Clinical trials: Propofol
Postoperative Pain
Total Knee Replacement TIVA With Robotic Arm Assisted
Total knee replacement (TKR) is a commonly performed surgical procedure, and is associated with moderate to severe acute postoperative pain.
- Trial name
- NCT04002271
- Testing
- Propofol, Sevoflurane, Spinal anaesthesia
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cancer, Perioperative Analgesia
Combined Pectoserratus and Superficial Cervical Plexus Block Versus Local Infiltration for Chemoport Implantation
Chemoport implantation is frequently performed in patients with cancer requiring long-term intravenous chemotherapy. Local infiltration anesthesia (LIA) remains the conventional anesthetic technique for this procedure.
- Trial name
- NCT07771712
- Testing
- Combined Pectoserratus Plane and Superficial Cervical Plexus Block, Local Infiltration Anesthesia with Bupivacaine 0.25%, Midazolam
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Indonesia
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL/min.
- Trial name
- NCT07670923
- Testing
- Propofol Injection, Ciprofol Injection
- Where
- China
- Volunteers
- 108 people
- Sponsor
- General Hospital of Ningxia Medical University
Spinal (Fusion) Surgery, Total Intravenous Anesthesia
Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider
This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients…
- Conditions
- Spinal (Fusion) Surgery, Total Intravenous Anesthesia, Target Controlled Infusion of Propofol, Anesthesia Depth Monitoring
- Trial name
- NCT07586189
- Testing
- TCI Propofol Injection Models- Eleveld, TCI Propofol Injection Schnider
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Efficacy and Safety
Clinical Study of Fospropofol Disodium for Injection in the Painless Endoscopic Diagnosis and Treatment
This is a study on the efficacy and safety of fospropofol disodium for injection in painless endoscopic diagnosis and treatment, project No.2024-YCRF-M1021, which will take more than 2 years to complete.
- Trial name
- NCT06732427
- Testing
- fospropofol Disodium for injection, Propofol
- Where
- 5 sites in China
- Volunteers
- 426 people
- Sponsor
- Affiliated Hospital of Nantong University
Ketamine, Anesthesia
Use of S+Ketamine During Target-Controlled Intravenous Anaesthesia After Abdominal Hysterectomy
The investigators want to investigate the effect of low dose S+ ketamine compared to placebo on cumulative morphine consumption at 24 hours in 90 women undergoing open abdominal hysterectomy with remifentanil-propofol target…
- Conditions
- Ketamine, Anesthesia, Morphine, Hysterectomy
- Trial name
- NCT03231683
- Testing
- Esketamine, Saline, Remifentanil
- Where
- Singapore
- Volunteers
- 90 people
- Sponsor
- KK Women's and Children's Hospital
Post-operative Nausea and Vomiting
Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion
The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.
- Trial name
- PONV (NCT05759481)
- Testing
- Hybrid anesthesia (propofol + sevoflurane), Propofol only TIVA
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Milton S. Hershey Medical Center
General Anesthetic Drug Adverse Reaction
Effect of Remimazolam on Postoperative Delirium
Remimazolam is a novel benzodiazepine with ultra-short onset and offset of its effect. It can be used for general anesthesia. However, classical benzodiazepine such as midazolam was reported to increase the risk of postoperative…
- Trial name
- RED (NCT06180876)
- Testing
- remimazolam, propofol
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Zhihong LU
Kidney Transplant
Effects Of Propofol And Sevoflurane On Plasma Mirna Levels İn Living Kidney Donors
Surgical interventions and associated tissue trauma induce a complex systemic inflammatory stress response characterized by the activation of neuroendocrine, metabolic, and immunological systems.
- Trial name
- NCT07760402
- Testing
- Sevoflurane, propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Elective Surgery Requiring Laryngeal Mask Airway General Anesthesia
ED90 of Tegileridine Combined With Propofol for LMA Insertion
This is a prospective two-group dose-finding trial using biased-coin sequential up-and-down design. We plan to enroll 108 patients who need general anesthesia with laryngeal mask airway placement, divided into young group (18-64…
- Trial name
- NCT07665151
- Testing
- Tegileridine combined with Propofol for anesthesia induction
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Shiyou Wei
Healthy, Covert Consciousness
Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study
This research is studying whether mental functions take place during different levels of anesthesia, using a commonly used drug (either dexmedetomidine [with propofol in some participants] or ketamine), which shows areas in the…
- Trial name
- NCT07705022
- Testing
- Dexmedetomidine (+propofol as indicated), Ketamine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Procedural Sedation, Gastrointestinal Endoscopy
Ketodex Versus Ketofol in Adolescent Gastrointestinal Endoscopy
Gastrointestinal endoscopic procedures in adolescents require effective sedoanalgesia to ensure procedural comfort and prevent agitation.
- Trial name
- NCT07401914
- Testing
- Ketodex, Ketofol
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Giresun University
Adverse Respiratory Events, Hypoxemia
Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy
Gastroscopy is important for diagnosing and treating upper gastrointestinal diseases in children. To ensure the procedure is safe and smooth, most children require sedation.
- Conditions
- Adverse Respiratory Events, Hypoxemia, Children, Gastroscopy
- Trial name
- NCT07748884
- Testing
- Fentanyl and Propofol, Esketamine and remimazolam
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Painless Gastroscopy Perioperative Sedation, Upper Gastrointestinal Tract Lesions
ED90 of Tegileridine Combined With Propofol For Painless Gastroscopy
This single-group, open-label, biased-coin up-and-down sequential dose-finding trial aims to determine the 90% effective dose (ED90) of intravenous tegileridine combined with fixed-dose propofol to eliminate body movement, cough…
- Trial name
- NCT07678411
- Testing
- Tegileridine combined with Propofol for gastroscopy
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Shiyou Wei
Bronchoscopy, Procedural Sedation
Ciprofol Versus Propofol With Low-Dose Sufentanil for Painless Bronchoscopy
Bronchoscopy may cause coughing, discomfort, body movement, and changes in breathing or blood pressure. Propofol is commonly used for sedation during bronchoscopy, but it may cause respiratory depression, circulatory depression…
- Trial name
- NCT07744061
- Testing
- Ciprofol, Propofol, Sufentanil
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wenzhou Central Hospital
Kyphoplasty, Prone Position
TCI Versus Manual TIVA for Sedation During Prone Kyphoplasty: Effects on Respiration, Recovery, and EEG
This single-center, prospective, observational study compares target-controlled infusion (TCI) versus manually administered total intravenous anesthesia (TIVA) for sedation in patients undergoing kyphoplasty in the prone…
- Conditions
- Kyphoplasty, Prone Position, Target Controlled Infusion of Propofol, End Tidal Carbon Dioxide
- Trial name
- NCT07745348
- Testing
- Target controlled infusion of propofol, non invasive ETCO2 monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Modified Thoracoabdominal Nerve Block (M-TAPA), Analgesic Technique
Bilateral Modified Thoracoabdominal Nerve Block as an Analgesic Technique in Comparison With Bilateral Thoracic Erector Spinae Plane Block in Abdominoplasty Operations
This study aimed to compare the analgesic effect of bilateral ultrasound-guided modified thoracoabdominal nerve block with bilateral ultrasound-guided erector spinae plane block in abdominoplasty surgery.
- Conditions
- Modified Thoracoabdominal Nerve Block (M-TAPA), Analgesic Technique, Thoracic Erector Spinae Plane Block, Abdominoplasty
- Trial name
- NCT07738900
- Testing
- General Anaesthesia using intravenous propofol, fentanyl intravenous, and atracurium besylate, Modified thoracoabdominal nerve block using 25 mL of bupivacaine 0.25%, Erector spinae plane block using 25 mL of bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Mansoura University
Intubating Conditions
Propofol-sevoflurane Induction for Pediatric Nasotracheal Intubation.
Pediatric anesthesia differs significantly from adult anesthesia due to physiological differences and increased sensitivity to anesthetic agents.
- Trial name
- NCT07680400
- Testing
- reduced pharmacologic exposure, conventional anesthetic induction
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Bezmialem Vakif University
Knee Osteoarthritis, Replacement, Knee
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA)…
- Conditions
- Knee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II Patients
- Trial name
- NCT07736352
- Testing
- Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Critical Illness, Mechanical Ventilation
Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults
The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit.
- Conditions
- Critical Illness, Mechanical Ventilation, Respiratory Insufficiency
- Trial name
- NCT07734350
- Testing
- Isoflurane, Propofol (Astra-Zeneca)
- Volunteers
- 400 people
- Sponsor
- Hospital H+ Queretaro