Clinical trials: open to volunteers, in Uzbekistan
Symptomatic Tricuspid Regurgitation (TR) Graded as Severe or Greater
First-in-man Trial to Assess the Safety, Performance and Clinical Benefit of the TRICENTO G2 Transcatheter Valve System for Tricuspid Regurgitation
The goal of this clinical trial is to assess if the TRICENTO G2 Transcatheter Valve System for Tricuspid Regurgitation (TRICENTO G2 TVSTR) is safe and efficient in treating severe tricuspid regurgitation in adult patients.
- Trial name
- FIM-TRICSTER (NCT07536724)
- Testing
- TRICENTOG2 Transcatheter Valve System for Tricuspid Regurgitation (TRICENTOG2 TVSTR)
- Where
- 2 sites in Uzbekistan
- Volunteers
- 10 people
- Sponsor
- Medira GmbH
Psychometric Validation of Men's Health Questionnaires
Validation of Uzbek-Language ADAM, AMS, and IPSS Questionnaires in Men Aged 35-59 Years
This observational study aims to evaluate the reliability and validity of the Uzbek-language versions of three questionnaires used to assess men's health: the Androgen Deficiency in Aging Males (ADAM), Aging Males' Symptoms…
- Trial name
- TESMEN-VALID (NCT07879183)
- Where
- Uzbekistan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Andijan State Medical Institute
Colorectal Cancer
ColoSeal™ ICD System Safety and Feasibility Studies
The studies aim to evaluate the safety and feasibility of the ColoSeal Intraluminal Colonic Diversion (ICD) System in two prospective, multicenter, single-arm studies.
- Trial name
- PROTECT I (NCT06402188)
- Testing
- ColoSeal ICD Device
- Where
- 3 sites in Armenia, Georgia and 1 more
- Volunteers
- 90 people
- Sponsor
- Averto Medical, Inc.
Chronic Hepatitis D Infection
A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)
This is a Phase 3, global, randomized, open-label, multicenter, trial evaluating brelovitug (BJT-778) vs bulevirtide for the treatment of chronic hepatitis delta infection (CHD).
- Trial name
- NCT07200908
- Testing
- Brelovitug 300 mg, Bulevirtide 2 mg and Brelovitug - 300 mg
- Where
- 57 sites in Austria, Czechia and 10 more
- Volunteers
- 172 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Cervical Cancer
Diagnostic Evaluation of Viral Persistence in Cervical Cancer
This study aims to evaluate the diagnostic value of an electroacupuncture-based method for detecting viral persistence (human papillomavirus and SARS-CoV-2) in patients with cervical cancer.
- Trial name
- PETCVOCC (NCT07325682)
- Testing
- Electroacupuncture
- Where
- Uzbekistan
- Volunteers
- 30 people
- Sponsor
- Oncology Center,Ministry Of Heath,Uzbekistan
Type B Aortic Dissection
EXtensive mulTilayer stEnt treatmeNt in Aortic disSectiOn
This clinical trial is a prospective, multicenter, open label study designed to evaluate the effectiveness and the safety of the Allay® Aortic Stent as adjunctive endovascular treatment of Type B aortic dissection in patients…
- Trial name
- EXTENSO (NCT06675617)
- Testing
- Allay Aortic Stent
- Where
- 21 sites in Austria, Belgium and 6 more
- Volunteers
- 72 people
- Sponsor
- Intressa Vascular SA
Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
First-in-Human Study Using the SiroMax™ Sirolimus-Coated Balloon Catheter as a Percutaneous Transluminal Coronary Angioplasty (PTCA) Balloon Catheter to Treat Subjects Who Have Coronary Artery Disease (CAD) Involving In-Stent Restenosis (ISR) or an Unstented Lesion in a Small Coronary Vessel (DNSV).
The goal of this clinical trial is to learn if the SiroMax™ drug-coated balloon catheter is safe and works to treat stenotic coronary lesions in adults.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), In-Stent Restenosis or De Novo Coronary Artery Lesions, In-Stent Stenosis (Restenosis) of Coronary Artery Stent
- Trial name
- SMART-I (NCT07811024)
- Testing
- Sirolimus-coated balloon catheter
- Where
- 2 sites in Uzbekistan
- Volunteers
- 60 people
- Sponsor
- Tonic Medical, Inc.
Acute Decompensated Heart Failure (ADHF)
Evaluation of FlowMod System While Intermittently Partially Occluding Vena Cava Blood Flow in Subjects With ADHF
FLOW-HF will assess the impact of intermittent partial occlusion of the SVC and/or IVC, the cardiac filling pressure and the difference of effects between the two occlusion locations (SVC and IVC) using the FlowMod flow…
- Trial name
- FLOW-HF (NCT07810335)
- Testing
- FlowMod System in subjects with acute decompensated heart failure (ADHF)
- Where
- 4 sites in Georgia, Uzbekistan
- Volunteers
- 30 people
- Sponsor
- FlowMod, Inc.
Respiratory Diseases, Congenital Heart Defects
Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children
The goal of the clinical study is to clarify the course of common congenital, infectious, and non-infectious diseases in children living in Uzbekistan, and to develop methods for their treatment and rehabilitation.
- Trial name
- NCT06267859
- Testing
- The use of a combination of microelements and vitamins against the background of physiotherapy
- Where
- Uzbekistan
- Volunteers
- 600 people
- Sponsor
- Tashkent State Medical University (Tashkent Pediatric Medical Institute), Uzbekistan
Acute Myeloid Leukemia
A Phase 1b Study of Lonitoclax + Azacitidine in Acute Myeloid Leukemia Patients
This is a clinical study aiming to evaluate the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of ZE50-0134 in relapsed and refractory Acute Myeloid Leukemia patients.
- Trial name
- NCT07303660
- Testing
- ZE50-0134, Azacitidine Days 1-7, ZE 50-0134
- Where
- 6 sites in Russia, Uzbekistan
- Volunteers
- 66 people
- Sponsor
- Lomond Therapeutics Holdings, Inc.
Hypothyroidism
Internal Organ and Musculoskeletal Assessment in Hypothyroidism (HYPOMORPH)
HYPOMORPH is a hospital-based observational cross-sectional study designed to comprehensively characterise internal-organ morphometry and musculoskeletal status in adults with previously diagnosed hypothyroidism receiving routine…
- Trial name
- HYPOMORPH (NCT07707830)
- Testing
- Comprehensive Morphometric and Functional Assessment
- Where
- Uzbekistan
- Volunteers
- 500 people
- Sponsor
- Andijan State Medical Institute
Testosterone Deficiency, Male Hypogonadism
Anthropometric, Functional and Lifestyle Factors Associated With Testosterone Levels in Middle-Aged Men
Decreased testosterone levels in middle-aged men are associated with multiple metabolic, functional and psychosocial consequences.
- Trial name
- TESMEN (NCT07476222)
- Testing
- Observational Assessment
- Where
- Uzbekistan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Andijan State Medical Institute
Advanced Solid Tumor Cancer, Metastatic Solid Tumor
A First-in-Human Study of ZE94-0605 in Patients With Advanced Solid Tumors
ZE94-0605 is an oral, selective cyclin-dependent kinase 2 (CDK2) inhibitor. This multicenter, open-label, first-in-human Phase 1 study will evaluate ZE94-0605 in adults with advanced, unresectable or metastatic solid tumors.
- Trial name
- NCT07524140
- Testing
- ZE94-0605
- Where
- 3 sites in Australia, Uzbekistan
- Volunteers
- 60 people
- Sponsor
- Eilean Therapeutics
Degenerative Disc Disease, Chronic Low-back Pain
"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)
This study will be a prospective, open-label, multi-center study including 72 patients that will collect additional safety and efficacy data for the Spinal Stabilization Technologies PerQdisc Nucleus Replacement System.
- Trial name
- LOPAIN2 (NCT05508360)
- Testing
- PerQdisc Nucleus Replacement System
- Where
- 11 sites in Colombia, Costa Rica and 3 more
- Volunteers
- 72 people
- Sponsor
- Spinal Stabilization Technologies
Distal Hypospadias, Hypospadias
Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias
Hypospadias is a common congenital condition in boys in which the opening of the urethra is located on the underside of the penis.
- Trial name
- FTIP-RCT (NCT07319780)
- Testing
- Fibrin-Enhanced TIP Urethroplasty, Grafted TIP Urethroplasty
- Where
- 2 sites in Indonesia, Uzbekistan
- Volunteers
- 100 people
- Sponsor
- National Children's Medical Center, Uzbekistan
COVID - 19
Early-stage Trial to Determine a Safe and Effective Dose for Ratutrelvir in Patients With Mild to Moderate COVID-19
This is an Early-stage Clinical Trial to Determine a Safe and Effective Dose for Ratutrelvir in Patients With Mild to Moderate COVID-19. It will also learn about the safety of drug Ratutrelvir.
- Trial name
- NCT07157007
- Testing
- Ratutrelvir (83-0060) non-randomised, Paxlovid, Ratutrelvir (83-0060)
- Where
- 15 sites in Australia, South Korea and 2 more
- Volunteers
- 90 people
- Sponsor
- Traws Pharma, Inc.
Long COVID, Post-Acute Sequelae of SARS-CoV-2 Infection
Long COVID Diagnostic Reactivity Assesment Test
This study is a diagnostic clinical investigation designed to evaluate bioelectrical response patterns assessed by electro-acupuncture-based medicament testing.
- Trial name
- EAV-LONGCOVID (NCT07343856)
- Testing
- Electrodiagnostic Bioelectrical Assessment
- Where
- Uzbekistan
- Volunteers
- 50 people
- Sponsor
- Oncology Center,Ministry Of Heath,Uzbekistan
Aneurysm, Abdominal Aortic
First-in-Human Trial of the A3-Shield System for Stabilizing Abdominal Aortic Aneurysms
This clinical trial evaluates the safety and feasibility of the A3-Shield implant for stabilising small abdominal aortic aneurysms in adult patients.
- Trial name
- PRINCIPIIS-FIH (NCT07330752)
- Testing
- A3-Shield Implantation
- Where
- Uzbekistan
- Volunteers
- 12 people
- Sponsor
- Angiolutions GmbH
Liver Cirrhosis, Liver Transplant; Complications
Verification of Risk Factors of Thrombohemorrhagic Complications in Recipients After Related Liver Transplantation
The aim of the study is to improve the results of related transplantation of the right liver lobe by verifying the general predictors of the development of hemostatic system disorders and optimizing a comprehensive program for…
- Trial name
- VORTAL (NCT06169592)
- Testing
- Liver transplantation
- Where
- Uzbekistan
- Volunteers
- 30 people
- Sponsor
- Republican Specialized Scientific and Practical Medical Center of Surgery Named After V. Vakhidov
Echinococcosis, Hepatic
Presentation of Protoscolexes and Acephalocysts in the Fibrous Capsule Area of the Liver With Echinococcosis
The objective of the study is to determine the presence of germinal elements of echinococcosis in the liver parenchyma next to and in the thickness of the fibrous capsule of hydatid cysts.
- Trial name
- PAFCLE (NCT06316154)
- Testing
- Echinococcectomy
- Where
- Uzbekistan
- Volunteers
- 100 people
- Sponsor
- Republican Specialized Scientific and Practical Medical Center of Surgery Named After V. Vakhidov