Clinical trials: in Ethiopia
HIV-related Stigma, Psychological Wellbeing
Digital Peer-support-based Anti-HIV Stigma Intervention Among Adolescents Living With HIV in Ethiopia
Advances in HIV care and treatment turned a once deadly disease into a chronic condition where people living with HIV, including perinatally HIV acquired children, can now lead a healthy life and live longer with their highly…
- Conditions
- HIV-related Stigma, Psychological Wellbeing, Retention in Care
- Trial name
- NCT07425925
- Testing
- Peer support based digital anti-HIV stigma intervention, A standard in-clinic in-person psychosocial support
- Where
- 5 sites in Ethiopia
- Volunteers
- 239 people
- Sponsor
- Lund University
Hepatitis B
Decentralization of Hepatitis B Care in Sub-Saharan Africa: a Pilot Program in Ethiopia
The goal of this observational study is to study models of care for decentralized hepatitis B treatment in Ethiopia. Three different models of decentralized HBV care (standard model, simplified model, test-and-treat model) will…
- Trial name
- NCT06586983
- Testing
- Tenofovir Disoproxil Fumarate
- Where
- Ethiopia
- Volunteers
- 4,500 people
- Sponsor
- Oslo University Hospital
Immunohematology
Molecular Immunohematology in Ethiopian Sub-Populations
Alloimmunization to blood products in transfused patients is a recognized management challenge in the clinical setting. In particular the ethnic and racial specificity of RBC antigens and the limited availability of matched…
- Trial name
- NCT01282021
- Where
- Ethiopia
- Volunteers
- 95 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cutaneous Leishmaniasis
Feasibility of Integrating Thermotherapy for Treatment of Cutaneous Leishmaniasis in Primary Health Care Setup
This study will look at how feasible it is to use thermotherapy (TT) as a treatment for skin(cutaneous) leishmaniasis (CL) in health centers in the Sodo and South Sodo districts, Ethiopia.
- Trial name
- TTCL (NCT06746350)
- Testing
- Thermotherapy
- Where
- Ethiopia
- Volunteers
- 103 people
- Sponsor
- Armauer Hansen Research Institute, Ethiopia
Diarrhea, Stunting
Effect of Water, Sanitation and Hygiene Educational Intervention on Incidence of Diarrhea and Childhood Stunting Among Under Five Children in Bule Hora Wereda, Southern Ethiopia
Background: Childhood malnutrition and diarrhea remains life-threatening, yet these conditions are preventable. Water, Sanitation, and Hygiene (WASH) interventions are among the most effective measures against diarrhea and…
- Conditions
- Diarrhea, Stunting, Children Under 5 Years
- Trial name
- NCT07867860
- Testing
- WASH Education Intervention
- Where
- Ethiopia
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Bule Hora University
Major Depressive Disorder (MDD)
Prescribing the Right Agent for Depression in Adults
Depression is a common mental health problem affecting almost 300 million people worldwide. Antidepressants are recommended as one of the first line treatments for people with moderate-to-severe symptoms of depression.
- Trial name
- PRADA (NCT07796295)
- Testing
- PRADA Tool, PETRUSHKA Tool
- Where
- 3 sites in Ethiopia, Pakistan and 1 more
- Volunteers
- 2,142 people
- Sponsor
- University of Oxford
Patient Safety, Patient Safety Education
Patient Safety Competency-Building Program for Healthcare Professionals in Pediatric Cardiac Critical Care in Ethiopia
This study aims to develop and evaluate a patient safety competency-building program for healthcare professionals involved in pediatric cardiac critical care in Ethiopia.
- Trial name
- NCT07844369
- Testing
- Patient Safety Competency-Building Program
- Where
- Ethiopia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Woong-Han Kim
Dietary Intake, Sexual and Reproductive Health
Advancing Female University Students' Health Through Mobile Technology in Ethiopia
Background: Female university students in Ethiopia experience a high burden of sexual and reproductive health, nutrition, and psychosocial problems, exacerbated by limited access to essential health services and support.
- Conditions
- Dietary Intake, Sexual and Reproductive Health, Psychosocial Wellbeing
- Trial name
- EMPOWER (NCT07746791)
- Testing
- Behavioural change intervention will be provided through mobile application, Routine care
- Where
- Ethiopia
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Bahir Dar University
Postoperative Care, Complications of Surgical Procedures or Medical Care
Prevalence of Post Anesthesia Care Unit Complications and Associated Factors
The post-anesthesia care unit (PACU) is a crucial component of the surgical process, providing patients with vital support and monitoring as they recover from anesthesia.
- Conditions
- Postoperative Care, Complications of Surgical Procedures or Medical Care, Inpatients, Ethiopia
- Trial name
- NCT06815510
- Testing
- Questionnaire and Physical Exam
- Where
- 4 sites in Ethiopia, Spain
- Volunteers
- 1,778 people
- Sponsor
- Ángel Becerra-Bolaños, MD PhD
Tuberculosis, Pulmonary
Digital Health Intervention to Improve TPT Uptake
Despite the evidence of the prevention and control measures of tuberculosis (TB), it still has an impact on the health, social, and economic aspects of the population.
- Trial name
- DHiTPT (NCT07313995)
- Testing
- Digital health intervention
- Where
- 14 sites in Ethiopia
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Arba Minch University
Plasmodium Vivax Malaria Without Complication, Plasmodium Falciparum Malaria (Uncomplicated)
Ethiopian Antimalarial Therapeutic Efficacy Study 2026
Background: The WHO recommends monitoring the efficacy of antimalarial drugs at least once every two years after implementation.
- Trial name
- TES2026 (NCT07840898)
- Testing
- Artemether-Lumefantrine + Primaquine and Chloroquine + Primaquine
- Where
- Ethiopia
- Volunteers
- 1,200 people
- Sponsor
- Ethiopian Public Health Institute
Acute Malnutrition, Severe, Malnutrition, Child
Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia
The R-SWITCH intervention aims to address the low coverage of treatment for severe wasting (SAM) by leveraging existing community groups to deliver an integrated package focused on prevention, screening, referral, and treatment…
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06380504)
- Testing
- R-SWITCH integrated intervention package
- Where
- Ethiopia
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Chronic Low-back Pain
Feasibility of an Interprofessional Rehabilitation Program for Chronic Low Back Patients in the Ethiopian Health Setting
The overall aim of this pilot RCT is to assess the feasibility of conducting a future definitive randomized control trial (RCT) for evaluating the effectiveness of an interprofessional rehabilitation program compared to the usual…
- Trial name
- IRP (NCT05866146)
- Testing
- Interprofessional rehabilitation program, Usual standard care
- Where
- Ethiopia
- Volunteers
- 40 people
- Sponsor
- Sintayehu Wami
Malaria Vivax, Malaria Falciparum
Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar
The resilience of P. vivax to malaria elimination efforts is due to its ability to form dormant liver stages (hypnozoites) that reactivate weeks to months after the initial infection causing recurrent episodes of malaria…
- Conditions
- Malaria Vivax, Malaria Falciparum, Plasmodium Vivax, Plasmodium Falciparum
- Trial name
- PvSTATEM (NCT06923592)
- Testing
- PvSeroTAT, Control
- Where
- 2 sites in Ethiopia, Madagascar
- Volunteers
- 19,200 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Visceral Leishmaniasis
Evaluation of Less Invasive Procedures for Visceral Leishmaniasis Treatment Efficacy Monitoring Test of Cure
Left untreated, visceral leishmaniasis (VL) is fatal. The highest burden of VL worldwide is in eastern Africa where field-adapted diagnostic and test-of-cure tools and treatment are lacking.
- Trial name
- VL-ToC (NCT05426577)
- Testing
- ELISA, LAMP, Cytokine Release Assay
- Where
- Ethiopia
- Volunteers
- 60 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Palliative Care
Effectiveness and Implementation of the DINKNESH Digital Palliative Care Tool in Ethiopia
The goal of this clinical trial is to learn if a digital health app called DINKNESH is effective for palliative care identification compared to traditional paper-based assessment tools.
- Trial name
- NCT07574281
- Testing
- DINKNESH App, Paper based tool
- Where
- Ethiopia
- Volunteers
- 1,152 people
- Sponsor
- Addis Ababa University
Perinatal Depression, Social Support
Midwife-led Cognitive Behavioral Intervention for Perinatal Depression. Multisite RCT
Perinatal depression(PND), or depression during pregnancy and within one year following childbirth, is the most burdensome maternal mental illness. Women in low-income countries like Ethiopia have suffered from the disease.
- Conditions
- Perinatal Depression, Social Support, Perceived Stress
- Trial name
- NCT07800299
- Testing
- Midwife-led Cognitive Behaviroal Intervention
- Where
- 3 sites in Ethiopia
- Volunteers
- 192 people
- Sponsor
- The Hong Kong Polytechnic University
Malaria Fever
Non-invasive Malaria Diagnostic Data Collection in Ethiopia
This project supports the development of a non-invasive diagnostic tool for malaria, focusing on validating the link between VOCs (volatile organic compounds) and malaria infection using thermodynamic sensors.
- Trial name
- NCT07456969
- Where
- Ethiopia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
HIV-1-infection, Antiretroviral Therapy
HIV Transmission in the Era of Scaling up Antiretroviral Therapy in Ethiopia
The goal of this observational study is to understand patterns of HIV transmission in a high-prevalence area in Ethiopia, and to compare viral genetic information in people with HIV who are newly diagnosed and have not been…
- Trial name
- THESA (NCT05652400)
- Testing
- Exposure to antiretroviral therapy
- Where
- Ethiopia
- Volunteers
- 2,200 people
- Sponsor
- Lund University
Pregnancy Related, Tuberculosis Infection
Effects of Tuberculosis Infection on Development and Function of the Placenta
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on…
- Conditions
- Pregnancy Related, Tuberculosis Infection, Placenta Diseases
- Trial name
- NCT06352970
- Testing
- TB infection
- Where
- Ethiopia
- Volunteers
- 500 people
- Sponsor
- Lund University