Clinical trials: in Zambia
Smoking
GN Tobacco Use Survey
Smoking can contribute to many health problems for mothers and their babies. In developing countries, there is little information about the number of pregnant women that smoke and the reasons why some pregnant women choose to…
- Trial name
- NCT00121368
- Where
- 9 sites in Argentina, Brazil and 6 more
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Complementary Feeding, Infant Growth
First Bites: Complementary Feeding - A Global Network Cluster Randomized Controlled Trial
The specific aims of this project is to determine the impact of a daily intake of one half ounce of lyophilized meat between 6-18 months of age (0.5 oz for 6-12 mo; 0.75 oz for 12-18 mo) on linear growth velocity, zinc and iron…
- Trial name
- First Bites (NCT01084109)
- Testing
- Lyophilized meat, Cereal
- Where
- 4 sites in Guatemala, Pakistan and 2 more
- Volunteers
- 1,236 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Maternal Morbidity and Mortality, Stillbirth and Neonatal Mortality
Emergency Obstetric and Neonatal Care: The EmONC Trial
The objective of this cluster randomized controlled trial is to reduce maternal and neonatal mortality by increasing access to and improving the quality of obstetric and neonatal care for pregnant women in study clusters.
- Trial name
- EmONC (NCT01073488)
- Testing
- Community Mobilization, HBLSS and facility improvement
- Where
- 7 sites in Argentina, Guatemala and 4 more
- Volunteers
- 267,181 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Malaria in Pregnancy, HIV Infections
Establishing Effectiveness of Daily Co-trimoxazole Prophylaxis For Prevention of Malaria in Pregnancy
Malaria is a major contributor of disease burden in Sub-Saharan Africa: 90% of global cases occur there, and pregnant women and children under 5 years are the most vulnerable.
- Trial name
- NCT01053325
- Testing
- Cotrimoxazole prophylaxis, SP IPT
- Where
- Zambia
- Volunteers
- 848 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Hypothermia, Newborn
Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates
The overall hypothesis is that placing infants 1000-2500 grams in plastic bags when compared to routine care will reduce the risk of hypothermia (< 36.5 degrees C) without increasing hyperthermia (> 37.5 degrees C).
- Trial name
- NCT01403623
- Testing
- Resuscitation and post resuscitation care with plastic bag, Resuscitation- no plastic bag for temperature regulation
- Where
- Zambia
- Volunteers
- 106 people
- Sponsor
- University of Alabama at Birmingham
Tuberculosis
Trial of Point-of-treatment Xpert MTB/RIF Assay
Xpert MTB/RIF assay is a novel automated molecular tool for the diagnosis of TB. Xpert can detect TB genetic material in sputum samples as well as test for genetic resistance to rifampicin providing results within 2 hours.
- Trial name
- TBNEATXpert (NCT01554384)
- Testing
- Xpert MTB/RIF assay, Smear microscopy
- Where
- 4 sites in South Africa, Zambia and 1 more
- Volunteers
- 1,472 people
- Sponsor
- University of Cape Town
HIV Infections
Safety and Immunogenicity Study of 2 Investigational Preventive HIV Vaccines
The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of an adjuvanted GSK investigational HIV vaccine and Ad35-GRIN in 4 different regimens at months 1, 2, 3, and 4.
- Trial name
- NCT01264445
- Testing
- Adjuvanted GSK investigational HIV vaccine formulation 1, Adjuvanted GSK investigational HIV vaccine formulation 2, Ad35 investigational HIV vaccine
- Where
- 4 sites in Kenya, Uganda and 1 more
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Hypothermia, Newborn
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part V
The overall hypothesis is that plastic bags used in combination with WHO thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine WHO…
- Trial name
- NCT01604460
- Testing
- Resuscitation with torso plastic bag, Resuscitation-no plastic bag
- Where
- Zambia
- Volunteers
- 275 people
- Sponsor
- University of Alabama at Birmingham
Human Immunodeficiency Virus Infections, HIV Infections
Safety and Immunogenicity Study of tgAAC09, an HIV Vaccine in an Adeno-associated Virus (AAV) Capsid
This phase 2 study will evaluate the safety, immunogenicity and optimal timing of two injections at three dose levels of the tgAAC09 vaccine in healthy volunteers.
- Trial name
- TGC14F (NCT00888446)
- Testing
- tgAAC09, Formulation buffer
- Where
- 5 sites in South Africa, Uganda and 1 more
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Male Circumcision
A Prospective Field Study: Introducing the Shang Ring in Routine Clinical Settings
Male Circumcision (MC) is the only new biomedical method to demonstrate consistent efficacy as an HIV prevention intervention in randomized controlled trials (WHO and UNAIDS, 2007), based on three randomized controlled trials in…
- Trial name
- NCT01567436
- Testing
- Shang Ring
- Where
- 2 sites in Kenya, Zambia
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections, Gonorrhea
Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection
The objective of the study is to determine the efficacy and safety of 0.5% and 2% PRO 2000/5 gels compared to placebo in preventing vaginally acquired HIV infection.
- Conditions
- HIV Infections, Gonorrhea, Chlamydial Infections, Genital Herpes
- Trial name
- NCT00262106
- Testing
- PRO 2000/5
- Where
- 6 sites in South Africa, Tanzania and 2 more
- Volunteers
- 9,404 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
HIV, Contraception
Impact of Different Contraceptives on the Immune System of HIV Infected Women in Zambia
In this study, 66 HIV-infected women who desire contraception will be randomly assigned to use either an IUD or Depo Provera, and will be followed for six months.
- Conditions
- HIV, Contraception, HIV Infections
- Trial name
- MSRC (NCT00807625)
- Testing
- Depo Provera, Copper T Intrauterine contraception device
- Where
- Zambia
- Volunteers
- 66 people
- Sponsor
- University of Alabama at Birmingham
Neonatal Male Circumcision
Feasibility, Acceptability, and Safety of Neonatal Male Circumcision in Lusaka, Zambia
In this study of neonatal male circumcision (NMC), the investigators will examine acceptability of among parents, feasibility of training providers and implementing services in various clinical settings, and the safety of service…
- Trial name
- NCT01115335
- Testing
- Neonatal male circumcision
- Where
- Zambia
- Volunteers
- 661 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
HIV, Pregnancy
Maternal TDF and FTC to Reduce NNRTI Resistance Mutations After Intrapartum NVP
The purpose of this study is to determine whether the addition of tenofovir (TDF) and emtricitabine (FTC)to a standard PMTCT regimen containing single-dose nevirapine (NVP) can reduce the development of post-ingestion HIV…
- Trial name
- TD-2 (NCT00204308)
- Testing
- Combination tenofovir-emtricitabine
- Where
- 2 sites in Zambia
- Volunteers
- 400 people
- Sponsor
- University of North Carolina, Chapel Hill
Circumcision, Male
Comparison of the Shang Ring With Conventional Surgical Methods
This is a randomized control trial of 400 adult male circumcision procedures with a one to one ratio between Shang Ring and the in-country standard surgical technique (forceps guided in Kenya and dorsal slit in Zambia).
- Trial name
- NCT01300910
- Testing
- Shang Ring, Male circumcision
- Where
- 2 sites in Kenya, Zambia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infection, Pregnancy
Universal Use of EFV-TDF-FTC and AZT-3TC-LPV/r Combinations for HIV-1 PMTCT in Pregnant and Breastfeeding Women : a Phase 3 Trial
To assess the maternal and infant safety of a single daily fixed-dose combination of TDF/FTC/EFV (Atripla®), compared to the association of LPV/r (Kaletra® or Aluvia®) and 3TC/ZDV (Combivir®) given to African women to prevent…
- Conditions
- HIV Infection, Pregnancy, Breastfeeding, HIV Infections
- Trial name
- UMA (NCT00936195)
- Testing
- Efavirenz-Tenofovir-Emtricitabine, Zidovudine-Lamivudine-Lopinavir/Ritonavir
- Where
- 2 sites in Côte d’Ivoire, Zambia
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV
Targeting Interventions at Venues Where Risk of HIV Transmission is High
The aim of this study is to investigate whether distribution of condoms and condom demonstrations by youth peer educators in venues where people meet new sexual partners in Livingstone, Zambia, leads to increased condom use among…
- Trial name
- PLACE (NCT01423357)
- Testing
- Condom distribution and peer education
- Where
- 2 sites in Zambia
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- University of Zambia
Diarrhea, HIV Infection
Safe Drinking Water For Households With Infants Born to HIV-Positive Mothers Pilot Study
The purpose of this study is to assess whether children under 2 years and other members of households in which HIV-positive mothers are providing replacement and complementary feeding would potentially benefit from the use of a…
- Trial name
- SWIM (NCT01116908)
- Testing
- LifeStraw Family
- Where
- Zambia
- Volunteers
- 120 people
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infection
Zambia Exclusive Breastfeeding Study
The study is designed as a randomized, controlled trial with specific observational objectives. All HIV-seropositive pregnant subjects electing to breastfeed their child will be counselled to exclusively breastfeed through 4…
- Trial name
- NCT00310726
- Testing
- abrupt weaning at 4 months, Continued exclusive breastfeeding
- Where
- Zambia
- Volunteers
- 1,435 people
- Sponsor
- Boston Medical Center
Diarrhea, Waterborne Disease
Trial of Safe Water Storage Among People Living With HIV
Environmental health-related pathogens include faecal-oral, diarrhoeagenic microbes that may be transmitted via drinking water and are related to sanitation and hygiene.
- Conditions
- Diarrhea, Waterborne Disease, HIV
- Trial name
- NCT01376336
- Testing
- Safe storage device
- Where
- Zambia
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine