Clinical trials: Ondansetron
Healthy
Bioavailability Study of Ondansetron 24 mg Orally Disintegrating Tablets Under Fasting Conditions
Single-dose cross over comparative bioavailability of Ondansetron 24 mg oDT and Zofran 24 mg ODT
- Trial name
- NCT00659074
- Testing
- Ondansetron, Zofran
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Vomiting
Hyoscine Butyl-bromide Versus Ondansetron for Nausea and Vomiting During Cesarean Section Under Spinal Anesthesia
overall incidence of intraoperative nausea and vomiting(IONV) during regional anesthesia for cesarean section is extremely variable, up to 80 percent , depending on the anesthetic technique used (spinal, epidural or combined…
- Trial name
- NCT04785118
- Testing
- Hyoscine N Butylbromide, Ondansetron, Saline
- Where
- Egypt
- Volunteers
- 165 people
- Sponsor
- Assiut University
Opioid Use, Bariatric Surgery Candidate
Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery
The goal of this clinical trial is to compare the effects of Opioid Free Anesthesia (OFA) with and without volatile anesthetics (in this case desflurane) in patients undergoing bariatric surgery.
- Conditions
- Opioid Use, Bariatric Surgery Candidate, TCI Eleveld, Obesity
- Trial name
- NCT07568938
- Testing
- opioid free anesthesia, Opiod Free Anesthesia with TCI ELEVELD
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- G.Gennimatas General Hospital
Vomiting, Nausea Post Chemotherapy
Aprepitant for Nause and Vomiting Induced by Chemoradiotherapy in HNSCC
To evaluate the safety and efficacy of aprepitant combined with ondansetron and dexamethasone to prevent nausea and vomiting induced by Intensity-modulated Radiotherapy (IMRT) cisplatin-chemotherapy regimen in locally advanced…
- Conditions
- Vomiting, Nausea Post Chemotherapy, Head Neck Cancer
- Trial name
- NCT03572829
- Testing
- Aprepitant
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Chinese Academy of Medical Sciences
Caffeine, Pain, Joint
Pain Management After Shoulder Arthroplasty
Pain control is a critical after many surgical procedures. It is well known that orthopaedic surgeries are among the most painful procedures, with total joint arthroplasty being a clear example of this situation.
- Trial name
- NCT04872270
- Testing
- Total Shoulder Arthroplasty, Caffeine Pill, Percocet 10Mg-325Mg Tablet
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Chemotherapy-induced Nausea and Vomiting
Study of the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Children (MK-0517-029)
The purpose of this study was to determine the appropriate dosing regimen of fosaprepitant, when administered with ondansetron (with or without dexamethasone), for the prevention of CINV in children from birth to <17 years of…
- Trial name
- NCT01697579
- Testing
- Fosaprepitant, Ondansetron, 5-hydroxytryptamine 3 antagonist
- Volunteers
- 240 people
- Sponsor
- Merck Sharp & Dohme LLC
Nausea
Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED
The purpose of this study is to compare the effectiveness of ondansetron, metoclopramide, and promethazine for the treatment of nausea in the adult emergency department population.
- Trial name
- NCT00655642
- Testing
- Ondansetron, Metoclopramide, Promethazine
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Vanderbilt University
Pain, Postoperative
The Effect of Parecoxib Sodium Intravenous Patient-controlled Analgesia in Laparotomic Liver Resection
The investigators hypothesized that using new intravenous infusion pump of patient-controlled analgesia (parecoxib sodium 1 mg/mL + normal saline) would significantly improve postoperative pain control compare to conventional…
- Trial name
- NCT02408146
- Testing
- conventional intravenous infusion pump, parecoxib, intravenous infusion pump of patient-controlled analgesia
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Recurrent Miscarriage
Walking and Dietary Modification for Recurrent Early Miscarriages
This study is part of a big one aiming to evaluate how lifestyle interventions during pregnancy affect obstetric results, neonatal metabolism and the intelligence of the offspring (study not yet completed).
- Trial name
- W&D (NCT03023137)
- Testing
- Walking & dietary modification
- Where
- Brazil
- Volunteers
- 480 people
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Post-Spinal Shivering
Efficacy of Oral Ondansetron Strips on Prevention of Post-Spinal Shivering
This study aims to investigate the efficacy of oral ondansetron film strips on the incidence of post-spinal shivering in patients undergoing surgeries using spinal anesthesia at Kasr Alainy hospitals, Cairo University.
- Trial name
- OOPS (NCT07088601)
- Testing
- Oral ondansetron strips
- Volunteers
- 50 people
- Sponsor
- Cairo University
Dehydration, Gastroenteritis
Efficacy Study of IV Fluids Only vs Ondansetron to Treat Dehydration
Dehydration due to vomiting is a common complication of acute gastroenteritis in children. Persistent vomiting following rehydration is a problem in outpatient management using oral rehydration therapy.
- Trial name
- NCT00691275
- Testing
- Ondansetron, Saline
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Prolonged QTc Interval
Granisetron Versus Ondansetron: Comparative Effects on ECG, QTc
Postoperative nausea and vomiting [PONV] are common and distressing symptoms after surgery performed under general anaesthesia. 5HT3 antagonists are routinely used for prevention as well as treatment of PONV.
- Trial name
- NCT01352130
- Testing
- Ondansetron, Granisetron
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Tata Memorial Hospital
Total Knee Arthroplasty
Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Currently, the regional anesthetic standard of care for total knee replacement surgery is combined spinal/epidural, with or without a femoral nerve block, or FNB.
- Trial name
- NCT01333943
- Testing
- Study Group: Experimental, Control Group
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Hospital for Special Surgery, New York
Nausea, Abdominal Pain
Ondansetron Versus Dexamethasone/Ondansetron to Treat Acute Nausea in the Emergency Department
Nausea is a common complaint in patients who present to the emergency department (ED). Although the number of conditions that can present with nausea are numerous, the mainstay of treatment has become intravenous ondansetron…
- Trial name
- NCT02985840
- Testing
- Ondansetron, Dexamethasone
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- OhioHealth
Shoulder Pain
Effect of Pericapsular Nerve Block on the Quality of Recovery After Shoulder Arthroscopy
Shoulder arthroscopy surgery is one of the most common orthopedic surgical procedures. Participants experience severe pain after shoulder arthroscopy surgery.
- Trial name
- NCT06225089
- Testing
- pericapsuler nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Nausea
Bioavailability Study of Anti Nausea Medication With and Without Food
This study is to assess the effect of food on a single dose of EUR-1025 when taken with a meal and taken on an empty stomach.
- Trial name
- EUR-1025 (NCT00905190)
- Testing
- Ondansetron
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Forest Laboratories
Nausea and Vomiting Post-foregut Surgery
Reletex Versus Standard of Care Therapy for Post-Operative Nausea Control in Patients Undergoing Foregut Surgery
The effect a ReletexTM device has on postoperative nausea and vomiting when used with ondansetron after foregut surgery will be studied.
- Trial name
- Reletex (NCT01510379)
- Testing
- Reletex, IV ondansetron 4 mg q 6 hours for a total of 4 doses, IV promethazine 25 mg q 6 hours prn
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Kyle A Perry
Pancreatic Neoplasms
Safety and Feasibility Study of Enhanced Recovery in Pancreaticoduodenectomy
The purpose of this study is to assess the adherence to an enhanced recovery after surgery (ERAS) pathway and the impact of the ERAS protocol on postoperative short-term outcome in patients undergoing pancreaticoduodenectomy (PD).
- Trial name
- NCT01759706
- Testing
- Enhanced recovery after surgery protocol, Standard perioperative care, PONV prophylaxis with Ondansetron + Dexamethasone
- Where
- Italy
- Volunteers
- 123 people
- Sponsor
- Università Vita-Salute San Raffaele
Pain, Postoperative
The Efface of Ketamine vs. Lidocaine in the Management of Pain After Laparoscopic Cholecystectomy
This prospective interventional study conducted at Liaquat National Hospital and Medical College compared the analgesic efficacy of ketamine and lidocaine in managing postoperative pain after laparoscopic cholecystectomy.
- Trial name
- NCT07248384
- Testing
- IV ketamine 0.5 mg/kg, IV Lidocain 60 mg/kg
- Where
- Pakistan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Liaquat National Hospital & Medical College
Nausea, Vomiting
A Korean Study of Efficacy and Safety of Aprepitant-based Triple Regimen for the Prevention of Chemotherapy-Induced Nausea and Vomiting in the First Cycle of Moderately Emetogenic Chemotherapy (Non-doxorubicin Hydrochloride [Adriamycin] and Cyclophosphamide Regimens) (MK-0869-225) (KMEC)
This is an efficacy and safety study to compare aprepitant with ondansetron for the prevention of nausea and vomiting in the first cycle of moderately emetogenic chemotherapy (MEC) in participants with solid tumors.
- Trial name
- KMEC (NCT01636947)
- Testing
- Aprepitant, Ondansetron, Dexamethasone
- Volunteers
- 494 people
- Sponsor
- Merck Sharp & Dohme LLC