Clinical trials: Prednisolone
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPD
Comparison of aerosol inhalation and intravenous glucocorticoid in the treatment of severe AECOPD-------Multicenter, prospective, randomized, controlled clinical study
- Trial name
- NCT06189586
- Testing
- aerosol inhalation of glucocorticoids, intravenous injection of glucocorticoids
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Dong Yang
Allergic Contact Eczema
Assess Itch Behavior in Nickel Sulphate Sensitized Volunteers
Determine the mean time to itch relief from the start of treatment with topic methylprednisolone aceponate.
- Trial name
- NCT01529320
- Testing
- Adventan® (methylprednisolone aceponate 0,1%)
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Fundacion IMIM
Cardiac Sarcoidosis, Sarcoidosis
Cardiac Sarcoidosis Randomized Trial
Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active clinically manifest cardiac…
- Trial name
- CHASM-CS-RCT (NCT03593759)
- Testing
- Prednisone or Prednisolone, Methotrexate
- Where
- 31 sites in United States, Canada and 3 more
- Volunteers
- 160 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Shoulder Impingement, Ultrasound Guided Injection
Comparison of the Effectiveness of the Ultrasound Guided Injections in Patients With Shoulder Impingement Syndrome
Shoulder pain, which is the third most common cause of musculoskeletal pain, has different etiologies. Muscle, bone structures and connective tissue pathologies can cause shoulder pain.
- Trial name
- NCT05015322
- Testing
- bupivacaine and methylprednisolone
- Volunteers
- 88 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis
The DanNORMS study is a phase 3, non-inferiority clinical trial examining whether treatment of active multiple sclerosis with rituximab is non-inferior to ocrelizumab regarding efficacy and safety.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
- Trial name
- DanNORMS (NCT04688788)
- Testing
- Rituximab, Ocrelizumab, Fexofenadine
- Where
- 11 sites in Denmark
- Volunteers
- 600 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Posner Schlossman Syndrome
The Effectiveness and Safety of FK-506 for the Treatment of Posner-Schlossman Syndrome
To evaluate the effectiveness and safety of tacrolimus eye drops (FK-506) in the treatment of Posner-Schlossman Syndrome. It is expected to collect 30 patients with PSS who are in the Ophthalmology Department of Peking University…
- Trial name
- NCT04590183
- Testing
- FK-506 (Drug), Prednisolone Acetate 1% Oph Susp
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University
Alcoholic Hepatitis, Alcoholic Liver Disease
Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone
Treatment of reference of severe alcoholic hepatitis is based on corticosteroids, given for 28 days. However, about 25-35% of patients do not take benefit from this treatment and die within the 6 months following the diagnosis.
- Trial name
- AntibioCor (NCT02281929)
- Testing
- Amoxicillin, Prednisolone
- Where
- 20 sites in France
- Volunteers
- 297 people
- Sponsor
- University Hospital, Lille
Neuromuscular Block, Residual, Pain
Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults
This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective septoplasty or rhinoplasty.
- Conditions
- Neuromuscular Block, Residual, Pain, Postoperative Nausea
- Trial name
- NCT07187037
- Testing
- Methylprednisolone (MP), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Osteoarthritis, Knee
A Study Comparing Viscosupplementation and Corticosteroid Injections for Knee Osteoarthritis
Do differences exist between patients who receive a single intra-articular injection of corticosteroid versus patients who receive a single intra-articular injection of hyaluronic acid for the treatment of knee osteoarthritis at…
- Trial name
- NCT01132677
- Testing
- Hylan G-F 20 (Synvisc One), Methylprednisolone (Corticosteroid)
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- LifeMark Health
Asthma, Acute Asthma
Budesonide Inhalation Suspension for Acute Asthma in Children
The purpose of this study is to determine whether the addition of budesonide inhalation suspension (BIS) to the standard therapy of albuterol, ipratropium bromide, and systemic corticosteroids (SCS) for moderate to severe asthma…
- Conditions
- Asthma, Acute Asthma, Reactive Airway Exacerbation
- Trial name
- NCT00393367
- Testing
- Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg, Prednisolone, prednisone, or methylprednisolone, Albuterol, ipratropium bromide
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Children's Hospital of Philadelphia
ACL Reconstruction
Methylprednisolone Addition to Multimodal Pain Regimens After Anterior Cruciate Ligament Reconstruction
Patients who are being seen for ACL tears will be approached in the UAB Orthopedic Clinic. Included patients will be those aged 14-65 undergoing ACL Reconstruction.
- Trial name
- NCT07605923
- Testing
- Methyl Prednisolone (MP), Standard Post-Operative Pain Control, Surgeon's Standard ACL Postoperative Regimen
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Alabama at Birmingham
Stenosing Tenosynovitis
Corticosteroid vs. Amniotic Fluid Injections in Patients With Trigger Finger
The proposed study aims to investigate whether amniotic fluid injections are a better alternative to corticosteroid injections as a conservative treatment for stenosing tenosynovitis.
- Trial name
- NCT03583151
- Testing
- Amniotic fluid injection, Steroid injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- J&M Shuler
Chronic Obstructive Pulmonary Disease
Two Different Dosages of Nebulized Steroid Versus Parenteral Steroid in the Management of COPD Exacerbations
Chronic obstructive pulmonary disease (COPD) is a common disease that has a chronic and progressive course. Patients with COPD may have exacerbations one to four times in a year.
- Trial name
- NCT01865500
- Testing
- Budesonide 4 mg, Budesonide 8 mg, Metil prednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ataturk University
Lymphoma, Large B-Cell, Diffuse
A Study of Subcutaneous Versus Intravenous MabThera/Rituxan (Rituximab) in Combination With CHOP Chemotherapy in Patients With Previously Untreated CD20-Positive Diffuse Large B-Cell Lymphoma
This multicenter, randomized, open label parallel-group study will evaluate the efficacy and safety of subcutaneous versus intravenous MabThera/Rituxan (rituximab) in combination with CHOP chemotherapy in patients with previously…
- Trial name
- NCT01649856
- Testing
- CHOP, rituximab [MabThera/Rituxan]
- Where
- 186 sites in Algeria, Argentina and 25 more
- Volunteers
- 572 people
- Sponsor
- Hoffmann-La Roche
Vitreoretinal Surgery, Ocular Inflammation
Dextenza in the Post-op Management of Vitreoretinal Surgeries
This study will assess the control of inflammation at days 1, 7, 14, and 21 days following the vitreoretinal surgical procedure analyzing two randomized study arms: Intracanalicular dexamethasone insert group or topical steroid…
- Conditions
- Vitreoretinal Surgery, Ocular Inflammation, Post-operative Pain, Post-Operative Inflammation
- Trial name
- NCT04371445
- Testing
- Dexamethasone Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
OTC Deficiency
Clinical Study of DTX301 AAV-Mediated Gene Transfer for Ornithine Transcarbamylase (OTC) Deficiency
The primary objective is to evaluate the efficacy of DTX301 on the improvement of ornithine transcarbamylase (OTC) function by maintaining safe plasma ammonia levels.
- Trial name
- NCT05345171
- Testing
- DTX301, Oral Corticosteroids, Sodium Acetate
- Where
- 16 sites in United States, Argentina and 8 more
- Volunteers
- 37 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Rheumatoid Arthritis (RA)
Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis
This multicenter, randomized, controlled, single-blind prospective study aims to establish an evidence-based protocol for discontinuing long-term low-dose glucocorticoids in patients with rheumatoid arthritis (RA).
- Trial name
- NCT07227428
- Testing
- Prednisolone
- Volunteers
- 206 people
- Sponsor
- Seoul National University Hospital
Acute Graft Versus Host Disease
Mini-dose MTX Plus Standard-dose Steroid for the Initial Treatment of Acute GVHD
This trial is a randomized (1:1) phase III open label study of frontline mini-MTX plus methylprednisolone 2mg/kg/day compared to methylprednisolone 2mg/kg in allogeneic stem cell transplant recipients with grade 2-4 aGVHD.
- Trial name
- NCT05921305
- Testing
- MTX, Corticosteroid
- Where
- 2 sites in China
- Volunteers
- 218 people
- Sponsor
- Peking University People's Hospital
Prostate Cancer Metastatic
Early Switch From First-Line Docetaxel/Prednisone to Cabazitaxel/Prednisone and the Opposite Sequence, Exploring Molecular Markers in Men With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Docetaxel and cabazitaxel are cancer chemotherapy agents of the taxane drug class. The purpose of this study is to explore the benefit, for treatment of metastatic castration-resistant prostate cancer (mCRPC), of a regimen in…
- Trial name
- TAXYNERGY (NCT01718353)
- Testing
- DOCETAXEL (XRP6976), CABAZITAXEL (XRP6258), Prednisone
- Where
- 19 sites in United States, Canada
- Volunteers
- 63 people
- Sponsor
- Sanofi
Chronic Shoulder Pain
Comparison of the Efficacy of Two Different Suprascapular Nerve Block Techniques in Patients With Chronic Shoulder Pain
The aim of this study is to compare the efficacy and safety of the suprascapular nerve block (SSNB) at the spinoglenoid notch with SSNB at the suprascapular notch, which is the most commonly used technique in patients with…
- Trial name
- NCT04938037
- Testing
- US guided, SSNB with 1ml methylprednisolone acetate (1ml / 40mg) and 5 ml 0.5% bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- TC Erciyes University