Clinical trials: in Martinique
Prostatic Neoplasms
Contributions of a Paramedical Approach in the Prevention and Treatment of Side Effects Associated With Radical Prostatectomy
The paramedic urology team at Martinique University Hospital has developed a "personalized rehabilitation oncosexology program for patients undergoing radical prostatectomy (RP) for localized prostate cancer".
- Trial name
- VITALITE (NCT05266313)
- Testing
- Oncosexology program
- Where
- Martinique
- Volunteers
- 135 people
- Sponsor
- University Hospital Center of Martinique
Multiple Sclerosis
Serum Neurofilament-light Chain and GFAP Levels in Patients From the OFSEP Cohort at Different Landmarks of Multiple Sclerosis
The investigators hypothesize that serum neurofilament-light chain (NfL) levels can provide information about the level of activity and progression of Multiple Sclerosis at different stages and landmarks of the disease.
- Trial name
- NeurofilMS (NCT03981003)
- Testing
- Blood sample
- Where
- 28 sites in France, Martinique
- Volunteers
- 1,150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Zika Virus Infection on Fetus and Child During the Pregnancy
Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America
The Zika epidemic has spread into the three French Overseas Departments in the Caribbean (DFAs). It is therefore urgent to set up tools to collect clinical and paraclinical data for the evaluation of potential complications due…
- Trial name
- ZIKA-DFA-BB (NCT02810210)
- Testing
- fundus examination, Head ultrasound
- Where
- 6 sites in France, French Guiana and 2 more
- Volunteers
- 1,180 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Gene Mutation-Related Cancer, Genetic Predisposition
COsegregation of VARiants in Panel of Genes
The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling.
- Trial name
- COVAR (NCT01689584)
- Testing
- salivary kit
- Where
- 62 sites in France, Guadeloupe and 3 more
- Volunteers
- 11,000 people
- Sponsor
- Institut Curie
Amyloidosis, Amyloid Cardiomyopathy
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Transthyretin amyloidosis (ATTR) is a disease where the normally occurring transthyretin (TTR) protein falls apart and forms amyloid, a sticky plaque-like substance that accumulates in different organs in the body and can cause…
- Conditions
- Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis, Cardiomyopathies
- Trial name
- NCT06563895
- Testing
- Acoramidis
- Where
- 104 sites in United States, Argentina and 22 more
- Volunteers
- 587 people
- Sponsor
- Eidos Therapeutics, a BridgeBio company
High Risk Prostate Carcinoma, Prostate Cancer
Study Evaluating the Efficacy and Safety of Darolutamide and Stereotactic Dose Escalated Radiotherapy in Patients With Localized Prostate Cancer and High-risk Features of Relapse
PEACE 7 is an international, multicenter, randomized, open-label phase III study that aims at evaluating the efficacy and safety of darolutamide and of stereotactic dose escalated prostate radiotherapy in patients with localised…
- Trial name
- PEACE 7 (NCT06625970)
- Testing
- Darolutamide, Stereotactic Body RadioTherapy (SBRT), ADT (Standard of Care)
- Where
- 6 sites in France, Martinique
- Volunteers
- 700 people
- Sponsor
- UNICANCER
Sepsis
Validation of a Capillary Leak Index During Septic Shock, Based on Haemoglobin Level Variations Induced by Fluid Resuscitation. A Pilot Study.
This study aims to validate a simple and reproducible index of capillary leak (CLI) in septic shock, based on haemoglobin (Hb) variation induced by standardised fluid resuscitation.
- Trial name
- IFC-sepsis (NCT07733206)
- Testing
- TEST GROUP: A standardised fluid bolus of 8 mL/kg of ideal body weight using Ringer's lactate will be administered in septic shock patients., CONTROL GROUP: A standardised fluid bolus of 8 mL/kg of ideal body weight using Ringer's lactate will be administered in non-septic postoperative patients.
- Where
- Martinique
- Volunteers
- 100 people
- Sponsor
- University Hospital Center of Martinique
Multiple Sclerosis
OFSEP High Definition Cohort
For neurologists and patients, it appears that one major unmet need, beside of course a cure to multiple sclerosis (MS), is to better appreciate the causal factors of disease progression, and even to obtain reliable predictive…
- Trial name
- OFSEP HD (NCT03603457)
- Where
- 25 sites in France, Martinique
- Volunteers
- 2,842 people
- Sponsor
- EDMUS Foundation
Post Extubation Respiratory Failure
Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units
In intensive care units (ICUs), around 20% of patients experience respiratory failure after planned extubation. Nearly 40-50% of them eventually require reintubation with subsequently high mortality rates reaching 30-40%.
- Trial name
- VENTILO (NCT05686850)
- Testing
- High-Flow Oxygen, Non invasive ventilation
- Where
- 47 sites in Belgium, France and 3 more
- Volunteers
- 670 people
- Sponsor
- Poitiers University Hospital
Esophageal Atresia
National Register of Oesophageal Atresia
The esophageal atresia is a group of birth defects including a break in continuity of the esophagus with or without persistent communication with the trachea (tracheoesophageal fistula), sometimes associated (from 50%) of other…
- Trial name
- REGATE (NCT02883725)
- Testing
- data collection
- Where
- 37 sites in France, Guadeloupe and 1 more
- Volunteers
- 1,460 people
- Sponsor
- University Hospital, Lille
Prostate Cancer
CHLORDECONE EXPOSURE AND PROSTATE CANCER IN THE FRENCH REGION OF MARTINIIQUE
Prostate cancer is the most common male cancer in industrialized countries, including France, with over 60,000 new cases each year, and represents the third leading cause of cancer-related death in men.
- Trial name
- CHLOECAPA (NCT06773806)
- Where
- 2 sites in Martinique
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Prostate Cancer Metastatic
ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)
This is a Phase III, international, multicentre, randomised, double-blinded placebo controlled trial, evaluating the efficacy and safety of ADT +/- darolutamide in castration-naïve de novo metastatic prostate cancer patients with…
- Trial name
- GETUG-AFU 40 (NCT04916613)
- Testing
- Darolutamide 300 mg, Androgen deprivation therapy
- Where
- 95 sites in Belgium, France and 10 more
- Volunteers
- 300 people
- Sponsor
- UNICANCER
Esophageal Atresia
Long Term Outcome of Easophageal Atresia : Transmics Profiles in Adolescence
Oesophageal atresia (OAEA), a malformation of the oesophagus present from birth, is characterized by the interruption of the continuity of the oesophagus, which then ends in a cul-de-sac.
- Trial name
- TransEAsome (NCT05995171)
- Testing
- Questionnaire
- Where
- 33 sites in France, Martinique and 1 more
- Volunteers
- 300 people
- Sponsor
- University Hospital, Lille
Sudden Cardiac Death, Myocardial Infarction
Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation
Patients who have survived a myocardial infarction (MI) are at increased risk for sudden cardiac death (SCD) caused by ventricular tachycardia and ventricular fibrillation.
- Trial name
- PROFID EHRA (NCT05665608)
- Testing
- Implantable cardioverter-defibrillator (ICD), Optimal Medical Therapy (OMT)
- Where
- 86 sites in Austria, Belgium and 11 more
- Volunteers
- 3,595 people
- Sponsor
- Charite University, Berlin, Germany
Prostate Cancer
Quality of Life in Prostate Cancer Patients
Recording cancer data in cancer registries is essential for producing reliable population-based data for service planning, monitoring and evaluation.
- Trial name
- QoLProstateMQ (NCT04357925)
- Where
- Martinique
- Volunteers
- 304 people
- Sponsor
- University Hospital Center of Martinique
Breast Neoplasms, Quality of Life
Assessment of Quality of Life and Treatment Times for Patients With Invasive Type Breast Cancer in Martinique
Cancer and its treatments can be factors that alter the quality of life of patients. The induced alteration of the quality of life can influence compliance and impact survival.
- Conditions
- Breast Neoplasms, Quality of Life, Survivorship
- Trial name
- Qualibreast-MQ (NCT04918082)
- Testing
- Quality of life questionnaires
- Where
- Martinique
- Volunteers
- 133 people
- Sponsor
- University Hospital Center of Martinique
Stomach Neoplasms, Gastric Neoplasms
Prevalence of Helicobacter Pylori Infection and Gastric Cancer in the West Indies
Estimating the prevalence of Helicobacter Pylori infection in newly diagnosed stomach cancers in the West-Indies will help to understand the epidemiology of this cancer, which is over-incident in the West Indies compared to…
- Conditions
- Stomach Neoplasms, Gastric Neoplasms, Helicobacter Pylori
- Trial name
- Hélico-MQ (NCT04949737)
- Testing
- Helicobacter Pylori detection
- Where
- Martinique
- Volunteers
- 112 people
- Sponsor
- University Hospital Center of Martinique
Prostate Cancer
Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique
In Martinique, prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms.
- Trial name
- HOXB13_Mart (NCT05231915)
- Testing
- HOXB13 c.853delT mutation
- Where
- Martinique
- Volunteers
- 465 people
- Sponsor
- University Hospital Center of Martinique
Hereditary Heart Diseases
Stratification of Arrhythmic Risk and/or Heart Failure Risk in Patients With Hereditary Heart Disease
Sudden cardiac death (SCD) is one of the leading causes of death in developed countries. These deaths (more than 5,000 per year in France) are due to hereditary arrhythmias or cardiomyopathies.
- Trial name
- PREVENT (NCT07257289)
- Where
- 15 sites in France, Martinique and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Nantes University Hospital
Thrombotic Thrombocytopenic Purpura, Acquired
Efficacy of a Personalized Caplacizumab Regimen Based on ADAMTS13 Activity Monitoring in Adult aTTP
The aim of the study is to evaluate the efficacy of a personalized caplacizumab regimen based on ADAMTS13 activity monitoring in adult acquired thrombotic thrombocytopenic purpura (aTTP): This study is a phase II, prospective…
- Trial name
- CAPLAVIE (NCT04720261)
- Testing
- Caplacizumab
- Where
- 24 sites in France, Martinique
- Volunteers
- 58 people
- Sponsor
- University Hospital, Rouen