Clinical trials: open to volunteers, in Singapore
Machine Learning
Impact of Machine Learning-based Clinician Decision Support Algorithms in Perioperative Care
Predicting surgical risks are important to patients and clinicians for shared decision making process and management plan. The study team aim to conduct a hybrid type 1 effectiveness implementation study design.
- Trial name
- IMAGINATIVE (NCT05809232)
- Testing
- CARES-guided Group
- Where
- Singapore
- Volunteers
- 9,200 people
- Sponsor
- Singapore General Hospital
Lymphoblastic Leukemia, Lymphoblastic Leukemia in Children
CD19-Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory B-Lineage Leukaemia / Lymphoma - A Feasibility Protocol
The purpose of this study is to describe feasibility of delivering point-of-care manufactured CD19-directed CAR T-cell therapy to patients with relapsed/ refractory B-lineage leukaemia/ lymphoma.
- Conditions
- Lymphoblastic Leukemia, Lymphoblastic Leukemia in Children, Lymphoblastic Leukemia, Acute Adult, B-cell Acute Lymphoblastic Leukemia
- Trial name
- NCT05648019
- Testing
- Anti-CD19 CAR T-cells
- Where
- 2 sites in Singapore
- Volunteers
- 40 people
- Sponsor
- KK Women's and Children's Hospital
Plaque Psoriasis
Outcomes With Treatment and Withdraw of Secukinumab in Patients With Plaque Psoriasis
Psoriasis (PsO) is a systemic immune disease that affect 2-4% of the population worldwide. PsO causes tremendous burden in terms of quality of life, psychological impact, disability and work productivity of affected individuals.
- Trial name
- NCT04239859
- Testing
- secukinumab, Methotrexate, Cyclosporin A
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore General Hospital
Plaque Psoriasis
Outcomes With Treatment and Withdraw of Ixekizumab in Patients With Plaque Psoriasis
Psoriasis (PsO) is a systemic immune disease that affect 2-4% of the population worldwide. PsO causes tremendous burden in terms of quality of life, psychological impact, disability and work productivity of affected individuals.
- Trial name
- NCT04537689
- Testing
- Ixekizumab, Methotrexate, Cyclosporin A
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore General Hospital
Coronary Artery Disease
JARVISDHL Screening Tools
The main purpose of this study is to pioneer an easy risk stratification tools, which is developed using novel artificial intelligence (AI) algorithms, that will be able to detect common and fatal heart diseases easily simply…
- Trial name
- NCT05626517
- Testing
- Ocular Imaging, Questionnaires
- Where
- Singapore
- Volunteers
- 2,000 people
- Sponsor
- National Heart Centre Singapore
Mild Cognitive Impairment, Cerebrovascular Disease
EGb 761 in the Syndrome of MCI With Concomitant CVD
EGb 761 has been demonstrated to be useful in improving cognitive and global clinical outcomes in patients with cognitive impairment or dementia, when administered at a daily dosage of 240mg in randomised controlled trials…
- Trial name
- NCT04525144
- Testing
- Tebonin Forte
- Where
- Singapore
- Volunteers
- 134 people
- Sponsor
- National Neuroscience Institute
Postoperative Delirium, Aging
Singapore Perioperative Ageing Study (Sing-PAS)
The specific aim of the study will be to set up a perioperative database to longitudinally track the progress of elderly patients undergoing major surgery from the preoperative period to five years postoperatively.
- Conditions
- Postoperative Delirium, Aging, Myocardial Injury
- Trial name
- NCT04792554
- Testing
- Neurocognitive tests and blood taking
- Where
- 2 sites in Singapore
- Volunteers
- 600 people
- Sponsor
- National University Hospital, Singapore
CAD, Coronary Artery Disease
AI Driven National Platform for CT cOronary Angiography for clinicaL and industriaL applicatiOns Registry
The overall aim is to build an AI driven national Platform for CT cOronary angiography for clinicaL and industriaL applicatiOns (APOLLO) for automated anonymization, reporting, Agatston scoring and plaque quantification in CAD.
- Conditions
- CAD, Coronary Artery Disease, Coronary Stenosis, Plaques; Epicardial
- Trial name
- APOLLO (NCT05509010)
- Testing
- CTCA
- Where
- 3 sites in Singapore
- Volunteers
- 8,000 people
- Sponsor
- National Heart Centre Singapore
Kidney Cancer
International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors
Partial nephrectomy (PN) is the standard treatment for localized renal masses and should be preferred in clinical T1 (<7 cm tumor diameter) renal tumors over radical nephrectomy (RN) whenever technically feasible.
- Trial name
- i-RECORd (NCT05363657)
- Testing
- Partial Nephrectomy (PN), Radical Nephrectomy (RN), Ablation therapy (AT)
- Where
- 37 sites in United States, Austria and 11 more
- Volunteers
- 10,000 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Obesity, Bariatric Surgery Candidate
Crural Repair During Laparoscopic Sleeve Gastrectomy in Patients With a Lax Gastroesophageal Junction
Background: Laparoscopic sleeve gastrectomy (LSG) is one of the commonest bariatric procedures. However, it is associated with postoperative gastroesophageal reflux disease (GERD) and erosive esophagitis (EE).
- Conditions
- Obesity, Bariatric Surgery Candidate, Esophagus Injury, Gastroesophageal Reflux
- Trial name
- REPAIR (NCT05330910)
- Testing
- Laparoscopic sleeve gastrectomy with concomitant hiatal hernia repair arm, Laparoscopic sleeve gastrectomy arm
- Where
- 2 sites in Singapore
- Volunteers
- 96 people
- Sponsor
- Sengkang General Hospital
Lymphoblastic Leukemia, Acute, Childhood, Lymphoblastic Leukemia
CARTALL: Chimeric-Antigen Receptor (CAR) T-Cell Therapy for Relapsed/ Refractory T-Lineage Acute Lymphoblastic Leukaemia
The objective of this study is to assess the safety and efficacy of anti-CD7 CAR T-cells in patients with refractory or relapsed T-lineage acute lymphoblastic leukemia (T-ALL).
- Conditions
- Lymphoblastic Leukemia, Acute, Childhood, Lymphoblastic Leukemia, Lymphoblastic Leukemia, Acute Adult, Lymphoblastic Leukemia in Children
- Trial name
- NCT05043571
- Testing
- CAR T-cell therapy
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Breast Cancer
Prophylactic Irradiation to the Contralateral Breast for BCAs Patients
Breast cancer is the most common cancer in women worldwide, with high mortality. About 5% to 10% of breast cancers are hereditary.
- Trial name
- PICB (NCT04960839)
- Testing
- Prophylactic contralateral breast irradiation
- Where
- 8 sites in China, Singapore
- Volunteers
- 323 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes Mellitus, Cardiovascular Diseases
Asian Diabetes Outcomes Prevention Trial
The aim of this study is to identify patients with DM at high risk of CVD using elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (>125pg/mL), and (2) intensify therapy using renin-angiotensin system (RAS)…
- Trial name
- ADOPT (NCT04286399)
- Testing
- Renin-angiotensin-aldosterone system inhibitors, Beta blocker, SGLT2 Inhibitor - Sodium Glucose Cotransporter Subtype 2 Inhibitor Product
- Where
- Singapore
- Volunteers
- 2,400 people
- Sponsor
- National Heart Centre Singapore
Coronary Artery Calcification
ROVUS Asia Registry (Evaluate Safety and Effectiveness of Rotational Atherectomy and Intravascular Ultrasound for Heavily Calcified Coronary Lesion)
Rotablation with or without other calcium debulking therapies is a safe adjunctive procedure for patients with severe coronary calcification requiring Percutaneous Coronary Intervention (PCI).
- Trial name
- ROVUS (NCT04742478)
- Testing
- Rotational Atherectomy
- Where
- 2 sites in Japan, Singapore
- Volunteers
- 1,000 people
- Sponsor
- National Heart Centre Singapore
Heart Failure, Cardiac Resynchronisation Therapy
Prospective Evaluation of Asians With CRT for Heart Failure
Aim:To determine the baseline characteristics of heart failure patients in Singapore undergoing cardiac resynchronization therapy (CRT); the long term outcome and predictors of response to CRT.
- Trial name
- PEACH (NCT02814942)
- Testing
- Cardiac Resynchronization Therapy
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- National University Heart Centre, Singapore
Nasopharyngeal Carcinoma, Radiotherapy
Reduced vs Conventional Dosage Intensity-modulated Radiotherapy for Chemotherapy-sensitive Stage II-III Nasopharyngeal Carcinoma
Through multicenter, open-label, randomised clinical trials, we intend to demonstrate that radiotherapy with reduced dose could significantly reduce the incidence of radiotherapy toxicities, improve the quality of life of…
- Conditions
- Nasopharyngeal Carcinoma, Radiotherapy, Chemotherapy
- Trial name
- NCT04448522
- Testing
- reduced dosage IMRT, conventional dosage IMRT
- Where
- 6 sites in China, Singapore
- Volunteers
- 508 people
- Sponsor
- Sun Yat-sen University
Healthy, Dilated Cardiomyopathy
Molecular and Imaging Studies of Cardiovascular Health and Disease
Biobank is a program which collects biological samples, health information and imaging data from consented patients and stored them at the core facility.
- Conditions
- Healthy, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Ischemic Heart Disease
- Trial name
- Biobank (NCT02804269)
- Testing
- Cardiovascular Magnetic Resonance, Fatmass measurement
- Where
- Singapore
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Myocardial Infarction
Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People
A prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI), cardiovascular exercise physiology, metabolomics and genetic analysis.
- Trial name
- SingHEART (NCT02791152)
- Where
- Singapore
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore