Clinical trials: sponsored by Brigham and Women's Hospital
Pulmonary Disease, Chronic Obstructive, Emphysema
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic
- Trial name
- COPDGene (NCT00608764)
- Where
- 20 sites in United States
- Volunteers
- 10,718 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Inflammatory Bowel Disease (IBD)
Biophysical Assessments of Acupuncture Points in Inflammatory Bowel Disease
Acupuncture points or acupoints are fundamental to the practice of acupuncture, yet their scientific basis remains unclear. According to traditional explanations of acupuncture, acupoints can become tender or more sensitive to…
- Trial name
- NCT07681895
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dietary Intervention
Eating to Adjust the Timing System
The goal of this clinical trial is to test the effects of dietary composition on the rhythms of food intake, appetite regulation, and rhythms of energy expenditure.
- Trial name
- EATS (NCT05800990)
- Testing
- dietary intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dietary Habits
Can Food Timing Reduce Your Diabetes Risk?
The goal of this clinical trial is to test whether food timing impacts metabolic health in healthy participants. Participants will: complete 2 inpatient stays be provided with test meals have frequent blood draws
- Trial name
- NCT05862818
- Testing
- Day shift protocol - Diet order A-B, Day shift protocol - Diet order B-A, Night shift protocol - Diet order A-B
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cancer, Cardiovascular Disease
Vitamin D and Omega-3 Trial (VITAL)
The VITamin D and OmegA-3 TriaL (VITAL) is a randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor® fish oil, 1 gram)…
- Trial name
- VITAL (NCT01169259)
- Testing
- vitamin D3, omega-3 fatty acids (fish oil)
- Where
- United States
- Volunteers
- 25,871 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Epilepsy
A Device to Prevent Unexpected Death in Epilepsy
The study has the objective to demonstrate safety and effectiveness of the Korus device in identifying body positioning. Primary Objective Validate the sensor system in Korus for body position detection using a pressure-based…
- Trial name
- NCT07877896
- Testing
- Study Subjects
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Disorder
Randomized Trial of a Sleep Disorders Program on Firefighter Safety and Disability ...
The investigators have shown that sleep health education and sleep disorders screening improve health and safety of employees. There is potential to increase the benefits of the sleep health education and screening program if…
- Trial name
- NCT04519177
- Testing
- Sleep Health Education Program (SHEP)
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Herpes Zoster (HZ)
Obesity and Obesity-Related Factors and Risk of Herpes Zoster (Shingles) and Postherpetic Neuralgia
The investigators' objectives are to examine the longitudinal association of obesity and obesity-related factors and risk of incident herpes zoster (HZ), also known as shingles, and the longitudinal association of obesity and…
- Trial name
- NCT06638177
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Genetic Predisposition to Disease, Hereditary Diseases
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
This research study is exploring the use of genomic sequencing in the newborn period to screen healthy babies for current and future health risks.
- Trial name
- NCT05161169
- Testing
- Genome Sequencing
- Where
- 3 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Design and Usability Testing of a Tailored Intervention About Sleep and Sleep Disorders Among Transportation Workers
The objective of this protocol is to conduct a focus group to identify OSA beliefs, attitudes, and knowledge among employees in the transportation industry on shift schedules.
- Trial name
- NCT05039528
- Testing
- Personalized OSA messages, Control
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pregnancy Related
Cesarean 123 Trial: Randomized Trial Comparing Single, Double and Triple Layer Uterine Closures During Cesarean Delivery
The goal of this clinical trial is to compare post-operative uterine scar thickness in people who have had the uterus closed during cesarean sections by one of three different methods.
- Trial name
- C123T (NCT05750394)
- Testing
- Uterine layers closed, Suture Type, Endometrium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Bladder Cancer, Cystectomy
Patient-Centered Surgical Prehabilitation
The purpose of this research is to validate the prehabilitation program which is defined as a set of interventions meant to prepare the body physically and nutritionally for the cystectomy procedure.
- Trial name
- Prehab (NCT05715684)
- Testing
- Exercise Training, Nutritional Intervention
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy Subjects
Lysine-specific Demethylase 1 and Salt-sensitivity in Humans
The purpose of this study is to investigate the role dietary salt plays in epigenetic regulation of blood pressure, focusing on the salt-sensitive regulatory enzyme Lysine-specific demethylase 1.
- Trial name
- NCT03029806
- Testing
- Aldosterone response to AngII LS, Renal blood flow response to salt, Vascular Stiffness
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Infertility of Uterine Origin
Deceased Uterine Transplant in Absolute Uterine Infertility (AUIF)
Our study will explore the feasibility of initiating a deceased donor uterine transplant program in addition to the existing living donor IRB at BWH.
- Trial name
- NCT04026893
- Testing
- Uterine Transplant from Deceased Donor
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Stress
Photobiomodulation, Heart Rate Variability, and Acute Stress
Photobiomodulation (PBM) is a form of light therapy that uses red or near-infrared light to influence biological processes. In prior studies, PBM has been shown to improve various physiological functions, including tissue repair…
- Trial name
- NCT07475858
- Testing
- Vielight Vagus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Life Style
Effect of Physical Activity Pattern on Cardiometabolic Health
The goal of this study is to understand the interaction between the circadian system and physical activity. Participants will: complete 2 inpatient stays perform moderate exercise be provided with identical meals have frequent…
- Trial name
- PACE (NCT05838508)
- Testing
- Exercise intervention
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Pain, Hiv
Harmonized Healing: Personalized Music Interventions to Address Chronic Pain in People Living With HIV
The goal of this randomized controlled trial is to understand the feasibility and acceptability of a music-based mobile application to address chronic pain in people with HIV.
- Trial name
- NCT07214077
- Testing
- Harmonized Healing App, Psychoeducation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Amyloidosis Cardiac
Ultrasound Therapy In Cardiac Amyloidosis
This is a prospective pilot clinical study of subjects with cardiac amyloidosis and control subjects without amyloidosis where we plan to evaluate changes in myocardial blood flow, systolic and diastolic function before and after…
- Trial name
- UTICA (NCT04667494)
- Testing
- Sonotherapy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Epidural Analgesia, Epidural Analgesia for Labour and Delivery
EpiFaith Resident Learning Curve Trial
This study aims to evaluate the impact of the EpiFaith® syringe on the learning curve of anesthesia residents for the labor epidural technique.
- Conditions
- Epidural Analgesia, Epidural Analgesia for Labour and Delivery, Learning Curve
- Trial name
- NCT07395622
- Testing
- EpiFaith epidural syringe, Control (glass) syringe
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital