Clinical trials: lifestyle and therapy programmes, open to volunteers
Lung Carcinoma, Head and Neck Carcinoma
A New Way to Share Radiation Therapy Plans Between Doctors, CORRECT Trial
This clinical trial tests a new way to share radiation therapy plans using the Collaborative Oncology between Radiologists and Radiation oncologists for the Evaluation of Contoured Targets (CORRECT) workflow to improve…
- Trial name
- CORRECT (NCT07282444)
- Testing
- Training and Education, Communication Intervention, Survey Administration
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Prehabilitation, Cardiac Surgery
Feasibility of Physical Prehabilitation for High-Risk Patients Undergoing Cardiac Surgery Via Sternotomy
Rationale Cardiac surgery via median sternotomy carries an elevated risk of postoperative complications and delayed functional recovery.
- Conditions
- Prehabilitation, Cardiac Surgery, Risk Assesment, Aortic Valve
- Trial name
- PREPA-STER (NCT07893184)
- Testing
- Physical Prehabilitation Intervention
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Perinatal Mental Health, Fathers
Fathers and Babies (FAB) Research Study
The purpose of this study is to examine the effectiveness of the Fathers and Babies intervention (FAB). FAB aims to improve the mental health of fathers and provide strategies that help fathers support the mental health of their…
- Conditions
- Perinatal Mental Health, Fathers, Stress Management
- Trial name
- NCT07893210
- Testing
- Fathers and Babies Program, Mothers and Babies Program
- Where
- United States
- Volunteers
- 624 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Suicide Attempt, Suicidal and Self-injurious Behavior
Suicide Preventive Psychosocial Treatment for Youths
Suicide is the leading cause of death amongst 10-18-year-olds in Sweden. Suicide attempts are the strongest predictor of subsequent death by suicide, often lead to inpatient care, and are associated with substantial societal…
- Conditions
- Suicide Attempt, Suicidal and Self-injurious Behavior, Suicide Attempted, Suicide, Attempted
- Trial name
- NCT06931639
- Testing
- Safe Alternatives for Teens and Youth (SAFETY), Enhanced Treatment As Usual
- Where
- 5 sites in Sweden
- Volunteers
- 282 people
- Sponsor
- Karolinska Institutet
Metabolic Syndrome
Immersive Virtual Reality Training for Improving Cognition in Adults With Metabolic Syndrome
This study aims to evaluate the effectiveness of a multimodal intervention using immersive virtual reality (Virtual-METS) to improve cognitive function in middle-aged adults with metabolic syndrome and subjective cognitive…
- Trial name
- VIRTUAL-METS (NCT07040748)
- Testing
- Immersive VR-Based Multimodal Intervention (Virtual-METS)
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Consorci Sanitari de Terrassa
Type 2 Diabetes Mellitus (T2DM)
Flaxseed Consumption on Biochemical and Quality of Life in Type 2 Diabetes
The main goal of this clinical trial is to determine the effect of flaxseed added to the diet on biochemical parameters and quality of life in patients with Type 2 diabetes mellitus (T2DM).
- Trial name
- NCT06911060
- Testing
- Flaxseed, Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ondokuz Mayıs University
Inflammation, Depression Disorder
Inflammatory Pathways Modulated by Prenatal Mindfulness: A Route to Improve Maternal Child Emotional Well Being and Whole Person Health
The goal of this study is to investigate inflammation as the biological mechanism by which mindfulness based cognitive therapy for perinatal depression (MBCT-PD) administered during pregnancy improves women's emotional well-being…
- Conditions
- Inflammation, Depression Disorder, Mindfulness, Emotional Well-being
- Trial name
- NCT07892326
- Testing
- Mindfulness-based cognitive therapy for perinatal depression, Pregnancy Health Group
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Lung Cancer (NSCLC), KRAS G12C Lung Cancer
Phase II Neoadjuvant Study of Garsorasib Followed by Ivonescimab Plus Chemotherapy in Resectable Stage IIA-IIIB KRAS G12C-Mutant NSCLC (GIVEN Study)
This study is a multicenter, prospective, open-label clinical trial. It enrolls previously untreated patients with resectable stage IB-IIIB KRAS G12C mutation-positive NSCLC to evaluate the efficacy and safety of glesorasib…
- Trial name
- GIVEN (NCT07472478)
- Testing
- Garsorasib, Ivonescimab Combined With Chemotherapy, Surgery
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Guangdong Provincial People's Hospital
Smoking Behaviors
Therapeutic Contact Intensity in a Psychological Smoking Cessation Intervention With an App
This randomized controlled trial intends to examine the efficacy of a smoking cessation intervention with an App according to the intensity of therapeutic contact. Participants will be assigned to one of three groups.
- Trial name
- TREATINTSMOKE (NCT06900985)
- Testing
- 8-sessions CBT + App, 4-sessions CBT+App, Smoking cessation App
- Where
- Spain
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Stroke
Behavioral Intervention and Guided Stepping Training Early Post-Stroke
Low daily steps and prolonged sedentary behavior are associated with reduced functional outcomes and quality of life in patients with stroke.
- Trial name
- BIG STEPS (NCT07702643)
- Testing
- Behavior and guided stepping training intervention (BIG STEPS), DELAYED Behavior and guided stepping training intervention
- Where
- 6 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Language Disorders
Neurophysiological Mechanisms of Language Comprehension
First, in a recording-only self-paced reading experiment, patients with epilepsy undergoing intracranial monitoring for clinical purposes will read or listen to sentences presented to them one word at time while the investigators…
- Trial name
- NCT05283265
- Testing
- Sentence Type, Direct brain stimulation
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Alabama at Birmingham
Psychological Stress
Feasibility Pilot of Remote Mindfulness Training Across Multiple Sites (REFORM Pilot)
This is an operational feasibility pilot preceding the main REFORM multi-site randomized controlled trial. Approximately 60 adults across three sites will be randomized equally to one of four remotely delivered audio-guided…
- Trial name
- REFORM Pilot (NCT07888725)
- Testing
- Formal-Heavy Audio-Guided Mindfulness Training, Balanced Audio-Guided Mindfulness Training, Informal-Heavy Audio-Guided Mindfulness Training
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Atopic Dermatitis, Eczema
Digital Mindfulness Meditation in Adolescents With Atopic Dermatitis
Atopic dermatitis is well reported to have a significant impact on well-being in adolescents with atopic dermatitis, without clear recommendations for intervention.
- Trial name
- MIND-AD (NCT07746427)
- Testing
- Digital App Mindfulness Meditation, Mindfulness Meditation Sheet
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University
Schizophrenia Disorder, Schizoaffective Disorder
Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization
This study is a randomized controlled trial evaluating the impact of financial incentives on medication adherence among individuals with schizophrenia, schizoaffective disorder, or bipolar disorder and/or co-occurring substance…
- Conditions
- Schizophrenia Disorder, Schizoaffective Disorder, Bipolar Disorder (BD), Substance Use Disorder (SUD)
- Trial name
- NCT07130500
- Testing
- Financial incentives for adherence to long-acting injectable medication, Standard of care with monthly surveys
- Where
- 6 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Stanford University
Depression and/or Anxiety Symptoms, Problematic Phone Use Behavior
The Mindful Smartphone Use Study
The goal of this clinical trial is to understand the feasibility and acceptability on a mindfulness-based intervention to address co-existing smartphone addiction and psychological distress among adolescents ages 13-19…
- Trial name
- NCT07892807
- Testing
- Mindwire
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Acute Ischemic Stroke
Prehospital Response and Emergency Stroke Transport Optimisation
This study aims to develop and evaluate an innovative prehospital emergency transport system for patients with acute ischemic stroke to reduce delays in reperfusion treatment.
- Trial name
- PRESTO (NCT07892053)
- Testing
- Innovative pre-hospital emergency transport system for acute ischemic stroke
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Xuanwu Hospital, Beijing
Obsessive-Compulsive Disorder
tDCS Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive Disorder
This is a single-center study about patients with severe resistant OCD. Main assumption is that performing 10 tDCS sessions with the anode positioned at the level of the right orbitofrontal cortex, and the cathode at the level of…
- Trial name
- PPSTDCS-TOC (NCT06017713)
- Testing
- tDCS + symptoms provocation
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Henri Laborit
Solid Tumor, Solid Tumor, Adult
DESCANSO, a Mental Health Intervention for Depression, Insomnia, and Fatigue Symptoms in Latino People With Cancer
The purpose of this study is to improve ways of providing mental health support to Spanish-speaking Latino participants who have cancer and experience depression, insomnia, and fatigue.
- Trial name
- NCT07225088
- Testing
- DESCANSO/Depresión/Depressed Mood, Cansancio/Fatigue, and Sueño/Sleep; Rest in English
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Ponce Medical School Foundation, Inc.
Intubation, Endotracheal Tube Cuff Pressure
Effect of a Brief Educational Intervention on Endotracheal Tube Cuff Pressure
Endotracheal tube cuff pressure outside the recommended range of 20-30 cmH₂O is common in routine anesthesia practice. Over-inflation can injure the tracheal mucosa, while under-inflation increases the risk of aspiration and…
- Conditions
- Intubation, Endotracheal Tube Cuff Pressure, Anesthesia, Anesthesia,General
- Trial name
- NCT07891195
- Testing
- Brief educational intervention (educational video and reminder posters)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Fibrotic Interstitial Lung Disease
Ambulatory Oxygen Therapy for Individuals With Mild-to-moderate Interstitial Lung Disease
The investigators plan to conduct a study to find out if giving portable oxygen therapy (during physical activity) to patients with interstitial lung disease will improve quality of life, exercise tolerance, shortness of breath…
- Trial name
- NCT06053164
- Testing
- Exertional Oxygen, Education and Support
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
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