Clinical trials: Propofol
Aged
Development of a Pharmacodynamic Model for Propofol in Older Adults
The goal of this pharmacodynamic study is to develop a model for Propofol administration for older adults (>65 years). The main objective is to create a model based on a new pharmacodynamic parameter, derived from frontal…
- Trial name
- DROPLET (NCT05790720)
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Sedation and Analgesia
a Comparive Study of Ketamine-Propofol Versus Dexmedetomidine-Propofol Sedation in Pediatric Patients Undergoing Cardiac Catheterization for Device Closure of Simple Left-to-right Shunts
This study aims To compare the safety and efficacy of ketamine-propofol versus dexmedetomidine-propofol sedation in pediatric patients undergoing cardiac catheterization for device closure of simple left-to-right shunts
- Trial name
- NCT07669012
- Testing
- Ketamine + propofol, Dexmedetomidine + propofol
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
Anesthesia
Effect of Subanaesthetic Dose of Ketamine on Depth of Anaesthesia Consistency
General Anaesthesia (GA) is a medical state of controlled unconsciousness that inhibits two dimensions of consciousness: the content and the level of consciousness.
- Trial name
- NCT06986109
- Testing
- Ketamine, Propofol
- Where
- India
- Volunteers
- 106 people
- Sponsor
- Sir Ganga Ram Hospital
Anesthesia for Urologic Endoscopic Surgery, Urinary Calculi
Fospropofol Disodium Versus Propofol for Patient Satisfaction in Ureteroscopy
This single-center single-blind randomized trial compares fospropofol disodium and propofol for anesthesia in elective ureteroscopy patients.
- Trial name
- NCT07659132
- Testing
- Fospropofol disodium plus sufentanil for anesthesia induction, Propofol plus sufentanil for anesthesia induction
- Volunteers
- 190 people
- Sponsor
- Shiyou Wei
Obesity (BMI>30), Postoperative Cognitive Function
Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients
Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial.
- Trial name
- NCT07665645
- Testing
- Sevoflurane (Volatile Anesthetic), propofol, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Upper Gastrointestinal Endoscopy, Topical Anesthesia
Oropharyngeoesophageal Topical Anesthesia Versus Intravenous Propofol -Ketamine Sedation for Upper Gastrointestinal Endoscopy
Esophagogastroduodenoscopy (EGD) is an essential and widely used diagnostic and therapeutic procedure in gastroenterology. EGD can be performed in association with topical anesthesia of the pharynx, intravenous anesthesia, or…
- Conditions
- Upper Gastrointestinal Endoscopy, Topical Anesthesia, Intravenous Sedation
- Trial name
- NCT07563062
- Testing
- Propofol and Ketamine Mixture (Ketofol), Modified Oropharyngeo-esophygeal Topical Anesthesia by OPETA Prototype tool
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Hypotension
Propofol vs. Ciprofol for Anesthesia Induction in Frail Elderly Patients
Post-induction hypotension (PIH) is a common and critical complication during general anesthesia, particularly in frail elderly patients whose physiological reserves are significantly diminished.
- Trial name
- NCT07663695
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 96 people
- Sponsor
- General Hospital of Ningxia Medical University
Hysteroscopy, Ambulatory Surgery
Remimazolam-Flumazenil Versus Sevoflurane for Hysteroscopic Day Surgery
This prospective, single-center, randomized controlled trial aims to compare remimazolam anesthesia with planned flumazenil reversal and sevoflurane-based balanced anesthesia in adult women undergoing ambulatory hysteroscopic…
- Conditions
- Hysteroscopy, Ambulatory Surgery, General Anesthesia
- Trial name
- NCT07663877
- Testing
- Remimazolam, Flumazenil, Sevoflurane
- Where
- South Korea
- Volunteers
- 124 people
- Sponsor
- Chung-Ang University Gwangmyeong Hospital
Upper Gastrointestinal Endoscopy, Anesthesia
Efficacy of Propofol Combination With Either Ketamine, Dexmedetomidine or Midazolam for Sedation During Upper Gastrointestinal Endoscopic Procedures
The investigators are comparing the efficacy of three different sedative agents in gastrointestinal endoscopic procedures.
- Trial name
- NCT07190612
- Testing
- Dexmedetomidine and propofol, Midazolam and propofol, ketamine and propofol
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Healthy Volunteers
Induction of Dreaming With EEG and Anesthesia in Healthy Adults
This open-label, randomized crossover study in healthy adults tests two propofol protocols to produce distinct experiential states.
- Trial name
- IDEA (NCT07198711)
- Testing
- Propofol - Emergence-from-LOR Protocol, Propofol - Light Sedation Protocol
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stanford University
Colonoscopy (Procedure)
Patient Controlled Propofol Sedation Versus Nurse-assisted Propofol Sedation in Diagnostic Colonoscopies With a Focus on Patient Satisfaction
The goal of this clinical trial is to learn if patient administered propofol sedation results in superior patient satisfaction compared to nurse administered propofol sedation in diagnostic colonoscopies.
- Trial name
- PCAPS1 (NCT07653867)
- Testing
- Self administred propofol, Nurse assisted propofol sedation
- Where
- 2 sites in Sweden
- Volunteers
- 135 people
- Sponsor
- Karolinska Institutet
Prevention of Delirium
Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation
The objective of the study is to determine the impact on the frequency of occurrence of delirium of an early inhaled sedation strategy (from induction in rapid sequence if intubation in intensive care, or from admission if…
- Trial name
- INASED (NCT04341350)
- Testing
- Propofol + analgesic drug, Isoflurane + analgesic drug
- Where
- 12 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Electroencephalogram (EEG), Anesthesia
The Effects of Different Anesthetics on the Brain's Neural Networks
This study aims to analyze the electroencephalographic power spectrum and connectivity during unresponsive states induced by propofol, esketamine and dexmedetomidine, respectively.
- Trial name
- NCT07644663
- Testing
- propofol, Dexmeditomidine, Esketamine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fudan University
Respiratory Distress Syndrome in Premature Infant
Respiratory Effect of the LISA Method With Sedation by Propofol Versus Absence of Sedation.
The investigators propose to evaluate premedication with Propofol compared to a control strategy including a placebo with a possible rescue treatment with ketamine to ensure pain control before LISA Procedure .
- Trial name
- PROLISA (NCT04016246)
- Testing
- Propofol-Lipuro
- Where
- 13 sites in France
- Volunteers
- 233 people
- Sponsor
- University Hospital, Grenoble
Loss of Consciousness, Parkinson Disease
Brain Networks and Consciousness
General anesthesia (GA) is a medically induced state of unresponsiveness and unconsciousness, which millions of people experience every year.
- Conditions
- Loss of Consciousness, Parkinson Disease, Essential Tremor, Anesthesia
- Trial name
- NCT04502550
- Testing
- Propofol
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Texas Southwestern Medical Center
Deep Sedations, Conscious Sedation
Comparison of Safety and Efficacy for Different Sedation Regimens During Colonoscopy
This is a randomized, double-blinded, prospective study which will be conducted at the Department of Gastroenterology, King Saud Hospital, Unaizah, Qassim, Saudi Arabia.
- Conditions
- Deep Sedations, Conscious Sedation, Colonoscopy
- Trial name
- NCT06763705
- Testing
- Midazolam, Propofol, Fentanyl
- Where
- Saudi Arabia
- Volunteers
- 183 people
- Sponsor
- Qassim Health Cluster
Sleep Disorders
Providing "Good Sleep" for ICU Sedation
Cognitive dysfunction, either alone or as an element in the syndrome of delirium, is a common occurrence with an incidence as high as 75% in intensive care unit (ICU) patients and can independently result in serious consequences…
- Trial name
- ASRV (NCT01342328)
- Testing
- Normal saline infusion, Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Respiratory Failure, Respiratory Infection
Avoiding Neuromuscular Blockers to Reduce Complications
The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.
- Conditions
- Respiratory Failure, Respiratory Infection, Aspiration Pneumonia, Pneumonitis
- Trial name
- NCT03962725
- Testing
- Neuromuscular Blocking Agents, Anesthetic Adjuncts
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU).
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- ISO-DRIVE (NCT06014138)
- Testing
- Propofol, Isoflurane
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Operative Sedation of Pediatric, Operative Sedation of Adolescent Patients
A Trial of Remimazolam for Intraoperative Sedation in Pediatric and Adolescent Patients
The study is being conducted to evaluate the efficacy and safety of Remimazolam for intraoperative sedation in pediatric and adolescent patients.
- Trial name
- NCT07036419
- Testing
- Remimazolam Tosilate for injection, Propofol Injection
- Where
- China
- Volunteers
- 249 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.