Clinical trials: completed, in France
Intensive Care Psychosis
Follow-up in Pediatric Intensive Care Unit
Background In developed countries, mortality rates in pediatric intensive care units (PICUs) are around 4% and thus, most children admitted to these units survive.
- Trial name
- APRELAREA (NCT06363344)
- Testing
- Questionnaires : PHQ-9 (Kroenke, 2001), the PSC (Sheldrick, 2012), the ASQ-SE (Squires, 2015), the PedsQL (Varni, 1999)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Echocardiography in Intubated Children in Pediatric Intensive Care, Intubation Complication
Estimation of Central Venous Pressure by Echocardiography in Intubated Children in Pediatric Intensive Care
Central venous pressure (CVP) is a parameter used very regularly in pediatric resuscitation units. According to international recommendations, it should be measured during resuscitation of acute circulatory failure, severe head…
- Trial name
- PVCECHO (NCT05195424)
- Testing
- Estimation of central venous pressure by echocardiography in intubated children in pediatric intensive care
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hereditary Angioedema (HAE)
Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of once-daily orally administered deucrictibant extended-release tablet compared to placebo for prophylaxis to…
- Trial name
- CHAPTER-3 (NCT06669754)
- Testing
- Deucrictibant
- Where
- 56 sites in United States, Argentina and 22 more
- Volunteers
- 85 people
- Sponsor
- Pharvaris Netherlands B.V.
Muscle-invasive Bladder Cancer
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
This is a global Phase III, randomized, placebo-controlled, double-blind study designed to evaluate the efficacy and safety of adjuvant treatment with atezolizumab compared with placebo in participants with MIBC who are…
- Trial name
- IMvigor011 (NCT04660344)
- Testing
- Atezolizumab, Signatera
- Where
- 140 sites in United States, Argentina and 21 more
- Volunteers
- 761 people
- Sponsor
- Hoffmann-La Roche
Gastroesophageal Reflux
Jejunal Feeding Via Gastrojejunal Tube in Refractory Gastroesophageal Reflux
Gastroesophageal reflux disease (GERD) in children can be severe and lead to multiple complications, dizziness, esophagitis, respiratory failure or ENT infections.
- Trial name
- ReJej (NCT05278689)
- Testing
- No intervention
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn Disease
Management of Moderate POstoperative Recurrence in Crohn's Disease: a randoMizEd contROLled Trial of Therapeutic Escalation, the POMEROL Trial. (POMEROL)
Study type : A 30 months, multicentre, open-label strategic randomized controlled trial Population : Chron's Disease (CD) patients with an i2 endoscopic postoperative recurrence in the year following ileocolonic resection…
- Trial name
- POMEROL (NCT05072782)
- Testing
- Infliximab CT-P13, Immunosuppressors (Thiopurines or Methotrexate)
- Where
- France
- Volunteers
- 213 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Amyotrophic Lateral Sclerosis
ALS Phase II Study of NX210c
This study will investigate the efficacy, safety, tolerability and pharmacokinetics (PK) of multiple intravenous infusions of NX210c, at two dose levels, in patients with Amyotrophic lateral sclerosis (ALS).
- Trial name
- SEALS (NCT06365216)
- Testing
- NX210c
- Where
- 16 sites in France
- Volunteers
- 83 people
- Sponsor
- Axoltis Pharma
Aortic Aneurysm, Aortic Aneurysm Abdominal
Evaluation of the iCover Stent as a Bridging Stent in Fenestrated Endovascular Aneurysm Repair (fEVAR) for Complex Aortic Aneurysms.
ReiCo is a French retrospective, multicenter, single-arm study focused on assessing the safety and clinical performance of the iCover balloon-expandable covered stent (iVascular) when implanted as a bridging stent during fEVAR…
- Trial name
- ReiCo (NCT07742254)
- Where
- 3 sites in France
- Volunteers
- 154 people
- Sponsor
- iVascular S.L.U.
Arthritis, Rheumatoid
Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders
Rheumatoid arthritis (RA) is the most common inflammatory rheumatoid disease in France, affecting 0.3% of the general population.
- Trial name
- SUNSTAR (NCT03227419)
- Testing
- Tocilizumab Prefilled Syringe, Abatacept Prefilled Syringe
- Where
- 26 sites in France
- Volunteers
- 224 people
- Sponsor
- Lille Catholic University
Airway Management, Tracheal Extubation
Interest of Tracheal Extubation in Positive Pressure on Postoperative Oxygenation in Adult Digestive Surgery
Evaluation of a postoperative tracheal extubation protocol under positive pressure in accordance with international recommendations.
- Conditions
- Airway Management, Tracheal Extubation, Postoperative Respiratory Complications, Postoperative Hypoxemia
- Trial name
- ExPress (NCT04381949)
- Testing
- positive pressure extubation
- Where
- France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Rouen
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)
A Phase 2/3 Study of Evorpacept (ALX148) in Combination With Trastuzumab, Ramucirumab, and Paclitaxel in Patients With Advanced HER2-overexpressing gastric/GEJ adenocarcinoma.
- Conditions
- Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Gastric Adenocarcinoma
- Trial name
- NCT05002127
- Testing
- Evorpacept (ALX148), Trastuzumab, Ramucirumab
- Where
- 83 sites in United States, Australia and 10 more
- Volunteers
- 127 people
- Sponsor
- ALX Oncology Inc.
Traumatic Brain Injury
Neurorehabilitation After Traumatic Brain Injury: Functional Magnetic Resonance Imaging Study
The current study aims to better understand cerebral plasticity mechanisms to optimize non-pharmacological rehabilitation approaches for patients with traumatic brain injury.
- Trial name
- RemCog-TC (NCT02698449)
- Testing
- transcranial direct current stimulation, Specific cognitive rehabilitation, Nonspecific cognitive rehabilitation
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Toulouse
Dementia
Dementia in Long Term Care Facilities: Telemedicine for the Management of Neuropsychiatric Symptoms
Telemedicine may facilitate adequate treatment of Neuropsychiatric symptoms (NPS) by identifying underlying causes and tailoring a treatment plan (pharmacological or non-pharmacologic treatments including provision of staff…
- Trial name
- DETECT (NCT02472015)
- Testing
- telemedicine
- Where
- 2 sites in France
- Volunteers
- 143 people
- Sponsor
- University Hospital, Toulouse
Hidradenitis Suppurativa (HS)
A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa (HS)
The purpose of this study is to evaluate the efficacy and safety of Povorcitinib (INCB054707) in participants with moderate to severe Hidradenitis Suppurativa (HS) over a 12-week placebo-controlled period, followed by a 42-week…
- Trial name
- STOP-HS2 (NCT05620836)
- Testing
- Povorcitinib
- Where
- 101 sites in United States, Australia and 9 more
- Volunteers
- 619 people
- Sponsor
- Incyte Corporation
Brain Metastases, Diffuse Gliomas
Preclinical Brain Tumor Models
Background: Primary or secondary brain tumors (metastases) remain associated with a very poor prognosis linked to significant therapeutic resistance.
- Trial name
- HITCH (NCT06045065)
- Testing
- Fresh tumor sampling
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Angioplasty, Peripheral Arterial Disease
Safety and Effectiveness Evaluation of iCover Covered Stent for the Treatment of the Aorto-iliac Occlusive Disease
The objective of this prospective, multi-center, non-randomized, single-arm observational study is to evaluate the safety and the efficacy of the iCover covered stent over a 24-month follow-up period for the treatment of de novo…
- Conditions
- Angioplasty, Peripheral Arterial Disease, Iliac Artery Disease, Covered Stent
- Trial name
- iliCo (NCT05192616)
- Testing
- Covered stent implantation
- Where
- 18 sites in Belgium, France and 2 more
- Volunteers
- 241 people
- Sponsor
- iVascular S.L.U.
Hematologic Neoplasms
Assistance Program for Outpatients Following an Allogeneic Hematopoietic Stem-cell Transplant
After the initial monitoring period during hospitalization and isolation, patients with recent transplants are regularly monitored in monthly consultations but are still fragile, immunosuppressed and undergoing many treatments.
- Trial name
- AMA-ALLO (NCT04323605)
- Testing
- Outpatient assistance program for transplant patients (AMA-ALLO) based on a "navigation" nurse
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Meningioma, Tumor, Brain
MiDura-Study (Neuro-Patch in Duraplasty)
The aim of this study is to collect systematically and proactively data regarding the performance of Neuro-Patch, like complications and handling, under daily clinical practice when used as intended by the manufacturer
- Conditions
- Meningioma, Tumor, Brain, Chiari Malformation, Vascular Malformation
- Trial name
- MiDura (NCT04189172)
- Where
- 4 sites in France, Germany
- Volunteers
- 328 people
- Sponsor
- Aesculap AG
Falling
Preserving Autonomy Through Foot Health: a Study on the Acceptability of a Program Including Various Workshops for the Elderly
Every year in France, 2 million falls by people over 65 are responsible for 10,000 deaths, the leading cause of accidental death, and more than 130,000 hospitalizations.
- Trial name
- MINIPAS (NCT06421623)
- Testing
- Program Including Various Workshops aiming to preserve elderly's autonomy through foot health
- Where
- 5 sites in France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Emile Roux
Non-Muscle Invasive Bladder Cancer
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)
The goal of the study is to learn about the safety of Sacituzumab Tirumotecan and if people can tolerate it when given in the bladder and find the highest dose that people can take without having certain problems.
- Trial name
- TroFuse-027 (NCT06637423)
- Testing
- Sacituzumab tirumotecan, Rescue medication, Supportive care measures
- Where
- 13 sites in United States, Canada and 4 more
- Volunteers
- 35 people
- Sponsor
- Merck Sharp & Dohme LLC
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