Clinical trials: in Trinidad and Tobago
Coronary Artery Disease, High On-treatment Platelet Reactivity (HTPR)
Effect of Two Weeks of Low-Dose Apixaban on Platelet Reactivity in Patients With Stable Coronary Artery Disease on Dual Antiplatelet Therapy (Aspirin and Clopidogrel)
The goal of this clinical trial is to learn whether a low dose of apixaban, a blood-thinning medicine, changes how active the platelets are in adults with stable coronary artery disease who are already taking aspirin and…
- Trial name
- ACER (NCT07853612)
- Testing
- Apixaban
- Where
- Trinidad and Tobago
- Volunteers
- 16 people
- Sponsor
- The University of The West Indies
Platelet Dysfunction Due to Drugs
Aspirin Resistance in Trinidad.
Aspirin's beneficial effect is mediated via the inhibition of arachidonic acid (AA) activation of platelets. It is detected by demonstrating a decrease in platelet function and/or a decrease in prostaglandin metabolites.
- Trial name
- ART (NCT06228820)
- Testing
- Aspirin 81Mg Ec Tab
- Where
- Trinidad and Tobago
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Coronary Artery Disease
The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease
The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties.
- Trial name
- ECLIPSE (NCT06567678)
- Testing
- Colchicine 0.5 MG oral tablet twice daily
- Where
- Trinidad and Tobago
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Platelet Dysfunction Due to Drugs
The Effect of empagliFlozin on Platelet Function profilEs in diabetiC patienTs - The EFFECT Study.
The mechanistic effects of empagliflozin on platelet function profiles have not yet been ascertained.
- Trial name
- EFFECT (NCT04342819)
- Testing
- SGLT2 inhibitor
- Where
- Trinidad and Tobago
- Volunteers
- 25 people
- Sponsor
- The University of The West Indies
Diabetes
Diabetes Prevention With Lifestyle Intervention and Metformin Escalation
Specific Aim: Implement an evidence-based diabetes prevention pragmatic trial for high risk pre-diabetic individuals of Caribbean-descent to reduce the incidence of diabetes.
- Trial name
- LIME (NCT03258723)
- Testing
- Lifestyle Intervention, Metformin
- Where
- 4 sites in Barbados, Puerto Rico and 2 more
- Volunteers
- 114 people
- Sponsor
- Yale University
Cardiovascular Diseases, Cardiomyopathies
Effectiveness and Safety of Distal Left Transradial Access in Coronary Procedures.
To evaluate the effectiveness and safety of distal left radial (dLR) access in coronary procedures at a tertiary center in Trinidad and Tobago.
- Trial name
- NCT06031077
- Testing
- cardiac catheterization
- Where
- Trinidad and Tobago
- Volunteers
- 150 people
- Sponsor
- The University of The West Indies
Platelet Dysfunction
The Effect of Dapagliflozin on Platelet Function testinG Profiles in Diabetic PatiEnts.
Sodium GLucose Transport 2 inhibitors (SGLT2I), including dapagliflozin, reduce the likelihood of hospitalization for heart failure and death in persons with type 2 diabetes, of which the mechanism has not been fully elucidated.
- Trial name
- EDGE (NCT04400760)
- Testing
- DAPA Tx
- Where
- Trinidad and Tobago
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Coronary Artery Disease
Correlation of Cardiac Computed Tomography Angiography Dimensions and Ethnicity in Trinidad
The aim of this study is to compare coronary artery dimensions on Cardiac CT angiography amongst different ethnicities in Trinidad.
- Trial name
- CADET (NCT04774861)
- Where
- Trinidad and Tobago
- Volunteers
- 170 people
- Sponsor
- The University of The West Indies
Limb Salvage Rates With Endovascular Therapy
Endovascular Limb Salvage in Trinidad and Tobago
The purpose of this study was to investigate limb salvage rates in patients with critical limb ischemia after endovascular revascularization.
- Trial name
- NCT05547022
- Testing
- Endovascular revascularisation
- Where
- Trinidad and Tobago
- Volunteers
- 157 people
- Sponsor
- Naveen Seecheran
Platelet Dysfunction
The Effect of Cocoa on Platelet Function Profiles in Patients
The effects of chocolate on cardiovascular health are still a matter of debate. It can potentially favor cardiovascular health through the antioxidative effects of cocoa ingredients, such as polyphenols (present in dark but not…
- Trial name
- ECLAIR (NCT04554901)
- Testing
- Cocoa
- Where
- Trinidad and Tobago
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Retinal Disease
Correlation of Microvascular Ophthalmic Disease With Macrovascular Coronary Artery Disease in Trinidad
Coronary artery disease (CAD) is the leading cause of death in Trinidad and Tobago. Early detection and management can help improve morbidity and mortality.
- Trial name
- EYE-MI TNT (NCT04233619)
- Testing
- optical coherence tomography
- Where
- Trinidad and Tobago
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Stroke
Stroke Outcome Analysis and Registry in Trinidad and Tobago
This is a prospective observational study to assess risk factors, functional outcomes and mortality at three months for persons admitted to hospital with stroke and transient ischemic attack.
- Trial name
- StART (NCT05256550)
- Where
- Trinidad and Tobago
- Volunteers
- 1,320 people
- Sponsor
- Naveen Seecheran
Polycystic Ovary Syndrome
Prevalence of Polycystic Ovary Syndrome In Trinidad
According to World Health Organization (WHO), in 2010, Polycystic Ovarian Syndrome (PCOS) affected approximately 116 million women worldwide (3.4% of the population).
- Trial name
- NCT05937360
- Testing
- cross-sectional community based study
- Where
- Trinidad and Tobago
- Volunteers
- 300 people
- Sponsor
- The University of The West Indies
Cancer, Cardiovascular Disease
Eastern Caribbean Health Outcomes Research Network (ECHORN)
The Eastern Caribbean Health Outcomes Research Network (ECHORN) is a collaborative research study that examines the lifestyles, eating habits, and health behaviors associated with cancer, diabetes and heart disease in adult men…
- Conditions
- Cancer, Cardiovascular Disease, Diabetes
- Trial name
- ECHORN (NCT01994811)
- Where
- 4 sites in Barbados, Puerto Rico and 2 more
- Volunteers
- 2,961 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV Infections, HIV Seronegativity
ALVAC-HIV vCP1452 Alone and Combined With MN rgp120
The purpose of this study is to test how the body's immune system responds to the vaccine ALVAC-HIV vCP1452 and to determine if the vaccine is safe when given alone and with MN rgp120.
- Trial name
- NCT00011037
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452), MN rgp120/HIV-1
- Where
- 4 sites in Brazil, Haiti and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Iodine Deficiency
Caribbean Island Urinary Iodine Survey 2018
Many of the Caribbean island nations have no data on iodine status in their populations. Iodine deficiency in children can reduce IQ but can be easily corrected through a program of salt iodization.
- Trial name
- CRUISE (NCT04388540)
- Where
- 10 sites in Antigua and Barbuda, Barbados and 8 more
- Volunteers
- 3,080 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Platelet Dysfunction Due to Drugs
The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease
This study aims to assess the effects of low dose ticagrelor on platelet function testing in patients with stable coronary artery disease.
- Trial name
- TWIST (NCT04206176)
- Testing
- Ticagrelor
- Where
- Trinidad and Tobago
- Volunteers
- 25 people
- Sponsor
- The University of The West Indies
Depression
Screening for Depression in cADiovasCular pAtients at a Tertiary Center in Trinidad.
This was an observational study aimed to screen patients with cardiovascular disease for depression in Trinidad and Tobago in a tertiary center and to determine if there is a significant association between patients with symptoms…
- Trial name
- SAD-CAT (NCT03863262)
- Where
- 2 sites in Trinidad and Tobago
- Volunteers
- 1,203 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Platelet Dysfunction Due to Drugs
Trimetazidine as an Adjunct to Enhance Clopidogrel Response.
Hypothesis: Trimetazidine improves Clopidogrel response in patients. The investigators postulate that the inhibition of platelet aggregation in response to Clopidogrel may be accentuated by Trimetazidine, i.e.
- Trial name
- TRACER (NCT03603249)
- Testing
- Trimetazidine
- Where
- Trinidad and Tobago
- Volunteers
- 24 people
- Sponsor
- The University of The West Indies
Bimaxillary Proclination
A Randomized Clinical Trial to Investigate Whether Self Ligating Brackets or Conventional Brackets Are Better for Treating Bimaxillary Proclination
The study is a single blind randomised control trial.The patients will be randomly assigned to have conventional brackets placed or self ligating brackets placed. All patients will undergo full Orthodontic records.
- Trial name
- NCT04001816
- Testing
- Orthodontic Brackets
- Where
- Trinidad and Tobago
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies