Clinical trials: not yet recruiting, in France
Subarachnoid Hemorrhage, Aneurysmal, Brain Ischemia
TicAgreLor Versus Placebo to Prevent Cerebral ISCHemia in anEuRysmal Low Grade SAH A Double Blinded Randomised Controlled Study
Among aneurysmal subarachnoid hemorrhage (aSAH) survivors, ischemic injuries such as peri procedural thromboembolic events (TEE) and delayed cerebral ischemia (DCI) represent the most important disabling complications.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Ischemia, Endovascular Procedure
- Trial name
- TALISCHER-SAH (NCT07821008)
- Testing
- Experimental group: ticagrelor
- Where
- 7 sites in France
- Volunteers
- 274 people
- Sponsor
- University Hospital, Toulouse
Hematologic Cancer, MACE
MACE and BTK Inhibitors
Bruton's tyrosine kinase inhibitors (BTKis) have demonstrated substantial therapeutic efficacy across multiple B-cell malignancies.
- Conditions
- Hematologic Cancer, MACE, BTK Inhibitors
- Trial name
- NCT07923162
- Testing
- ibrutinib, Acalabrutinib, Zanubrutinib
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Caen
Pediatric Acute Respiratory Failure
Regional Lung Ventilation During Prone Position in in Intubated Children
Mechanical ventilation can lead to pulmonary, diaphragmatic, and hemodynamic complications due to an increase in global and regional transpulmonary pressure.
- Trial name
- ChildProne-EIT (NCT07921745)
- Testing
- Thoracic electric impedance tomography to assed regional ventilation, Positive end-expiratory pressure (PEEP) trial titration, Collection of clinical Data
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD (Chronic Obstructive Pulmonary Disease), Sarcopenia in Elderly
The Aim of the Study is to Decipher the Alterations in Signalling Pathways of Skeletal Muscle Stem Cells (Satellite Cells (SCs)) in Individuals With COPD, as Well as to Examine the Effect of Exercise Training on SCs.
The aim of the study is to decipher the alterations in signalling pathways of skeletal muscle stem cells (satellite cells (SCs)) in individuals with COPD, as well as to examine the effect of exercise training on SCs.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Sarcopenia in Elderly, Skeletal Muscle Atrophy, Cachexia-Anorexia Syndrome
- Trial name
- SCOOP (NCT07923656)
- Testing
- Exercise training
- Where
- 3 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Bordeaux
Rectal Cancer, Chemoradiotherapy
Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Treatment
Rectal cancer presents a significant global health challenge. Despite improvements in clinical outcomes, significant disparities persist across Europe.
- Conditions
- Rectal Cancer, Chemoradiotherapy, Mri
- Trial name
- RESTAGE (NCT07404228)
- Testing
- questionnaire completion
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Surgery Ambulatory, ENT Surgery
Feasibility Study of a Conversational Chatbot for Outpatient Postoperative Follow-up in Otorhinolaryngology (ENT): Acceptability, Patterns of Use, and Patient Experience.
Artificial intelligence (AI), and particularly large language models (LLMs), is playing an increasingly important role in medical practice by facilitating documentation, data analysis, and communication with patients.
- Conditions
- Surgery Ambulatory, ENT Surgery, Post Surgical Management
- Trial name
- ORL-CareBOT (NCT07917975)
- Testing
- Post op care evaluation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Smoking Cessation, Lung Cancer Screening
PROMETHEE: A Shared Interregional Tele-Tobacco Cessation Platform Embedded Within the IMPULSION Lung Cancer Screening Program
This prospective observational study aims to evaluate whether an intensive tele-tobacco cessation program delivered through the PROMETHEE platform improves smoking cessation among smokers participating in the French national lung…
- Trial name
- PROMETHEE (NCT07921719)
- Testing
- PROMETHEE Cohort, Control Cohort
- Where
- France
- Volunteers
- 5,400 people
- Sponsor
- Hospices Civils de Lyon
Post-Traumatic Stress Disorder, PTSD
Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic Memories Using Propranolol
Post-traumatic stress disorder (PTSD) develops after life-threatening events, with domestic violence and sexual assault being major risk factors.
- Trial name
- VIOFEM (NCT07792122)
- Testing
- Propranolol, Psychotherapy
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Toulouse
PARKINSON DISEASE (Disorder), Bipolar 1 Disorder
Compulsive Eating and Brain's Reward System in Different Pathologies
Compulsive eating behaviors represent a significant issue across various disorders such as Parkinson's disease, bipolar disorders, and obesity.
- Conditions
- PARKINSON DISEASE (Disorder), Bipolar 1 Disorder, Obesity (BMI>30)
- Trial name
- BI-POTATOS (NCT07923513)
- Testing
- MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Squamous Cell Cancer of Head and Neck (SCCHN)
Tumoral Versus Luminal Microbiome in Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC), France's 5th most common cancer (15,000 annual cases), presents significant public health challenges due to high morbidity and functional/aesthetic sequelae from treatments…
- Trial name
- MIC-VADS (NCT07809100)
- Testing
- Tissue and secretion sampling via biopsy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Sud Francilien
Methicillin-Resistant Staphylococcus Aureus Colonization
Farm-originated Antimicrobial Resistance Modeling: Exploring Humans-to-Animal Dissemination
Antimicrobial resistance is a major public health issue. Methicillin resistance in Staphylococcus aureus (MRSA) is one of the indicators that is monitored particularly closely.
- Trial name
- FARMHAND (NCT07898930)
- Testing
- Sample collection
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Adult Carriers of a Pathogenic or Probably Pathogenic (Class 4 and 5) Germline Variation in the TP53 Gene
Reduce All Avoidable Cancer-promoting Exposures in Individuals at High Genetic Risk of Cancer Carrying a Constitutional Variant of the TP53 Gene
45% of cancer deaths are linked to modifiable factors (behavioral, metabolic). Li-Fraumeni syndrome (LFS), caused by germline TP53 mutations, leads to an extremely high, early-onset cancer risk (≈24× higher than general…
- Trial name
- LIFPREV (NCT07921537)
- Testing
- Single Group Assignment
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
ECMO Cannula Infection, Extracorporeal Membrane Oxygenation Complication
Diagnosis of ECMO Cannula Infection: Prospective Comparison of Sampling Methods
Extracorporeal membrane oxygenation (ECMO) is increasingly used as rescue support in patients with refractory respiratory and/or circulatory failure.
- Trial name
- ECMO-CSI-DIAG (NCT07893639)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
MItochondrial Myopathies
Role of AMPKalpha2 in Myonuclear Accretion in Mitochondrial Myopathies
Mitochondrial cytopathies are a heterogeneous group of rare inherited diseases characterized by primary mitochondrial dysfunction caused by a pathogenic mutation located either in nuclear DNA or mitochondrial DNA.
- Trial name
- MITOMYO (NCT07920562)
- Testing
- Analysis of signaling pathway : AMPK
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Prostate Cancer - Recurrent, Prostate Cancer (Diagnosis)
Analysis of the Performance of PSMA Emission Tomography in Patients With Prostate Cancer Treated With HIFU
There would appear to be a strong interest in functional nuclear imaging for assessing the response to focal PaC treatment. Investigator team hypothesise that the diagnostic performance of PSMA PET is noninferior to that of MRI…
- Trial name
- ECETEP (NCT07766122)
- Testing
- Nuclear imaging (PSMA PET) with intravenous injection of a radiotracer one year after treatment (focal therapy)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Anterior Cruciate Ligament (ACL) Reconstruction Surgery
Nerve Block of the Vastus Medialis and Anterior Obturator Branch in Anterior Cruciate Ligament Reconstruction With DIDT Graft
The goal of this randomized clinical trial is to evaluate whether a targeted regional anesthesia strategy combining an adductor canal block, a nerve to the vastus medialis (NVM) block, an anterior obturator nerve branch block…
- Trial name
- RECUP-NVM (NCT07919756)
- Testing
- Femoral Nerve Block, iPACK Block, Nerve to Vastus Medialis Block
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Hypersensitivity, Food, Legumes Allergy
Observational Study of IgE-Mediated Leguminous Allergies in a Pediatric Population
Prospective, monocentric, observational study with standard care follow-up during 5 years or until the patient reaches the age of 18.
- Trial name
- FabALL (NCT07811141)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Clostridioides Difficile Infection
Epidemiology of Clostridioides Difficile Infection (CDI) in Long-term Care Facilities, Assessment of Professional Practices Related to CDI Risk Prevention, and Strategies for Improving Care.
Clostridioides difficile infection (CDI) is the leading cause of infectious diarrhea among older adults. The epidemiology of community-acquired CDI, particularly among residents of long-term care facilities, remains poorly…
- Trial name
- EpiCE (NCT07920627)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Heart Failure, Cardiac Surgery
Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery
SGLT-2 inhibitors are recommended treatments for managing heart failure patients. In cases of surgery, it is recommended to stop the treatment 3 days before surgery due to the risk of postoperative euglycemic diabetic…
- Trial name
- DISCO (NCT07766109)
- Testing
- treatment discontinuation, treatment continuation, ketone levels
- Where
- France
- Volunteers
- 434 people
- Sponsor
- University Hospital, Toulouse
Acute Ischemic Stroke
Efficacy and Safety Evaluation of iNstroke 5F Aspiration Catheter for Thrombectomy
Prospective, single-arm, multi-centre study to evaluate the efficacy and safety of the iNstroke 5F thromboaspiration catheter in patients with acute ischaemic stroke
- Trial name
- iNFLOW-5 (NCT07571954)
- Testing
- Thromboaspiration catheter
- Where
- 7 sites in France, Spain
- Volunteers
- 45 people
- Sponsor
- iVascular S.L.U.
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