Clinical trials: Treatment as usual
Low Back Pain
The Effect of Graded Activity and Pain Education (GAPE) for Patients Early After Lumbar Spinal Fusion
Background An increasing number of patients with chronic low back pain (CLBP) undergo lumbar spinal fusion (LSF). Unfortunately, a substantial part of the patients still has persistent pain, functional disability and poor quality…
- Trial name
- NCT04103970
- Testing
- Graded Activity and Pain Education (GAPE)
- Where
- Denmark
- Volunteers
- 144 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Aggression, Substance-Related Disorders
Preventing Violence Among Veterans in Substance Use Disorder Treatment
The purpose of this study is to examine the impact on both clinical (violence and substance use) outcomes and health services use (substance use disorder and mental health treatment) compared to standard SUD treatment (enhanced…
- Trial name
- NCT01337973
- Testing
- MI-CBT, MI-CBT+CC, E-TAU
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- VA Office of Research and Development
Angina, Stable, Coronary Vasospasm
CORonary MICrovascular Angina (CorMicA)
Angina is form of chest pain that is due to a lack of blood to the heart muscle. Angina is commonly triggered by stress and exertion, and is a common health problem worldwide.
- Conditions
- Angina, Stable, Coronary Vasospasm, Coronary Circulation, Coronary Syndrome
- Trial name
- CorMicA (NCT03193294)
- Testing
- Stratified medicine involving a diagnostic intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 151 people
- Sponsor
- NHS National Waiting Times Centre Board
Carcinoma, Small Cell Lung Cancer
Efficacy and Safety of DEB-BACE Combined With Serplulimab in First-line Treatment of SCLC
This project aims to conduct a prospective, single-center, randomized, open-label, two-arm study to compare the clinical efficacy and safety of bronchial arterial chemoembolization with drug-eluting beads (DEB-BACE) combined with…
- Trial name
- NCT06364046
- Testing
- Drug-eluting beads bronchial arterial chemoembolization, Serplulimab, Intravenous chemotherapy
- Where
- China
- Volunteers
- 56 people
- Sponsor
- The Central Hospital of Lishui City
Emotional Problem, Mental Health Issue
REThinkWELL- the Use of Therapeutic Game to Reduce Mental Health Symptoms in Children and Adolescents
To test the effect of a game-based intervention in reducing clinical and subclinical symptoms of children and adolescents.
- Trial name
- NCT06529510
- Testing
- REThink therpeutic game
- Where
- Romania
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Irritable Bowel Syndrome (IBS), Functional Abdominal Pain
Peer Mentorship: An Intervention To Promote Effective Pain Self-Management In Adolescents
This protocol matches child subjects with peer mentors of similar age who have learned to function successfully with a chronic pain disorder.
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Abdominal Pain, Fibromyalgia, Complex Regional Pain Syndrome (CRPS)
- Trial name
- NCT01118988
- Testing
- Mentorship
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Los Angeles
Suicidal Ideation Active, Suicidal and Self-injurious Behavior
Operation Worth Living Project With Suicidal Soldiers at Ft. Stewart
This is a randomized controlled trial comparing the use of new clinical intervention (the "Collaborative Assessment and Management of Suicidality--CAMS") versus enhanced care as usual for suicidal Soldiers who are seen at…
- Trial name
- OWL (NCT01300169)
- Testing
- The Collaborative Assessment and Management of Suicidality, Enhanced Care as Usual
- Volunteers
- 150 people
- Sponsor
- The Catholic University of America
COVID-19
Evaluation of the Impact of the Anti COVID-19 Vaccination Campaign Addressed to the Employees of an Italian Hospital.
Health workers, especially those in patient-facing roles, had a significantly increased risk of COVID-19 infection, having serious outcomes, and risking spreading the virus to patients and staff.
- Trial name
- NCT05774418
- Testing
- BNT162b2 COVID-19 Vaccine
- Where
- Italy
- Volunteers
- 6,649 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Suicidal Ideation, Suicide, Attempted
Improving Treatment Outcomes for Suicidal Veterans With PTSD
The efficacy of cognitive processing therapy (CPT) for reducing the symptoms of posttraumatic stress disorder (PTSD) across populations including military personnel and veterans is well supported.
- Conditions
- Suicidal Ideation, Suicide, Attempted, Ptsd
- Trial name
- NCT04690582
- Testing
- Cognitive Processing Therapy (CPT), Crisis Response Plan (CRP), Safety Planning Intervention (SPI)
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Ohio State University
Shoulder Pain, Frozen Shoulder
Simple and Evidence-based Examination and Treatment of Shoulder Pain in General Practice
Previous research suggests that general practitioners find handling patients with shoulder pain difficult and that the current care for shoulder pain is not in line with the best available evidence (1).This project aims to assess…
- Conditions
- Shoulder Pain, Frozen Shoulder, Rotator Cuff Tendinosis, Myalgia
- Trial name
- EASIER (NCT04806191)
- Testing
- Evidence based treatment strategy, Targeted patient information package, Treatment as usual (TAU)
- Where
- 2 sites in Norway
- Volunteers
- 160 people
- Sponsor
- University of Oslo
Suicidal Ideation
Development of a Treatment Prognosis Calculator for the Prevention of Suicide
The goal of this interventional study is to develop and test a treatment prognosis calculator to identify which service members with suicidal ideation or behavior are likely to respond well to the current standard of care…
- Trial name
- NCT06094218
- Testing
- Brief Cognitive Behavioral Therapy (BCBT), Treatment as usual (TAU)
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Ohio State University
Chronic Non-specific Low Back Pain
Effect of VR-MBCT in Chronic Nonspecific Low Back Pain
This is a multi-center, prospective, open-label randomized controlled trial evaluating the efficacy and safety of virtual reality-based mindfulness-based cognitive therapy (VR-MBCT) as an adjunct to usual care in adults with…
- Trial name
- VR-MBCT-CNLBP (NCT07589790)
- Testing
- Virtual Reality-Based Mindfulness Cognitive Therapy (VR-MBCT), Waitlist Usual Care Control Group
- Where
- China
- Volunteers
- 214 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Bipolar Disorder, Depression
Implementing Health Plan-Level Care Management for Solo & Small Practices
This study will determine if a version of the chronic care model for individuals with mood disorders seen in small or solo practices can improve patient health.
- Trial name
- NCT02041962
- Testing
- Chronic Care Model for Mood Disorders, Educational Control
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Michigan
Breast Cancer Lymphedema, Survivorship
Lymphatic Response to Resistance Exercise in Breast Cancer Survivors
The objective of this study is 1) to study the acute and chronic effect of resistance therapeutic physical exercise (RTPE) in the prevention of breast cancer-related lymphedema (BCRL) in breast cancer survivors at risk using…
- Conditions
- Breast Cancer Lymphedema, Survivorship, Lymphedema of Upper Limb
- Trial name
- LinfoGYM (NCT06113627)
- Testing
- Resistance Therapeutic Exercise
- Where
- Spain
- Volunteers
- 170 people
- Sponsor
- University of Malaga
Type 1 Diabetes Mellitus, Depressive Symptoms
Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus
This study evaluates the use of an established internet-based cognitive behavioral therapy intervention in a group of adolescents with type 1 diabetes and mild to moderate depressive symptoms.
- Trial name
- NCT03655067
- Testing
- CATCH-IT
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Pain
Digital Behavioural Treatment for Chronic Pain
Overall project aim: to develop, evaluate, and implement a digital behavioural health treatment to improve well-being in individuals with chronic pain.
- Trial name
- DAHLIA (NCT05066087)
- Testing
- DAHLIA treatment, Treatment as usual
- Where
- 4 sites in Sweden
- Volunteers
- 410 people
- Sponsor
- Karolinska Institutet
Retinopathy of Prematurity (ROP)
To Assess the Effect of Dexamethasone Eye Drops on the Retinopathy of Prematurity Outcome
The purpose is to compare the treatment frequency of preterm infants who developed severe Retinopathy of Prematurity (ROP) during the years 2015-2018 with 2020-2021 in the country, using the statistical method 'difference in…
- Trial name
- NCT06775353
- Testing
- Dexamethasone eyedrop
- Where
- Sweden
- Volunteers
- 2,017 people, healthy volunteers welcome
- Sponsor
- Region Skane
Anxiety
A Pilot RCT on the Efficacy of TranS-C Intervention on Anxiety Symptoms
This study will examine whether the Transdiagnostic Sleep and Circadian Intervention (TranS-C; Harvey \& Buysse, 2017) can improve sleep and circadian functioning and reduce disorder-focused symptoms in patients with anxiety…
- Trial name
- NCT05453981
- Testing
- Transdiagnostic Sleep and Circadian Intervention
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Pressure Ulcers, Nursing Cares
Pilot Study for Evaluation of the Procedure Impact of Mobilization Adapted to Pressure Ulcer Risk for Patients in Intensive Care.
Pressure ulcers (PU) represent a major health issue because of their high incidence and of their important consequences. There is an important risk of pressure ulcer acquisition for ICU patient with acute organ failure.
- Conditions
- Pressure Ulcers, Nursing Cares, Decubitus Ulcer, Pressure Injury
- Trial name
- PROMESReaPilot (NCT03454230)
- Testing
- Positioning schedule
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer, Colorectal Cancer
The ONE-MIND Study: Evaluating the Efficacy of Online Mindfulness-Based Cancer Recovery During Chemotherapy Treatment
Background: Chemotherapy treatment (CT) can have burdensome side effects such as fatigue, nausea-vomiting, and sleep problems that can significantly affect patients' quality of life.
- Conditions
- Breast Cancer, Colorectal Cancer, Chemotherapy Effect
- Trial name
- NCT03484000
- Testing
- Online Mindfulness Based Cancer Recovery (MBCR)
- Where
- Canada
- Volunteers
- 178 people
- Sponsor
- University of Calgary
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