Clinical trials: Ibuprofen, active
Postoperative Pain, Facial Swelling
Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery
This randomized, single-blind, controlled clinical trial aims to evaluate the efficacy and safety of Aescin-based herbal extract (Reparil®) compared with Ibuprofen in managing postoperative sequelae following surgical removal of…
- Conditions
- Postoperative Pain, Facial Swelling, Trismus
- Trial name
- Reparil (NCT07244029)
- Testing
- Escin, Ibuprofen 400 mg
- Where
- Oman
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oman Medical Speciality Board
Post Operative Analgesia
Intravenous Ibuprofen Postoperative Analgesia After Abdominal Hysterectomy
The current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.
- Trial name
- NCT05750264
- Testing
- Ibuprofen
- Where
- Egypt
- Volunteers
- 152 people
- Sponsor
- Menoufia University
Kidney Cancer, Renal Cancer
NSAID Use After Robotic Partial Nephrectomy
The purpose of this study is to see how effective non-steroidal anti-inflammatory drugs (NSAIDs) are at controlling pain without side effects in participants after robotic-assisted partial nephrectomy.
- Conditions
- Kidney Cancer, Renal Cancer, Renal Neoplasm
- Trial name
- No-PAIN (NCT05842044)
- Testing
- Ketorolac, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Miami
Pain, Postoperative
Scheduled or as Needed Pain Regimen?
The aim of this study is to determine feasibility of a randomized controlled trial and estimates of efficacy for pain control of a scheduled pain regimen versus an as needed pain regimen for participants undergoing same day…
- Trial name
- NCT06495632
- Testing
- Motrin and narcotic
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cape Fear Valley Health System
Surgery, Pain, Post Operative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll.
- Trial name
- CARES for Kids (NCT06671002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 9 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Musculoskeletal Pain
Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries
In this pilot study, the investigators aim to compare two short-term pain relief methods administered over the course of 6 days in the setting of acute musculoskeletal (MSK) pain: 1.
- Trial name
- MOTION (NCT07393503)
- Testing
- Methylprednisolone 4Mg Tab, Acetaminophen 500Mg Tab, Ibuprofen 200Mg Oral Tablet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- State University of New York at Buffalo
Postsurgical Pain Management, Postsurgical Pain, Chronic
An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service
The goal of this clinical trial is to learn whether a pain-management program called a Transitional Pain Service can help prevent long-term pain and reduce opioid needs after surgery in adult surgical patients who may be at…
- Conditions
- Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery
- Trial name
- TPS-Select (NCT07296770)
- Testing
- TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures
- Where
- United States
- Volunteers
- 474 people
- Sponsor
- University of California, San Francisco
Electronic Moxibustion, Low Back Pain
Study on the Effect of Electronic Moxibustion on Non-Specific Low Back Pain in Young Adults
This is an interventional clinical study. A total of 90 subjects aged 18 to 40 years are planned to be recruited. The subjects have low back pain that affects daily work and life, resulting in reduced exercise tolerance or…
- Conditions
- Electronic Moxibustion, Low Back Pain, Muscle Hardness
- Trial name
- NCT07858188
- Testing
- Electronic Moxibustion, ibuprofen or celecoxib analgesics
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Nail Diseases
Post-op Analgesia of Nail Unit Procedures
The purpose of this study is to directly compare the efficacy of suzetrigine vs. oxycodone+acetaminophen vs. alternating acetaminophen/ibuprofen in controlling post-operative pain after the following nail unit procedures.
- Trial name
- NCT07820969
- Testing
- Suzetrigine, Oxycodone/Acetaminophen, Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Miami
Postoperative Pain, Acute Pain
Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery
This randomized clinical trial will compare suzetrigine with standard analgesia for postoperative pain management after skin cancer surgery.
- Conditions
- Postoperative Pain, Acute Pain, Skin Cancer, Cutaneous Malignancy
- Trial name
- NCT07843134
- Testing
- Suzetrigine, Acetaminophen Plus Ibuprofen
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- University of Minnesota
Vasectomy, NSAIDs
Post-Vasectomy Pain Study
This is a prospective four-armed unblinded randomized controlled trial to assess four different potential post-operative treatment options for men who undergo a vasectomy.
- Conditions
- Vasectomy, NSAIDs, Post-operative Care
- Trial name
- NCT07824258
- Testing
- Acetaminophen, ibuprofen, oxycodone
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Acute Pain
A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain
Combogesic® IV is an intravenous medicine (given by vein) containing a combination of two pain relief (analgesic) medicines called ibuprofen and acetaminophen.
- Trial name
- NCT07225634
- Testing
- Combogesic® IV (fixed-dose combination containing acetaminophen 10 mg/ml + ibuprofen 3 mg/ml in 100 ml solution for infusion)
- Where
- 4 sites in Hungary
- Volunteers
- 60 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Patent Ductus Arteriosus After Premature Birth
Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants
Patent ductus arteriosus (PDA), the most common cardiovascular complication of prematurity, is associated with higher mortality and morbidities in extremely low gestational age neonates (ELGANs, < 27+0 weeks).
- Trial name
- NCT05340582
- Testing
- Acetaminophen Injection, Ibuprofen 20 mg/mL oral suspension or Ibuprofen lysine 10 mg/mL injection solution (Neoprofen), Sodium chloride 0.9% injection
- Where
- 9 sites in Australia, Canada and 2 more
- Volunteers
- 310 people
- Sponsor
- Mount Sinai Hospital, Canada
Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI)
Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery
Suzetrigine is a selective NaV1.8 inhibitor that provides peripheral analgesia without opioid-related CNS effects. This single-center stepped-wedge randomized clinical trial evaluates whether a suzetrigine-based postoperative…
- Conditions
- Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI), Postoperative Pain
- Trial name
- NCT07600697
- Testing
- Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Post Operative Pain, Orthognathic Surgery
Impact of Preemptive Analgesia on Postoperative Pain in Orthognathic Surgery
This randomized controlled clinical trial evaluates the effect of preemptive analgesia on postoperative pain outcomes in adult patients undergoing orthognathic surgery.
- Trial name
- NCT07571252
- Testing
- Acetaminophen, ibuprofen
- Where
- Puerto Rico
- Volunteers
- 72 people
- Sponsor
- University of Puerto Rico
Cesarean Delivery, Postpartum Comfort
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks.
- Conditions
- Cesarean Delivery, Postpartum Comfort, Postpartum Pain, Post-operative Pain
- Trial name
- PACESS (NCT07102641)
- Testing
- Acetaminophen, NSAID (Ketorolac/Ibuprofen)
- Where
- United States
- Volunteers
- 825 people
- Sponsor
- Thomas Jefferson University
Cancer Pain, Cancer Palliative Care
Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain Management
The investigators investigate the efficacy of non-opioid analgesics compared to placebo together with opioid therapy for cancer pain management.
- Trial name
- NoDoubt (NCT07682558)
- Testing
- Metamizole, Ibuprofen
- Where
- Switzerland
- Volunteers
- 318 people
- Sponsor
- University Hospital, Basel, Switzerland
Stomach Neoplasms
Maxigesic for Postoperative Pain Control After Laparoscopic or Robotic Gastrectomy
This prospective, randomized, phase 4 clinical trial aims to evaluate the efficacy and safety of intravenous Maxigesic, a fixed-dose combination of acetaminophen and ibuprofen, for postoperative pain control in patients…
- Trial name
- NCT07768514
- Testing
- Acetaminophen and Ibuprofen, Acetaminophen
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Bundang Hospital
Osteoarthritis, Knee
Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis
The goal of this randomized clinical trial is to learn whether taking ibuprofen, a nonsteroidal anti-inflammatory drug, after a platelet-rich plasma (PRP) injection changes pain relief and knee function in adults with knee…
- Trial name
- NCT07766330
- Testing
- Leukocyte-Rich Platelet-Rich Plasma, ibuprofen, Acetaminophen
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Federal University of São Paulo
Pain, Postoperative
Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
The purpose of this study is to investigate the effectiveness of various oral analgesic regimens in minimizing post-operative pain and discomfort in young children following dental rehabilitation under general anesthesia (DRGA).
- Trial name
- NCT06757075
- Testing
- Ibuprofen, Acetominophen
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Boston University