Clinical trials: completed, in Ethiopia
Anaemia
Triple Outcome Evaluation of Red Teff Intervention for Infant Anemia, Environmental Health, and Economic Feasibility in Ethiopia: A Self-controlled Pre-post Study
Background. Childhood anemia affects more than 40% of under-five children in Ethiopia, where iron supplementation has achieved limited success and locally grounded, sustainable strategies are needed.
- Trial name
- NCT07912697
- Testing
- Red teff (Eragrostis teff) porridge
- Where
- Ethiopia
- Volunteers
- 32 people
- Sponsor
- Debre Markos University
Peer Support Intervention
Effect of a Peer Support Intervention on Glycemic Control and Economic Burden Among Patients With Diabetes
Diabetes imposes a growing global burden due to rising care costs and reduced quality of life from its complications. Managing the disease remains challenging for many patients, highlighting the need for effective, scalable…
- Trial name
- PSI (NCT07499375)
- Testing
- Peer led educational intervention program
- Where
- Ethiopia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Addis Ababa University
Immunohematology
Molecular Immunohematology in Ethiopian Sub-Populations
Alloimmunization to blood products in transfused patients is a recognized management challenge in the clinical setting. In particular the ethnic and racial specificity of RBC antigens and the limited availability of matched…
- Trial name
- NCT01282021
- Where
- Ethiopia
- Volunteers
- 95 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV-related Stigma, Psychological Wellbeing
Digital Peer-support-based Anti-HIV Stigma Intervention Among Adolescents Living With HIV in Ethiopia
Advances in HIV care and treatment turned a once deadly disease into a chronic condition where people living with HIV, including perinatally HIV acquired children, can now lead a healthy life and live longer with their highly…
- Conditions
- HIV-related Stigma, Psychological Wellbeing, Retention in Care
- Trial name
- NCT07425925
- Testing
- Peer support based digital anti-HIV stigma intervention, A standard in-clinic in-person psychosocial support
- Where
- 5 sites in Ethiopia
- Volunteers
- 239 people
- Sponsor
- Lund University
Diarrhea, Stunting
Effect of Water, Sanitation and Hygiene Educational Intervention on Incidence of Diarrhea and Childhood Stunting Among Under Five Children in Bule Hora Wereda, Southern Ethiopia
Background: Childhood malnutrition and diarrhea remains life-threatening, yet these conditions are preventable. Water, Sanitation, and Hygiene (WASH) interventions are among the most effective measures against diarrhea and…
- Conditions
- Diarrhea, Stunting, Children Under 5 Years
- Trial name
- NCT07867860
- Testing
- WASH Education Intervention
- Where
- Ethiopia
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Bule Hora University
Postoperative Care, Complications of Surgical Procedures or Medical Care
Prevalence of Post Anesthesia Care Unit Complications and Associated Factors
The post-anesthesia care unit (PACU) is a crucial component of the surgical process, providing patients with vital support and monitoring as they recover from anesthesia.
- Conditions
- Postoperative Care, Complications of Surgical Procedures or Medical Care, Inpatients, Ethiopia
- Trial name
- NCT06815510
- Testing
- Questionnaire and Physical Exam
- Where
- 4 sites in Ethiopia, Spain
- Volunteers
- 1,778 people
- Sponsor
- Ángel Becerra-Bolaños, MD PhD
Chronic Low-back Pain
Feasibility of an Interprofessional Rehabilitation Program for Chronic Low Back Patients in the Ethiopian Health Setting
The overall aim of this pilot RCT is to assess the feasibility of conducting a future definitive randomized control trial (RCT) for evaluating the effectiveness of an interprofessional rehabilitation program compared to the usual…
- Trial name
- IRP (NCT05866146)
- Testing
- Interprofessional rehabilitation program, Usual standard care
- Where
- Ethiopia
- Volunteers
- 40 people
- Sponsor
- Sintayehu Wami
Visceral Leishmaniasis
Evaluation of Less Invasive Procedures for Visceral Leishmaniasis Treatment Efficacy Monitoring Test of Cure
Left untreated, visceral leishmaniasis (VL) is fatal. The highest burden of VL worldwide is in eastern Africa where field-adapted diagnostic and test-of-cure tools and treatment are lacking.
- Trial name
- VL-ToC (NCT05426577)
- Testing
- ELISA, LAMP, Cytokine Release Assay
- Where
- Ethiopia
- Volunteers
- 60 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Palliative Care
Effectiveness and Implementation of the DINKNESH Digital Palliative Care Tool in Ethiopia
The goal of this clinical trial is to learn if a digital health app called DINKNESH is effective for palliative care identification compared to traditional paper-based assessment tools.
- Trial name
- NCT07574281
- Testing
- DINKNESH App, Paper based tool
- Where
- Ethiopia
- Volunteers
- 1,152 people
- Sponsor
- Addis Ababa University
HIV-1-infection, Antiretroviral Therapy
HIV Transmission in the Era of Scaling up Antiretroviral Therapy in Ethiopia
The goal of this observational study is to understand patterns of HIV transmission in a high-prevalence area in Ethiopia, and to compare viral genetic information in people with HIV who are newly diagnosed and have not been…
- Trial name
- THESA (NCT05652400)
- Testing
- Exposure to antiretroviral therapy
- Where
- Ethiopia
- Volunteers
- 2,200 people
- Sponsor
- Lund University
Upper Respiratory Infection, Lower Resp Tract Infection
Holistic Approach Supporting the Uptake of Innovative Diagnostic Technologies for Respiratory Infections
This observational diagnostic validation study aims to evaluate the clinical performance of novel lateral flow and microfluidic-based technologies for the detection of upper and lower respiratory tract infections in children and…
- Trial name
- HOLICARE (NCT07651865)
- Where
- 3 sites in Ethiopia, Senegal and 1 more
- Volunteers
- 1,765 people
- Sponsor
- Karolinska Institutet
Folate Deficiency, Vitamin B 12 Deficiency
Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls
Folic acid and vitamin B12 play an interdependent role in key cellular processes, namely deoxyribonucleic acid synthesis, cell division, red blood cell formation, and nervous system myelination.
- Conditions
- Folate Deficiency, Vitamin B 12 Deficiency, Anemia, Megaloblastic, Cognitive Development
- Trial name
- NCT06100146
- Testing
- Folic acid and vitamin B12 fortified flour, Unfortified cereal flour
- Where
- 2 sites in Ethiopia
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- University Ghent
Small for Gestational Age at Delivery, Gestational Weight Gain
BEP Targeting Strategies in Ethiopia
The goal of this randomized effectiveness study is to evaluate the different targeting strategies for the delivery of balanced energy and protein (BEP) supplements among pregnant women in Addis Ababa, Ethiopia.
- Conditions
- Small for Gestational Age at Delivery, Gestational Weight Gain, Stillbirth, Preterm Birth
- Trial name
- BEP (NCT06125860)
- Testing
- Targeted BEP based on baseline nutritional status, Targeted BEP based on baseline nutritional status and monthly GWG monitoring, Universal BEP
- Where
- Ethiopia
- Volunteers
- 7,851 people
- Sponsor
- Harvard School of Public Health (HSPH)
Malaria Vivax
Efficacy of Chloroquine-Primaquine Treatment for Uncomplicated Plasmodium Vivax Malaria
The study was designed to evaluate the current efficacy of this combination therapy against P. vivax, given the possibility of misuse or inadequate adherence to the regimen due to its lengthy treatment duration, in one of a…
- Trial name
- CQ-PQ (NCT07753967)
- Testing
- CQ-PQ
- Where
- Ethiopia
- Volunteers
- 192 people
- Sponsor
- Jimma University
Athletic Injuries
Machine Learning-Guided Training for Elite Athletes (MLGT)
Plaintext The purpose of this study is to evaluate whether a personalized training protocol driven by machine learning can successfully reduce time-loss sports injuries and enhance athletic performance in elite athletes.
- Trial name
- MLGT (NCT07683091)
- Testing
- Adaptive Machine Learning Workload Optimization
- Where
- 2 sites in Ethiopia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Debre Berhan University
Prenatal Exposure Delayed Effects
Nutrition and Inflammation in Pregnancy: Impacts on Early Human Brain Development in Ethiopia
The goal of this observational child follow-up study is to examine the effects of prenatal nutrition and infection management interventions on long-term child neurodevelopment.
- Trial name
- NCT06296238
- Where
- Ethiopia
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- Brown University
Maternal Behavior
Evaluation of Prototype Solutions for Optimizing Maternal Health Behaviors
This study is a three-year implementation research project that aims to develop and test the effectiveness and acceptability of interventions to promote three outcomes: institutional delivery, antenatal care, and iron-folic acid…
- Trial name
- NCT05907720
- Testing
- Human-centered design prototype solutions for vulnerable pregnant women
- Where
- Ethiopia
- Volunteers
- 1,468 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Trachoma
Sanitation, Water, and Instruction in Face-washing for Trachoma I/II
SWIFT I is a series of 3 cluster-randomized trials designed to assess several alternative strategies for trachoma control in communities that have been treated with many years of mass azithromycin distributions.
- Trial name
- SWIFT I/II (NCT02754583)
- Testing
- Water, sanitation, and hygiene (WASH) intervention, Standard of care WASH intervention, Azithromycin
- Where
- Ethiopia
- Volunteers
- 47,605 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diarrheal Diseases
Effects of Multiple Interventions on Under-Five Diarrhea
Diarrhea is the leading cause of death, especially in developed nations. Though there are effective interventions, diarrhea remains the leading cause of death among children in Ethiopia
- Trial name
- NCT07158632
- Testing
- handwashing education, water chlorination, combined intervention
- Where
- Ethiopia
- Volunteers
- 835 people
- Sponsor
- Jimma University
Post Partum Depression
Prevalence and Determinant Factors of Postpartum Depression Among Mothers Visiting Postnatal and Immunization Clinics in Selected Public Health Institutions, Mekelle, Tigray
This study looks at depression among mothers after childbirth (also called postpartum depression) in Mekelle City, Tigray, Ethiopia.
- Trial name
- NCT07563712
- Where
- Ethiopia
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- Mekelle University