06538376
- Testing
- Portable Dynamic Digital Radiography (DDR)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea, Insomnia
Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.
Rural communities in the southern U.S. suffer a disproportionate burden of morbidity and mortality from cardiometabolic disease, with traditional risk factors explaining only a modest proportion of the excess burden of disease.
- Conditions
- Sleep Apnea, Insomnia, Sleep Deprivation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT06336525
- Where
- United States
- Volunteers
- 3,680 people
- Sponsor
- Brigham and Women's Hospital
Ulcerative Colitis, Ulcerative Colitis Chronic Moderate
Study of Novel Therapeutics for Acute Remedy of Colitis
This study is a clinical trial being done to investigate the efficacy of drug BRS201 as a treatment in patients with acute ulcerative colitis.
- Conditions
- Ulcerative Colitis, Ulcerative Colitis Chronic Moderate, Ulcerative Colitis Chronic Severe
- Trial name
- SHARC (NCT06420492)
- Testing
- BRS201
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Retroperitoneal Sarcoma
Short Course Radiation Treatment for Patients With Primary or Locally Recurrent Retroperitoneal Sarcoma Prior to Surgery
To determine the safety of moderately hypofractionated radiation in the treatment of primary and locally recurrent RPS, based on the evaluation of acute radiation-related toxicity profile of each participant (30-day radiation…
- Trial name
- NCT06812052
- Testing
- Radiation Therapy, Hypofractionationed Radiation Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Brigham and Women's Hospital
Tibia Fractures, Trauma (Including Fractures)
Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool
This study aims to evaluate a preoperative fracture analysis tool that uses 3D visualization and biomechanical modeling to assist surgeons in planning screw and plate fixation for complex tibial plateau fractures.
- Conditions
- Tibia Fractures, Trauma (Including Fractures), Surgical Planning
- Trial name
- NCT07193524
- Testing
- 3D Fracture Analysis Tool
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Diseases
Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine
This study is designed to determine the efficacy and safety of colchicine in patients with chronic kidney disease.
- Trial name
- NCT04500665
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Glioblastoma (GBM)
Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial
Glioblastoma (GBM) is an aggressive malignancy of the central nervous system. Older adults with GBM have a unique constellation of medical, psychosocial, and supportive care needs.
- Trial name
- ELITE-GBM (NCT06835803)
- Testing
- Dose-escalated radiation therapy, Standard hypofractionated radiation
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea (OSA)
Assessment of Circuit Rebreathing During CPAP Therapy
The goal of this research is to better understand how different CPAP mask designs affect airflow and rebreathing of exhaled carbon dioxide (CO₂) during sleep in individuals with obstructive sleep apnea (OSA).
- Trial name
- NCT07062770
- Testing
- Continuous positive airway pressure (CPAP), Mask exhaust port flow
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Brigham and Women's Hospital
Malignancy, Immune Related Adverse Events
Evaluating Informatics-assisted Immune-related Adverse Event Detection to Improve Registration Onto a Biorepository
Immunotherapies have improved cancer outcomes, but have a unique profile of immune-related adverse events (irAEs). Biorepositories have been established to collect data and samples to help improve our understanding of irAEs…
- Trial name
- NCT06789601
- Testing
- Informatics system for eligibility monitoring, Standard eligibility monitoring
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Aging, Cognitive Impairment
Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities
The aim of this study is to design a sleep and mindfulness intervention to improve sleep, quality of life, and cognitive function among older adults.
- Conditions
- Aging, Cognitive Impairment, Sleep
- Trial name
- NCT06989619
- Testing
- Sleep health and mindfulness intervention
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression
Brain Connectivity in Depression
This study originally included 140 subjects with medication-refractory depression undergoing 10 Hz transcranial magnetic stimulation (10Hz-TMS) to the left dorsal lateral prefrontal cortex (DLPFC), with the goal of having 60…
- Trial name
- NCT03276793
- Testing
- MRI scan, Behavioral testing
- Where
- 4 sites in United States
- Volunteers
- 260 people
- Sponsor
- Brigham and Women's Hospital
Water, Child Nutrition
Water is K'é: Multi-level Intervention to Promote Healthy Beverage Choices Among Navajo Families
The goal of this clinical trial is to understand if a cultural intervention for Navajo families will improve healthy beverage habits, health outcomes, and family cohesion.
- Conditions
- Water, Child Nutrition, Family Dynamics, Healthy Nutrition
- Trial name
- NCT06020027
- Testing
- Water is K'é
- Where
- United States
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
OSA
Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA
Obstructive sleep apnea (OSA) is a highly prevalent disorder that has major consequences for cardiovascular health, neurocognitive function, risk of traffic accidents, daytime sleepiness, and quality of life.
- Trial name
- NCT06091098
- Testing
- Dynamic CO2
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Brigham and Women's Hospital
Amyloid Cardiomyopathy, Transthyretin Cardiac Amyloidosis
Exercise Training in Transthyretin Cardiac Amyloidosis
Transthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training program to improve functional capacity in patients on optimal treatment for…
- Trial name
- NCT05797857
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Trazodone on OSA Endotypes
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for…
- Trial name
- NCT06286189
- Testing
- Trazodone Hydrochloride
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Brigham and Women's Hospital
Small Fiber Neuropathy
Detection of Small Fiber Neuropathy Using Skin Properties
Small fiber neuropathy affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, too much or too little sweating.
- Trial name
- NCT04759443
- Testing
- Image processing of skin
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction
- Trial name
- CABGGenomics (NCT01258231)
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Brigham and Women's Hospital