Clinical trials: sponsored by Dana-Farber Cancer Institute
Covid19
Implementation of COVID-19 Testing Strategies in Community Health Centers
This project is part of a competitive revision to accelerate COVID-19 testing in underserved populations. The overall aim is to implement strategies to expand COVID testing in hotspot communities in MA, through 6 community health…
- Trial name
- NCT04802187
- Testing
- RADx CHCs testing intervention strategy, Usual care control
- Where
- 2 sites in United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Ovarian Cancer
Stepping Into Survivorship: Harnessing Behavioral Economics to Improve Quality of Life in Ovarian Cancer
This research study will test whether using wearable fitness trackers with a social incentive, delivered through a game-based mobile health intervention, increases physical activity and quality of life in ovarian cancer survivors.
- Trial name
- NCT03364673
- Testing
- Fitness Tracker, Social Incentive (Way to Health)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Breast Neoplasms
Post-Treatment Surveillance in Breast Cancer: Bringing CER to the Alliance
Nearly three million living women have survived breast cancer. Physicians rely on clinical practice guidelines to make decisions on follow-up care.
- Trial name
- NCT02171078
- Where
- United States
- Volunteers
- 34,359 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Breast Cancer
Development of a Horizontal Data Integration Classifier for Noninvasive Early Diagnosis of Breast Cancer
This is a translational no-profit study. Our proposal aims at creating a noninvasive Horizontal Data Integration (HDI) classifier for early diagnosis of breast cancer, with the final goal of avoiding in most cases useless…
- Trial name
- RENOVATE (NCT04781062)
- Testing
- Blood and urine molecular analysis (Timing 0), Blood and urine molecular analysis (Timing 1)
- Where
- Italy
- Volunteers
- 367 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino
Mindfulness, Meditation
My Mindful Moments: A Mindfulness Meditation and Digital Art Activity
The purpose of this evidence-based practice project is to evaluate the feasibility of providing a relaxation mindfulness meditation and an expressive digital arts activity among clinical staff at Dana Farber Cancer Institute .
- Trial name
- NCT04557033
- Testing
- Mindfulness intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Advanced Care Planning, Shared Decision Making
Advance Care Planning: Communicating With Outpatients for Vital Informed Decision
This Pre-Post, open-cohort design, pragmatic trial with 150 clinicians and will evaluate the effectiveness of the use of telehealth Advanced Care Planning (ACP) Program by comparing ACP documentation among 13,000 patients over 65
- Conditions
- Advanced Care Planning, Shared Decision Making, Video Decision Aids, Communication Skills
- Trial name
- ACP-COVID (NCT04660422)
- Testing
- VitalTalk communication skills training, ACP Decisions Video Program, Intervention training:
- Where
- United States
- Volunteers
- 42,019 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Cancer, Chemotherapy-induced Peripheral Neuropathy
Clinician Decision Support Algorithm for Chemotherapy-Induced Peripheral Neuropathy
This research study is evaluating how well a decision support tool works to improve clinicians' use of recommended chemotherapy-induced peripheral neuropathy (CIPN) assessment and management strategies in participants receiving…
- Trial name
- NCT03514680
- Testing
- CIPN Assessment and Management Algorithm
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Understanding Barriers to Initiation and Adherence to Endocrine Therapy in Young Breast Cancer Survivors of Diverse Backgrounds
The overall goal of this study is to qualitatively explore how behavioral, cultural, psychosocial, and economic barriers and facilitators affect the decision to start and adhere to endocrine therapy (ET) among young breast cancer…
- Trial name
- NCT03447886
- Testing
- Phone interview
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Sickle Cell Disease, Sickle Cell-Beta0-Thalassemia
Isoquercetin in Sickle Cell Anemia
This research study is being done to assess the safety and effectiveness of isoquercetin to reduce levels of soluble P-Selectin in patients with sickle cell disease. Isoquercetin is a naturally occurring flavonoid-or vitamin.
- Trial name
- NCT04474626
- Testing
- Isoquercetin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jeffrey Zwicker, MD
Neoplasms, HIV
Potlako: A Programmatic Intervention to Improve Access to Timely Oncology Care
Diagnostic and treatment delays contribute substantially to disparities in cancer morbidity and mortality between low- and middle- income countries (LMICs) and high-income countries.
- Conditions
- Neoplasms, HIV, Healthcare Disparity
- Trial name
- NCT02752061
- Testing
- Potlako intervention
- Where
- Botswana
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Breast Cancer
Improving Surgical Decision-making in Young Women With Breast Cancer
The overall goal of this study is to qualitatively assess the surgical decision-making process from both the patient and physician perspective 1. Conduct short in-person interviews with young women prior to surgery 2.
- Trial name
- NCT02644382
- Testing
- qualitative data collection, survey, decision aid
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Non-Small-Cell Lung Carcinoma
Study of OSI-774 (Tarceva) in Previously Untreated Elderly Lung Cancer Patients
The primary purpose of this study is to determine whether the drug OSI-774 is less toxic and potentially as good as or better than standard chemotherapy drugs, when given to subjects with non-small cell lung cancer, who are 70…
- Trial name
- NCT00137800
- Testing
- OSI-774 (Tarceva)
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Comparison of Contrast-enhanced Spectral Mammography (CESM) to MRI in Screening High Risk Women for Breast Cancer
This research study is comparing Dual-Energy Contrast-Enhanced Spectral Mammography (CESM) to MRI as a screening tool for breast cancer.
- Trial name
- NCT02275871
- Testing
- MRI, CESM
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cancer
Improving Communication Between Cancer Patients & Oncologists
The overarching goal of this project is to improve communication between oncologists and their patients by ensuring that the patient's voice is heard in the medical encounter.
- Trial name
- NCT02969031
- Testing
- Enhanced SCOPE training, Standard Communication training
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Pediatric Acute Myeloid Leukemia
Home Away From Home - Quality of Life Surveys
Treatment for pediatric acute myeloid leukemia (AML) involves intensive chemotherapy regimens that result in periods of profound neutropenia leaving patients susceptible to severe infectious complications.
- Trial name
- Aim 3 (NCT02777021)
- Where
- 15 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
HIV/AIDS
Storytelling Narrative Communication Intervention for Smoking Cessation in Women Living With HIV
HIV has transformed into a chronic illness due to the advent of effective treatments in the absence of a cure. As a result, the prevalence of non-AIDS defining cancers (NADCs), including lung cancer, has increased three-fold…
- Trial name
- WISE (NCT03289676)
- Testing
- Storytelling Narrative Intervention
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Cancer
Promoting Organizational Capacity to Implement Cancer Control Programs Among Latino Churches
This research study aims to develop an organizational-level intervention to enable communities to adopt, adapt, implement and sustain evidence-based interventions (EBIs) to address cancer disparities among Latinos.
- Trial name
- CRUZA (NCT01740219)
- Testing
- Capacity Enhancement, Standard Dissemination
- Where
- 3 sites in United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Healthy
Safety Study of Mibefradil When Given Four Times a Day in Healthy Volunteers
The objective of the study is to determine the safety and pharmacokinetics of a 7 day course of oral mibefradil given four times a day in healthy volunteers.
- Trial name
- NCT01550458
- Testing
- mibefradil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cavion, Inc.
End of Life Care, Cancer
Serious Illness Communication Project
The purpose of the study is to evaluate the impact of implementing a "Serious Illness Conversation Guide" to guide patient/family-clinician discussions and planning about end-of-life care decisions.
- Trial name
- NCT01786811
- Testing
- Training
- Where
- United States
- Volunteers
- 994 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Health Behavior, Risk Reduction Behavior
Multiple Risk Behavior Intervention in Health Care Settings
This study (aka Healthy Directions2 or HD2) builds on an earlier study titled Healthy Directions (aka Healthy Directions 1 or HD1).
- Trial name
- HD2 (NCT01415492)
- Testing
- HD2, HD2+
- Where
- United States
- Volunteers
- 2,440 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute