Clinical trials: completed, in Gabon
Immune Reconstitution Inflammatory Syndrome, Opportunistic Infections
Prediction and Pathogenesis of the Immune Reconstitution Inflammatory Syndrome
The objective of this project is to determine clinical and biological predictors of Immune Reconstitution Inflammatory Syndrome (IRIS) occurrence in HIV infected patients who are started on antiretroviral therapy (ART), and to…
- Trial name
- IRIS (NCT01557803)
- Where
- Gabon
- Volunteers
- 107 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pregnancy, Malaria
Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy
The study aims at comparing the safety, tolerability and efficacy of Mefloquine (MQ) to Sulfadoxine-Pyrimethamine (SP) as Interment Preventive Treatment in pregnancy (IPTp) for the prevention of malaria effects on the mother and…
- Conditions
- Pregnancy, Malaria, HIV Infections
- Trial name
- MiPPAD (NCT00811421)
- Testing
- Sulphadoxine-pyrimethamine, Mefloquine (full dose), Mefloquine (split dose)
- Where
- 5 sites in Benin, Gabon and 3 more
- Volunteers
- 5,820 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Fever, Malaria
Evaluation of 4 Artemisinin-based Combinations for Treating Uncomplicated Malaria in African Children
The main objective is to compare the safety and efficacy of 4 artemisinin-based combinations (ACT) [amodiaquine-artesunate (AQ+AS), dihydroartemisinin-piperaquine (DHAPQ), artemether-lumefantrine (AL) and chlorproguanil/dapsone…
- Trial name
- NCT00393679
- Testing
- amodiaquine-artesunate (ASAQ), dihydroartemisinin-piperaquine (DHAPQ), artemether-lumefantrine (AL)
- Where
- 8 sites in Burkina Faso, Gabon and 5 more
- Volunteers
- 4,112 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Blood Pressure
Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) Trial
The purpose of this study is to compare the blood pressure lowering efficacy of a treatment regimen based on a dihydropyridine calcium-channel blocker combined with an angiotensin II type-1 receptor blocker with the recommended…
- Trial name
- NOAAH (NCT01030458)
- Testing
- amlodipine 5/10 mg per day plus valsartan 160 mg/day, hydrochlorothiazide 6.25 mg/day plus bisoprolol 5/10 mg/day
- Where
- 7 sites in Cameroon, Côte d’Ivoire and 3 more
- Volunteers
- 183 people
- Sponsor
- KU Leuven
Malaria
Efficacy, Safety and Pharmacokinetic of ArtequinTM P. Falciparum Malaria
Treatment of Plasmodium falciparum malaria in Africa is increasingly difficult. Resistance to cheap efficient antimalarial drugs poses an increasing threat.
- Trial name
- NCT00243737
- Testing
- Artesunate-Mefloquine
- Where
- 2 sites in Gabon
- Volunteers
- 70 people
- Sponsor
- Albert Schweitzer Hospital
Intestinal Diseases, Helminthiasis
Efficacy of Albendazole to Treat Intestinal Helminths and Its Effect on Gut Microflora
Albendazole is a main anti-helminth, however there is a lack of data regarding its efficacy in the school children population. The aim of this study is to evaluate the efficacy of the albendazole one versus two and three doses…
- Trial name
- NCT01192802
- Testing
- albendazole
- Where
- Gabon
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Albert Schweitzer Hospital
Urinary Schistosomiasis
Activity of Mefloquine Against Urinary Schistosomiasis
Urinary schistosomiasis is a debilitating disease in Central Africa and pregnant women are frequently suffering from this condition.
- Trial name
- NCT01132248
- Testing
- Mefloquine, S/P
- Where
- 2 sites in Gabon
- Volunteers
- 65 people
- Sponsor
- Albert Schweitzer Hospital
Malaria
Reducing the Effects of Malaria in Children by Administering Repeated Preventive Doses
The general goal of the project is to assess the infectious status and immunity of mothers and children living in a malaria region.
- Trial name
- NCT00167843
- Testing
- sulfadoxine-pyrimethamine
- Where
- Gabon
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Albert Schweitzer Hospital
Acute Non-falciparum Malaria
Treatment of Non-falciparum Malaria
Patients with non-falciparum infection will be given artemether-lumefantrine for three days and will be followed up for 28 days. Besides efficacy and safety evaluations a substudy on immunology will be performed.
- Trial name
- NCT00725777
- Testing
- artemether-lumefantrine
- Where
- Gabon
- Volunteers
- 40 people
- Sponsor
- Albert Schweitzer Hospital
Malaria
Phase II Artesunate Study in Severe Malaria
The primary objective of the study is to evaluate the effectiveness of 2 intravenous artesunate dosing regimens (2.4 mg/kg initially and at 12, 24, 48, and 72 hours or 4.0 mg/kg initially and at 24 and 48 hours) in clearing P.
- Trial name
- NCT00522132
- Testing
- Artesunate
- Where
- 3 sites in Gabon, Malawi
- Volunteers
- 200 people
- Sponsor
- Medicines for Malaria Venture
Malaria
A Comparative Safety and Activity Study With Ferroquine Associated With Artesunate Versus Amodiaquine Associated With Artesunate in African Adult Patients With Uncomplicated Malaria
The primary objective is to assess the safety of different doses of ferroquine with artesunate (AS) in adult African patients with uncomplicated malaria.
- Trial name
- NCT00563914
- Testing
- ferroquine (SSR97193), amodiaquine
- Where
- 2 sites in Gabon, Kenya
- Volunteers
- 72 people
- Sponsor
- Sanofi
Malaria
Efficacy of Fosmidomycin-Clindamycin for Treating Malaria in Gabonese Children
There is a necessity for the development of new malaria drugs. Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effective against malaria, although it cannot…
- Trial name
- NCT00214643
- Testing
- Fosmidomycin, clindamycin
- Where
- Gabon
- Volunteers
- 160 people
- Sponsor
- Albert Schweitzer Hospital, Netherlands
Malaria
Treatment of Malaria in Gabon With Fosmidomycin-Clindamycin
Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effective against malaria, although it cannot achieve a total cure in all patients.
- Trial name
- NCT00217451
- Testing
- Fosmidomycin-clindamycin
- Where
- Gabon
- Volunteers
- 51 people
- Sponsor
- Albert Schweitzer Hospital
Malaria
Treatment of Malaria With Quinine Plus Sulfadoxine-Pyrimethamine
Quinine remains the treatment of choice of hospitalised malaria cases. The long treatment duration of 7 days, and adverse reactions often hamper its adequate use.
- Trial name
- NCT00167739
- Testing
- Quinine plus sulfadoxine-pyrimethamine
- Where
- Gabon
- Volunteers
- 50 people
- Sponsor
- Albert Schweitzer Hospital
Fever
Treatment of Fever Due to Malaria With Ibuprofen
Drugs to treat fever are widely used in children with fever. But there is a controversy about the benefit of reducing fever in children with malaria. Ibuprofen is often used to treat malarial fever.
- Trial name
- NCT00167713
- Testing
- Ibuprofen
- Where
- Gabon
- Volunteers
- 50 people
- Sponsor
- Albert Schweitzer Hospital